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The map label for this gene is cofD

Identifier: 20094925

GI number: 20094925

Start: 1508860

End: 1509792

Strand: Direct

Name: cofD

Synonym: MK1489

Alternate gene names: 20094925

Gene position: 1508860-1509792 (Clockwise)

Preceding gene: 20094924

Following gene: 20094926

Centisome position: 89.02

GC content: 62.27

Gene sequence:

>933_bases
TTGAACTTGCGATTGACGGTACTCTCCGGTGGCACCGGGACACCGAAGCTGCTCCGGGGCTTGCGGGAGCTAGAGGCGGA
CTTCTCGGTGATAGTCAACACCGGAGAGGACGACGAGATCCTCGGTCTGTACGTGTCCCCGGACGTGGATACGGTGCTAT
ACACCCTCGCCGGCATCGTCAACGACGAAACCTGGTACGGTATCAAGGACGACGGGTTCCGTGGACACGAGTTCCTGGAG
AGGCTAGGAGTTGACGAGCCCCTGAGGATCGGTGACGCCGACCGCGCGCTCAAGCAGTACCGGACGTACCTGATGCGGGA
AAAGGGACTGAAGCTCTCCGAGGCCGTCGACGAGATCCGACGGCGGCTCGGTATCAAGTGGAAGGTGTACCCGATGACCG
ACGATCGGGTCACGACTATAGTCGAGACCGACGAAGGGGACTTACACTTCAGGGAGTTCTGGGTCGAGCGGGGCGGCAAG
CCCCCGGTACGCGGAGTGAGGTACGAGGGGGCCGAGGAAGCCTCCCCGCCGCCCGACGCCGTCGACGAGTTGCTTAGGGC
CGACGTGGTCCTGATAGGCCCTAGCAATCCGGTGACGAGTATCGGGCCTATACTATCGATCTCCGAAATCCGCCACATCG
TCCGGGAGAAACCCGTCGTGATGGTGTCCCCGTTCATCGGGCGCGAGCCCGTGAGTGGTCCTGCGGGTAAGCTCATGAGA
GCCGTCGGTTTCGAGCCCTCGGTCCGTGGTCTCGTGGAGTACTACCGGGAGTGGGGTGTAGAACCGGACGTCCTGATCAT
GGACGAGCGGGACGACGTGGAACTCCCCGAGGGATTGGAAGTCGTTCGGACCGACACCCTCATGCGCGATGAGAAGGACT
CCGTGAGGCTAGCTCGCGAGGTCCTCCGTATCGTGGAGGAATTGGTGGGGTAA

Upstream 100 bases:

>100_bases
GTCATCCGTCCGTCCGGGGTGGGCTCGTCATCGGGCGCGCGGCAAGCCTTTTGGTGGACCCGCACCCGTCAGGTATGCTC
GATCCCCACAGGCGCGGGGT

Downstream 100 bases:

>100_bases
CACGATGTCACCACGACTCGTTGTACCCGCCGCCGTGGTCGTCGTCGCGATCGGTCTCCTGGCTTATTGGTACCTTTACC
CCTCCGAGGGGGCTTCGGAG

Product: LPPG:FO 2-phospho-L-lactate transferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 310; Mature: 310

Protein sequence:

>310_residues
MNLRLTVLSGGTGTPKLLRGLRELEADFSVIVNTGEDDEILGLYVSPDVDTVLYTLAGIVNDETWYGIKDDGFRGHEFLE
RLGVDEPLRIGDADRALKQYRTYLMREKGLKLSEAVDEIRRRLGIKWKVYPMTDDRVTTIVETDEGDLHFREFWVERGGK
PPVRGVRYEGAEEASPPPDAVDELLRADVVLIGPSNPVTSIGPILSISEIRHIVREKPVVMVSPFIGREPVSGPAGKLMR
AVGFEPSVRGLVEYYREWGVEPDVLIMDERDDVELPEGLEVVRTDTLMRDEKDSVRLAREVLRIVEELVG

Sequences:

>Translated_310_residues
MNLRLTVLSGGTGTPKLLRGLRELEADFSVIVNTGEDDEILGLYVSPDVDTVLYTLAGIVNDETWYGIKDDGFRGHEFLE
RLGVDEPLRIGDADRALKQYRTYLMREKGLKLSEAVDEIRRRLGIKWKVYPMTDDRVTTIVETDEGDLHFREFWVERGGK
PPVRGVRYEGAEEASPPPDAVDELLRADVVLIGPSNPVTSIGPILSISEIRHIVREKPVVMVSPFIGREPVSGPAGKLMR
AVGFEPSVRGLVEYYREWGVEPDVLIMDERDDVELPEGLEVVRTDTLMRDEKDSVRLAREVLRIVEELVG
>Mature_310_residues
MNLRLTVLSGGTGTPKLLRGLRELEADFSVIVNTGEDDEILGLYVSPDVDTVLYTLAGIVNDETWYGIKDDGFRGHEFLE
RLGVDEPLRIGDADRALKQYRTYLMREKGLKLSEAVDEIRRRLGIKWKVYPMTDDRVTTIVETDEGDLHFREFWVERGGK
PPVRGVRYEGAEEASPPPDAVDELLRADVVLIGPSNPVTSIGPILSISEIRHIVREKPVVMVSPFIGREPVSGPAGKLMR
AVGFEPSVRGLVEYYREWGVEPDVLIMDERDDVELPEGLEVVRTDTLMRDEKDSVRLAREVLRIVEELVG

Specific function: Catalyzes the transfer of the 2-phospholactate moiety from lactyl (2) diphospho-(5')guanosine (LPPG) to 7,8-didemethyl- 8-hydroxy-5-deazariboflavin (FO) with the formation of the L- lactyl phosphodiester of 7,8-didemethyl-8-hydroxy-5- deazariboflavin (F42

COG id: COG0391

COG function: function code S; Uncharacterized conserved protein

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the CofD family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): COFD_METKA (Q8TVA3)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614772.1
- ProteinModelPortal:   Q8TVA3
- SMR:   Q8TVA3
- GeneID:   1478084
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK1489
- NMPDR:   fig|190192.1.peg.1485
- HOGENOM:   HBG374278
- OMA:   SNPITSI
- ProtClustDB:   PRK13606
- BioCyc:   MKAN190192:MK1489-MONOMER
- HAMAP:   MF_01257
- InterPro:   IPR002882
- InterPro:   IPR010115
- TIGRFAMs:   TIGR01819

Pfam domain/function: PF01933 UPF0052

EC number: NA

Molecular weight: Translated: 34882; Mature: 34882

Theoretical pI: Translated: 4.46; Mature: 4.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNLRLTVLSGGTGTPKLLRGLRELEADFSVIVNTGEDDEILGLYVSPDVDTVLYTLAGIV
CCEEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHH
NDETWYGIKDDGFRGHEFLERLGVDEPLRIGDADRALKQYRTYLMREKGLKLSEAVDEIR
CCCCEECCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
RRLGIKWKVYPMTDDRVTTIVETDEGDLHFREFWVERGGKPPVRGVRYEGAEEASPPPDA
HHHCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHH
VDELLRADVVLIGPSNPVTSIGPILSISEIRHIVREKPVVMVSPFIGREPVSGPAGKLMR
HHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCHHHHHHH
AVGFEPSVRGLVEYYREWGVEPDVLIMDERDDVELPEGLEVVRTDTLMRDEKDSVRLARE
HHCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHH
VLRIVEELVG
HHHHHHHHHC
>Mature Secondary Structure
MNLRLTVLSGGTGTPKLLRGLRELEADFSVIVNTGEDDEILGLYVSPDVDTVLYTLAGIV
CCEEEEEEECCCCCHHHHHHHHHHCCCEEEEEECCCCCCEEEEEECCCHHHHHHHHHHHH
NDETWYGIKDDGFRGHEFLERLGVDEPLRIGDADRALKQYRTYLMREKGLKLSEAVDEIR
CCCCEECCCCCCCCHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHH
RRLGIKWKVYPMTDDRVTTIVETDEGDLHFREFWVERGGKPPVRGVRYEGAEEASPPPDA
HHHCCEEEEEECCCCCEEEEEECCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHH
VDELLRADVVLIGPSNPVTSIGPILSISEIRHIVREKPVVMVSPFIGREPVSGPAGKLMR
HHHHHHCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCHHHHHHH
AVGFEPSVRGLVEYYREWGVEPDVLIMDERDDVELPEGLEVVRTDTLMRDEKDSVRLARE
HHCCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCHHHHHHHHHHHCCHHHHHHHHH
VLRIVEELVG
HHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014