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The map label for this gene is SerS

Identifier: 20806566

GI number: 20806566

Start: 28805

End: 30082

Strand: Direct

Name: SerS

Synonym: TTE0025

Alternate gene names: 20806566

Gene position: 28805-30082 (Clockwise)

Preceding gene: 20806565

Following gene: 20806568

Centisome position: 1.07

GC content: 41.71

Gene sequence:

>1278_bases
GTGCTTGACATAAAATTTATAAGGAGTAATCCAGATGTAGTCAGAAGGGCTATAGAATTAAAAGGAGAAAAAGCGGACTT
GGACAGGCTGCTTTTACTGGATGAAAAAAGAAGAGAGATGCTTGTGGAACTGGAGGCTCTTAAAAATAAGAGGAATACAG
AATCAGACAATATAGCTCGGCTAAAAAGAGAAGGGAAAGATGCGTCAGAACTTATCGCTAAAATGAAAGAACTTTCAGAT
AAGATAAAAGACATGGAACAGGAATTGAGGGAAATAGAAGAAGAAATGGAAAAGATACTCTGGACAATTCCCAATATTCC
TCATGAGAGTGTGCCTATAGGAGAAAGCGATGAGGACAACGTAGAGGTTAGAAGATGGGGAGAGCCCAGAAAGTTTGACT
TTGAACCTAAGCCCCATTGGGAAATAGGTGAGGCTTTGGGAATACTGGATTTTGAAGCGGCTTCTAGGGTTACAGGTTCT
CGTTTTGTATTTTACAAAGGGTTAGGAGCAAGGCTTGAGAGAGCTTTGATAAACTTTATGTTGGACCTTCACATAGAAAA
GCACGGCTATAAAGAAGTTTTTCCTCCATTCCTTGTACATAGGAGAAGCATGTTTGGGACAGGCCAGCTTCCAAAATTTG
AAGAAGATGCCTTCAAAGTAGAAGGCACAGACTATTTCCTGATTCCGACTGCAGAAGTTCCTGTGACTAACCTTTACAGA
GAGACTATAATAGACGGAGAACAGCTTCCTATATACCACTGCGCTTACAGTGCTTGTTTCAGGCAGGAAGCAGGGGCTGC
TGGAAGAGATACCAGAGGGCTTATAAGGCAGCATCAGTTCGACAAGGTAGAGCTGGTTAAATTCACAGAACCGGACAAAT
CTTACGAGGAATTGGAAAAAATGACAAGAGATGCAGAAGAAGTTCTGCAGGCTCTTGGCCTTCCTTACAGAGTGGTTGCT
ATATGCACAGGGGATTTAGGATTTACTGCATCAAAGAAATACGACATAGAAGTTTGGATGCCAAGTTATGGAAGATACGT
AGAGATATCTTCCTGCAGCAATTGTGAGGACTTCCAGGCCAGAAGAGCCAATATAAGGTATAGGCCAAAAGGTGGAGGAA
AACTCCAATATGTTCACACTTTAAATGGTTCTGGAGTGGCAGTTGGGAGGACTTTTGCGGCTATTCTAGAAAATTATCAG
CAGGAAGACGGATCTGTAGTTGTGCCTGAAGTATTGAGGCCATATATGAAAGTAGATGTTATAAGGAAGGAAGAATGA

Upstream 100 bases:

>100_bases
ATGTGGAGGGCCCAATTTTTGGGCCGAAAGAGGGTGGCAACACGGGGTTCCCGTCCCTTTGTGGGACGGGAATTATTTTT
AGAAAGGAGGAGGGGTGTAG

Downstream 100 bases:

>100_bases
TTTCCCAGTATTTTACTGGCAGATAATATTGACAATAAGGCTGGGTTGTGATATACTTTATATCGTCCCAGCTGGGAGAG
GTGTCCGAGTGGCTTAAGGA

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MLDIKFIRSNPDVVRRAIELKGEKADLDRLLLLDEKRREMLVELEALKNKRNTESDNIARLKREGKDASELIAKMKELSD
KIKDMEQELREIEEEMEKILWTIPNIPHESVPIGESDEDNVEVRRWGEPRKFDFEPKPHWEIGEALGILDFEAASRVTGS
RFVFYKGLGARLERALINFMLDLHIEKHGYKEVFPPFLVHRRSMFGTGQLPKFEEDAFKVEGTDYFLIPTAEVPVTNLYR
ETIIDGEQLPIYHCAYSACFRQEAGAAGRDTRGLIRQHQFDKVELVKFTEPDKSYEELEKMTRDAEEVLQALGLPYRVVA
ICTGDLGFTASKKYDIEVWMPSYGRYVEISSCSNCEDFQARRANIRYRPKGGGKLQYVHTLNGSGVAVGRTFAAILENYQ
QEDGSVVVPEVLRPYMKVDVIRKEE

Sequences:

>Translated_425_residues
MLDIKFIRSNPDVVRRAIELKGEKADLDRLLLLDEKRREMLVELEALKNKRNTESDNIARLKREGKDASELIAKMKELSD
KIKDMEQELREIEEEMEKILWTIPNIPHESVPIGESDEDNVEVRRWGEPRKFDFEPKPHWEIGEALGILDFEAASRVTGS
RFVFYKGLGARLERALINFMLDLHIEKHGYKEVFPPFLVHRRSMFGTGQLPKFEEDAFKVEGTDYFLIPTAEVPVTNLYR
ETIIDGEQLPIYHCAYSACFRQEAGAAGRDTRGLIRQHQFDKVELVKFTEPDKSYEELEKMTRDAEEVLQALGLPYRVVA
ICTGDLGFTASKKYDIEVWMPSYGRYVEISSCSNCEDFQARRANIRYRPKGGGKLQYVHTLNGSGVAVGRTFAAILENYQ
QEDGSVVVPEVLRPYMKVDVIRKEE
>Mature_425_residues
MLDIKFIRSNPDVVRRAIELKGEKADLDRLLLLDEKRREMLVELEALKNKRNTESDNIARLKREGKDASELIAKMKELSD
KIKDMEQELREIEEEMEKILWTIPNIPHESVPIGESDEDNVEVRRWGEPRKFDFEPKPHWEIGEALGILDFEAASRVTGS
RFVFYKGLGARLERALINFMLDLHIEKHGYKEVFPPFLVHRRSMFGTGQLPKFEEDAFKVEGTDYFLIPTAEVPVTNLYR
ETIIDGEQLPIYHCAYSACFRQEAGAAGRDTRGLIRQHQFDKVELVKFTEPDKSYEELEKMTRDAEEVLQALGLPYRVVA
ICTGDLGFTASKKYDIEVWMPSYGRYVEISSCSNCEDFQARRANIRYRPKGGGKLQYVHTLNGSGVAVGRTFAAILENYQ
QEDGSVVVPEVLRPYMKVDVIRKEE

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=365, Percent_Identity=39.4520547945205, Blast_Score=234, Evalue=9e-62,
Organism=Homo sapiens, GI8923421, Length=438, Percent_Identity=31.9634703196347, Blast_Score=211, Evalue=8e-55,
Organism=Homo sapiens, GI225579074, Length=441, Percent_Identity=31.0657596371882, Blast_Score=206, Evalue=5e-53,
Organism=Escherichia coli, GI1787120, Length=424, Percent_Identity=51.8867924528302, Blast_Score=447, Evalue=1e-127,
Organism=Caenorhabditis elegans, GI17539260, Length=468, Percent_Identity=31.6239316239316, Blast_Score=211, Evalue=5e-55,
Organism=Caenorhabditis elegans, GI17542084, Length=401, Percent_Identity=29.6758104738155, Blast_Score=150, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6320226, Length=442, Percent_Identity=35.7466063348416, Blast_Score=251, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6321799, Length=369, Percent_Identity=34.9593495934959, Blast_Score=228, Evalue=1e-60,
Organism=Drosophila melanogaster, GI24581334, Length=464, Percent_Identity=32.7586206896552, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI17737985, Length=333, Percent_Identity=32.4324324324324, Blast_Score=166, Evalue=2e-41,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_THETN (Q8RDJ5)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_621737.1
- ProteinModelPortal:   Q8RDJ5
- SMR:   Q8RDJ5
- GeneID:   998036
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE0025
- NMPDR:   fig|273068.3.peg.35
- HOGENOM:   HBG629391
- OMA:   PDGETDE
- ProtClustDB:   PRK05431
- BioCyc:   TTEN273068:TTE0025-MONOMER
- BRENDA:   6.1.1.11
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 49007; Mature: 49007

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 284-284 BINDING 384-384

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDIKFIRSNPDVVRRAIELKGEKADLDRLLLLDEKRREMLVELEALKNKRNTESDNIAR
CCEEEEECCCHHHHHHHHHHCCCHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
LKREGKDASELIAKMKELSDKIKDMEQELREIEEEMEKILWTIPNIPHESVPIGESDEDN
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VEVRRWGEPRKFDFEPKPHWEIGEALGILDFEAASRVTGSRFVFYKGLGARLERALINFM
CCEEECCCCCCCCCCCCCCCCHHHHHCCEEHHHHHCCCCCEEEEECCHHHHHHHHHHHHH
LDLHIEKHGYKEVFPPFLVHRRSMFGTGQLPKFEEDAFKVEGTDYFLIPTAEVPVTNLYR
HHHHCCCCCCHHHCCHHHHHHHHHCCCCCCCCCCCCCEEECCCEEEEEECCCCCHHHHHH
ETIIDGEQLPIYHCAYSACFRQEAGAAGRDTRGLIRQHQFDKVELVKFTEPDKSYEELEK
HHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEEECCCCCHHHHHHH
MTRDAEEVLQALGLPYRVVAICTGDLGFTASKKYDIEVWMPSYGRYVEISSCSNCEDFQA
HHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEEEEEECCCCCCEEEECCCCCCHHHHH
RRANIRYRPKGGGKLQYVHTLNGSGVAVGRTFAAILENYQQEDGSVVVPEVLRPYMKVDV
HHCCCEECCCCCCEEEEEEEECCCCEEHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHE
IRKEE
EECCC
>Mature Secondary Structure
MLDIKFIRSNPDVVRRAIELKGEKADLDRLLLLDEKRREMLVELEALKNKRNTESDNIAR
CCEEEEECCCHHHHHHHHHHCCCHHCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHH
LKREGKDASELIAKMKELSDKIKDMEQELREIEEEMEKILWTIPNIPHESVPIGESDEDN
HHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCC
VEVRRWGEPRKFDFEPKPHWEIGEALGILDFEAASRVTGSRFVFYKGLGARLERALINFM
CCEEECCCCCCCCCCCCCCCCHHHHHCCEEHHHHHCCCCCEEEEECCHHHHHHHHHHHHH
LDLHIEKHGYKEVFPPFLVHRRSMFGTGQLPKFEEDAFKVEGTDYFLIPTAEVPVTNLYR
HHHHCCCCCCHHHCCHHHHHHHHHCCCCCCCCCCCCCEEECCCEEEEEECCCCCHHHHHH
ETIIDGEQLPIYHCAYSACFRQEAGAAGRDTRGLIRQHQFDKVELVKFTEPDKSYEELEK
HHHCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHCCCCCEEEEEECCCCCHHHHHHH
MTRDAEEVLQALGLPYRVVAICTGDLGFTASKKYDIEVWMPSYGRYVEISSCSNCEDFQA
HHHHHHHHHHHCCCCEEEEEEEECCCCCCCCCEEEEEEECCCCCCEEEECCCCCCHHHHH
RRANIRYRPKGGGKLQYVHTLNGSGVAVGRTFAAILENYQQEDGSVVVPEVLRPYMKVDV
HHCCCEECCCCCCEEEEEEEECCCCEEHHHHHHHHHHHHHHCCCCEECHHHHHHHHHHHE
IRKEE
EECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11997336