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The map label for this gene is AvtA [H]

Identifier: 20806822

GI number: 20806822

Start: 316997

End: 318163

Strand: Direct

Name: AvtA [H]

Synonym: TTE0301

Alternate gene names: 20806822

Gene position: 316997-318163 (Clockwise)

Preceding gene: 20806821

Following gene: 20806823

Centisome position: 11.79

GC content: 40.1

Gene sequence:

>1167_bases
ATGAACTTTGAAGACAGGATTGCCAAAAGAGCAAAGGCCATAGAAATATCCACAATTAGGTATTTTTTTAACATGGCTAG
AGAAGTTGAAGGGGCGATTTCTCTTGCCATTGGAGAGCCAGATTTTATAACACCAGAGCACATAAGAAATGCGGCAAAAA
AGGCTTTAGATGAGGGCATGACAGGGTACACTGTGAACGCAGGACTCATTGAGCTTAGAAGAGAAATTGCAGATTATCTA
AAAAGAAGGTATAGCCTATATTATGACCCTGAAAAAGAAATTTTAGTTACAATAGGGGCTACAGAAGCAATATATGTAAC
TTTAAGCACCTTGGCAGAAGAAGGGGACGAAGTGCTAATACCAGAACCCTCTTTTGTAGCTTATCATCCCTGCACTGTTA
TAGCTGGAGCAAAATCAGTTTTTGTTCCTACTTATGAAGAAGACGACTTTATATTAAGAGCAGATGTGCTGGAAAAATAT
ATAACCGAAAGGTCAAAAGTCTTGATATTACCCTATCCAAACAATCCTACAGGAGCAGTAATGCCAAAAGAGGCTTTAGA
GGAGATAGCCAAAGTAGTAGAAAAACATGACCTTATTGTAGTAACAGATGAGATTTACTCCGAATTGGTATACGGTGGAT
TTAAGCATACAAGTTTTGCCTCCCTGCCTGGCATGTGGGAAAGAACTATTACCATTAACGGATTTTCAAAATCCTACGCT
ATGACGGGATGGCGTCTCGGGTATATAGCTGCTCCTGAGCATTTTACCAAACATATAGCTAAACTTCATCAATACGCTGT
TACAGCTGCGGCTACAATGTGTCAGTATGCGGGAATTGAGGCTATGAGAAATGGGGATGAGGATATAATAAAAATGAGAG
AAGAATATGACAAGAGGAGAAAGTTCTTACTTGAAAGCGTAAGGGAGATGGGGCTTTCCTGTTTTGAGCCTAAAGGGGCA
TTTTATATATTCCCATCGATAAAAACTACAGGGCTTACATCAATGGAATTTGCAAAAAGGCTTCTTTATGAGGCGAAAGT
TGCAGTTGTGCCGGGCAATGCCTTTGGGGAACATGGAGAAGGGTATGTGCGGCTGGCCTATGCCACATCAATGGAAAACT
TAGAAGAAGCGGTAAAGAGGATGAAAGAATTTATGGCAAAACTTTAA

Upstream 100 bases:

>100_bases
ACCTGCCTTCTTGGCGGGTAATTTTTTTATTTTTAAAGGATTTTTAGTATTTTTGTAGAAGTATAATAGTAGAAATTTTT
ATAAGACAGGGGGATTAGAA

Downstream 100 bases:

>100_bases
AAGGGGGTGACTCCTTTATTTTTTTGGCAAAATAATAGTTTACTTTTGCCACAATTCTATTGAAAAATGTTAAGCTTTTC
ATTATCATAGAAGTATAATA

Product: PLP-dependent aminotransferase

Products: NA

Alternate protein names: AspAT; Transaminase A [H]

Number of amino acids: Translated: 388; Mature: 388

Protein sequence:

>388_residues
MNFEDRIAKRAKAIEISTIRYFFNMAREVEGAISLAIGEPDFITPEHIRNAAKKALDEGMTGYTVNAGLIELRREIADYL
KRRYSLYYDPEKEILVTIGATEAIYVTLSTLAEEGDEVLIPEPSFVAYHPCTVIAGAKSVFVPTYEEDDFILRADVLEKY
ITERSKVLILPYPNNPTGAVMPKEALEEIAKVVEKHDLIVVTDEIYSELVYGGFKHTSFASLPGMWERTITINGFSKSYA
MTGWRLGYIAAPEHFTKHIAKLHQYAVTAAATMCQYAGIEAMRNGDEDIIKMREEYDKRRKFLLESVREMGLSCFEPKGA
FYIFPSIKTTGLTSMEFAKRLLYEAKVAVVPGNAFGEHGEGYVRLAYATSMENLEEAVKRMKEFMAKL

Sequences:

>Translated_388_residues
MNFEDRIAKRAKAIEISTIRYFFNMAREVEGAISLAIGEPDFITPEHIRNAAKKALDEGMTGYTVNAGLIELRREIADYL
KRRYSLYYDPEKEILVTIGATEAIYVTLSTLAEEGDEVLIPEPSFVAYHPCTVIAGAKSVFVPTYEEDDFILRADVLEKY
ITERSKVLILPYPNNPTGAVMPKEALEEIAKVVEKHDLIVVTDEIYSELVYGGFKHTSFASLPGMWERTITINGFSKSYA
MTGWRLGYIAAPEHFTKHIAKLHQYAVTAAATMCQYAGIEAMRNGDEDIIKMREEYDKRRKFLLESVREMGLSCFEPKGA
FYIFPSIKTTGLTSMEFAKRLLYEAKVAVVPGNAFGEHGEGYVRLAYATSMENLEEAVKRMKEFMAKL
>Mature_388_residues
MNFEDRIAKRAKAIEISTIRYFFNMAREVEGAISLAIGEPDFITPEHIRNAAKKALDEGMTGYTVNAGLIELRREIADYL
KRRYSLYYDPEKEILVTIGATEAIYVTLSTLAEEGDEVLIPEPSFVAYHPCTVIAGAKSVFVPTYEEDDFILRADVLEKY
ITERSKVLILPYPNNPTGAVMPKEALEEIAKVVEKHDLIVVTDEIYSELVYGGFKHTSFASLPGMWERTITINGFSKSYA
MTGWRLGYIAAPEHFTKHIAKLHQYAVTAAATMCQYAGIEAMRNGDEDIIKMREEYDKRRKFLLESVREMGLSCFEPKGA
FYIFPSIKTTGLTSMEFAKRLLYEAKVAVVPGNAFGEHGEGYVRLAYATSMENLEEAVKRMKEFMAKL

Specific function: Unknown

COG id: COG0436

COG function: function code E; Aspartate/tyrosine/aromatic aminotransferase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI95147551, Length=417, Percent_Identity=28.7769784172662, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI169881279, Length=417, Percent_Identity=28.7769784172662, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI56713256, Length=409, Percent_Identity=28.8508557457213, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI56713254, Length=409, Percent_Identity=28.8508557457213, Blast_Score=187, Evalue=2e-47,
Organism=Homo sapiens, GI169881281, Length=305, Percent_Identity=28.8524590163934, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI4507369, Length=382, Percent_Identity=26.4397905759162, Blast_Score=121, Evalue=1e-27,
Organism=Homo sapiens, GI215599424, Length=402, Percent_Identity=24.8756218905473, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI19263340, Length=402, Percent_Identity=24.8756218905473, Blast_Score=87, Evalue=3e-17,
Organism=Homo sapiens, GI4885351, Length=373, Percent_Identity=25.7372654155496, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI187936925, Length=358, Percent_Identity=25.1396648044693, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI14211921, Length=358, Percent_Identity=25.1396648044693, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1788722, Length=377, Percent_Identity=33.42175066313, Blast_Score=211, Evalue=5e-56,
Organism=Escherichia coli, GI1786816, Length=359, Percent_Identity=28.133704735376, Blast_Score=173, Evalue=2e-44,
Organism=Escherichia coli, GI1788627, Length=360, Percent_Identity=28.6111111111111, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1787909, Length=360, Percent_Identity=23.3333333333333, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI1790797, Length=338, Percent_Identity=23.9644970414201, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1787710, Length=304, Percent_Identity=24.0131578947368, Blast_Score=75, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71994472, Length=423, Percent_Identity=28.8416075650118, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71994476, Length=419, Percent_Identity=28.6396181384248, Blast_Score=156, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17567369, Length=395, Percent_Identity=29.1139240506329, Blast_Score=152, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17567663, Length=374, Percent_Identity=27.2727272727273, Blast_Score=131, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI71981209, Length=369, Percent_Identity=25.2032520325203, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322401, Length=391, Percent_Identity=28.1329923273657, Blast_Score=132, Evalue=1e-31,
Organism=Saccharomyces cerevisiae, GI6320317, Length=350, Percent_Identity=25.7142857142857, Blast_Score=102, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6323118, Length=386, Percent_Identity=25.6476683937824, Blast_Score=90, Evalue=7e-19,
Organism=Drosophila melanogaster, GI28573069, Length=412, Percent_Identity=26.9417475728155, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI24646114, Length=412, Percent_Identity=26.9417475728155, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI28573067, Length=412, Percent_Identity=26.9417475728155, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI28573065, Length=412, Percent_Identity=26.9417475728155, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI18859735, Length=390, Percent_Identity=27.6923076923077, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24641770, Length=401, Percent_Identity=27.1820448877805, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24641760, Length=401, Percent_Identity=27.1820448877805, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24641768, Length=401, Percent_Identity=27.1820448877805, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24641766, Length=401, Percent_Identity=27.1820448877805, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24641764, Length=401, Percent_Identity=27.1820448877805, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI45551451, Length=401, Percent_Identity=27.1820448877805, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI21356535, Length=375, Percent_Identity=22.6666666666667, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001176
- InterPro:   IPR004839
- InterPro:   IPR004838
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.1 [H]

Molecular weight: Translated: 43846; Mature: 43846

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00105 AA_TRANSFER_CLASS_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFEDRIAKRAKAIEISTIRYFFNMAREVEGAISLAIGEPDFITPEHIRNAAKKALDEGM
CCHHHHHHHHHHHEEHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHCCC
TGYTVNAGLIELRREIADYLKRRYSLYYDPEKEILVTIGATEAIYVTLSTLAEEGDEVLI
CCEEECHHHHHHHHHHHHHHHHHHCEEECCCCEEEEEECCCCEEEEEHHHHHHCCCEEEC
PEPSFVAYHPCTVIAGAKSVFVPTYEEDDFILRADVLEKYITERSKVLILPYPNNPTGAV
CCCCEEEECCEEEEECCCEEEEECCCCCCEEEEHHHHHHHHCCCCCEEEEECCCCCCCCC
MPKEALEEIAKVVEKHDLIVVTDEIYSELVYGGFKHTSFASLPGMWERTITINGFSKSYA
CCHHHHHHHHHHHHHCCEEEEEHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCC
MTGWRLGYIAAPEHFTKHIAKLHQYAVTAAATMCQYAGIEAMRNGDEDIIKMREEYDKRR
CCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHH
KFLLESVREMGLSCFEPKGAFYIFPSIKTTGLTSMEFAKRLLYEAKVAVVPGNAFGEHGE
HHHHHHHHHCCCEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHCEEEEECCCCCCCCCC
GYVRLAYATSMENLEEAVKRMKEFMAKL
CEEEEEEHHCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNFEDRIAKRAKAIEISTIRYFFNMAREVEGAISLAIGEPDFITPEHIRNAAKKALDEGM
CCHHHHHHHHHHHEEHHHHHHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHCCC
TGYTVNAGLIELRREIADYLKRRYSLYYDPEKEILVTIGATEAIYVTLSTLAEEGDEVLI
CCEEECHHHHHHHHHHHHHHHHHHCEEECCCCEEEEEECCCCEEEEEHHHHHHCCCEEEC
PEPSFVAYHPCTVIAGAKSVFVPTYEEDDFILRADVLEKYITERSKVLILPYPNNPTGAV
CCCCEEEECCEEEEECCCEEEEECCCCCCEEEEHHHHHHHHCCCCCEEEEECCCCCCCCC
MPKEALEEIAKVVEKHDLIVVTDEIYSELVYGGFKHTSFASLPGMWERTITINGFSKSYA
CCHHHHHHHHHHHHHCCEEEEEHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCC
MTGWRLGYIAAPEHFTKHIAKLHQYAVTAAATMCQYAGIEAMRNGDEDIIKMREEYDKRR
CCCEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHHHHHH
KFLLESVREMGLSCFEPKGAFYIFPSIKTTGLTSMEFAKRLLYEAKVAVVPGNAFGEHGE
HHHHHHHHHCCCEEECCCCCEEEECCCCCCCCCHHHHHHHHHHHCEEEEECCCCCCCCCC
GYVRLAYATSMENLEEAVKRMKEFMAKL
CEEEEEEHHCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12622808 [H]