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The map label for this gene is CobB_1 [H]

Identifier: 20095009

GI number: 20095009

Start: 1585777

End: 1587114

Strand: Direct

Name: CobB_1 [H]

Synonym: MK1573

Alternate gene names: 20095009

Gene position: 1585777-1587114 (Clockwise)

Preceding gene: 20095008

Following gene: 20095010

Centisome position: 93.56

GC content: 63.38

Gene sequence:

>1338_bases
ATGCTAGCCGTAGCCATCGCTGGAGTTCGCAGCGGCTGCGGTAAAACTTCGCTCTCGATCGGGTTGGTGAGGGCGTTACG
CGAGGAGGGAACCCGAGTGCGTCCCTTTAAGGTCGGTCCCGATTACATAGATCCCACGTACTTGGAAGTCGCGGCTGGCC
TAGAGGCGTTCAACCTGGACGTCTGGATGATGGGAGAGAGCGGCGTGGTGGACGCTTTCGGGAGGTACACCCGGAGATGC
GATGCGGCGGTCATTGAAGGCGTGATGGGGATGTTCGACGGGCACGGGGAAGGCACCGTCGAGGGGAGCACCGCCCACGT
AGCGGCCCTTTTGGGCGTCCCGGTGGTTCTGGTGGTGGACTGTAGGAGTTATGCTACGACGGTCGCAGCCGAGGTCCGCG
GGTTCCGGGACATGGCCCATGAGATCGGGACCCGACTCGAAGGGGTGATCCTCAACAGGGTCGGAAGCGAGCGTCACGAG
CGGCTGCTGATCACAGCGCTGAGGCGTTACTGTCCAGATGTTCGGGTGTTCGGGGTAATCCCCAGGCTCGAGGATGCCGT
CATACCGGACAGGCATCTGGGTCTCATCCCGGCGGACGAGCGCAACGAGTTCGCCGAGCGGGTGGCGGAGTACTGGGGCG
AGGTCGTCGCCGAGCACGTGGACCTCGACGCGCTTCGGGAGCTGGAAGTCGAAGGGCCCTCGGTCGAGCCCAGTCCACCA
CCCGAACCGGAGCGCGTCGAGACCAAGGTGGCGGTAATCTCGGGTCGCGTGTTCACCTTCTATTACCGGGAGAACTTACG
CTTCCTAGCGGAATCCGCGGAGGTCGTGCCGGTGGATCCGGAGAAGGATCGGCTTCCGGACGTCGACGCCGTGTACATCC
CTGGCGGGTACCCCGAAGTGTACGCCGATAACCTCGACGACCGGTTGATGAGGGACCTCCTGGAGTTCCACGAGGAGGGA
GGCAGGATCCTGGGAGAGTGCGGAGGACTGATGTACCTGTGCTCCGAGGTAGTGGACGCGGACGGCGATCGTCACGATAT
GGTGGGAGTGTTCGACGCGGTGGCACGAATGCGGGAACGGTTGGCCGCGCTGGGATACGTCGAAGGTCGTGTGACCGACG
CGCACCCGTTCGCGCCCTCCGGATCCGAAATCCGGGGTCACGAGTTCCACTACTCCGTCGTGGACGTTAGGGAGGATCTG
GAGTACGCGTACAGGCTCTCACGAGGGACTGGGGTAAGAGAGGGCCTGGACGGGCTCGTTAAGGGGAACACGGTAGCCTC
GTACACGCATCTCCACATCAGGTCGGACGGCGGTGTGTTCCGCGGTCTAGTACAGTAG

Upstream 100 bases:

>100_bases
TGATGGGATACGTTGTCATTAGGATTCATGTGGCGTATATCGCCCGAAACCTCCAAGGAGCACGTAGCCATCGAATCGCG
GAGTCACCCGGGGGATCTCG

Downstream 100 bases:

>100_bases
GGGGTTCCGTCGGATGGTCGAGATCACCATCGTGGTGGACAACCGGGTCGGTATGGTCCGTGATCCCTACGTCGCCCGGC
ACGGCCTGGCGATCATCGTG

Product: cobyrinic acid a,c-diamide synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 445; Mature: 445

Protein sequence:

>445_residues
MLAVAIAGVRSGCGKTSLSIGLVRALREEGTRVRPFKVGPDYIDPTYLEVAAGLEAFNLDVWMMGESGVVDAFGRYTRRC
DAAVIEGVMGMFDGHGEGTVEGSTAHVAALLGVPVVLVVDCRSYATTVAAEVRGFRDMAHEIGTRLEGVILNRVGSERHE
RLLITALRRYCPDVRVFGVIPRLEDAVIPDRHLGLIPADERNEFAERVAEYWGEVVAEHVDLDALRELEVEGPSVEPSPP
PEPERVETKVAVISGRVFTFYYRENLRFLAESAEVVPVDPEKDRLPDVDAVYIPGGYPEVYADNLDDRLMRDLLEFHEEG
GRILGECGGLMYLCSEVVDADGDRHDMVGVFDAVARMRERLAALGYVEGRVTDAHPFAPSGSEIRGHEFHYSVVDVREDL
EYAYRLSRGTGVREGLDGLVKGNTVASYTHLHIRSDGGVFRGLVQ

Sequences:

>Translated_445_residues
MLAVAIAGVRSGCGKTSLSIGLVRALREEGTRVRPFKVGPDYIDPTYLEVAAGLEAFNLDVWMMGESGVVDAFGRYTRRC
DAAVIEGVMGMFDGHGEGTVEGSTAHVAALLGVPVVLVVDCRSYATTVAAEVRGFRDMAHEIGTRLEGVILNRVGSERHE
RLLITALRRYCPDVRVFGVIPRLEDAVIPDRHLGLIPADERNEFAERVAEYWGEVVAEHVDLDALRELEVEGPSVEPSPP
PEPERVETKVAVISGRVFTFYYRENLRFLAESAEVVPVDPEKDRLPDVDAVYIPGGYPEVYADNLDDRLMRDLLEFHEEG
GRILGECGGLMYLCSEVVDADGDRHDMVGVFDAVARMRERLAALGYVEGRVTDAHPFAPSGSEIRGHEFHYSVVDVREDL
EYAYRLSRGTGVREGLDGLVKGNTVASYTHLHIRSDGGVFRGLVQ
>Mature_445_residues
MLAVAIAGVRSGCGKTSLSIGLVRALREEGTRVRPFKVGPDYIDPTYLEVAAGLEAFNLDVWMMGESGVVDAFGRYTRRC
DAAVIEGVMGMFDGHGEGTVEGSTAHVAALLGVPVVLVVDCRSYATTVAAEVRGFRDMAHEIGTRLEGVILNRVGSERHE
RLLITALRRYCPDVRVFGVIPRLEDAVIPDRHLGLIPADERNEFAERVAEYWGEVVAEHVDLDALRELEVEGPSVEPSPP
PEPERVETKVAVISGRVFTFYYRENLRFLAESAEVVPVDPEKDRLPDVDAVYIPGGYPEVYADNLDDRLMRDLLEFHEEG
GRILGECGGLMYLCSEVVDADGDRHDMVGVFDAVARMRERLAALGYVEGRVTDAHPFAPSGSEIRGHEFHYSVVDVREDL
EYAYRLSRGTGVREGLDGLVKGNTVASYTHLHIRSDGGVFRGLVQ

Specific function: Responsible for the amidation of carboxylic groups at position A and C of either cobyrinic acid or hydrogenobrynic acid. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation [H]

COG id: COG1797

COG function: function code H; Cobyrinic acid a,c-diamide synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR004484
- InterPro:   IPR017929
- InterPro:   IPR011698 [H]

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3 [H]

EC number: NA

Molecular weight: Translated: 48988; Mature: 48988

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: PS01032 PP2C

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLAVAIAGVRSGCGKTSLSIGLVRALREEGTRVRPFKVGPDYIDPTYLEVAAGLEAFNLD
CEEEEEECHHCCCCCCHHHHHHHHHHHHCCCEECEEECCCCCCCCHHHHHHCCCEEEEEE
VWMMGESGVVDAFGRYTRRCDAAVIEGVMGMFDGHGEGTVEGSTAHVAALLGVPVVLVVD
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHCCCEEEEEE
CRSYATTVAAEVRGFRDMAHEIGTRLEGVILNRVGSERHERLLITALRRYCPDVRVFGVI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEC
PRLEDAVIPDRHLGLIPADERNEFAERVAEYWGEVVAEHVDLDALRELEVEGPSVEPSPP
CCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCC
PEPERVETKVAVISGRVFTFYYRENLRFLAESAEVVPVDPEKDRLPDVDAVYIPGGYPEV
CCCHHHHEEEEEEECCEEEEEEHHHHHHHHCCCCEEECCCCCCCCCCCCEEEECCCCCHH
YADNLDDRLMRDLLEFHEEGGRILGECGGLMYLCSEVVDADGDRHDMVGVFDAVARMRER
HHCCHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LAALGYVEGRVTDAHPFAPSGSEIRGHEFHYSVVDVREDLEYAYRLSRGTGVREGLDGLV
HHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
KGNTVASYTHLHIRSDGGVFRGLVQ
CCCEEEEEEEEEEECCCCHHHHCCC
>Mature Secondary Structure
MLAVAIAGVRSGCGKTSLSIGLVRALREEGTRVRPFKVGPDYIDPTYLEVAAGLEAFNLD
CEEEEEECHHCCCCCCHHHHHHHHHHHHCCCEECEEECCCCCCCCHHHHHHCCCEEEEEE
VWMMGESGVVDAFGRYTRRCDAAVIEGVMGMFDGHGEGTVEGSTAHVAALLGVPVVLVVD
EEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEECCCHHHHHHHHCCCEEEEEE
CRSYATTVAAEVRGFRDMAHEIGTRLEGVILNRVGSERHERLLITALRRYCPDVRVFGVI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEEEC
PRLEDAVIPDRHLGLIPADERNEFAERVAEYWGEVVAEHVDLDALRELEVEGPSVEPSPP
CCHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCC
PEPERVETKVAVISGRVFTFYYRENLRFLAESAEVVPVDPEKDRLPDVDAVYIPGGYPEV
CCCHHHHEEEEEEECCEEEEEEHHHHHHHHCCCCEEECCCCCCCCCCCCEEEECCCCCHH
YADNLDDRLMRDLLEFHEEGGRILGECGGLMYLCSEVVDADGDRHDMVGVFDAVARMRER
HHCCHHHHHHHHHHHHHHHCCHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHH
LAALGYVEGRVTDAHPFAPSGSEIRGHEFHYSVVDVREDLEYAYRLSRGTGVREGLDGLV
HHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHHCCCCHHHHHHHHH
KGNTVASYTHLHIRSDGGVFRGLVQ
CCCEEEEEEEEEEECCCCHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA