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The map label for this gene is Ffh

Identifier: 20095048

GI number: 20095048

Start: 1619379

End: 1620722

Strand: Reverse

Name: Ffh

Synonym: MK1612

Alternate gene names: 20095048

Gene position: 1620722-1619379 (Counterclockwise)

Preceding gene: 20095049

Following gene: 20095047

Centisome position: 95.62

GC content: 59.15

Gene sequence:

>1344_bases
GTGATAGGATTCGCCGATAGGCTTGCTGAAATCACCAAGAAGATCAAAGGAGCCTCGATAATCGATGAGGATTTCGTTAA
GGAGGTGGTACGCGACGTTCAACGTGCGCTTCTGGAGGCGGACGTCGACGTAAAGCTCGTGCTAGAACTGAGCAAGCGCA
TTGAAAAGCGAGCCCTCGAGGAGGAACCACCCGCGGGAGTGCCGAAACGTGACTACCTACTGCGGATAGTGTACGAGGAG
CTCGTGGAGCTTCTTGGAGGTGAGAAGACGGAAGGCCTCGACATCGACCTCTCCCGCGACGTGAACGTCATCATGCTCGT
CGGACTGTACGGTATGGGTAAAACCACCACGGCCGCGAAACTGGCCAGATACCTCCAGCGGAAGGGATACCGTGTCGGGC
TCGTCGGTGCGGACCCGTATCGTCCCGCGGCGGGTGAGCAGCTGCGTCAACTGGCCGAAGAGGTAGATGTCCCAGTCCAC
GTGGAGGACGTTGATGACGCCGTCGAGATGGCCGTCAAAGGTGTGGAGGCACTCAAGGACGAGTGTGATGTCGTGATCGT
GGACACGGCGGGTAGGGACCGCCTGAGCGAGGACCTCATCGACGAGCTTCGGGAGATGGCGGAACGTATCGAGCCGCACG
AGGTACTCTTGGTCCTGGACGCCACGGTAGGGCAGAAGGCGGGAGATCACGCGGAGGCGTTCCACGAGGCGGTTCAGCTC
ACGGGTGTGGTCATCACCAAGTTGGACACCGCGGCGAAAGGCGGTGGAGCGCTCTCCGCGGTGGCACGGACCGGAGCTCC
GATCAAGTTCGTCGGTACCGGAGAACGCGTGGATGACCTGGAAGAATTCAACCCGAGGAGCTTCGTCGCGAGGCTCCTGG
GCATCGGAGACATCGACGAGCTCCTGCGTCGGACCGAAGAGATGCTGGAAGAGGAGGAAAAGGCAGAGGACGTCCTGGAA
GGAGAGTTCACCCTCAAGGACCTCTACGAGCAGCTAGAGGCACTGAGTAAGATGGGACCCGTCGACAAGCTCCTGCAGTA
CGTGCCCGGTATGGGAGGCGGAAGGAACGTTCGGAAGATCTCCCAGATCACCGAGGAGCGCCTGAAGAAGTACAAGGTCA
TTATGGACTCGATGACGGAGAAGGAGTTGGAAAATCCTGAAATTCTCAACAAGTCACGAATCCGGCGCATCGCCATCGGT
TCGGGTACGTCAGAGCGCGACGTAATCGAGCTCCTGAACCACTACCGCATGATGAAGGACGTGATCGAGGACATCCAGAG
CGGGAGGATCCCACGCATCGGCGGAGAGCTCGGAAGGGTAATTCGGAACGTACTAAGGGGGTAG

Upstream 100 bases:

>100_bases
GAGCCCCCATCCTGTATCTGGGTGTCGGTCAGGATTACGACGACTTAAAGGCGTTCTCGCCGGAATGGTTCGTCGAGCGC
GTAATTGGGGGGGAAGAATC

Downstream 100 bases:

>100_bases
ACAGTTGTCGAAAGAGCGAGTATACAAAGCGTTTATCGTAGGCCTTCAAGAGGCCCTATTCGAGACTCACGGTGAAATGG
CATTGGCGCTAAATAGAATT

Product: Signal recognition particle GTPase

Products: NA

Alternate protein names: SRP54

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MIGFADRLAEITKKIKGASIIDEDFVKEVVRDVQRALLEADVDVKLVLELSKRIEKRALEEEPPAGVPKRDYLLRIVYEE
LVELLGGEKTEGLDIDLSRDVNVIMLVGLYGMGKTTTAAKLARYLQRKGYRVGLVGADPYRPAAGEQLRQLAEEVDVPVH
VEDVDDAVEMAVKGVEALKDECDVVIVDTAGRDRLSEDLIDELREMAERIEPHEVLLVLDATVGQKAGDHAEAFHEAVQL
TGVVITKLDTAAKGGGALSAVARTGAPIKFVGTGERVDDLEEFNPRSFVARLLGIGDIDELLRRTEEMLEEEEKAEDVLE
GEFTLKDLYEQLEALSKMGPVDKLLQYVPGMGGGRNVRKISQITEERLKKYKVIMDSMTEKELENPEILNKSRIRRIAIG
SGTSERDVIELLNHYRMMKDVIEDIQSGRIPRIGGELGRVIRNVLRG

Sequences:

>Translated_447_residues
MIGFADRLAEITKKIKGASIIDEDFVKEVVRDVQRALLEADVDVKLVLELSKRIEKRALEEEPPAGVPKRDYLLRIVYEE
LVELLGGEKTEGLDIDLSRDVNVIMLVGLYGMGKTTTAAKLARYLQRKGYRVGLVGADPYRPAAGEQLRQLAEEVDVPVH
VEDVDDAVEMAVKGVEALKDECDVVIVDTAGRDRLSEDLIDELREMAERIEPHEVLLVLDATVGQKAGDHAEAFHEAVQL
TGVVITKLDTAAKGGGALSAVARTGAPIKFVGTGERVDDLEEFNPRSFVARLLGIGDIDELLRRTEEMLEEEEKAEDVLE
GEFTLKDLYEQLEALSKMGPVDKLLQYVPGMGGGRNVRKISQITEERLKKYKVIMDSMTEKELENPEILNKSRIRRIAIG
SGTSERDVIELLNHYRMMKDVIEDIQSGRIPRIGGELGRVIRNVLRG
>Mature_447_residues
MIGFADRLAEITKKIKGASIIDEDFVKEVVRDVQRALLEADVDVKLVLELSKRIEKRALEEEPPAGVPKRDYLLRIVYEE
LVELLGGEKTEGLDIDLSRDVNVIMLVGLYGMGKTTTAAKLARYLQRKGYRVGLVGADPYRPAAGEQLRQLAEEVDVPVH
VEDVDDAVEMAVKGVEALKDECDVVIVDTAGRDRLSEDLIDELREMAERIEPHEVLLVLDATVGQKAGDHAEAFHEAVQL
TGVVITKLDTAAKGGGALSAVARTGAPIKFVGTGERVDDLEEFNPRSFVARLLGIGDIDELLRRTEEMLEEEEKAEDVLE
GEFTLKDLYEQLEALSKMGPVDKLLQYVPGMGGGRNVRKISQITEERLKKYKVIMDSMTEKELENPEILNKSRIRRIAIG
SGTSERDVIELLNHYRMMKDVIEDIQSGRIPRIGGELGRVIRNVLRG

Specific function: Binds to the signal sequence of presecretory protein when they emerge from the ribosomes

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family

Homologues:

Organism=Homo sapiens, GI4507215, Length=433, Percent_Identity=39.2609699769053, Blast_Score=308, Evalue=7e-84,
Organism=Homo sapiens, GI226371618, Length=379, Percent_Identity=40.6332453825858, Blast_Score=279, Evalue=5e-75,
Organism=Homo sapiens, GI89061728, Length=144, Percent_Identity=45.1388888888889, Blast_Score=136, Evalue=5e-32,
Organism=Homo sapiens, GI23308697, Length=290, Percent_Identity=27.9310344827586, Blast_Score=92, Evalue=1e-18,
Organism=Homo sapiens, GI295424842, Length=290, Percent_Identity=27.9310344827586, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1788963, Length=422, Percent_Identity=40.0473933649289, Blast_Score=256, Evalue=2e-69,
Organism=Escherichia coli, GI1789874, Length=200, Percent_Identity=40, Blast_Score=144, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17539958, Length=436, Percent_Identity=38.302752293578, Blast_Score=299, Evalue=2e-81,
Organism=Caenorhabditis elegans, GI193206261, Length=248, Percent_Identity=35.0806451612903, Blast_Score=99, Evalue=4e-21,
Organism=Saccharomyces cerevisiae, GI6325345, Length=436, Percent_Identity=37.3853211009174, Blast_Score=278, Evalue=9e-76,
Organism=Saccharomyces cerevisiae, GI6320498, Length=330, Percent_Identity=25.4545454545455, Blast_Score=94, Evalue=6e-20,
Organism=Drosophila melanogaster, GI17647949, Length=419, Percent_Identity=36.9928400954654, Blast_Score=263, Evalue=1e-70,
Organism=Drosophila melanogaster, GI24641198, Length=217, Percent_Identity=32.7188940092166, Blast_Score=96, Evalue=7e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SRP54_METKA (Q8TUY9)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614895.1
- ProteinModelPortal:   Q8TUY9
- SMR:   Q8TUY9
- GeneID:   1478207
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK1612
- NMPDR:   fig|190192.1.peg.1608
- HOGENOM:   HBG562580
- OMA:   SKKEHII
- BioCyc:   MKAN190192:MK1612-MONOMER
- HAMAP:   MF_00306
- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004125
- InterPro:   IPR022941
- Gene3D:   G3DSA:1.20.120.140
- Gene3D:   G3DSA:1.10.260.30
- SMART:   SM00382
- SMART:   SM00962
- SMART:   SM00963

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB; SSF47446 Signal_recog_particle_SRP54_M; SSF47364 SRP54

EC number: NA

Molecular weight: Translated: 49733; Mature: 49733

Theoretical pI: Translated: 4.59; Mature: 4.59

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGFADRLAEITKKIKGASIIDEDFVKEVVRDVQRALLEADVDVKLVLELSKRIEKRALE
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
EEPPAGVPKRDYLLRIVYEELVELLGGEKTEGLDIDLSRDVNVIMLVGLYGMGKTTTAAK
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCEEEEEECCCCCCHHHHHH
LARYLQRKGYRVGLVGADPYRPAAGEQLRQLAEEVDVPVHVEDVDDAVEMAVKGVEALKD
HHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHC
ECDVVIVDTAGRDRLSEDLIDELREMAERIEPHEVLLVLDATVGQKAGDHAEAFHEAVQL
CCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHCCCCCHHHHHHHHHHHH
TGVVITKLDTAAKGGGALSAVARTGAPIKFVGTGERVDDLEEFNPRSFVARLLGIGDIDE
HHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEECCCCHHHHHHCCHHHHHHHHHCCCCHHH
LLRRTEEMLEEEEKAEDVLEGEFTLKDLYEQLEALSKMGPVDKLLQYVPGMGGGRNVRKI
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHH
SQITEERLKKYKVIMDSMTEKELENPEILNKSRIRRIAIGSGTSERDVIELLNHYRMMKD
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHCHHHHHEEEECCCCCHHHHHHHHHHHHHHHH
VIEDIQSGRIPRIGGELGRVIRNVLRG
HHHHHHCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure
MIGFADRLAEITKKIKGASIIDEDFVKEVVRDVQRALLEADVDVKLVLELSKRIEKRALE
CCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHC
EEPPAGVPKRDYLLRIVYEELVELLGGEKTEGLDIDLSRDVNVIMLVGLYGMGKTTTAAK
CCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEECCCCCCEEEEEECCCCCCHHHHHH
LARYLQRKGYRVGLVGADPYRPAAGEQLRQLAEEVDVPVHVEDVDDAVEMAVKGVEALKD
HHHHHHHCCCEEEEECCCCCCCCHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHC
ECDVVIVDTAGRDRLSEDLIDELREMAERIEPHEVLLVLDATVGQKAGDHAEAFHEAVQL
CCCEEEEECCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECHHCCCCCHHHHHHHHHHHH
TGVVITKLDTAAKGGGALSAVARTGAPIKFVGTGERVDDLEEFNPRSFVARLLGIGDIDE
HHHHHHHHHHHCCCCCHHHHHHHCCCCEEEEECCCCHHHHHHCCHHHHHHHHHCCCCHHH
LLRRTEEMLEEEEKAEDVLEGEFTLKDLYEQLEALSKMGPVDKLLQYVPGMGGGRNVRKI
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCCHHHHH
SQITEERLKKYKVIMDSMTEKELENPEILNKSRIRRIAIGSGTSERDVIELLNHYRMMKD
HHHHHHHHHHHHHHHHHHHHHHCCCCHHHCHHHHHEEEECCCCCHHHHHHHHHHHHHHHH
VIEDIQSGRIPRIGGELGRVIRNVLRG
HHHHHHCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014