Click here to switch to the map view.

The map label for this gene is murQ

Identifier: 20806738

GI number: 20806738

Start: 218608

End: 219528

Strand: Direct

Name: murQ

Synonym: TTE0212

Alternate gene names: 20806738

Gene position: 218608-219528 (Clockwise)

Preceding gene: 20806737

Following gene: 20806739

Centisome position: 8.13

GC content: 40.28

Gene sequence:

>921_bases
ATGACGCTAGAGGAATTAATAACCGAAGGAAGAAATCCAAACACTATGGATATAGATAGACTTAGCACCGTTGATATGCT
TAAAAAGATCAACGAAGAGGACAAGAAAGTGCCACTTGCAGTGGAGAAAGTTATACCTTCTATAGCTGAAGCGATTGACA
GAATCGTACCGAGGATGAAAAAAGGAGGGCGCCTTATATACGTTGGAGCCGGTACAAGTGGGCGTATTGGTATTTTGGAT
GCTTCCGAATGCCCTCCTACCTTTGGGGTAGACCCTGGACTGGTGGTAGGGATAATAGCAGGTGGAGATAGTGCAATAAG
AAATGCAATAGAGAGCGCAGAAGACGATGTAGAAGGGGGGAGGCAGGACCTTGTAAATATAAATTTGACAGAGCGAGATA
GTGTAATAGGTATATCTGCTAGTGGCAGGACGCCTTATGTCATAGGAGCTTTAAGATATGCTAAAGAGGTAGGAGCCCTT
ACAATAGGATTATTCTGCAATGAAAATAAAAATGTTGAAAACATAGTAGATGTGATGATTACTCCAATAGTGGGTCCAGA
GGTTATAATGGGTTCTACTCGAATGAAGGCCGGTACTGCCCAAAAACTTGTGCTGAACATGATTTCTACAGGAGTAATGA
TAAAGCTTGGGAAAGTTTATAGTAATTTAATGGTAGACCTTCAAGCCAGCAACGAAAAATTGAGAGAAAGAGCAAGGCGG
ATGGTAAAATTGGCTACTGGTGCAAAGGAGGACTTGATAGAGAGAGTTCTTAATGAAACAAATTATAATGTAAAATTGGC
AATTTTAATGATAGTAGGAGATATGGAGAAAGAAAAAGCTCAAAAGCTTTTGGAGATGGCGGACGGATATATAGCAGAGG
CGATTAAGCTAAAAGATTTAGTTTTACAAGGAGAGGAATAA

Upstream 100 bases:

>100_bases
CAAAAAAAGTATAACGACGTAGTCAGATATCTTGAAAACACCAGTGAAGTGCTATCTATGCGCAAAATAAATAATTAAAT
CAAAGAAAGGACTGGGTTTA

Downstream 100 bases:

>100_bases
ATTATGAGTTTTAATCTTTCGAAGTTGGAAAAGGCTTTTATGTTATTGGATAAAGGGATAGAAGAAGGAGTATTTCCAGG
AGTTGCGGCAGCAGTAGGTG

Product: N-acetylmuramic acid-6-phosphate etherase

Products: NA

Alternate protein names: MurNAc-6-P etherase; N-acetylmuramic acid 6-phosphate hydrolase; N-acetylmuramic acid 6-phosphate lyase

Number of amino acids: Translated: 306; Mature: 305

Protein sequence:

>306_residues
MTLEELITEGRNPNTMDIDRLSTVDMLKKINEEDKKVPLAVEKVIPSIAEAIDRIVPRMKKGGRLIYVGAGTSGRIGILD
ASECPPTFGVDPGLVVGIIAGGDSAIRNAIESAEDDVEGGRQDLVNINLTERDSVIGISASGRTPYVIGALRYAKEVGAL
TIGLFCNENKNVENIVDVMITPIVGPEVIMGSTRMKAGTAQKLVLNMISTGVMIKLGKVYSNLMVDLQASNEKLRERARR
MVKLATGAKEDLIERVLNETNYNVKLAILMIVGDMEKEKAQKLLEMADGYIAEAIKLKDLVLQGEE

Sequences:

>Translated_306_residues
MTLEELITEGRNPNTMDIDRLSTVDMLKKINEEDKKVPLAVEKVIPSIAEAIDRIVPRMKKGGRLIYVGAGTSGRIGILD
ASECPPTFGVDPGLVVGIIAGGDSAIRNAIESAEDDVEGGRQDLVNINLTERDSVIGISASGRTPYVIGALRYAKEVGAL
TIGLFCNENKNVENIVDVMITPIVGPEVIMGSTRMKAGTAQKLVLNMISTGVMIKLGKVYSNLMVDLQASNEKLRERARR
MVKLATGAKEDLIERVLNETNYNVKLAILMIVGDMEKEKAQKLLEMADGYIAEAIKLKDLVLQGEE
>Mature_305_residues
TLEELITEGRNPNTMDIDRLSTVDMLKKINEEDKKVPLAVEKVIPSIAEAIDRIVPRMKKGGRLIYVGAGTSGRIGILDA
SECPPTFGVDPGLVVGIIAGGDSAIRNAIESAEDDVEGGRQDLVNINLTERDSVIGISASGRTPYVIGALRYAKEVGALT
IGLFCNENKNVENIVDVMITPIVGPEVIMGSTRMKAGTAQKLVLNMISTGVMIKLGKVYSNLMVDLQASNEKLRERARRM
VKLATGAKEDLIERVLNETNYNVKLAILMIVGDMEKEKAQKLLEMADGYIAEAIKLKDLVLQGEE

Specific function: Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate

COG id: COG2103

COG function: function code R; Predicted sugar phosphate isomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 SIS domain

Homologues:

Organism=Escherichia coli, GI1788768, Length=295, Percent_Identity=56.9491525423729, Blast_Score=339, Evalue=1e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): MURQ_THETN (Q8RD35)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_621909.1
- ProteinModelPortal:   Q8RD35
- SMR:   Q8RD35
- GeneID:   996617
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE0212
- NMPDR:   fig|273068.3.peg.882
- HOGENOM:   HBG703490
- OMA:   EDNTEQG
- ProtClustDB:   PRK05441
- BioCyc:   TTEN273068:TTE0212-MONOMER
- HAMAP:   MF_00068
- InterPro:   IPR005486
- InterPro:   IPR005488
- InterPro:   IPR001347
- TIGRFAMs:   TIGR00274

Pfam domain/function: PF01380 SIS

EC number: NA

Molecular weight: Translated: 33209; Mature: 33078

Theoretical pI: Translated: 4.85; Mature: 4.85

Prosite motif: PS01272 GCKR; PS51464 SIS

Important sites: ACT_SITE 83-83 ACT_SITE 114-114

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTLEELITEGRNPNTMDIDRLSTVDMLKKINEEDKKVPLAVEKVIPSIAEAIDRIVPRMK
CCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KGGRLIYVGAGTSGRIGILDASECPPTFGVDPGLVVGIIAGGDSAIRNAIESAEDDVEGG
CCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCC
RQDLVNINLTERDSVIGISASGRTPYVIGALRYAKEVGALTIGLFCNENKNVENIVDVMI
CHHEEEEEEECCCCEEEEECCCCCCEEHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHH
TPIVGPEVIMGSTRMKAGTAQKLVLNMISTGVMIKLGKVYSNLMVDLQASNEKLRERARR
CCCCCCHHEECCCCCCCCHHHHHHHHHHHCCHHEEHHHHHHHHEEEEECCHHHHHHHHHH
MVKLATGAKEDLIERVLNETNYNVKLAILMIVGDMEKEKAQKLLEMADGYIAEAIKLKDL
HHHHHCCCHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHH
VLQGEE
HCCCCC
>Mature Secondary Structure 
TLEELITEGRNPNTMDIDRLSTVDMLKKINEEDKKVPLAVEKVIPSIAEAIDRIVPRMK
CHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHH
KGGRLIYVGAGTSGRIGILDASECPPTFGVDPGLVVGIIAGGDSAIRNAIESAEDDVEGG
CCCEEEEEECCCCCCEEEEECCCCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCC
RQDLVNINLTERDSVIGISASGRTPYVIGALRYAKEVGALTIGLFCNENKNVENIVDVMI
CHHEEEEEEECCCCEEEEECCCCCCEEHHHHHHHHHHCCEEEEEEECCCCCHHHHHHHHH
TPIVGPEVIMGSTRMKAGTAQKLVLNMISTGVMIKLGKVYSNLMVDLQASNEKLRERARR
CCCCCCHHEECCCCCCCCHHHHHHHHHHHCCHHEEHHHHHHHHEEEEECCHHHHHHHHHH
MVKLATGAKEDLIERVLNETNYNVKLAILMIVGDMEKEKAQKLLEMADGYIAEAIKLKDL
HHHHHCCCHHHHHHHHHHCCCCCEEEEEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHH
VLQGEE
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336