Click here to switch to the map view.

The map label for this gene is DnaX [H]

Identifier: 20806577

GI number: 20806577

Start: 48666

End: 50222

Strand: Direct

Name: DnaX [H]

Synonym: TTE0039

Alternate gene names: 20806577

Gene position: 48666-50222 (Clockwise)

Preceding gene: 20806576

Following gene: 20806578

Centisome position: 1.81

GC content: 37.96

Gene sequence:

>1557_bases
ATGTATCAGTCTTTGTACAGGAAATACAGGCCAAAAAGTTTCAGTGAAGTTGTGGGGCAGGACCACATTGTGAGGACTCT
GAGGAATCAAATAAAAATGGGAAGGATAGGGCATGCATATCTTTTTACAGGCACAAGGGGGACAGGGAAAACTAGTGTAG
CAAAAATTTTTGCAAAGGCGGTAAACTGTTTAAATCCAAAAGACGGTGAGCCCTGCAATTCCTGTGAGGTGTGTCAGGCG
ATAAACACTGGTACTACTATGGATGTCTTGGAAATAGATGCTGCATCTAATAACAGCGTGAATGACGTGAGAGAACTTAG
AGAGTCTGTAATCTACTCTCCTTCTCTGACAAAGTACAAAGTATATATAATAGATGAAGTGCATATGCTTTCTACAGGAG
CTTTTAACGCCCTTTTAAAAACACTTGAAGAGCCCCCTCGCCATGTGATTTTCATTCTTGCTACCACTGAACCTGAGAAA
CTGCCTGACACTATCCTCTCGCGTTGCCAGAGGTTCGATTTTAAAAAGATACCGACAAAGCAGATTGCACAGAATCTAGA
AAGGATTTGCCAAGATAGCGGTATACAGATTGAACAAAACGGGATAAGAGCTATCGCTCTTTATGGAAATGGTTCAATGA
GAGATGCGATAAGTCTTTTAGAGCAATGCGCTTCTTACAAGGAAGGATTAATAACCTATGAAGATGTTTGTGAAATATTG
GGAGTTGCGAATGAAGAAATGCTTTTTTCACTTTTAGATCATATTTACGAGAAGGATGCGGTAGCTTCTTTACAGCAACT
GGATAAAATATTGTCCTATGGAATAGATTTAGGAAATTTTCTAAGGTCCTTTACTTATATGCTAAGAGATATGGTTATAT
ACAAAACTGGGGGAGATGAGCTAATAGAGATTTTGTACGGAGATCAAGAGACCATAAAAGCAAAGTCGCAGAAATACAGC
ATAGGATTTTTGACAAATGCTTTGGAGAAGTTTACTGCTTTGCAGAGAGAGATAAGATATGCTGTTTCACCTGTTACATT
GCTTGAATTGACGATTTTAAGACTTATTAGGCCGGAAATTTCTTACGATATGGGAAGCTTGATAGCTAGAATAGAAGAGC
TAGAGGAAAAAATAAATAAAGGGTATGTGGTAACAAAAGAAGAGAGTGCGAAAACACATGAAAAAGATGAGCTAGAAAAA
AAGGTTGATGCTACAAAAGAGGCAAAAAAAGAAAGGGAGGAAATTGATTTAGGAAGAGTTTGGCTTGAAGTAAAGGGAAT
TCTCAAAAAGGAAAGGATGATGCTCTATACTTTCCTAGAGAAGGGTGTTCCCCATTTAAAGGATGGCAAAATTGTTGTGG
AGTATTCCGAAGAAGACGCTCTTTTGGTGGAACAGCTTGGTAGGCCAGAGAATAAAGACTTTATTGAAGGAGTAGTAGAA
AAAGTAGTGAAGAAAAGAATTCCAATAGAGTTTGCTCTAAAAAAAAGCGAAGAGGACCTTTTAATTAAGCAGGTAAAGGA
ATTTTTTGGGGATGGAATTGACATAGAAATAATATAG

Upstream 100 bases:

>100_bases
TAAAAGCTCGGTCTTTGAGAAGAGACCGAGTTTTATTTTGAAAAAGTGTAGCGAAGTCTAAATTTTTTTGCTACAATTTA
ATATAACGGGGTGTTAGAGT

Downstream 100 bases:

>100_bases
TGCAAAAGAGGCAAAAAGCACATATTCTAAAATAGAGTAAAAGAATTGGGAGGTAATGAAATGGCAAAAGGTGGATTTCC
AGGAGGATTTAATATTAACA

Product: DNA polymerase III, gamma/tau subunits

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 518; Mature: 518

Protein sequence:

>518_residues
MYQSLYRKYRPKSFSEVVGQDHIVRTLRNQIKMGRIGHAYLFTGTRGTGKTSVAKIFAKAVNCLNPKDGEPCNSCEVCQA
INTGTTMDVLEIDAASNNSVNDVRELRESVIYSPSLTKYKVYIIDEVHMLSTGAFNALLKTLEEPPRHVIFILATTEPEK
LPDTILSRCQRFDFKKIPTKQIAQNLERICQDSGIQIEQNGIRAIALYGNGSMRDAISLLEQCASYKEGLITYEDVCEIL
GVANEEMLFSLLDHIYEKDAVASLQQLDKILSYGIDLGNFLRSFTYMLRDMVIYKTGGDELIEILYGDQETIKAKSQKYS
IGFLTNALEKFTALQREIRYAVSPVTLLELTILRLIRPEISYDMGSLIARIEELEEKINKGYVVTKEESAKTHEKDELEK
KVDATKEAKKEREEIDLGRVWLEVKGILKKERMMLYTFLEKGVPHLKDGKIVVEYSEEDALLVEQLGRPENKDFIEGVVE
KVVKKRIPIEFALKKSEEDLLIKQVKEFFGDGIDIEII

Sequences:

>Translated_518_residues
MYQSLYRKYRPKSFSEVVGQDHIVRTLRNQIKMGRIGHAYLFTGTRGTGKTSVAKIFAKAVNCLNPKDGEPCNSCEVCQA
INTGTTMDVLEIDAASNNSVNDVRELRESVIYSPSLTKYKVYIIDEVHMLSTGAFNALLKTLEEPPRHVIFILATTEPEK
LPDTILSRCQRFDFKKIPTKQIAQNLERICQDSGIQIEQNGIRAIALYGNGSMRDAISLLEQCASYKEGLITYEDVCEIL
GVANEEMLFSLLDHIYEKDAVASLQQLDKILSYGIDLGNFLRSFTYMLRDMVIYKTGGDELIEILYGDQETIKAKSQKYS
IGFLTNALEKFTALQREIRYAVSPVTLLELTILRLIRPEISYDMGSLIARIEELEEKINKGYVVTKEESAKTHEKDELEK
KVDATKEAKKEREEIDLGRVWLEVKGILKKERMMLYTFLEKGVPHLKDGKIVVEYSEEDALLVEQLGRPENKDFIEGVVE
KVVKKRIPIEFALKKSEEDLLIKQVKEFFGDGIDIEII
>Mature_518_residues
MYQSLYRKYRPKSFSEVVGQDHIVRTLRNQIKMGRIGHAYLFTGTRGTGKTSVAKIFAKAVNCLNPKDGEPCNSCEVCQA
INTGTTMDVLEIDAASNNSVNDVRELRESVIYSPSLTKYKVYIIDEVHMLSTGAFNALLKTLEEPPRHVIFILATTEPEK
LPDTILSRCQRFDFKKIPTKQIAQNLERICQDSGIQIEQNGIRAIALYGNGSMRDAISLLEQCASYKEGLITYEDVCEIL
GVANEEMLFSLLDHIYEKDAVASLQQLDKILSYGIDLGNFLRSFTYMLRDMVIYKTGGDELIEILYGDQETIKAKSQKYS
IGFLTNALEKFTALQREIRYAVSPVTLLELTILRLIRPEISYDMGSLIARIEELEEKINKGYVVTKEESAKTHEKDELEK
KVDATKEAKKEREEIDLGRVWLEVKGILKKERMMLYTFLEKGVPHLKDGKIVVEYSEEDALLVEQLGRPENKDFIEGVVE
KVVKKRIPIEFALKKSEEDLLIKQVKEFFGDGIDIEII

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506491, Length=308, Percent_Identity=26.6233766233766, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI31881687, Length=308, Percent_Identity=26.6233766233766, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI6677723, Length=265, Percent_Identity=25.2830188679245, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI194306571, Length=268, Percent_Identity=25, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI194306567, Length=268, Percent_Identity=25, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI31563534, Length=277, Percent_Identity=25.2707581227437, Blast_Score=75, Evalue=2e-13,
Organism=Escherichia coli, GI1786676, Length=280, Percent_Identity=44.2857142857143, Blast_Score=265, Evalue=5e-72,
Organism=Escherichia coli, GI1787341, Length=245, Percent_Identity=30.2040816326531, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI1787119, Length=239, Percent_Identity=26.7782426778243, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17554730, Length=217, Percent_Identity=29.0322580645161, Blast_Score=84, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17541988, Length=255, Percent_Identity=24.7058823529412, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI71986063, Length=220, Percent_Identity=28.1818181818182, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6324039, Length=290, Percent_Identity=25.8620689655172, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324478, Length=237, Percent_Identity=24.4725738396624, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI18859927, Length=252, Percent_Identity=27.7777777777778, Blast_Score=89, Evalue=9e-18,
Organism=Drosophila melanogaster, GI19921076, Length=216, Percent_Identity=27.3148148148148, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17647857, Length=271, Percent_Identity=24.7232472324723, Blast_Score=76, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 58989; Mature: 58989

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYQSLYRKYRPKSFSEVVGQDHIVRTLRNQIKMGRIGHAYLFTGTRGTGKTSVAKIFAKA
CCHHHHHHHCCCCHHHHHCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHH
VNCLNPKDGEPCNSCEVCQAINTGTTMDVLEIDAASNNSVNDVRELRESVIYSPSLTKYK
HHHCCCCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEE
VYIIDEVHMLSTGAFNALLKTLEEPPRHVIFILATTEPEKLPDTILSRCQRFDFKKIPTK
EEEEECHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCHH
QIAQNLERICQDSGIQIEQNGIRAIALYGNGSMRDAISLLEQCASYKEGLITYEDVCEIL
HHHHHHHHHHHCCCCEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
GVANEEMLFSLLDHIYEKDAVASLQQLDKILSYGIDLGNFLRSFTYMLRDMVIYKTGGDE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEECCCHH
LIEILYGDQETIKAKSQKYSIGFLTNALEKFTALQREIRYAVSPVTLLELTILRLIRPEI
HHHHHHCCHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
SYDMGSLIARIEELEEKINKGYVVTKEESAKTHEKDELEKKVDATKEAKKEREEIDLGRV
CCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
WLEVKGILKKERMMLYTFLEKGVPHLKDGKIVVEYSEEDALLVEQLGRPENKDFIEGVVE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHCCCCCCHHHHHHHHH
KVVKKRIPIEFALKKSEEDLLIKQVKEFFGDGIDIEII
HHHHHHCCCCEEECCCCHHHHHHHHHHHHCCCCEEEEC
>Mature Secondary Structure
MYQSLYRKYRPKSFSEVVGQDHIVRTLRNQIKMGRIGHAYLFTGTRGTGKTSVAKIFAKA
CCHHHHHHHCCCCHHHHHCHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHH
VNCLNPKDGEPCNSCEVCQAINTGTTMDVLEIDAASNNSVNDVRELRESVIYSPSLTKYK
HHHCCCCCCCCCCCHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCCCCCEEE
VYIIDEVHMLSTGAFNALLKTLEEPPRHVIFILATTEPEKLPDTILSRCQRFDFKKIPTK
EEEEECHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHCCCCCCCHH
QIAQNLERICQDSGIQIEQNGIRAIALYGNGSMRDAISLLEQCASYKEGLITYEDVCEIL
HHHHHHHHHHHCCCCEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHH
GVANEEMLFSLLDHIYEKDAVASLQQLDKILSYGIDLGNFLRSFTYMLRDMVIYKTGGDE
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHEEECCCHH
LIEILYGDQETIKAKSQKYSIGFLTNALEKFTALQREIRYAVSPVTLLELTILRLIRPEI
HHHHHHCCHHHHHHCCCCEEHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
SYDMGSLIARIEELEEKINKGYVVTKEESAKTHEKDELEKKVDATKEAKKEREEIDLGRV
CCCHHHHHHHHHHHHHHHHCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
WLEVKGILKKERMMLYTFLEKGVPHLKDGKIVVEYSEEDALLVEQLGRPENKDFIEGVVE
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEECCCCHHHHHHCCCCCCHHHHHHHHH
KVVKKRIPIEFALKKSEEDLLIKQVKEFFGDGIDIEII
HHHHHHCCCCEEECCCCHHHHHHHHHHHHCCCCEEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]