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The map label for this gene is Gnd [H]

Identifier: 20806721

GI number: 20806721

Start: 201175

End: 202578

Strand: Direct

Name: Gnd [H]

Synonym: TTE0195

Alternate gene names: 20806721

Gene position: 201175-202578 (Clockwise)

Preceding gene: 20806720

Following gene: 20806722

Centisome position: 7.48

GC content: 34.4

Gene sequence:

>1404_bases
ATGAATGATGTGGGTTTAATAGGATTGGCGGTAATGGGACAAAATTTTGCCTTGAACATGGCAAGGAAAGGTTATAGAGT
TTCGGTTTATAATAGGACCCCTGAGAGAACAAAGAAGTTTGTTGAGGAAAAAGTTAGAGACGAATCAATTTTTCCGTTTT
ATACTATAGAAGAGTTTGTGAAAAGTTTAAAAAAACCTAGAAAAATAATTCTGATGATAAAGGCTGGAAAGGCTGTAGAT
GACATGATTGCTGAAATTCTTCCATATCTGGAGCTAGGGGACCTTATAGTAGACAGTGGGAATTCGCATTTTGCTGATAC
TGCTAGAAGGCTAGAATATTTATCGCAAAAAAACATTTTGTTTCTCGGAATGGGTATTTCTGGAGGAGAGTACGGGGCTT
TACATGGACCCTCATTAATGCCAGGTGGTACAAAAGAGGCTTATGACTTAATAAAAGATATTCTTTTAAAGGCTGCAGCA
AAGACGGAAGATGGACCTTGCTGTACATATGTGGGAAAGGGTTCAGCAGGTCATTTTGTGAAAATGGTTCATAATGGTAT
TGAATATGCTATTATGCAGTTAATTGCTGAAGTATATGATTTTATGAAAAAAGTATTGAATATGACTAATGAACAAATAG
GCGATGTCTTTGAAAAATGGAATAAGGGAGAACTTAATTCCTATTTAATGGAAATTTCTTATAAGATTATGAGATATAAA
GACAAGGAGACAGGAGGATTTTTGATAGACTACATTTTGGATAAAGCAGAACAAAAGGGTACTGGGAAATGGACTGCTCA
AACTTCTTTGGATTTAGGGGTTCCTACGCCAACATTGAATTTGGCGGTAGAAGCCAGAATTATTTCTCACTATAAAGAAG
AGAGAAAGATTTTATCGAAATTATATTCGAAAGAAAAGAATATAATCTCTGTGAATAAAGAAGAAATGATAGAGCATTTA
AAGAAAGCACTGCTTTTTGGAGTATTTATGTCTTTCTCTCAAGGCTTATGGCTAATTGACGAAGCATCCAAGCAATATAA
TTATGGAATAGACCTTAGCGAAATATTAAGAATTTGGAAAGGAGGCTGTATTATAAGGGCCGAAATTCTAGACTTTTTGA
GGGATATCATTAGAGAAAATGAGGAAGATGCAAATCTTTTGCATAGTGATAAGGCTATAGACTTTATTAAAGATAAATTA
AATTCCATCTACCAAGTTACAGAAATTGGGAAAAATTACAGAATACCTCTTATGACAATGAATTCTGCACTTGATTATTA
TTTTGCTTTAACAGAAGAGAATCTCCCAGCAAACATTATTCAAGCTCAACGGGACTTTTTTGGAGCTCATACTTACGAAA
GAATTGACAGAGAAGGGATATTTCATACAGAGTGGGAAAGATAA

Upstream 100 bases:

>100_bases
GAGTTCTATAAAAATATTGATTCCACCCTCTTGGGTGGAATCAATATTTTGCATTATATTACATTTATTACATTTAAAAT
ATAAAAGGAGGATAGGACAA

Downstream 100 bases:

>100_bases
AATAGAGGTAAATCACTTAAAGCCATGGAGAAGTTACTCCGTGGCTTTATAACTGAAAGGAGTACTATCTCAAGGAAAGT
AGAATGATTGACTCTATGAC

Product: 6-phosphogluconate dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 467; Mature: 467

Protein sequence:

>467_residues
MNDVGLIGLAVMGQNFALNMARKGYRVSVYNRTPERTKKFVEEKVRDESIFPFYTIEEFVKSLKKPRKIILMIKAGKAVD
DMIAEILPYLELGDLIVDSGNSHFADTARRLEYLSQKNILFLGMGISGGEYGALHGPSLMPGGTKEAYDLIKDILLKAAA
KTEDGPCCTYVGKGSAGHFVKMVHNGIEYAIMQLIAEVYDFMKKVLNMTNEQIGDVFEKWNKGELNSYLMEISYKIMRYK
DKETGGFLIDYILDKAEQKGTGKWTAQTSLDLGVPTPTLNLAVEARIISHYKEERKILSKLYSKEKNIISVNKEEMIEHL
KKALLFGVFMSFSQGLWLIDEASKQYNYGIDLSEILRIWKGGCIIRAEILDFLRDIIRENEEDANLLHSDKAIDFIKDKL
NSIYQVTEIGKNYRIPLMTMNSALDYYFALTEENLPANIIQAQRDFFGAHTYERIDREGIFHTEWER

Sequences:

>Translated_467_residues
MNDVGLIGLAVMGQNFALNMARKGYRVSVYNRTPERTKKFVEEKVRDESIFPFYTIEEFVKSLKKPRKIILMIKAGKAVD
DMIAEILPYLELGDLIVDSGNSHFADTARRLEYLSQKNILFLGMGISGGEYGALHGPSLMPGGTKEAYDLIKDILLKAAA
KTEDGPCCTYVGKGSAGHFVKMVHNGIEYAIMQLIAEVYDFMKKVLNMTNEQIGDVFEKWNKGELNSYLMEISYKIMRYK
DKETGGFLIDYILDKAEQKGTGKWTAQTSLDLGVPTPTLNLAVEARIISHYKEERKILSKLYSKEKNIISVNKEEMIEHL
KKALLFGVFMSFSQGLWLIDEASKQYNYGIDLSEILRIWKGGCIIRAEILDFLRDIIRENEEDANLLHSDKAIDFIKDKL
NSIYQVTEIGKNYRIPLMTMNSALDYYFALTEENLPANIIQAQRDFFGAHTYERIDREGIFHTEWER
>Mature_467_residues
MNDVGLIGLAVMGQNFALNMARKGYRVSVYNRTPERTKKFVEEKVRDESIFPFYTIEEFVKSLKKPRKIILMIKAGKAVD
DMIAEILPYLELGDLIVDSGNSHFADTARRLEYLSQKNILFLGMGISGGEYGALHGPSLMPGGTKEAYDLIKDILLKAAA
KTEDGPCCTYVGKGSAGHFVKMVHNGIEYAIMQLIAEVYDFMKKVLNMTNEQIGDVFEKWNKGELNSYLMEISYKIMRYK
DKETGGFLIDYILDKAEQKGTGKWTAQTSLDLGVPTPTLNLAVEARIISHYKEERKILSKLYSKEKNIISVNKEEMIEHL
KKALLFGVFMSFSQGLWLIDEASKQYNYGIDLSEILRIWKGGCIIRAEILDFLRDIIRENEEDANLLHSDKAIDFIKDKL
NSIYQVTEIGKNYRIPLMTMNSALDYYFALTEENLPANIIQAQRDFFGAHTYERIDREGIFHTEWER

Specific function: Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH [H]

COG id: COG0362

COG function: function code G; 6-phosphogluconate dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 6-phosphogluconate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI40068518, Length=466, Percent_Identity=44.8497854077253, Blast_Score=385, Evalue=1e-107,
Organism=Escherichia coli, GI1788341, Length=463, Percent_Identity=48.1641468682505, Blast_Score=454, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17542558, Length=467, Percent_Identity=43.8972162740899, Blast_Score=409, Evalue=1e-114,
Organism=Saccharomyces cerevisiae, GI6321695, Length=455, Percent_Identity=45.2747252747253, Blast_Score=410, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6321977, Length=453, Percent_Identity=45.2538631346578, Blast_Score=386, Evalue=1e-108,
Organism=Drosophila melanogaster, GI24639279, Length=465, Percent_Identity=44.0860215053763, Blast_Score=384, Evalue=1e-106,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR006114
- InterPro:   IPR006113
- InterPro:   IPR006115
- InterPro:   IPR006184
- InterPro:   IPR013328
- InterPro:   IPR012284
- InterPro:   IPR016040
- InterPro:   IPR006183 [H]

Pfam domain/function: PF00393 6PGD; PF03446 NAD_binding_2 [H]

EC number: =1.1.1.44 [H]

Molecular weight: Translated: 53392; Mature: 53392

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: PS00461 6PGD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDVGLIGLAVMGQNFALNMARKGYRVSVYNRTPERTKKFVEEKVRDESIFPFYTIEEFV
CCCCCEEHHHHHCCCCEEHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHH
KSLKKPRKIILMIKAGKAVDDMIAEILPYLELGDLIVDSGNSHFADTARRLEYLSQKNIL
HHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCHHEECCCCHHHHHHHHHHHHCCCCEE
FLGMGISGGEYGALHGPSLMPGGTKEAYDLIKDILLKAAAKTEDGPCCTYVGKGSAGHFV
EEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHH
KMVHNGIEYAIMQLIAEVYDFMKKVLNMTNEQIGDVFEKWNKGELNSYLMEISYKIMRYK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
DKETGGFLIDYILDKAEQKGTGKWTAQTSLDLGVPTPTLNLAVEARIISHYKEERKILSK
CCCCCCCHHHHHHHHHHCCCCCCEEEECEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LYSKEKNIISVNKEEMIEHLKKALLFGVFMSFSQGLWLIDEASKQYNYGIDLSEILRIWK
HHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHC
GGCIIRAEILDFLRDIIRENEEDANLLHSDKAIDFIKDKLNSIYQVTEIGKNYRIPLMTM
CCCEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
NSALDYYFALTEENLPANIIQAQRDFFGAHTYERIDREGIFHTEWER
CCHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MNDVGLIGLAVMGQNFALNMARKGYRVSVYNRTPERTKKFVEEKVRDESIFPFYTIEEFV
CCCCCEEHHHHHCCCCEEHHCCCCCEEEEECCCHHHHHHHHHHHHCCCCCCCHHHHHHHH
KSLKKPRKIILMIKAGKAVDDMIAEILPYLELGDLIVDSGNSHFADTARRLEYLSQKNIL
HHHCCCCEEEEEEECCCHHHHHHHHHHHHHHHCCHHEECCCCHHHHHHHHHHHHCCCCEE
FLGMGISGGEYGALHGPSLMPGGTKEAYDLIKDILLKAAAKTEDGPCCTYVGKGSAGHFV
EEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHH
KMVHNGIEYAIMQLIAEVYDFMKKVLNMTNEQIGDVFEKWNKGELNSYLMEISYKIMRYK
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCC
DKETGGFLIDYILDKAEQKGTGKWTAQTSLDLGVPTPTLNLAVEARIISHYKEERKILSK
CCCCCCCHHHHHHHHHHCCCCCCEEEECEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHH
LYSKEKNIISVNKEEMIEHLKKALLFGVFMSFSQGLWLIDEASKQYNYGIDLSEILRIWK
HHHCCCCEEECCHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCCCCCCHHHHHHHHC
GGCIIRAEILDFLRDIIRENEEDANLLHSDKAIDFIKDKLNSIYQVTEIGKNYRIPLMTM
CCCEEHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEC
NSALDYYFALTEENLPANIIQAQRDFFGAHTYERIDREGIFHTEWER
CCHHHEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]