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The map label for this gene is ArgD

Identifier: 20095042

GI number: 20095042

Start: 1615336

End: 1616505

Strand: Reverse

Name: ArgD

Synonym: MK1606

Alternate gene names: 20095042

Gene position: 1616505-1615336 (Counterclockwise)

Preceding gene: 20095043

Following gene: 20095038

Centisome position: 95.37

GC content: 60.77

Gene sequence:

>1170_bases
CTGGACGCACGTGAGCTCATTGATAAGTACCACATGAACACGTATTCGAGGTTCCCGGTTACCCTGGTCCCCGGTGAGGG
TGCTAGGGTCTGGGACGACGAGGGGAACGAGTACATCGACCTAGTTGCGGGAATAGCCGTCAACGTCCTCGGACACTGTC
ACCCGGCCGTGGTCGAGGCGGTTAAGGAGCAGGTAGAGCGGCTCATCCACTGCTCGAACCTCTACTACAACGAGCCGCAG
GCGGAGGCTGCAAGGCTTTTGGCTGAAGCGGCTCCCAAGGACTTGAACAAGGTCTTCTTCTGTAACTCCGGAACGGAGAG
TGTGGAGTGTGCGATAAAGCTGGCACGCAAGTTTACCGGCTGCACCAAGTTCATCGCGTTCGAAGGCGGTTTCCACGGCA
GAACGATGGGGGCTCTATCGGCCACCTGGAAGCCCGAATTCCGTGAGCCGTTCGAGCCGCTAGTACCGGAGTTCGAGCAC
GTACCTTACGGCGACGTGAATGCTGTGGAGAAAGCTATCGACGACGATACCGCCGCCGTCATCGTGGAACCCGTGCAAGG
TGAGGCGGGAGTGAGGATACCGCCAGAGGGATTCCTCCGAGAGCTACGGGAGCTATGCGACGAACACGGGCTGCTCCTGA
TCGTCGATGAGGTGCAGTCCGGCATGGGACGAACCGGCCAGTTCTTCGCGTTCGAACACGAGGACGTCCTGCCGGACATC
GTCTGTCTGGCCAAGGGGCTCGGAGGCGGTGTGCCAGTAGGCGCGACGATAGCGCGGGAGGAGGTGGCCGAAGCGTTCGA
GCCCGGTGATCATGGGTCCACTTTCGGTGGTAATCCGCTGGCCTGCGCAGCGGTATGTGCGGCGGTCAGCACAGTACTCG
AGGAGAACCTTCCGGAGGCCGCGGAGCGGAAAGGGAAGCTAGCGATGAGAATACTGTCCGAGGCGGAGGACGTCGTGGAA
GAGGTCCGAGGTCGCGGTCTGATGATGGGAGTGGAGGTCGGCGACGACGAAAGAGCGAAAGACGTGGCTCGGGAGATGCT
GGACCGTGGAGCTCTCGTGAACGTAACCTCTGGTGACGTGATCAGACTAGTACCTCCGCTCGTGATCGGAGAGGACGAAC
TCGAGAAGGCCTTGGCCGAACTTGCCGACGCGTTACGTGCTTCCGGCTGA

Upstream 100 bases:

>100_bases
TCCCCCTAGACCACCACTTAAGGAAGCTCGCGAAGACACCAAGGAGTTGCTTCGGAGGGAACTCAAAAAGCTAGGATTAT
TGCCCGAGGGGGGGTGACCG

Downstream 100 bases:

>100_bases
AACGTACTCCCGCAACCACCTTATCTCCCTAATTTTCTCGTCGATGCGGTCTTCCAAGAGACCCCCGGGCTTCTCGTAGC
GTCGAACGCACTCCGTCGTC

Product: pyridoxal-phosphate-dependent aminotransferase

Products: NA

Alternate protein names: ACOAT

Number of amino acids: Translated: 389; Mature: 389

Protein sequence:

>389_residues
MDARELIDKYHMNTYSRFPVTLVPGEGARVWDDEGNEYIDLVAGIAVNVLGHCHPAVVEAVKEQVERLIHCSNLYYNEPQ
AEAARLLAEAAPKDLNKVFFCNSGTESVECAIKLARKFTGCTKFIAFEGGFHGRTMGALSATWKPEFREPFEPLVPEFEH
VPYGDVNAVEKAIDDDTAAVIVEPVQGEAGVRIPPEGFLRELRELCDEHGLLLIVDEVQSGMGRTGQFFAFEHEDVLPDI
VCLAKGLGGGVPVGATIAREEVAEAFEPGDHGSTFGGNPLACAAVCAAVSTVLEENLPEAAERKGKLAMRILSEAEDVVE
EVRGRGLMMGVEVGDDERAKDVAREMLDRGALVNVTSGDVIRLVPPLVIGEDELEKALAELADALRASG

Sequences:

>Translated_389_residues
MDARELIDKYHMNTYSRFPVTLVPGEGARVWDDEGNEYIDLVAGIAVNVLGHCHPAVVEAVKEQVERLIHCSNLYYNEPQ
AEAARLLAEAAPKDLNKVFFCNSGTESVECAIKLARKFTGCTKFIAFEGGFHGRTMGALSATWKPEFREPFEPLVPEFEH
VPYGDVNAVEKAIDDDTAAVIVEPVQGEAGVRIPPEGFLRELRELCDEHGLLLIVDEVQSGMGRTGQFFAFEHEDVLPDI
VCLAKGLGGGVPVGATIAREEVAEAFEPGDHGSTFGGNPLACAAVCAAVSTVLEENLPEAAERKGKLAMRILSEAEDVVE
EVRGRGLMMGVEVGDDERAKDVAREMLDRGALVNVTSGDVIRLVPPLVIGEDELEKALAELADALRASG
>Mature_389_residues
MDARELIDKYHMNTYSRFPVTLVPGEGARVWDDEGNEYIDLVAGIAVNVLGHCHPAVVEAVKEQVERLIHCSNLYYNEPQ
AEAARLLAEAAPKDLNKVFFCNSGTESVECAIKLARKFTGCTKFIAFEGGFHGRTMGALSATWKPEFREPFEPLVPEFEH
VPYGDVNAVEKAIDDDTAAVIVEPVQGEAGVRIPPEGFLRELRELCDEHGLLLIVDEVQSGMGRTGQFFAFEHEDVLPDI
VCLAKGLGGGVPVGATIAREEVAEAFEPGDHGSTFGGNPLACAAVCAAVSTVLEENLPEAAERKGKLAMRILSEAEDVVE
EVRGRGLMMGVEVGDDERAKDVAREMLDRGALVNVTSGDVIRLVPPLVIGEDELEKALAELADALRASG

Specific function: Unknown

COG id: COG4992

COG function: function code E; Ornithine/acetylornithine aminotransferase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily

Homologues:

Organism=Homo sapiens, GI4557809, Length=383, Percent_Identity=40.9921671018277, Blast_Score=285, Evalue=4e-77,
Organism=Homo sapiens, GI284507298, Length=290, Percent_Identity=43.448275862069, Blast_Score=227, Evalue=1e-59,
Organism=Homo sapiens, GI13994255, Length=439, Percent_Identity=32.3462414578588, Blast_Score=202, Evalue=3e-52,
Organism=Homo sapiens, GI24119277, Length=404, Percent_Identity=29.7029702970297, Blast_Score=175, Evalue=5e-44,
Organism=Homo sapiens, GI37574042, Length=416, Percent_Identity=28.6057692307692, Blast_Score=174, Evalue=9e-44,
Organism=Homo sapiens, GI226442709, Length=385, Percent_Identity=29.0909090909091, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI226442705, Length=416, Percent_Identity=27.4038461538462, Blast_Score=157, Evalue=1e-38,
Organism=Homo sapiens, GI188536080, Length=427, Percent_Identity=24.5901639344262, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI38679950, Length=427, Percent_Identity=24.5901639344262, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI38679946, Length=427, Percent_Identity=24.5901639344262, Blast_Score=109, Evalue=4e-24,
Organism=Escherichia coli, GI145693181, Length=374, Percent_Identity=46.7914438502674, Blast_Score=327, Evalue=7e-91,
Organism=Escherichia coli, GI1788044, Length=392, Percent_Identity=42.8571428571429, Blast_Score=309, Evalue=2e-85,
Organism=Escherichia coli, GI1789759, Length=396, Percent_Identity=41.9191919191919, Blast_Score=309, Evalue=3e-85,
Organism=Escherichia coli, GI1787560, Length=390, Percent_Identity=36.9230769230769, Blast_Score=223, Evalue=2e-59,
Organism=Escherichia coli, GI1789016, Length=393, Percent_Identity=36.6412213740458, Blast_Score=222, Evalue=3e-59,
Organism=Escherichia coli, GI1786991, Length=420, Percent_Identity=30.7142857142857, Blast_Score=160, Evalue=2e-40,
Organism=Escherichia coli, GI1786349, Length=341, Percent_Identity=36.6568914956012, Blast_Score=156, Evalue=2e-39,
Organism=Caenorhabditis elegans, GI25144271, Length=391, Percent_Identity=39.1304347826087, Blast_Score=278, Evalue=3e-75,
Organism=Caenorhabditis elegans, GI32564660, Length=436, Percent_Identity=32.5688073394495, Blast_Score=234, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI25144274, Length=253, Percent_Identity=43.0830039525692, Blast_Score=212, Evalue=3e-55,
Organism=Caenorhabditis elegans, GI71992977, Length=423, Percent_Identity=28.6052009456265, Blast_Score=169, Evalue=2e-42,
Organism=Caenorhabditis elegans, GI17541228, Length=446, Percent_Identity=25.7847533632287, Blast_Score=109, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71981843, Length=179, Percent_Identity=33.5195530726257, Blast_Score=100, Evalue=1e-21,
Organism=Saccharomyces cerevisiae, GI6324432, Length=405, Percent_Identity=36.5432098765432, Blast_Score=256, Evalue=5e-69,
Organism=Saccharomyces cerevisiae, GI6323470, Length=408, Percent_Identity=35.2941176470588, Blast_Score=249, Evalue=5e-67,
Organism=Saccharomyces cerevisiae, GI6324386, Length=464, Percent_Identity=24.5689655172414, Blast_Score=110, Evalue=3e-25,
Organism=Saccharomyces cerevisiae, GI6321456, Length=425, Percent_Identity=22.5882352941176, Blast_Score=90, Evalue=5e-19,
Organism=Drosophila melanogaster, GI21357415, Length=387, Percent_Identity=39.5348837209302, Blast_Score=274, Evalue=9e-74,
Organism=Drosophila melanogaster, GI161085790, Length=422, Percent_Identity=31.042654028436, Blast_Score=202, Evalue=3e-52,
Organism=Drosophila melanogaster, GI28574759, Length=421, Percent_Identity=31.1163895486936, Blast_Score=198, Evalue=4e-51,
Organism=Drosophila melanogaster, GI21356575, Length=417, Percent_Identity=30.2158273381295, Blast_Score=181, Evalue=8e-46,
Organism=Drosophila melanogaster, GI281366494, Length=421, Percent_Identity=25.41567695962, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24667139, Length=421, Percent_Identity=25.41567695962, Blast_Score=103, Evalue=2e-22,
Organism=Drosophila melanogaster, GI24667143, Length=421, Percent_Identity=25.41567695962, Blast_Score=103, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ARGD_METKA (Q8TUZ5)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614889.1
- ProteinModelPortal:   Q8TUZ5
- SMR:   Q8TUZ5
- GeneID:   1478201
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK1606
- NMPDR:   fig|190192.1.peg.1602
- HOGENOM:   HBG725944
- OMA:   FIATENS
- BioCyc:   MKAN190192:MK1606-MONOMER
- BRENDA:   2.6.1.11
- GO:   GO:0005737
- HAMAP:   MF_01107
- InterPro:   IPR004636
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PANTHER:   PTHR11986
- PANTHER:   PTHR11986:SF19
- TIGRFAMs:   TIGR00707

Pfam domain/function: PF00202 Aminotran_3; SSF53383 PyrdxlP-dep_Trfase_major

EC number: =2.6.1.11

Molecular weight: Translated: 42025; Mature: 42025

Theoretical pI: Translated: 4.30; Mature: 4.30

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: BINDING 131-131 BINDING 134-134 BINDING 273-273 BINDING 274-274

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDARELIDKYHMNTYSRFPVTLVPGEGARVWDDEGNEYIDLVAGIAVNVLGHCHPAVVEA
CCHHHHHHHHHCCCCCCCCEEEECCCCCEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHH
VKEQVERLIHCSNLYYNEPQAEAARLLAEAAPKDLNKVFFCNSGTESVECAIKLARKFTG
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHH
CTKFIAFEGGFHGRTMGALSATWKPEFREPFEPLVPEFEHVPYGDVNAVEKAIDDDTAAV
HHHEEEECCCCCCCCHHCCCCCCCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHCCCCEEE
IVEPVQGEAGVRIPPEGFLRELRELCDEHGLLLIVDEVQSGMGRTGQFFAFEHEDVLPDI
EEEECCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEHHHHHCCCCCCCEEEECCCCHHHHH
VCLAKGLGGGVPVGATIAREEVAEAFEPGDHGSTFGGNPLACAAVCAAVSTVLEENLPEA
HHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHH
AERKGKLAMRILSEAEDVVEEVRGRGLMMGVEVGDDERAKDVAREMLDRGALVNVTSGDV
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEECCCCE
IRLVPPLVIGEDELEKALAELADALRASG
EEECCCEEECHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDARELIDKYHMNTYSRFPVTLVPGEGARVWDDEGNEYIDLVAGIAVNVLGHCHPAVVEA
CCHHHHHHHHHCCCCCCCCEEEECCCCCEEECCCCCHHHHHHHHHHHHHHHCCCHHHHHH
VKEQVERLIHCSNLYYNEPQAEAARLLAEAAPKDLNKVFFCNSGTESVECAIKLARKFTG
HHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHH
CTKFIAFEGGFHGRTMGALSATWKPEFREPFEPLVPEFEHVPYGDVNAVEKAIDDDTAAV
HHHEEEECCCCCCCCHHCCCCCCCCCCCCCCCHHCCCCCCCCCCCHHHHHHHHCCCCEEE
IVEPVQGEAGVRIPPEGFLRELRELCDEHGLLLIVDEVQSGMGRTGQFFAFEHEDVLPDI
EEEECCCCCCCCCCCHHHHHHHHHHHHHCCEEEEEHHHHHCCCCCCCEEEECCCCHHHHH
VCLAKGLGGGVPVGATIAREEVAEAFEPGDHGSTFGGNPLACAAVCAAVSTVLEENLPEA
HHHHHCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCHH
AERKGKLAMRILSEAEDVVEEVRGRGLMMGVEVGDDERAKDVAREMLDRGALVNVTSGDV
HHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCHHHHHHHHHHHHCCCEEEECCCCE
IRLVPPLVIGEDELEKALAELADALRASG
EEECCCEEECHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014