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The map label for this gene is LysA [H]

Identifier: 20806736

GI number: 20806736

Start: 216281

End: 217624

Strand: Direct

Name: LysA [H]

Synonym: TTE0210

Alternate gene names: 20806736

Gene position: 216281-217624 (Clockwise)

Preceding gene: 20806735

Following gene: 20806737

Centisome position: 8.04

GC content: 36.24

Gene sequence:

>1344_bases
ATGTTTTACAACTCTATAAAAGTAAATTCCAAGGGTCATTTAGTTATAGGTGGTTGTGATGCAGTAGAACTTGCTGAGAG
ATTTGGAACTCCTCTTTATGTAATAGATGAGGATGTACTCAGAGCCAATTCCAGAATCTTTTACAATGCATTAAAAAGCC
ACAACCCTGAAAATGAAGTGGTTTATGCAGGAAAAGCTTTTTTAACTACAGCTATGTGCAAAATAATACAGCAAGAAGGA
TTAGGACTTGATGTAGTATCAGGAGGAGAGCTGTATACTGCATTAAAAGCTGGTTTTCCGACAGAAAAGATTTATTTCCA
CGGGAATAACAAATCTGAAGAAGAGCTAATTATGGCTCTACAAAGTGAAGTCGGCAGGATAATTATTGATAATTGGGATG
AATTAGAACTTTTAGAAATTTTGGCAAAGAAGTTAAACAAAGAACCGGCAATCTATATAAGAGTTACGCCTGGGATAGAA
GCTCATACACACAGATATATAATGACAGGGCAGATAGACTCAAAGTTCGGCTTTACTATTTCTAACGGAGAAGCTTTTAA
AGCAGTAAAGAGAGCTTTAACCTCAGGAAGTTTAAAATTTAAAGGACTGCACTGCCATATAGGATCTCAAATATTGGAAT
CTACTCCTTATAAAATTGCAGTGAAAATCATGTTAGAGCTTTTAAAGGAAATAAAAGACACTTTAGGAAGAGGAGTAGAG
GAATTAGATTTAGGTGGAGGCTTTGGAATCCCATATGTGGAAGATGATAGTTACCAGCCAGTTGAAGAAATGCTAAGGGA
CATATTAGAGGAATTGGAGGCCCAAGTAAGTCTTCTTAAAATAAAACTACCAAAAATTATTGTGGAACCGGGAAGAGCAA
TTATAGGAAATACTGGTATTACTCTTTATAAAGTAGGAGGAGTAAAGGAAATACCTGGTGTGAGGAAATATGTTTTTGTA
GATGGCGGCATGTCAGATAATATTAGGACTGCTCTTTACGGTGCAAGGTATTCTGCTGTGATTGCAAATAGGGTATATAA
TGGACGTTTGGAAAAAGTAACAATTGCTGGGAAACTTTGCGAGTCAGGCGATGTAATTATATGGGATATTTTGCTACCTG
AAGTGAAAAAAGGAGATATAATTGCTGTACTTAATACAGGAGCGTATGGGTATTCTATGGCAAGCAATTACAATAGATTG
CCAAAACCTGCTGTGATTTTGGTTTCAAAAGGGAAAGCAGAGATTATTGTAAAAAGAGAGACATATGAGGATGTAATAAA
AAATGATGTAATACCAGAAAGGCTAGAGGAGAAGTTCCAAGGGCGGGAAATGCAAGCAATATGA

Upstream 100 bases:

>100_bases
TTTTATAAAGGTCGCTGGAACATTTCTCAACGACAAACATATAGATGTTTTAAGAATCGCTATAGAGGAACTGAAATAGG
GATTTAAGGGGGAATAAAAA

Downstream 100 bases:

>100_bases
ATCCTATTATAATGTTTATGAAGTAAAACTACACATTTTTTTAAAATTTAAGAAGGAATTTTACAACTTACGTCGAATAT
ATATATTAACAAGAAAGAGA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MFYNSIKVNSKGHLVIGGCDAVELAERFGTPLYVIDEDVLRANSRIFYNALKSHNPENEVVYAGKAFLTTAMCKIIQQEG
LGLDVVSGGELYTALKAGFPTEKIYFHGNNKSEEELIMALQSEVGRIIIDNWDELELLEILAKKLNKEPAIYIRVTPGIE
AHTHRYIMTGQIDSKFGFTISNGEAFKAVKRALTSGSLKFKGLHCHIGSQILESTPYKIAVKIMLELLKEIKDTLGRGVE
ELDLGGGFGIPYVEDDSYQPVEEMLRDILEELEAQVSLLKIKLPKIIVEPGRAIIGNTGITLYKVGGVKEIPGVRKYVFV
DGGMSDNIRTALYGARYSAVIANRVYNGRLEKVTIAGKLCESGDVIIWDILLPEVKKGDIIAVLNTGAYGYSMASNYNRL
PKPAVILVSKGKAEIIVKRETYEDVIKNDVIPERLEEKFQGREMQAI

Sequences:

>Translated_447_residues
MFYNSIKVNSKGHLVIGGCDAVELAERFGTPLYVIDEDVLRANSRIFYNALKSHNPENEVVYAGKAFLTTAMCKIIQQEG
LGLDVVSGGELYTALKAGFPTEKIYFHGNNKSEEELIMALQSEVGRIIIDNWDELELLEILAKKLNKEPAIYIRVTPGIE
AHTHRYIMTGQIDSKFGFTISNGEAFKAVKRALTSGSLKFKGLHCHIGSQILESTPYKIAVKIMLELLKEIKDTLGRGVE
ELDLGGGFGIPYVEDDSYQPVEEMLRDILEELEAQVSLLKIKLPKIIVEPGRAIIGNTGITLYKVGGVKEIPGVRKYVFV
DGGMSDNIRTALYGARYSAVIANRVYNGRLEKVTIAGKLCESGDVIIWDILLPEVKKGDIIAVLNTGAYGYSMASNYNRL
PKPAVILVSKGKAEIIVKRETYEDVIKNDVIPERLEEKFQGREMQAI
>Mature_447_residues
MFYNSIKVNSKGHLVIGGCDAVELAERFGTPLYVIDEDVLRANSRIFYNALKSHNPENEVVYAGKAFLTTAMCKIIQQEG
LGLDVVSGGELYTALKAGFPTEKIYFHGNNKSEEELIMALQSEVGRIIIDNWDELELLEILAKKLNKEPAIYIRVTPGIE
AHTHRYIMTGQIDSKFGFTISNGEAFKAVKRALTSGSLKFKGLHCHIGSQILESTPYKIAVKIMLELLKEIKDTLGRGVE
ELDLGGGFGIPYVEDDSYQPVEEMLRDILEELEAQVSLLKIKLPKIIVEPGRAIIGNTGITLYKVGGVKEIPGVRKYVFV
DGGMSDNIRTALYGARYSAVIANRVYNGRLEKVTIAGKLCESGDVIIWDILLPEVKKGDIIAVLNTGAYGYSMASNYNRL
PKPAVILVSKGKAEIIVKRETYEDVIKNDVIPERLEEKFQGREMQAI

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Escherichia coli, GI1789203, Length=417, Percent_Identity=27.8177458033573, Blast_Score=146, Evalue=3e-36,
Organism=Caenorhabditis elegans, GI17562780, Length=379, Percent_Identity=23.7467018469657, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24586472, Length=401, Percent_Identity=24.4389027431421, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24586474, Length=388, Percent_Identity=25.7731958762887, Blast_Score=72, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 49580; Mature: 49580

Theoretical pI: Translated: 6.21; Mature: 6.21

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFYNSIKVNSKGHLVIGGCDAVELAERFGTPLYVIDEDVLRANSRIFYNALKSHNPENEV
CCCCEEEECCCCCEEEECCCHHHHHHHHCCCEEEECHHHHHCCCHHEEHHHHCCCCCCCE
VYAGKAFLTTAMCKIIQQEGLGLDVVSGGELYTALKAGFPTEKIYFHGNNKSEEELIMAL
EEECHHHHHHHHHHHHHHCCCCEEEECCCCEEEHHHCCCCCCEEEEECCCCCHHHHHHHH
QSEVGRIIIDNWDELELLEILAKKLNKEPAIYIRVTPGIEAHTHRYIMTGQIDSKFGFTI
HHHCCEEEECCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEEEECCCCCCCEEE
SNGEAFKAVKRALTSGSLKFKGLHCHIGSQILESTPYKIAVKIMLELLKEIKDTLGRGVE
CCCHHHHHHHHHHHCCCEEEEEEEEECCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCE
ELDLGGGFGIPYVEDDSYQPVEEMLRDILEELEAQVSLLKIKLPKIIVEPGRAIIGNTGI
EEECCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHEEEECCEEEECCCCEEEECCCE
TLYKVGGVKEIPGVRKYVFVDGGMSDNIRTALYGARYSAVIANRVYNGRLEKVTIAGKLC
EEEEECCCCCCCCCEEEEEEECCCCCCCHHHHHCCHHHHHHHHHHCCCCEEEEEEEEEEC
ESGDVIIWDILLPEVKKGDIIAVLNTGAYGYSMASNYNRLPKPAVILVSKGKAEIIVKRE
CCCCEEEEEEECCCCCCCCEEEEEECCCCCCHHHCCCCCCCCCEEEEEECCCEEEEEEEC
TYEDVIKNDVIPERLEEKFQGREMQAI
HHHHHHHCCCCHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MFYNSIKVNSKGHLVIGGCDAVELAERFGTPLYVIDEDVLRANSRIFYNALKSHNPENEV
CCCCEEEECCCCCEEEECCCHHHHHHHHCCCEEEECHHHHHCCCHHEEHHHHCCCCCCCE
VYAGKAFLTTAMCKIIQQEGLGLDVVSGGELYTALKAGFPTEKIYFHGNNKSEEELIMAL
EEECHHHHHHHHHHHHHHCCCCEEEECCCCEEEHHHCCCCCCEEEEECCCCCHHHHHHHH
QSEVGRIIIDNWDELELLEILAKKLNKEPAIYIRVTPGIEAHTHRYIMTGQIDSKFGFTI
HHHCCEEEECCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCCCEEEEEEECCCCCCCEEE
SNGEAFKAVKRALTSGSLKFKGLHCHIGSQILESTPYKIAVKIMLELLKEIKDTLGRGVE
CCCHHHHHHHHHHHCCCEEEEEEEEECCHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCE
ELDLGGGFGIPYVEDDSYQPVEEMLRDILEELEAQVSLLKIKLPKIIVEPGRAIIGNTGI
EEECCCCCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHEEEECCEEEECCCCEEEECCCE
TLYKVGGVKEIPGVRKYVFVDGGMSDNIRTALYGARYSAVIANRVYNGRLEKVTIAGKLC
EEEEECCCCCCCCCEEEEEEECCCCCCCHHHHHCCHHHHHHHHHHCCCCEEEEEEEEEEC
ESGDVIIWDILLPEVKKGDIIAVLNTGAYGYSMASNYNRLPKPAVILVSKGKAEIIVKRE
CCCCEEEEEEECCCCCCCCEEEEEECCCCCCHHHCCCCCCCCCEEEEEECCCEEEEEEEC
TYEDVIKNDVIPERLEEKFQGREMQAI
HHHHHHHCCCCHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8215365 [H]