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The map label for this gene is dapA

Identifier: 20095043

GI number: 20095043

Start: 1616509

End: 1617411

Strand: Reverse

Name: dapA

Synonym: MK1607

Alternate gene names: 20095043

Gene position: 1617411-1616509 (Counterclockwise)

Preceding gene: 20095044

Following gene: 20095042

Centisome position: 95.42

GC content: 59.03

Gene sequence:

>903_bases
TTGGGATTTCAGATTGAGGGCGTCATCCCAGCCCTGATCACTCCCTTTACGGACGACCTGAAAGGGATCAATGAAGAGGG
ACTCCGCGAGAACGTCTCACGATTGCTCGAGGCCGGCGTGCACGGCGTGGTGCCCGCAGGGACCACCGGGGAATCGTCCA
CGCTGAGTCACGCAGAACATCGACGCGTCATCGAGATCGTCGTTGACGAGGTGAACGGGAAGGTGCCCGTAATCGCCGGA
GCGGGTTCGAACTCGACGCGCGAGGCCCTCGAGCTCTCCACGTACGCTGAAGACGTAGGGGCAGACGCGATCCTTTCCGT
GGTTCCCTACTACAACAAGCCACCTCAAGAGGGTCTTTTCATCCACTTCTCTAAGATCGCGGAAGCCGTCGAGTGCCCTA
TTATCCTCTACAACGTGCCGTCACGAACGGGCTGTGCGTTGGAACCGGAGACGGCCGCCAAGCTCGCGGAGGAATATTCT
CACATCGTCGGCGTCAAAGAGGCTAGTGGCGACCTGGACGTGGTCCAACGCTTCATCGAAGAGACTCCTGACGACTTCAT
CCTACTCTCCGGAGTCGATGAGTTGACGCTTCCGATCCTCGCCGTCGGAGGCGTCGGCGTGATATCCGTAACGGCCAACG
TAGCTCCCGAGTTGATGGTAGAAATGTACGAGGCGTGGAAGAGTGGCGACGTAGAGCGTGCCCGAGAGCTCCATTACGAG
CTCTTACCACTACACCGGGCGCTGTTCACCGAGACGAACCCGATACCCGTGAAAGCCGCCGTCGAGCTCGTGGGAATGGC
CTCGAGTCCCCCTAGACCACCACTTAAGGAAGCTCGCGAAGACACCAAGGAGTTGCTTCGGAGGGAACTCAAAAAGCTAG
GATTATTGCCCGAGGGGGGGTGA

Upstream 100 bases:

>100_bases
AAAGCTCAGGAACATGATCGCCGGTTACGTCACGCACCTCATGCGTCTCAAGGAGCGTCAGAGGGAAGAAGGGACAGAGT
GACCGGGAGGGGCGTACCCG

Downstream 100 bases:

>100_bases
CCGCTGGACGCACGTGAGCTCATTGATAAGTACCACATGAACACGTATTCGAGGTTCCCGGTTACCCTGGTCCCCGGTGA
GGGTGCTAGGGTCTGGGACG

Product: dihydrodipicolinate synthase

Products: NA

Alternate protein names: DHDPS

Number of amino acids: Translated: 300; Mature: 299

Protein sequence:

>300_residues
MGFQIEGVIPALITPFTDDLKGINEEGLRENVSRLLEAGVHGVVPAGTTGESSTLSHAEHRRVIEIVVDEVNGKVPVIAG
AGSNSTREALELSTYAEDVGADAILSVVPYYNKPPQEGLFIHFSKIAEAVECPIILYNVPSRTGCALEPETAAKLAEEYS
HIVGVKEASGDLDVVQRFIEETPDDFILLSGVDELTLPILAVGGVGVISVTANVAPELMVEMYEAWKSGDVERARELHYE
LLPLHRALFTETNPIPVKAAVELVGMASSPPRPPLKEAREDTKELLRRELKKLGLLPEGG

Sequences:

>Translated_300_residues
MGFQIEGVIPALITPFTDDLKGINEEGLRENVSRLLEAGVHGVVPAGTTGESSTLSHAEHRRVIEIVVDEVNGKVPVIAG
AGSNSTREALELSTYAEDVGADAILSVVPYYNKPPQEGLFIHFSKIAEAVECPIILYNVPSRTGCALEPETAAKLAEEYS
HIVGVKEASGDLDVVQRFIEETPDDFILLSGVDELTLPILAVGGVGVISVTANVAPELMVEMYEAWKSGDVERARELHYE
LLPLHRALFTETNPIPVKAAVELVGMASSPPRPPLKEAREDTKELLRRELKKLGLLPEGG
>Mature_299_residues
GFQIEGVIPALITPFTDDLKGINEEGLRENVSRLLEAGVHGVVPAGTTGESSTLSHAEHRRVIEIVVDEVNGKVPVIAGA
GSNSTREALELSTYAEDVGADAILSVVPYYNKPPQEGLFIHFSKIAEAVECPIILYNVPSRTGCALEPETAAKLAEEYSH
IVGVKEASGDLDVVQRFIEETPDDFILLSGVDELTLPILAVGGVGVISVTANVAPELMVEMYEAWKSGDVERARELHYEL
LPLHRALFTETNPIPVKAAVELVGMASSPPRPPLKEAREDTKELLRRELKKLGLLPEGG

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; first step. [C]

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family

Homologues:

Organism=Homo sapiens, GI31543060, Length=296, Percent_Identity=29.3918918918919, Blast_Score=119, Evalue=3e-27,
Organism=Homo sapiens, GI13540533, Length=303, Percent_Identity=31.023102310231, Blast_Score=109, Evalue=3e-24,
Organism=Escherichia coli, GI1788823, Length=291, Percent_Identity=44.6735395189003, Blast_Score=241, Evalue=4e-65,
Organism=Escherichia coli, GI87082415, Length=299, Percent_Identity=35.1170568561873, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI1786463, Length=282, Percent_Identity=34.0425531914894, Blast_Score=160, Evalue=9e-41,
Organism=Escherichia coli, GI1789620, Length=241, Percent_Identity=31.5352697095436, Blast_Score=117, Evalue=1e-27,

Paralogues:

None

Copy number: 840 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): DAPA_METKA (Q8TUZ4)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614890.1
- ProteinModelPortal:   Q8TUZ4
- SMR:   Q8TUZ4
- GeneID:   1478202
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK1607
- NMPDR:   fig|190192.1.peg.1603
- HOGENOM:   HBG358848
- OMA:   PAIITPF
- ProtClustDB:   PRK03170
- BioCyc:   MKAN190192:MK1607-MONOMER
- BRENDA:   4.2.1.52
- GO:   GO:0005737
- HAMAP:   MF_00418
- InterPro:   IPR013785
- InterPro:   IPR005263
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624
- Gene3D:   G3DSA:3.20.20.70
- PANTHER:   PTHR12128
- PRINTS:   PR00146
- TIGRFAMs:   TIGR00674

Pfam domain/function: PF00701 DHDPS

EC number: =4.2.1.52

Molecular weight: Translated: 32345; Mature: 32214

Theoretical pI: Translated: 4.40; Mature: 4.40

Prosite motif: PS00665 DHDPS_1; PS00666 DHDPS_2

Important sites: ACT_SITE 166-166 BINDING 110-110

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGFQIEGVIPALITPFTDDLKGINEEGLRENVSRLLEAGVHGVVPAGTTGESSTLSHAEH
CCEEECCCHHHHHCCCCHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
RRVIEIVVDEVNGKVPVIAGAGSNSTREALELSTYAEDVGADAILSVVPYYNKPPQEGLF
HHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCEE
IHFSKIAEAVECPIILYNVPSRTGCALEPETAAKLAEEYSHIVGVKEASGDLDVVQRFIE
EEHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
ETPDDFILLSGVDELTLPILAVGGVGVISVTANVAPELMVEMYEAWKSGDVERARELHYE
HCCCCEEEECCCCHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LLPLHRALFTETNPIPVKAAVELVGMASSPPRPPLKEAREDTKELLRRELKKLGLLPEGG
HHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
GFQIEGVIPALITPFTDDLKGINEEGLRENVSRLLEAGVHGVVPAGTTGESSTLSHAEH
CEEECCCHHHHHCCCCHHHCCCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHH
RRVIEIVVDEVNGKVPVIAGAGSNSTREALELSTYAEDVGADAILSVVPYYNKPPQEGLF
HHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHCHHHHHHHHCCCCCCCCCCEE
IHFSKIAEAVECPIILYNVPSRTGCALEPETAAKLAEEYSHIVGVKEASGDLDVVQRFIE
EEHHHHHHHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHH
ETPDDFILLSGVDELTLPILAVGGVGVISVTANVAPELMVEMYEAWKSGDVERARELHYE
HCCCCEEEECCCCHHHHHHHHCCCCEEEEEEHHHHHHHHHHHHHHHCCCCHHHHHHHHHH
LLPLHRALFTETNPIPVKAAVELVGMASSPPRPPLKEAREDTKELLRRELKKLGLLPEGG
HHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014