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The map label for this gene is GlcD [H]

Identifier: 20806747

GI number: 20806747

Start: 230080

End: 231489

Strand: Direct

Name: GlcD [H]

Synonym: TTE0224

Alternate gene names: 20806747

Gene position: 230080-231489 (Clockwise)

Preceding gene: 20806746

Following gene: 20806748

Centisome position: 8.55

GC content: 38.01

Gene sequence:

>1410_bases
GTGTATAATAAGCTGACAAATGAAATTGTAGAAGAGCTTAAAAAGATAGTTGGCACTAATAACGTTATATACGACGACCC
TGATGCATTAGAAGCTTATTCCCATGATGAAGTAGCAGAAAAACATTACGCCCATATGCCGGAAGCTGTTGTAAAACCTT
CGTCGGCAGAAGAAATAGCACGAATAATGAAGCTAGCAAACAAATACAAAATCCCTATTACGCCTAGAGGTGCTGGTAGT
GGCCTTTCTGGTGGAGCAGTACCTGTATACGGTGGGATTGTGTTATCTGTTGAAAGGATGAATAGAATTCTTGAAATAGA
TAAAGAAAATCTAGTAGTAGTTGTTGAACCTGGAGTTGTGACGAATGAGATTAATAATGCTGTTAAAGAATATGGCCTAT
TTTATGCAGGATATCCTATGAGTGTAGAAACCTGCTATATAGGTGGAAATGTTGCAGAAAATGCTGGAGGTGGAAGGGCT
GTAAAATACGGAGTCACTGGAAGATATGTAATAGGTTTAGAAGTGGTAACTCCAACAGGGGATATTGTTCACCTTGGAGG
GAAGGTGATGAAAGATGTTACAGGATATGACCTTATCCACCTTATGGTAGGTTCTGAAGGTACACTTGGAATATTTACAA
AGATATACCTTAAACTTATGCCACTCCCTCAAGCAAAGGTAGATCTACTGGTGCTGTTTCATGATATGGATACTGCTATT
AAAGTAGTGCCTAAGATCATGACATTTGGCAGAATAATTCCTACCTCAATAGAATTTATGGATGACTTATCATTTAAGGC
AGCATGTAAATATCTCAATGAAAAGATACCCTTTGAAGAAGCAGGAGCAATGCTTTTAATAGAACTTGACGGAAACAATA
AGACAGAATTAGAAGAGCAGTATGAAATTATAGGAAACTTGTGCATGGAAAATGGCGCAATAGAGGTGTATGTTGCTGAT
AATGCCACAACTTCAGAGAGAATATGGAGAATAAGGCGGAATATTGCGGAAGCTTGGAAACAGTTTAGTCCTCATCAAAG
TCTAGAGGATGTTGTAGTTCCTATATCTGAAATTCCTACTTTTCTCAAAAAAATAAGGGAAATTTCAAACAAATACAGAG
TACCTATTCCGTGTTATGGGCATGCAGGAGATGGAAATATCCACGCAACTCCCATAAAGCCGCCAGAACTTTCTATGGAA
GAGTGGCATGAAAAGCTCGAGAAACTTCTTGAAGAAATGTATGTTGTAGTAAAGGAGTTGGGCGGTGTAATAAGCGGTGA
ACACGGTATAGGGCATAAGAGAAAAAAATATCTTCCATTAGTATTGGAACCAGCGCATATAGAGATGATGAGAGCTATAA
AAAAGGCTTTAGATCCAGATCTTATACTTAATCCTGGGAAGATAATATAA

Upstream 100 bases:

>100_bases
AATATTTAAAATTGCTGATCTAGGCATAGTAGGAGACCTACATCAGGTAGTTCCATTGCTTATAGAAAAGATAAAGGAAT
ACAAGAAAGAGGCGAGGTAA

Downstream 100 bases:

>100_bases
AACTATATTGACAAAACTAAATAAATATGGTATAATTAGAGGGGATTTGTATATTCAAATAGCCACAATATAAAAGAAGG
GAGGTATACAAAAATTTACA

Product: FAD/FMN-containing dehydrogenase

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 469; Mature: 469

Protein sequence:

>469_residues
MYNKLTNEIVEELKKIVGTNNVIYDDPDALEAYSHDEVAEKHYAHMPEAVVKPSSAEEIARIMKLANKYKIPITPRGAGS
GLSGGAVPVYGGIVLSVERMNRILEIDKENLVVVVEPGVVTNEINNAVKEYGLFYAGYPMSVETCYIGGNVAENAGGGRA
VKYGVTGRYVIGLEVVTPTGDIVHLGGKVMKDVTGYDLIHLMVGSEGTLGIFTKIYLKLMPLPQAKVDLLVLFHDMDTAI
KVVPKIMTFGRIIPTSIEFMDDLSFKAACKYLNEKIPFEEAGAMLLIELDGNNKTELEEQYEIIGNLCMENGAIEVYVAD
NATTSERIWRIRRNIAEAWKQFSPHQSLEDVVVPISEIPTFLKKIREISNKYRVPIPCYGHAGDGNIHATPIKPPELSME
EWHEKLEKLLEEMYVVVKELGGVISGEHGIGHKRKKYLPLVLEPAHIEMMRAIKKALDPDLILNPGKII

Sequences:

>Translated_469_residues
MYNKLTNEIVEELKKIVGTNNVIYDDPDALEAYSHDEVAEKHYAHMPEAVVKPSSAEEIARIMKLANKYKIPITPRGAGS
GLSGGAVPVYGGIVLSVERMNRILEIDKENLVVVVEPGVVTNEINNAVKEYGLFYAGYPMSVETCYIGGNVAENAGGGRA
VKYGVTGRYVIGLEVVTPTGDIVHLGGKVMKDVTGYDLIHLMVGSEGTLGIFTKIYLKLMPLPQAKVDLLVLFHDMDTAI
KVVPKIMTFGRIIPTSIEFMDDLSFKAACKYLNEKIPFEEAGAMLLIELDGNNKTELEEQYEIIGNLCMENGAIEVYVAD
NATTSERIWRIRRNIAEAWKQFSPHQSLEDVVVPISEIPTFLKKIREISNKYRVPIPCYGHAGDGNIHATPIKPPELSME
EWHEKLEKLLEEMYVVVKELGGVISGEHGIGHKRKKYLPLVLEPAHIEMMRAIKKALDPDLILNPGKII
>Mature_469_residues
MYNKLTNEIVEELKKIVGTNNVIYDDPDALEAYSHDEVAEKHYAHMPEAVVKPSSAEEIARIMKLANKYKIPITPRGAGS
GLSGGAVPVYGGIVLSVERMNRILEIDKENLVVVVEPGVVTNEINNAVKEYGLFYAGYPMSVETCYIGGNVAENAGGGRA
VKYGVTGRYVIGLEVVTPTGDIVHLGGKVMKDVTGYDLIHLMVGSEGTLGIFTKIYLKLMPLPQAKVDLLVLFHDMDTAI
KVVPKIMTFGRIIPTSIEFMDDLSFKAACKYLNEKIPFEEAGAMLLIELDGNNKTELEEQYEIIGNLCMENGAIEVYVAD
NATTSERIWRIRRNIAEAWKQFSPHQSLEDVVVPISEIPTFLKKIREISNKYRVPIPCYGHAGDGNIHATPIKPPELSME
EWHEKLEKLLEEMYVVVKELGGVISGEHGIGHKRKKYLPLVLEPAHIEMMRAIKKALDPDLILNPGKII

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=474, Percent_Identity=32.4894514767932, Blast_Score=237, Evalue=2e-62,
Organism=Homo sapiens, GI37595754, Length=497, Percent_Identity=30.9859154929577, Blast_Score=228, Evalue=1e-59,
Organism=Homo sapiens, GI119964728, Length=478, Percent_Identity=28.6610878661088, Blast_Score=197, Evalue=2e-50,
Organism=Homo sapiens, GI4501993, Length=233, Percent_Identity=31.7596566523605, Blast_Score=116, Evalue=5e-26,
Organism=Escherichia coli, GI1789351, Length=427, Percent_Identity=36.2997658079625, Blast_Score=254, Evalue=8e-69,
Organism=Escherichia coli, GI1787977, Length=546, Percent_Identity=24.9084249084249, Blast_Score=148, Evalue=8e-37,
Organism=Escherichia coli, GI48994907, Length=493, Percent_Identity=26.9776876267748, Blast_Score=115, Evalue=9e-27,
Organism=Escherichia coli, GI48994914, Length=139, Percent_Identity=35.2517985611511, Blast_Score=77, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71992373, Length=465, Percent_Identity=30.1075268817204, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI71992381, Length=465, Percent_Identity=28.8172043010753, Blast_Score=192, Evalue=4e-49,
Organism=Caenorhabditis elegans, GI17534361, Length=430, Percent_Identity=28.3720930232558, Blast_Score=183, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI71992392, Length=385, Percent_Identity=29.3506493506493, Blast_Score=166, Evalue=4e-41,
Organism=Caenorhabditis elegans, GI17556096, Length=224, Percent_Identity=27.6785714285714, Blast_Score=100, Evalue=2e-21,
Organism=Saccharomyces cerevisiae, GI6320023, Length=482, Percent_Identity=30.9128630705394, Blast_Score=212, Evalue=8e-56,
Organism=Saccharomyces cerevisiae, GI6320764, Length=480, Percent_Identity=28.9583333333333, Blast_Score=193, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6320027, Length=478, Percent_Identity=26.3598326359833, Blast_Score=172, Evalue=1e-43,
Organism=Drosophila melanogaster, GI18921117, Length=481, Percent_Identity=33.6798336798337, Blast_Score=223, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24639277, Length=481, Percent_Identity=33.6798336798337, Blast_Score=223, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24639275, Length=481, Percent_Identity=33.6798336798337, Blast_Score=223, Evalue=3e-58,
Organism=Drosophila melanogaster, GI24653753, Length=227, Percent_Identity=29.9559471365639, Blast_Score=113, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 52040; Mature: 52040

Theoretical pI: Translated: 5.51; Mature: 5.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYNKLTNEIVEELKKIVGTNNVIYDDPDALEAYSHDEVAEKHYAHMPEAVVKPSSAEEIA
CCCHHHHHHHHHHHHHHCCCCEEECCCHHHHHCCCHHHHHHHHHHCCHHHCCCCCHHHHH
RIMKLANKYKIPITPRGAGSGLSGGAVPVYGGIVLSVERMNRILEIDKENLVVVVEPGVV
HHHHHHCCCCCCCCCCCCCCCCCCCCCEECCCEEEEHHHHHHHHEECCCCEEEEECCCCC
TNEINNAVKEYGLFYAGYPMSVETCYIGGNVAENAGGGRAVKYGVTGRYVIGLEVVTPTG
HHHHHHHHHHHCCEEECCCCEEEEEEECCCCCCCCCCCCEEEECCCCEEEEEEEEECCCC
DIVHLGGKVMKDVTGYDLIHLMVGSEGTLGIFTKIYLKLMPLPQAKVDLLVLFHDMDTAI
CEEECCCHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHH
KVVPKIMTFGRIIPTSIEFMDDLSFKAACKYLNEKIPFEEAGAMLLIELDGNNKTELEEQ
HHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHCCCHHHCCCEEEEEECCCCCCHHHHH
YEIIGNLCMENGAIEVYVADNATTSERIWRIRRNIAEAWKQFSPHQSLEDVVVPISEIPT
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHH
FLKKIREISNKYRVPIPCYGHAGDGNIHATPIKPPELSMEEWHEKLEKLLEEMYVVVKEL
HHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
GGVISGEHGIGHKRKKYLPLVLEPAHIEMMRAIKKALDPDLILNPGKII
CCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHCCCCEECCCCCCC
>Mature Secondary Structure
MYNKLTNEIVEELKKIVGTNNVIYDDPDALEAYSHDEVAEKHYAHMPEAVVKPSSAEEIA
CCCHHHHHHHHHHHHHHCCCCEEECCCHHHHHCCCHHHHHHHHHHCCHHHCCCCCHHHHH
RIMKLANKYKIPITPRGAGSGLSGGAVPVYGGIVLSVERMNRILEIDKENLVVVVEPGVV
HHHHHHCCCCCCCCCCCCCCCCCCCCCEECCCEEEEHHHHHHHHEECCCCEEEEECCCCC
TNEINNAVKEYGLFYAGYPMSVETCYIGGNVAENAGGGRAVKYGVTGRYVIGLEVVTPTG
HHHHHHHHHHHCCEEECCCCEEEEEEECCCCCCCCCCCCEEEECCCCEEEEEEEEECCCC
DIVHLGGKVMKDVTGYDLIHLMVGSEGTLGIFTKIYLKLMPLPQAKVDLLVLFHDMDTAI
CEEECCCHHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHH
KVVPKIMTFGRIIPTSIEFMDDLSFKAACKYLNEKIPFEEAGAMLLIELDGNNKTELEEQ
HHHHHHHHHCCCCCCHHHHHHCCCHHHHHHHHHHCCCHHHCCCEEEEEECCCCCCHHHHH
YEIIGNLCMENGAIEVYVADNATTSERIWRIRRNIAEAWKQFSPHQSLEDVVVPISEIPT
HHHHHHHHHCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHHHCCHHHHHH
FLKKIREISNKYRVPIPCYGHAGDGNIHATPIKPPELSMEEWHEKLEKLLEEMYVVVKEL
HHHHHHHHHHCCCCCCCCCCCCCCCCEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
GGVISGEHGIGHKRKKYLPLVLEPAHIEMMRAIKKALDPDLILNPGKII
CCCCCCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]