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The map label for this gene is IlvC

Identifier: 20806557

GI number: 20806557

Start: 18160

End: 19155

Strand: Direct

Name: IlvC

Synonym: TTE0015

Alternate gene names: 20806557

Gene position: 18160-19155 (Clockwise)

Preceding gene: 20806556

Following gene: 20806558

Centisome position: 0.68

GC content: 42.17

Gene sequence:

>996_bases
ATGGCAAAGATGTACTATGACCAAGATGCTGATGCAGAAGTTCTTAAGGGAAAGAAGATTGCGGTTATAGGTTTTGGAAG
TCAGGGACATGCGCATGCGTTAAATTTGAGAGATTCCGGTTTTGATGTAGTGGTAGGACTTTATGAGGGAAGCAAGTCAA
AAGAAAGGGCAGAAAAAGAAGGGCTTACAGTGTTAACCGTTGAAGAAGCGGCAAAAGTGGCAGATGTGATAATGATGCTC
ATACCTGATGAAAAACAGGCAAAAGTGTATAAGGAAAGCATTGAGAAAAACCTCACAGAAGGGAAAGCTTTAGCTTTTGC
TCATGGATTTAACATTCATTTCAAGCAGATAGTCCCTCCTGAGAATGTAGATGTGTTTATGGTAGCCCCAAAGGGGCCTG
GGCATTTAGTGAGGAGGATGTACCAGGAGGGGAAAGGGGTGCCATGTCTTGTAGCGGTACATCAAAACTACACAGGTAAA
GCCCTTGACATAGCTTTAGCTTATGCCAAAGGAATAGGAGGAACAAAAGCAGGTGCTATAGAGACTACCTTTAAAGAGGA
AACTGAGACAGATTTGTTTGGAGAACAGGCTGTGCTTTGCGGAGGCTTGACTGAACTCATGAAAGCTGGATTTGAAACGC
TTGTGGAGGCAGGGTATCAACCGGAGATCGCTTATTTTGAGTGCGTAAATGAGATGAAGCTCATAGTTGACCTCATATAC
GAAGGTGGGTTTAGCTACATGAGGTATTCAATTTCTGATACAGCAGAGTTTGGAGATTACATGACGGGTAAGAGGATAAT
AACTGAAGAGACGAGGAAGGAGATGAAGAAGATTCTGGAAGAGATTCAGACGGGCAAGTTTGCAAAAGAATGGCTTTTGG
AAAATCAGGTGGGAAGACCGCAGTATAACGCGATTAAAGAAAGAGAAGCAAACCATCCAATTGAAAAAGTTGGAAAAAGT
TTAAGGGAAATGATGCCATGGCTTAGTAAAAAATAA

Upstream 100 bases:

>100_bases
TTGATCAATAAGTTTGATGTGAAAGAGCTTGTAAGGACAGGACTTATATCTTTGGAAAGAGGTAATAAAACATTAAAGGA
ATATGAGGGGGAATTGTGAT

Downstream 100 bases:

>100_bases
AAAGGGGGTAGGTTAAAAATGGGGGTTAAGAGAGTTATAGTTTTTGACACTACTTTAAGAGATGGTGAACAGACGCCAGG
GGTAAATTTTAACAGCAGGG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MAKMYYDQDADAEVLKGKKIAVIGFGSQGHAHALNLRDSGFDVVVGLYEGSKSKERAEKEGLTVLTVEEAAKVADVIMML
IPDEKQAKVYKESIEKNLTEGKALAFAHGFNIHFKQIVPPENVDVFMVAPKGPGHLVRRMYQEGKGVPCLVAVHQNYTGK
ALDIALAYAKGIGGTKAGAIETTFKEETETDLFGEQAVLCGGLTELMKAGFETLVEAGYQPEIAYFECVNEMKLIVDLIY
EGGFSYMRYSISDTAEFGDYMTGKRIITEETRKEMKKILEEIQTGKFAKEWLLENQVGRPQYNAIKEREANHPIEKVGKS
LREMMPWLSKK

Sequences:

>Translated_331_residues
MAKMYYDQDADAEVLKGKKIAVIGFGSQGHAHALNLRDSGFDVVVGLYEGSKSKERAEKEGLTVLTVEEAAKVADVIMML
IPDEKQAKVYKESIEKNLTEGKALAFAHGFNIHFKQIVPPENVDVFMVAPKGPGHLVRRMYQEGKGVPCLVAVHQNYTGK
ALDIALAYAKGIGGTKAGAIETTFKEETETDLFGEQAVLCGGLTELMKAGFETLVEAGYQPEIAYFECVNEMKLIVDLIY
EGGFSYMRYSISDTAEFGDYMTGKRIITEETRKEMKKILEEIQTGKFAKEWLLENQVGRPQYNAIKEREANHPIEKVGKS
LREMMPWLSKK
>Mature_330_residues
AKMYYDQDADAEVLKGKKIAVIGFGSQGHAHALNLRDSGFDVVVGLYEGSKSKERAEKEGLTVLTVEEAAKVADVIMMLI
PDEKQAKVYKESIEKNLTEGKALAFAHGFNIHFKQIVPPENVDVFMVAPKGPGHLVRRMYQEGKGVPCLVAVHQNYTGKA
LDIALAYAKGIGGTKAGAIETTFKEETETDLFGEQAVLCGGLTELMKAGFETLVEAGYQPEIAYFECVNEMKLIVDLIYE
GGFSYMRYSISDTAEFGDYMTGKRIITEETRKEMKKILEEIQTGKFAKEWLLENQVGRPQYNAIKEREANHPIEKVGKSL
REMMPWLSKK

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=295, Percent_Identity=35.2542372881356, Blast_Score=148, Evalue=4e-37,
Organism=Saccharomyces cerevisiae, GI6323387, Length=327, Percent_Identity=34.8623853211009, Blast_Score=153, Evalue=4e-38,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_THETN (Q8RDK4)

Other databases:

- EMBL:   AE008691
- RefSeq:   NP_621728.1
- ProteinModelPortal:   Q8RDK4
- SMR:   Q8RDK4
- GeneID:   998028
- GenomeReviews:   AE008691_GR
- KEGG:   tte:TTE0015
- NMPDR:   fig|273068.3.peg.9
- HOGENOM:   HBG286525
- OMA:   AMKQCLK
- ProtClustDB:   PRK05479
- BioCyc:   TTEN273068:TTE0015-MONOMER
- BRENDA:   1.1.1.86
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 36897; Mature: 36766

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKMYYDQDADAEVLKGKKIAVIGFGSQGHAHALNLRDSGFDVVVGLYEGSKSKERAEKE
CCCCCCCCCCCHHHHCCCEEEEEEECCCCCEEEEEECCCCCEEEEEEECCCCHHHHHHHC
GLTVLTVEEAAKVADVIMMLIPDEKQAKVYKESIEKNLTEGKALAFAHGFNIHFKQIVPP
CCEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEECCCC
ENVDVFMVAPKGPGHLVRRMYQEGKGVPCLVAVHQNYTGKALDIALAYAKGIGGTKAGAI
CCCCEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCE
ETTFKEETETDLFGEQAVLCGGLTELMKAGFETLVEAGYQPEIAYFECVNEMKLIVDLIY
EHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EGGFSYMRYSISDTAEFGDYMTGKRIITEETRKEMKKILEEIQTGKFAKEWLLENQVGRP
HCCHHHEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCC
QYNAIKEREANHPIEKVGKSLREMMPWLSKK
HHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AKMYYDQDADAEVLKGKKIAVIGFGSQGHAHALNLRDSGFDVVVGLYEGSKSKERAEKE
CCCCCCCCCCHHHHCCCEEEEEEECCCCCEEEEEECCCCCEEEEEEECCCCHHHHHHHC
GLTVLTVEEAAKVADVIMMLIPDEKQAKVYKESIEKNLTEGKALAFAHGFNIHFKQIVPP
CCEEEEHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCEEEEEECCCEEEEECCCC
ENVDVFMVAPKGPGHLVRRMYQEGKGVPCLVAVHQNYTGKALDIALAYAKGIGGTKAGAI
CCCCEEEECCCCHHHHHHHHHHCCCCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCCE
ETTFKEETETDLFGEQAVLCGGLTELMKAGFETLVEAGYQPEIAYFECVNEMKLIVDLIY
EHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EGGFSYMRYSISDTAEFGDYMTGKRIITEETRKEMKKILEEIQTGKFAKEWLLENQVGRP
HCCHHHEEEECCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCC
QYNAIKEREANHPIEKVGKSLREMMPWLSKK
HHHHHHHHCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336