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The map label for this gene is tlyC [H]

Identifier: 203283985

GI number: 203283985

Start: 66423

End: 67202

Strand: Reverse

Name: tlyC [H]

Synonym: BDU_63

Alternate gene names: 203283985

Gene position: 67202-66423 (Counterclockwise)

Preceding gene: 203283986

Following gene: 203283984

Centisome position: 7.21

GC content: 27.31

Gene sequence:

>780_bases
TTGATGTTCAAGTTTTTTAATTTTAAAAATAAAAAGATGAAATATGTTGAGGGTAAAGATAGTGAAGAAAAATCGAGATT
TGAAACATCTTTGCTTAATAATTTTAATTCTCTTAAAGAAACGATTGTGAAAGAGATTATGGTTCCAAGAATAAGTGTAA
TATTTATTGATTATTCTGTAAGTAAAGATGATATTTTGAAAGTTGTAACGTCCAGCAATCATTCAAGATTTCCCGTTTAT
AAAGAAACAATAGACGATATTATAGGAATAATTCATACAAAAGACATATTGTTACATATGTGGAAGAAAGATTTTTATGA
TATAGATCTAAAAGATATTATGCGAAAAGTTATGTTTGTTCCTGAGAGTAAGAAAATAGATTCTCTTTTAAAAGAATTTC
AAGAAAATCATGTGCATATTGCTATTGTAGTTGATGAATATGGAGGAATTTCGGGGCTTGTTACACTTGAAGATATTCTT
GAAGAGATTGTGGGAGATATTCAGGATGAGTTTGATAATGAAGTTGATGAAATAGTTCCTCTTGATGATGGAAGTTATCT
TTGTACAGCTAGAGTGTTAATTGAAGATCTAAATGAAAAACTTGGATTATGTCTTCCTGATGGAGATTTTGATACTCTTG
GAGGTTTTGTTTATGATCTATTTGGAAGAATTCCTTTAAAGAATGAGAAGATAGAATATAATAATTTAATTTTTACTATT
AAAAATATGCATCAACGAAATATTAAAGTAATAAAGATTTCCCAAAAGGAAGGTTTATGA

Upstream 100 bases:

>100_bases
TTTTGCATTTAATAGGGTATACTCATGATACAAATGATTTTCAAAATGAGACAATGTTGATTATTCAGGAACGGGTTTTA
AGAGAAACCAGAAGGGTATT

Downstream 100 bases:

>100_bases
ATTTTAAGAGATTTTTTATCATGCTTTTGTTTTTTTATTTAAATTTTGGGAGTTTGATGGGTGCTACTATAACTGCGATT
GAATATTATCAAAAGGCACA

Product: hemolysin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 259; Mature: 259

Protein sequence:

>259_residues
MMFKFFNFKNKKMKYVEGKDSEEKSRFETSLLNNFNSLKETIVKEIMVPRISVIFIDYSVSKDDILKVVTSSNHSRFPVY
KETIDDIIGIIHTKDILLHMWKKDFYDIDLKDIMRKVMFVPESKKIDSLLKEFQENHVHIAIVVDEYGGISGLVTLEDIL
EEIVGDIQDEFDNEVDEIVPLDDGSYLCTARVLIEDLNEKLGLCLPDGDFDTLGGFVYDLFGRIPLKNEKIEYNNLIFTI
KNMHQRNIKVIKISQKEGL

Sequences:

>Translated_259_residues
MMFKFFNFKNKKMKYVEGKDSEEKSRFETSLLNNFNSLKETIVKEIMVPRISVIFIDYSVSKDDILKVVTSSNHSRFPVY
KETIDDIIGIIHTKDILLHMWKKDFYDIDLKDIMRKVMFVPESKKIDSLLKEFQENHVHIAIVVDEYGGISGLVTLEDIL
EEIVGDIQDEFDNEVDEIVPLDDGSYLCTARVLIEDLNEKLGLCLPDGDFDTLGGFVYDLFGRIPLKNEKIEYNNLIFTI
KNMHQRNIKVIKISQKEGL
>Mature_259_residues
MMFKFFNFKNKKMKYVEGKDSEEKSRFETSLLNNFNSLKETIVKEIMVPRISVIFIDYSVSKDDILKVVTSSNHSRFPVY
KETIDDIIGIIHTKDILLHMWKKDFYDIDLKDIMRKVMFVPESKKIDSLLKEFQENHVHIAIVVDEYGGISGLVTLEDIL
EEIVGDIQDEFDNEVDEIVPLDDGSYLCTARVLIEDLNEKLGLCLPDGDFDTLGGFVYDLFGRIPLKNEKIEYNNLIFTI
KNMHQRNIKVIKISQKEGL

Specific function: Bacterial hemolysins are exotoxins that attack blood cell membranes and cause cell rupture by mechanisms not clearly defined [H]

COG id: COG1253

COG function: function code R; Hemolysins and related proteins containing CBS domains

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI310128564, Length=198, Percent_Identity=35.8585858585859, Blast_Score=123, Evalue=2e-28,
Organism=Escherichia coli, GI1786879, Length=219, Percent_Identity=39.7260273972603, Blast_Score=143, Evalue=9e-36,
Organism=Escherichia coli, GI145693175, Length=249, Percent_Identity=28.5140562248996, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI87082033, Length=231, Percent_Identity=24.6753246753247, Blast_Score=93, Evalue=1e-20,
Organism=Escherichia coli, GI1788119, Length=248, Percent_Identity=28.2258064516129, Blast_Score=91, Evalue=6e-20,
Organism=Escherichia coli, GI1790664, Length=215, Percent_Identity=26.5116279069767, Blast_Score=86, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016169
- InterPro:   IPR000644
- InterPro:   IPR005170 [H]

Pfam domain/function: PF00571 CBS; PF03471 CorC_HlyC [H]

EC number: NA

Molecular weight: Translated: 30101; Mature: 30101

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMFKFFNFKNKKMKYVEGKDSEEKSRFETSLLNNFNSLKETIVKEIMVPRISVIFIDYSV
CEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECC
SKDDILKVVTSSNHSRFPVYKETIDDIIGIIHTKDILLHMWKKDFYDIDLKDIMRKVMFV
CHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
PESKKIDSLLKEFQENHVHIAIVVDEYGGISGLVTLEDILEEIVGDIQDEFDNEVDEIVP
CCCHHHHHHHHHHHHCCEEEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHCCCHHHEEC
LDDGSYLCTARVLIEDLNEKLGLCLPDGDFDTLGGFVYDLFGRIPLKNEKIEYNNLIFTI
CCCCCHHHHHHHHHHHHHHHCCEECCCCCHHHHHHHHHHHHCCCCCCCCCEEECCEEEEE
KNMHQRNIKVIKISQKEGL
ECCCCCCEEEEEECCCCCC
>Mature Secondary Structure
MMFKFFNFKNKKMKYVEGKDSEEKSRFETSLLNNFNSLKETIVKEIMVPRISVIFIDYSV
CEEEEECCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEECC
SKDDILKVVTSSNHSRFPVYKETIDDIIGIIHTKDILLHMWKKDFYDIDLKDIMRKVMFV
CHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCC
PESKKIDSLLKEFQENHVHIAIVVDEYGGISGLVTLEDILEEIVGDIQDEFDNEVDEIVP
CCCHHHHHHHHHHHHCCEEEEEEEECCCCCCCEEEHHHHHHHHHHHHHHHHCCCHHHEEC
LDDGSYLCTARVLIEDLNEKLGLCLPDGDFDTLGGFVYDLFGRIPLKNEKIEYNNLIFTI
CCCCCHHHHHHHHHHHHHHHCCEECCCCCHHHHHHHHHHHHCCCCCCCCCEEECCEEEEE
KNMHQRNIKVIKISQKEGL
ECCCCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7968456 [H]