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The map label for this gene is Ppa

Identifier: 20094886

GI number: 20094886

Start: 1480295

End: 1480825

Strand: Direct

Name: Ppa

Synonym: MK1450

Alternate gene names: 20094886

Gene position: 1480295-1480825 (Clockwise)

Preceding gene: 20094885

Following gene: 20094887

Centisome position: 87.33

GC content: 58.57

Gene sequence:

>531_bases
ATGATGAACCTCTGGAAAGACCTGGAACCGGGCCCGAATCCACCCGACGTAGTGTACGCGGTGATAGAAATCCCACGTGG
CTCGAGGAACAAGTACGAGTACGACGAAGAGCGTGGGTTCTTCAAGCTGGACCGAGTACTCTACTCGCCGTTCCACTATC
CACTGGACTACGGGTTTATCCCCCGAACGCTGTACGACGACGGTGACCCCCTCGACATCCTGGTGATCATGCAGGACCCC
ACGTTCCCCGGCTGCGTGATCGAGGCACGACCGATCGGTCTGATGAAGATGTTGGACGACAGCGACCAGGACGACAAGGT
TCTGGCGGTGCCCACTGAGGACCCCCGGTTCAAGGACGTTAAGGACCTGGATGACGTTCCCAAGCACCTGCTCGACGAGA
TCGCCCACATGTTCTCCGAGTACAAGCGACTGGAAGGCAAGGAGACCGAAGTCCTAGGGTGGGAAGGTGCGGACGCCGCT
AAGGAAGCCATAGTTCACGCGATAGAGCTGTACGAGGAGGAGCACGGGTGA

Upstream 100 bases:

>100_bases
CGTGAGATACTCGAATTGGAAGATGACATCAGGACCGACATCGCGGCCAACCGTGCATGGTGGGAGATCGTGCCGGATAA
GTTGGGGGGATGGTGAAGAG

Downstream 100 bases:

>100_bases
ATCCCGTTGTACGAGCTCGTGGAACTCGAAACCACGGTTAGAATTCCCCCCACCCAATTTACCTCCGACGTCGAGGATGC
CGTGCTCAAAGCCTTAGAGA

Product: inorganic pyrophosphatase

Products: NA

Alternate protein names: Pyrophosphate phospho-hydrolase; PPase

Number of amino acids: Translated: 176; Mature: 176

Protein sequence:

>176_residues
MMNLWKDLEPGPNPPDVVYAVIEIPRGSRNKYEYDEERGFFKLDRVLYSPFHYPLDYGFIPRTLYDDGDPLDILVIMQDP
TFPGCVIEARPIGLMKMLDDSDQDDKVLAVPTEDPRFKDVKDLDDVPKHLLDEIAHMFSEYKRLEGKETEVLGWEGADAA
KEAIVHAIELYEEEHG

Sequences:

>Translated_176_residues
MMNLWKDLEPGPNPPDVVYAVIEIPRGSRNKYEYDEERGFFKLDRVLYSPFHYPLDYGFIPRTLYDDGDPLDILVIMQDP
TFPGCVIEARPIGLMKMLDDSDQDDKVLAVPTEDPRFKDVKDLDDVPKHLLDEIAHMFSEYKRLEGKETEVLGWEGADAA
KEAIVHAIELYEEEHG
>Mature_176_residues
MMNLWKDLEPGPNPPDVVYAVIEIPRGSRNKYEYDEERGFFKLDRVLYSPFHYPLDYGFIPRTLYDDGDPLDILVIMQDP
TFPGCVIEARPIGLMKMLDDSDQDDKVLAVPTEDPRFKDVKDLDDVPKHLLDEIAHMFSEYKRLEGKETEVLGWEGADAA
KEAIVHAIELYEEEHG

Specific function: Unknown

COG id: COG0221

COG function: function code C; Inorganic pyrophosphatase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PPase family

Homologues:

Organism=Escherichia coli, GI1790673, Length=163, Percent_Identity=44.1717791411043, Blast_Score=128, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6319483, Length=186, Percent_Identity=26.8817204301075, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: 5480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 500 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 200 Molecules/Cell In: Early Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): IPYR_METKA (Q8TVE2)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614733.1
- ProteinModelPortal:   Q8TVE2
- SMR:   Q8TVE2
- GeneID:   1478045
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK1450
- NMPDR:   fig|190192.1.peg.1446
- HOGENOM:   HBG529150
- OMA:   YRDEIEN
- ProtClustDB:   CLSK436228
- BioCyc:   MKAN190192:MK1450-MONOMER
- BRENDA:   3.6.1.1
- GO:   GO:0005737
- HAMAP:   MF_00209
- InterPro:   IPR008162
- Gene3D:   G3DSA:3.90.80.10
- PANTHER:   PTHR10286

Pfam domain/function: PF00719 Pyrophosphatase; SSF50324 Pyrophosphatase

EC number: =3.6.1.1

Molecular weight: Translated: 20301; Mature: 20301

Theoretical pI: Translated: 4.18; Mature: 4.18

Prosite motif: PS00387 PPASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMNLWKDLEPGPNPPDVVYAVIEIPRGSRNKYEYDEERGFFKLDRVLYSPFHYPLDYGFI
CCCCCCCCCCCCCCHHHEEEEEECCCCCCCCCCCCHHCCHHHHHHHHHCCCCCCCCCCCC
PRTLYDDGDPLDILVIMQDPTFPGCVIEARPIGLMKMLDDSDQDDKVLAVPTEDPRFKDV
CCEECCCCCCEEEEEEEECCCCCCEEEECCCCHHHHHHCCCCCCCCEEEECCCCCCCCCH
KDLDDVPKHLLDEIAHMFSEYKRLEGKETEVLGWEGADAAKEAIVHAIELYEEEHG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MMNLWKDLEPGPNPPDVVYAVIEIPRGSRNKYEYDEERGFFKLDRVLYSPFHYPLDYGFI
CCCCCCCCCCCCCCHHHEEEEEECCCCCCCCCCCCHHCCHHHHHHHHHCCCCCCCCCCCC
PRTLYDDGDPLDILVIMQDPTFPGCVIEARPIGLMKMLDDSDQDDKVLAVPTEDPRFKDV
CCEECCCCCCEEEEEEEECCCCCCEEEECCCCHHHHHHCCCCCCCCEEEECCCCCCCCCH
KDLDDVPKHLLDEIAHMFSEYKRLEGKETEVLGWEGADAAKEAIVHAIELYEEEHG
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014