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The map label for this gene is HemD

Identifier: 20094986

GI number: 20094986

Start: 1566513

End: 1567199

Strand: Reverse

Name: HemD

Synonym: MK1550

Alternate gene names: NA

Gene position: 1567199-1566513 (Counterclockwise)

Preceding gene: 20094987

Following gene: 20094983

Centisome position: 92.46

GC content: 59.24

Gene sequence:

>687_bases
TTGAGGGCTCTGGTCGTCAGGGCACCGGGTCTCGAGAGGGAGACGGTTCAAGCCTTCAAGAAGGTCGACCTAGACGCTGA
AGTCGTGTGTCCTGTCGAGCTCGTATCGCTGGACCGTCCTAAGATAAGTGCCGGGTTACTGTCCGAGTACGACGCGGTAG
CTTTCACCAGCCCGCGCACCGTCGAGTTCCTTTCCGAGGAAGAGGTGAAAGAACTACGACGCTCGGATGTCGATATAGCT
GCCGTCGGTCCCAGAACGCGCGAGGCGCTCGAACGAGCTGGACTGCGCGTAGATGTGATGCCTACCGAATATACGACCGG
AAAGTTAGCCGAAGAACTCCGTCAATACGGTGCCGTGTTGGCGCTCCGTTCCAGACGGAGGACGGAGGACCTGAGAAGGA
CGCTCGAGTCTTACGGGGTCAAGGCCGAGGAGTTGGAGATGTACGACCTCAAACCCAAACGCGTTGAGGTGAACCCGAGG
AAGTTCGACGTGGTATGCTTCCTGAGCGCGTTCACCGCGCGGTGCTTCCTCGAGAACGTGGACCCTACTGAAATTCCGGA
GCCGGTAGTGAGTATAGGTCCGGTCACCACCAAGGAGCTCCGAAGAGCCGGCTTGAAGGTCGTGGAGGCCGAAGAACACA
CCGTGGAAGCCGTAGCGAAGACGGCGCTCCGGGTAATCGAGGCGTGA

Upstream 100 bases:

>100_bases
GGTGGTGGGACGACAAGGGAAGGCTGATCGTGGATAAGGTCGAATCGAAGCGGAAAACCCTCCTCATGATCGCCGAGAAG
CTGAAGGAGCGGAGAGAAAG

Downstream 100 bases:

>100_bases
AACTCACGCCTCCACTCCGAACACCTCCTTCAAAACCTCTTTGTGAGTCATGTCGACTCCGATCAGGAACGAGCCTCCGA
AGTGCCTCCACGATCTTTTC

Product: uroporphyrinogen-III synthase

Products: uroporphyrinogen III; H2O

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MRALVVRAPGLERETVQAFKKVDLDAEVVCPVELVSLDRPKISAGLLSEYDAVAFTSPRTVEFLSEEEVKELRRSDVDIA
AVGPRTREALERAGLRVDVMPTEYTTGKLAEELRQYGAVLALRSRRRTEDLRRTLESYGVKAEELEMYDLKPKRVEVNPR
KFDVVCFLSAFTARCFLENVDPTEIPEPVVSIGPVTTKELRRAGLKVVEAEEHTVEAVAKTALRVIEA

Sequences:

>Translated_228_residues
MRALVVRAPGLERETVQAFKKVDLDAEVVCPVELVSLDRPKISAGLLSEYDAVAFTSPRTVEFLSEEEVKELRRSDVDIA
AVGPRTREALERAGLRVDVMPTEYTTGKLAEELRQYGAVLALRSRRRTEDLRRTLESYGVKAEELEMYDLKPKRVEVNPR
KFDVVCFLSAFTARCFLENVDPTEIPEPVVSIGPVTTKELRRAGLKVVEAEEHTVEAVAKTALRVIEA
>Mature_228_residues
MRALVVRAPGLERETVQAFKKVDLDAEVVCPVELVSLDRPKISAGLLSEYDAVAFTSPRTVEFLSEEEVKELRRSDVDIA
AVGPRTREALERAGLRVDVMPTEYTTGKLAEELRQYGAVLALRSRRRTEDLRRTLESYGVKAEELEMYDLKPKRVEVNPR
KFDVVCFLSAFTARCFLENVDPTEIPEPVVSIGPVTTKELRRAGLKVVEAEEHTVEAVAKTALRVIEA

Specific function: Unknown

COG id: COG1587

COG function: function code H; Uroporphyrinogen-III synthase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 4.2.1.75

Molecular weight: Translated: 25572; Mature: 25572

Theoretical pI: Translated: 5.02; Mature: 5.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALVVRAPGLERETVQAFKKVDLDAEVVCPVELVSLDRPKISAGLLSEYDAVAFTSPRT
CCEEEEECCCCCHHHHHHHHHCCCCCEEECCHHHEECCCCCCHHHHHHHCCCEEECCCCH
VEFLSEEEVKELRRSDVDIAAVGPRTREALERAGLRVDVMPTEYTTGKLAEELRQYGAVL
HHHHCHHHHHHHHHCCCCEEEECCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHH
ALRSRRRTEDLRRTLESYGVKAEELEMYDLKPKRVEVNPRKFDVVCFLSAFTARCFLENV
HHHHHHHHHHHHHHHHHHCCCHHHHHEECCCCCEEECCCCEEHHHHHHHHHHHHHHHCCC
DPTEIPEPVVSIGPVTTKELRRAGLKVVEAEEHTVEAVAKTALRVIEA
CCCCCCCCHHHCCCCCHHHHHHCCCEEEECHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MRALVVRAPGLERETVQAFKKVDLDAEVVCPVELVSLDRPKISAGLLSEYDAVAFTSPRT
CCEEEEECCCCCHHHHHHHHHCCCCCEEECCHHHEECCCCCCHHHHHHHCCCEEECCCCH
VEFLSEEEVKELRRSDVDIAAVGPRTREALERAGLRVDVMPTEYTTGKLAEELRQYGAVL
HHHHCHHHHHHHHHCCCCEEEECCHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHH
ALRSRRRTEDLRRTLESYGVKAEELEMYDLKPKRVEVNPRKFDVVCFLSAFTARCFLENV
HHHHHHHHHHHHHHHHHHCCCHHHHHEECCCCCEEECCCCEEHHHHHHHHHHHHHHHCCC
DPTEIPEPVVSIGPVTTKELRRAGLKVVEAEEHTVEAVAKTALRVIEA
CCCCCCCCHHHCCCCCHHHHHHCCCEEEECHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: hydroxymethylbilane

Specific reaction: hydroxymethylbilane = uroporphyrinogen III + H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA