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The map label for this gene is vlp-a [H]

Identifier: 203283930

GI number: 203283930

Start: 7068

End: 8165

Strand: Reverse

Name: vlp-a [H]

Synonym: BDU_5

Alternate gene names: 203283930

Gene position: 8165-7068 (Counterclockwise)

Preceding gene: 203283932

Following gene: 203283929

Centisome position: 0.88

GC content: 37.34

Gene sequence:

>1098_bases
ATGAAGATAGAGAAAAAAGGAGAGGGGAAAGTAAGAGTAATATTATTGATGATGATGATGGTGATGATGGGATGTAATAG
TGGGGGAGTGAAAGGAGAAGGAGCAGCAGGAGGAGGCGGGAGTGGAGCTAAAAGTTTAAGTGAAGTACTGCTGGAAGTAG
GGAGAAGTGCAGAGAATGCATTTTATTCGTTTATAGAGTTAATGTCAGATACATTAGGCTTAAAAGTGACTAAGGATACA
ACTAAGCAACAAGTAGGAGAATATTTTAATAGCCTAGGTGGTAAACTTGGAGAGGCATCAGGTGAATTAGAAAAAGTAGC
AAGCAAAGCAATGGTCGGTGTTGATAGAAGCGATGAATCAAAGAATGCAAAAAATTCAATTCGAAGTGCAGTTGATACAG
CTAAGGGAGTTTTAAGTTTGTTGAAAACTCATTTAGAATCTTTGAAAGATATAGGTGATGATAAAAAGGTTGTTGATGTA
ACGAGTAATCAGGCCGGAGTGGCAGCAAATGAAAATGCATTAAAGAAGGTATATCAGGCCTTTAAAGGGATAGTAACGGT
AGCTAATAAAGAGGGTGTTGAAAAGTTGAAAGAAAGTAAGTTAACTTTGTCTCAAGAATCAATAGGTGTGGTTGATGCAA
AAAATGGAGTTAAGATATTAGGTACAGATTTAGCAGCAACAGCAGGGGATGCAGGTAAAGCAGCATTAATAGTATCAGCA
GTAAGTGGTGAGGAAATGTTAGAGTCTATTGTTCAAGCATCAGAAGATAAAGTTGTAAAAATAACAGGTAATGCAACTGC
ACAGACAACGTCATTGGAATTTGCAAAAGGAGGTAATGCAGCTCATGTGTCGCATTCATCTGATTCAAAAGCAGCAGCAG
TAGCAGGAGGGATAGCGTTGCGTTCATTAGTTAAAGAAGGTAAATTAGCTTCACATAATGCAAATAGCGATGAAAAAGCG
GTACAATTAGCAGGAGTAACAGCGGTAAATAAACTATTAGTAGCGTTGGAAGATATAATTAAAAAGACAGTAAAGAATGT
TTTGGATAAAGTGAAGAAAGATGTAGACGAAGCAAAAAAACCAAAGACAGTCAGTTAG

Upstream 100 bases:

>100_bases
GTGAATTGTCATTCATTCATGCGTTGCTGTATACATTTATTTTTTGTTTGTTTGCTTCCTTGTTAGAAAAAAATAATAAA
AAAACAAGGAGGCTAGAAGA

Downstream 100 bases:

>100_bases
CAATAAGATAGGTTAAAAAAATAAGACTAGAAGGAAATCTAGAGATAAATTGAGATTTCCTTTTATATTGTTATTTCAGT
AATTGTTTTATTAGAATGAA

Product: vlp protein, alpha subfamily

Products: NA

Alternate protein names: Variable major outer membrane lipoprotein 21 [H]

Number of amino acids: Translated: 365; Mature: 365

Protein sequence:

>365_residues
MKIEKKGEGKVRVILLMMMMVMMGCNSGGVKGEGAAGGGGSGAKSLSEVLLEVGRSAENAFYSFIELMSDTLGLKVTKDT
TKQQVGEYFNSLGGKLGEASGELEKVASKAMVGVDRSDESKNAKNSIRSAVDTAKGVLSLLKTHLESLKDIGDDKKVVDV
TSNQAGVAANENALKKVYQAFKGIVTVANKEGVEKLKESKLTLSQESIGVVDAKNGVKILGTDLAATAGDAGKAALIVSA
VSGEEMLESIVQASEDKVVKITGNATAQTTSLEFAKGGNAAHVSHSSDSKAAAVAGGIALRSLVKEGKLASHNANSDEKA
VQLAGVTAVNKLLVALEDIIKKTVKNVLDKVKKDVDEAKKPKTVS

Sequences:

>Translated_365_residues
MKIEKKGEGKVRVILLMMMMVMMGCNSGGVKGEGAAGGGGSGAKSLSEVLLEVGRSAENAFYSFIELMSDTLGLKVTKDT
TKQQVGEYFNSLGGKLGEASGELEKVASKAMVGVDRSDESKNAKNSIRSAVDTAKGVLSLLKTHLESLKDIGDDKKVVDV
TSNQAGVAANENALKKVYQAFKGIVTVANKEGVEKLKESKLTLSQESIGVVDAKNGVKILGTDLAATAGDAGKAALIVSA
VSGEEMLESIVQASEDKVVKITGNATAQTTSLEFAKGGNAAHVSHSSDSKAAAVAGGIALRSLVKEGKLASHNANSDEKA
VQLAGVTAVNKLLVALEDIIKKTVKNVLDKVKKDVDEAKKPKTVS
>Mature_365_residues
MKIEKKGEGKVRVILLMMMMVMMGCNSGGVKGEGAAGGGGSGAKSLSEVLLEVGRSAENAFYSFIELMSDTLGLKVTKDT
TKQQVGEYFNSLGGKLGEASGELEKVASKAMVGVDRSDESKNAKNSIRSAVDTAKGVLSLLKTHLESLKDIGDDKKVVDV
TSNQAGVAANENALKKVYQAFKGIVTVANKEGVEKLKESKLTLSQESIGVVDAKNGVKILGTDLAATAGDAGKAALIVSA
VSGEEMLESIVQASEDKVVKITGNATAQTTSLEFAKGGNAAHVSHSSDSKAAAVAGGIALRSLVKEGKLASHNANSDEKA
VQLAGVTAVNKLLVALEDIIKKTVKNVLDKVKKDVDEAKKPKTVS

Specific function: The vlp and vsp proteins are antigenically distinct proteins, only one vlp or vsp gene is transcriptionally active at any one time. Switching between these genes is a mechanism of host immune reponse evasion [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the variable large protein (vlp) family. Alpha subfamily [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000680 [H]

Pfam domain/function: PF00921 Lipoprotein_2 [H]

EC number: NA

Molecular weight: Translated: 37806; Mature: 37806

Theoretical pI: Translated: 9.56; Mature: 9.56

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIEKKGEGKVRVILLMMMMVMMGCNSGGVKGEGAAGGGGSGAKSLSEVLLEVGRSAENA
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHH
FYSFIELMSDTLGLKVTKDTTKQQVGEYFNSLGGKLGEASGELEKVASKAMVGVDRSDES
HHHHHHHHHHHHCCEEECHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCC
KNAKNSIRSAVDTAKGVLSLLKTHLESLKDIGDDKKVVDVTSNQAGVAANENALKKVYQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHH
FKGIVTVANKEGVEKLKESKLTLSQESIGVVDAKNGVKILGTDLAATAGDAGKAALIVSA
HHHHHHHHCHHHHHHHHHHHCCCCHHCCCEEECCCCCEEEECCHHHCCCCCCCEEEEEEE
VSGEEMLESIVQASEDKVVKITGNATAQTTSLEFAKGGNAAHVSHSSDSKAAAVAGGIAL
CCHHHHHHHHHHCCCCCEEEEECCCCEEECEEECCCCCCEEEECCCCCCCHHHHHHHHHH
RSLVKEGKLASHNANSDEKAVQLAGVTAVNKLLVALEDIIKKTVKNVLDKVKKDVDEAKK
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PKTVS
CCCCC
>Mature Secondary Structure
MKIEKKGEGKVRVILLMMMMVMMGCNSGGVKGEGAAGGGGSGAKSLSEVLLEVGRSAENA
CCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHH
FYSFIELMSDTLGLKVTKDTTKQQVGEYFNSLGGKLGEASGELEKVASKAMVGVDRSDES
HHHHHHHHHHHHCCEEECHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCCCC
KNAKNSIRSAVDTAKGVLSLLKTHLESLKDIGDDKKVVDVTSNQAGVAANENALKKVYQA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCHHHHHHHHHH
FKGIVTVANKEGVEKLKESKLTLSQESIGVVDAKNGVKILGTDLAATAGDAGKAALIVSA
HHHHHHHHCHHHHHHHHHHHCCCCHHCCCEEECCCCCEEEECCHHHCCCCCCCEEEEEEE
VSGEEMLESIVQASEDKVVKITGNATAQTTSLEFAKGGNAAHVSHSSDSKAAAVAGGIAL
CCHHHHHHHHHHCCCCCEEEEECCCCEEECEEECCCCCCEEEECCCCCCCHHHHHHHHHH
RSLVKEGKLASHNANSDEKAVQLAGVTAVNKLLVALEDIIKKTVKNVLDKVKKDVDEAKK
HHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
PKTVS
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1706456; 1484486; 2409197 [H]