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The map label for this gene is mutS_1 [H]

Identifier: 203284023

GI number: 203284023

Start: 105498

End: 107858

Strand: Reverse

Name: mutS_1 [H]

Synonym: BDU_101

Alternate gene names: 203284023

Gene position: 107858-105498 (Counterclockwise)

Preceding gene: 203284024

Following gene: 203284022

Centisome position: 11.58

GC content: 26.43

Gene sequence:

>2361_bases
GTGAACTTAAGAGATATAAAAGTTATGCAAGAGAAATATTTGGAAAAAATTGATTTTTATCAAATATTATCTTCAGTTGC
ATCTTATGTAACTGTTTCAGATACGGTTAAACTTTTAAATGAACAGCAAATATTAAAAACTGATAGAGAAATTCAGGAAG
TATGTTCTTTTGTTAATTTAATTAAAAATCTTATTGAACTTGATGAAGAATATCCAAATTATTGTCTTGAGAGTATAAAT
GAGTCTATTGTTTTACTCCTTAAAAAAAAATCAAGAATTTCTATCGAAGAGATTAAGAATATTATTCTCTTTCTAAAAGA
AATTTTAAGAATAATGTTTTTTTTAGAAAAACATGAACTTAAATTTCGGGGTGAAATTGATGTTTTAAAAAAATTATTAT
TTGTAGATCCAAATTTAAAATATTTACTAGAATTTTTATGTAAATATGTTGATATTGATGAACTTAAAATAAAGCATGGT
GTTGATAAGAGATATGATGAGATTGATTTTGAAATTAGAAATTTAAATAAAAAAATTGAAAAGCAAATTAAACAGATAAT
AAATTTAAATGCAAATTATTTAAGCTCTAATCTTATTTATTATAAATCAGGTAAATGTACCATTGCTCTTAAATCCAGTT
TTAAAAATAGAATTAAAGGCAATGTTATATCTGTTTCCTCATCTGGTGAAACATTCTATGTTGAACCAAATGAAATGATA
AGTGAAAATAATAGATTGAGTTTTTTAAATTTTGAAAAGACACATATCGTTTTTAGAATTTTGCAAAAATTATCAGATGA
AATACGAAAACATATTTTTATCTTAAAATCTCTTTATAGTAATTTTATATATTATGATTCTTTAAAATCCAGAGCAATTT
ATGGGATTCAAAATCAAGGAATTTTTCCTAAACTTGATGGTGATTTGAATATTATGAATGCTAGGCATCCTTTAATAAAG
AATGCAAAGCCTATTAATTTTTCTCCTTTAAATAATAGAGTTGTTGTTATTACAGGTCCTAATGCTGGTGGAAAAACAGC
AACATTAAAAACAGTTGCTCTTTTGAGCGCTATGTTCCAATTTGGAATTCCAATTCCAGTTGATGAGTCTAGTACCTTTA
AGATTTTTGATAACATTTTAGTTGATGTTGGAGATGAACAGTCAATTTTGAATTCTCTATCAACTTTTTCAAGTCATATG
AATAATATTGCTTATATTTTAAAGCATGCAACAAAAGATAGTCTTTTGATATTTGATGAATTTTGTTCAGGTACTGATAT
TGAACAAGGACAAGCATTGGCTATAGCTATTCTTGAACATTTGATTTTCATTAATGCTTTTGTGATTATCTCAACCCATT
ATAATGCTCTTAAATATTTTGCATATACTCATGAAAATGTTATTAATGCTTCAATGCAAATGGATTTAGATAAAATGGAG
CCCAGTTATAAGTTAATGTTTTCTGTTCCAGGGGAAAGCTTTGCTTTTAGTGTTGCAAGCAAATTTCTTGTTGATTTTAA
CATAATATCTAGAGCTAAAAATATTTATGAGTCTAGCAAGACGGAAGTTAATGAGATATTGGCAAGACTTACGGAAAAAG
AGAGAGAAATATATTTACTTGAGGAAAAAATAAAGAATAAGCTTAAATTTATTGAGCTTAAAGAAGTTGAGATTAATGAT
ATTCGGGAGACTCTTGTATTAAGAGAAAGAAATTTGGAAGAGAATCTTGTTAATGAACAAAAAGAGTTTTTAAAAAAATC
AAGACAGACCTTAGAAAATTTGGTTAGAGAGATAAAAGAAGAAGGTGTTTGTCTTTTTAAGAATAAAAAATTTATAGCTG
ATATTTCAGATAATATAGCTTCTAAGGTTACTAAAATTGAAATGTTAAATCAAAAAATTGCTACTAAAGTTGAATTTAGA
GTAGGAGATAAAGTTAGAGTATTAGGCTCAAATTTTTCAGGAGAGATAATAGGTGTTACCAAAAAAGGATTTATTATAAA
TACAGGTGTATTTAAGATTACAGTTGCAGCTGTTAGTTTAGAGAAAATATTGTATAATGATAGAGCTCCAAGAGGTTGTG
AGAAAAAATTTAGTTTTTCTTTTGAGCAGCAAGATGATACATTAAATTTAACAGTTGATATTAGGGGAATGAGGGTGGCT
GAGGCTATAAACTTCTTGGGTAAGAAAATAGATGATATGTTGCTTAAAAATGTTTCTAAATTTGAAATCATTCATGGCAA
AGGAGAAGGTTTGCTAATGGAAGGAGTGCACGCATTTTTAAAAGATATAACGTTTATTAAAAAATATTATTTTGCTCATC
CAAATGATGGAGGGGTTGGAAAAACAATAGTAGAATTTTAA

Upstream 100 bases:

>100_bases
AATTCTTGTTTACATATCAATGAGCCAAATTGTTTTGTAATAAGTCAAATTGGATTTAAAATTGCAGAAGCTAGGTATAA
TAGTTATTTGAAAATTTTTA

Downstream 100 bases:

>100_bases
ATGGGTATATTAAAGTTTGAAGAATTTGAGAGTGTATTGTTTAATATTTGTCTTTATGTTGACTCTATTCTTGAAGATGA
GTTTGGTAATGCTTATGAAT

Product: DNA mismatch repair protein MutS

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 786; Mature: 786

Protein sequence:

>786_residues
MNLRDIKVMQEKYLEKIDFYQILSSVASYVTVSDTVKLLNEQQILKTDREIQEVCSFVNLIKNLIELDEEYPNYCLESIN
ESIVLLLKKKSRISIEEIKNIILFLKEILRIMFFLEKHELKFRGEIDVLKKLLFVDPNLKYLLEFLCKYVDIDELKIKHG
VDKRYDEIDFEIRNLNKKIEKQIKQIINLNANYLSSNLIYYKSGKCTIALKSSFKNRIKGNVISVSSSGETFYVEPNEMI
SENNRLSFLNFEKTHIVFRILQKLSDEIRKHIFILKSLYSNFIYYDSLKSRAIYGIQNQGIFPKLDGDLNIMNARHPLIK
NAKPINFSPLNNRVVVITGPNAGGKTATLKTVALLSAMFQFGIPIPVDESSTFKIFDNILVDVGDEQSILNSLSTFSSHM
NNIAYILKHATKDSLLIFDEFCSGTDIEQGQALAIAILEHLIFINAFVIISTHYNALKYFAYTHENVINASMQMDLDKME
PSYKLMFSVPGESFAFSVASKFLVDFNIISRAKNIYESSKTEVNEILARLTEKEREIYLLEEKIKNKLKFIELKEVEIND
IRETLVLRERNLEENLVNEQKEFLKKSRQTLENLVREIKEEGVCLFKNKKFIADISDNIASKVTKIEMLNQKIATKVEFR
VGDKVRVLGSNFSGEIIGVTKKGFIINTGVFKITVAAVSLEKILYNDRAPRGCEKKFSFSFEQQDDTLNLTVDIRGMRVA
EAINFLGKKIDDMLLKNVSKFEIIHGKGEGLLMEGVHAFLKDITFIKKYYFAHPNDGGVGKTIVEF

Sequences:

>Translated_786_residues
MNLRDIKVMQEKYLEKIDFYQILSSVASYVTVSDTVKLLNEQQILKTDREIQEVCSFVNLIKNLIELDEEYPNYCLESIN
ESIVLLLKKKSRISIEEIKNIILFLKEILRIMFFLEKHELKFRGEIDVLKKLLFVDPNLKYLLEFLCKYVDIDELKIKHG
VDKRYDEIDFEIRNLNKKIEKQIKQIINLNANYLSSNLIYYKSGKCTIALKSSFKNRIKGNVISVSSSGETFYVEPNEMI
SENNRLSFLNFEKTHIVFRILQKLSDEIRKHIFILKSLYSNFIYYDSLKSRAIYGIQNQGIFPKLDGDLNIMNARHPLIK
NAKPINFSPLNNRVVVITGPNAGGKTATLKTVALLSAMFQFGIPIPVDESSTFKIFDNILVDVGDEQSILNSLSTFSSHM
NNIAYILKHATKDSLLIFDEFCSGTDIEQGQALAIAILEHLIFINAFVIISTHYNALKYFAYTHENVINASMQMDLDKME
PSYKLMFSVPGESFAFSVASKFLVDFNIISRAKNIYESSKTEVNEILARLTEKEREIYLLEEKIKNKLKFIELKEVEIND
IRETLVLRERNLEENLVNEQKEFLKKSRQTLENLVREIKEEGVCLFKNKKFIADISDNIASKVTKIEMLNQKIATKVEFR
VGDKVRVLGSNFSGEIIGVTKKGFIINTGVFKITVAAVSLEKILYNDRAPRGCEKKFSFSFEQQDDTLNLTVDIRGMRVA
EAINFLGKKIDDMLLKNVSKFEIIHGKGEGLLMEGVHAFLKDITFIKKYYFAHPNDGGVGKTIVEF
>Mature_786_residues
MNLRDIKVMQEKYLEKIDFYQILSSVASYVTVSDTVKLLNEQQILKTDREIQEVCSFVNLIKNLIELDEEYPNYCLESIN
ESIVLLLKKKSRISIEEIKNIILFLKEILRIMFFLEKHELKFRGEIDVLKKLLFVDPNLKYLLEFLCKYVDIDELKIKHG
VDKRYDEIDFEIRNLNKKIEKQIKQIINLNANYLSSNLIYYKSGKCTIALKSSFKNRIKGNVISVSSSGETFYVEPNEMI
SENNRLSFLNFEKTHIVFRILQKLSDEIRKHIFILKSLYSNFIYYDSLKSRAIYGIQNQGIFPKLDGDLNIMNARHPLIK
NAKPINFSPLNNRVVVITGPNAGGKTATLKTVALLSAMFQFGIPIPVDESSTFKIFDNILVDVGDEQSILNSLSTFSSHM
NNIAYILKHATKDSLLIFDEFCSGTDIEQGQALAIAILEHLIFINAFVIISTHYNALKYFAYTHENVINASMQMDLDKME
PSYKLMFSVPGESFAFSVASKFLVDFNIISRAKNIYESSKTEVNEILARLTEKEREIYLLEEKIKNKLKFIELKEVEIND
IRETLVLRERNLEENLVNEQKEFLKKSRQTLENLVREIKEEGVCLFKNKKFIADISDNIASKVTKIEMLNQKIATKVEFR
VGDKVRVLGSNFSGEIIGVTKKGFIINTGVFKITVAAVSLEKILYNDRAPRGCEKKFSFSFEQQDDTLNLTVDIRGMRVA
EAINFLGKKIDDMLLKNVSKFEIIHGKGEGLLMEGVHAFLKDITFIKKYYFAHPNDGGVGKTIVEF

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=268, Percent_Identity=30.9701492537313, Blast_Score=111, Evalue=2e-24,
Organism=Homo sapiens, GI284813531, Length=387, Percent_Identity=27.1317829457364, Blast_Score=98, Evalue=3e-20,
Organism=Homo sapiens, GI4557761, Length=172, Percent_Identity=36.6279069767442, Blast_Score=95, Evalue=3e-19,
Organism=Homo sapiens, GI4504191, Length=125, Percent_Identity=35.2, Blast_Score=81, Evalue=3e-15,
Organism=Homo sapiens, GI26638666, Length=156, Percent_Identity=35.2564102564103, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI4505253, Length=156, Percent_Identity=35.2564102564103, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI26638664, Length=157, Percent_Identity=35.031847133758, Blast_Score=75, Evalue=4e-13,
Organism=Homo sapiens, GI262231786, Length=157, Percent_Identity=35.031847133758, Blast_Score=74, Evalue=4e-13,
Organism=Escherichia coli, GI1789089, Length=220, Percent_Identity=31.3636363636364, Blast_Score=97, Evalue=4e-21,
Organism=Caenorhabditis elegans, GI17508445, Length=236, Percent_Identity=28.8135593220339, Blast_Score=97, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17534743, Length=399, Percent_Identity=24.812030075188, Blast_Score=93, Evalue=7e-19,
Organism=Caenorhabditis elegans, GI17539736, Length=209, Percent_Identity=29.1866028708134, Blast_Score=79, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17508447, Length=206, Percent_Identity=30.0970873786408, Blast_Score=77, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6319935, Length=269, Percent_Identity=30.8550185873606, Blast_Score=103, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6324482, Length=316, Percent_Identity=29.746835443038, Blast_Score=101, Evalue=6e-22,
Organism=Saccharomyces cerevisiae, GI6321109, Length=286, Percent_Identity=30.7692307692308, Blast_Score=87, Evalue=8e-18,
Organism=Saccharomyces cerevisiae, GI6321912, Length=192, Percent_Identity=29.6875, Blast_Score=86, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6320302, Length=224, Percent_Identity=28.5714285714286, Blast_Score=75, Evalue=3e-14,
Organism=Saccharomyces cerevisiae, GI6320047, Length=177, Percent_Identity=30.5084745762712, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24664545, Length=421, Percent_Identity=25.8907363420428, Blast_Score=94, Evalue=4e-19,
Organism=Drosophila melanogaster, GI24584320, Length=223, Percent_Identity=30.4932735426009, Blast_Score=93, Evalue=8e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 90455; Mature: 90455

Theoretical pI: Translated: 8.38; Mature: 8.38

Prosite motif: PS50828 SMR ; PS00486 DNA_MISMATCH_REPAIR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLRDIKVMQEKYLEKIDFYQILSSVASYVTVSDTVKLLNEQQILKTDREIQEVCSFVNL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKNLIELDEEYPNYCLESINESIVLLLKKKSRISIEEIKNIILFLKEILRIMFFLEKHEL
HHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
KFRGEIDVLKKLLFVDPNLKYLLEFLCKYVDIDELKIKHGVDKRYDEIDFEIRNLNKKIE
EECCCHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
KQIKQIINLNANYLSSNLIYYKSGKCTIALKSSFKNRIKGNVISVSSSGETFYVEPNEMI
HHHHHHHCCCCHHHCCCEEEEECCEEEEEEHHHHHHHHCCCEEEEECCCCEEEECCHHHH
SENNRLSFLNFEKTHIVFRILQKLSDEIRKHIFILKSLYSNFIYYDSLKSRAIYGIQNQG
CCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCC
IFPKLDGDLNIMNARHPLIKNAKPINFSPLNNRVVVITGPNAGGKTATLKTVALLSAMFQ
CCCCCCCCEEEECCCCCHHCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
FGIPIPVDESSTFKIFDNILVDVGDEQSILNSLSTFSSHMNNIAYILKHATKDSLLIFDE
CCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEH
FCSGTDIEQGQALAIAILEHLIFINAFVIISTHYNALKYFAYTHENVINASMQMDLDKME
HCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHHHHHHHHHHHCCHHHCC
PSYKLMFSVPGESFAFSVASKFLVDFNIISRAKNIYESSKTEVNEILARLTEKEREIYLL
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEH
EEKIKNKLKFIELKEVEINDIRETLVLRERNLEENLVNEQKEFLKKSRQTLENLVREIKE
HHHHHCHHEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EGVCLFKNKKFIADISDNIASKVTKIEMLNQKIATKVEFRVGDKVRVLGSNFSGEIIGVT
CCEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHEEEEEECCEEEEECCCCCCCEEEEE
KKGFIINTGVFKITVAAVSLEKILYNDRAPRGCEKKFSFSFEQQDDTLNLTVDIRGMRVA
CCCEEEECCCEEEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCHHHH
EAINFLGKKIDDMLLKNVSKFEIIHGKGEGLLMEGVHAFLKDITFIKKYYFAHPNDGGVG
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
KTIVEF
CHHHCC
>Mature Secondary Structure
MNLRDIKVMQEKYLEKIDFYQILSSVASYVTVSDTVKLLNEQQILKTDREIQEVCSFVNL
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
IKNLIELDEEYPNYCLESINESIVLLLKKKSRISIEEIKNIILFLKEILRIMFFLEKHEL
HHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCC
KFRGEIDVLKKLLFVDPNLKYLLEFLCKYVDIDELKIKHGVDKRYDEIDFEIRNLNKKIE
EECCCHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
KQIKQIINLNANYLSSNLIYYKSGKCTIALKSSFKNRIKGNVISVSSSGETFYVEPNEMI
HHHHHHHCCCCHHHCCCEEEEECCEEEEEEHHHHHHHHCCCEEEEECCCCEEEECCHHHH
SENNRLSFLNFEKTHIVFRILQKLSDEIRKHIFILKSLYSNFIYYDSLKSRAIYGIQNQG
CCCCCEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEECCCC
IFPKLDGDLNIMNARHPLIKNAKPINFSPLNNRVVVITGPNAGGKTATLKTVALLSAMFQ
CCCCCCCCEEEECCCCCHHCCCCCCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHH
FGIPIPVDESSTFKIFDNILVDVGDEQSILNSLSTFSSHMNNIAYILKHATKDSLLIFDE
CCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEH
FCSGTDIEQGQALAIAILEHLIFINAFVIISTHYNALKYFAYTHENVINASMQMDLDKME
HCCCCCCCCCCHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHHHHHHHHHHHCCHHHCC
PSYKLMFSVPGESFAFSVASKFLVDFNIISRAKNIYESSKTEVNEILARLTEKEREIYLL
CCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEH
EEKIKNKLKFIELKEVEINDIRETLVLRERNLEENLVNEQKEFLKKSRQTLENLVREIKE
HHHHHCHHEEEEEECCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EGVCLFKNKKFIADISDNIASKVTKIEMLNQKIATKVEFRVGDKVRVLGSNFSGEIIGVT
CCEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHEEEEEECCEEEEECCCCCCCEEEEE
KKGFIINTGVFKITVAAVSLEKILYNDRAPRGCEKKFSFSFEQQDDTLNLTVDIRGMRVA
CCCEEEECCCEEEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEECCHHHH
EAINFLGKKIDDMLLKNVSKFEIIHGKGEGLLMEGVHAFLKDITFIKKYYFAHPNDGGVG
HHHHHHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
KTIVEF
CHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9403685 [H]