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The map label for this gene is DapB

Identifier: 20094858

GI number: 20094858

Start: 1449777

End: 1450604

Strand: Direct

Name: DapB

Synonym: MK1422

Alternate gene names: 20094858

Gene position: 1449777-1450604 (Clockwise)

Preceding gene: 20094857

Following gene: 20094859

Centisome position: 85.53

GC content: 60.27

Gene sequence:

>828_bases
GTGATCGGGGTCGTCGTCCTCGGAGCCACGGGTAGGATGGGTCGCCGGATATGCCGGATGGTGATAGAAGATGAAGAGCT
CGAGCTGGTAGGAGCTATCGCCTCACCCACCTCCAAGCACCTAGGGAGGGACGTGGGGCTAGTCATAGGAGTGGGCGAGA
CGGGTGTAGAAATCGCCCCTCCGACCGCTTTACCTAACATCGCTAAGGACGCGGACGTCGCGATCGATTTCACCGTCCGT
GAGGCGACATTGGAGAACGCGCCCAAAGCCGCCCGTGCGGGATTGGATCTCGTAATCGGTACCACCGGGTTCAGCGATGA
AGACCTCAGGGTGCTCGAACACGAGATCGAGGAAGCTGGAGTTTCGGCCGTGATCTCCCCGAACATGTCCCTGGGAGTCA
ACTTGCTCTTCGAGCTTACGAGGCAGCTCGCTAGAGTGCTCGGAGACAACGGGTTCGATTTCGAGATCGTGGAGATCCAT
CATCGGCACAAGGTGGACGCACCGAGCGGGACGGCCCTCGAGTTGGCGGCCATCATAGAGGAGGAGCTGGGTAAGGGGGA
GAAGGTGTTCGGTCGTGAGGGGAACGTGGGACCGCGTGACGATGACGAGATCGGTGTGTTGGCCGTTCGGGGAGGTGAGG
TCGTAGGTGATCATACCGTCATGGCGTTAGGCGAGTACGAGAGGATCGAACTCACGCATAGGGCCCTCTCGCGTGACGCC
TTCGCCAAGGGAGCCTTGGTGGCCGCAAAGTTCGTCGTAGAGGCACCTCCGGGGATCTACTCAATGAGGGACGTGCTGTT
CGGCGGGAAGCGGGGGGAAGGATTATAA

Upstream 100 bases:

>100_bases
TCCGATACCTGGAACCCTCACCTGAGGACTTCAAGGGTGTGGAGTGGGAGCTCTCACCCAGGTACAAGCGTCACAAGCTC
GTGGTCGGGGGCAGGCGAAG

Downstream 100 bases:

>100_bases
ATCCGGAACTCCGGCTCCGGCGGGGGGTGAAGGTATGAGGCGCGTGCTGGTGGTCCTCTCCATCGCCCTGATGGCTCTGG
CGGCCCCAGGACTGGCGGAA

Product: dihydrodipicolinate reductase

Products: NA

Alternate protein names: DHPR

Number of amino acids: Translated: 275; Mature: 275

Protein sequence:

>275_residues
MIGVVVLGATGRMGRRICRMVIEDEELELVGAIASPTSKHLGRDVGLVIGVGETGVEIAPPTALPNIAKDADVAIDFTVR
EATLENAPKAARAGLDLVIGTTGFSDEDLRVLEHEIEEAGVSAVISPNMSLGVNLLFELTRQLARVLGDNGFDFEIVEIH
HRHKVDAPSGTALELAAIIEEELGKGEKVFGREGNVGPRDDDEIGVLAVRGGEVVGDHTVMALGEYERIELTHRALSRDA
FAKGALVAAKFVVEAPPGIYSMRDVLFGGKRGEGL

Sequences:

>Translated_275_residues
MIGVVVLGATGRMGRRICRMVIEDEELELVGAIASPTSKHLGRDVGLVIGVGETGVEIAPPTALPNIAKDADVAIDFTVR
EATLENAPKAARAGLDLVIGTTGFSDEDLRVLEHEIEEAGVSAVISPNMSLGVNLLFELTRQLARVLGDNGFDFEIVEIH
HRHKVDAPSGTALELAAIIEEELGKGEKVFGREGNVGPRDDDEIGVLAVRGGEVVGDHTVMALGEYERIELTHRALSRDA
FAKGALVAAKFVVEAPPGIYSMRDVLFGGKRGEGL
>Mature_275_residues
MIGVVVLGATGRMGRRICRMVIEDEELELVGAIASPTSKHLGRDVGLVIGVGETGVEIAPPTALPNIAKDADVAIDFTVR
EATLENAPKAARAGLDLVIGTTGFSDEDLRVLEHEIEEAGVSAVISPNMSLGVNLLFELTRQLARVLGDNGFDFEIVEIH
HRHKVDAPSGTALELAAIIEEELGKGEKVFGREGNVGPRDDDEIGVLAVRGGEVVGDHTVMALGEYERIELTHRALSRDA
FAKGALVAAKFVVEAPPGIYSMRDVLFGGKRGEGL

Specific function: Biosynthesis of diaminopimelate and lysine from aspartate semialdehyde; second step. [C]

COG id: COG0289

COG function: function code E; Dihydrodipicolinate reductase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dihydrodipicolinate reductase family

Homologues:

Organism=Escherichia coli, GI1786214, Length=268, Percent_Identity=41.044776119403, Blast_Score=172, Evalue=1e-44,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DAPB_METKA (Q8TVG7)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614705.1
- ProteinModelPortal:   Q8TVG7
- GeneID:   1478017
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK1422
- NMPDR:   fig|190192.1.peg.1418
- HOGENOM:   HBG594002
- OMA:   GRMGKTL
- BioCyc:   MKAN190192:MK1422-MONOMER
- BRENDA:   1.3.1.26
- GO:   GO:0005737
- GO:   GO:0005488
- HAMAP:   MF_00102
- InterPro:   IPR022663
- InterPro:   IPR000846
- InterPro:   IPR022664
- InterPro:   IPR011770
- InterPro:   IPR016040
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR20836
- TIGRFAMs:   TIGR00036

Pfam domain/function: PF05173 DapB_C; PF01113 DapB_N

EC number: =1.3.1.26

Molecular weight: Translated: 29190; Mature: 29190

Theoretical pI: Translated: 4.54; Mature: 4.54

Prosite motif: PS01298 DAPB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGVVVLGATGRMGRRICRMVIEDEELELVGAIASPTSKHLGRDVGLVIGVGETGVEIAP
CEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHCCCCEEEEEEECCCCCEECC
PTALPNIAKDADVAIDFTVREATLENAPKAARAGLDLVIGTTGFSDEDLRVLEHEIEEAG
CCCCCCCCCCCCEEEEEEEEHHHHHCCCHHHHCCCEEEEECCCCCCCHHHHHHHHHHHCC
VSAVISPNMSLGVNLLFELTRQLARVLGDNGFDFEIVEIHHRHKVDAPSGTALELAAIIE
CEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHH
EELGKGEKVFGREGNVGPRDDDEIGVLAVRGGEVVGDHTVMALGEYERIELTHRALSRDA
HHHCCCCEEECCCCCCCCCCCCCEEEEEEECCEEECCCEEEEECCCHHHHHHHHHHHHHH
FAKGALVAAKFVVEAPPGIYSMRDVLFGGKRGEGL
HHCCHHEEEEEEEECCCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MIGVVVLGATGRMGRRICRMVIEDEELELVGAIASPTSKHLGRDVGLVIGVGETGVEIAP
CEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCCCHHHHCCCCEEEEEEECCCCCEECC
PTALPNIAKDADVAIDFTVREATLENAPKAARAGLDLVIGTTGFSDEDLRVLEHEIEEAG
CCCCCCCCCCCCEEEEEEEEHHHHHCCCHHHHCCCEEEEECCCCCCCHHHHHHHHHHHCC
VSAVISPNMSLGVNLLFELTRQLARVLGDNGFDFEIVEIHHRHKVDAPSGTALELAAIIE
CEEEECCCCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCCCCHHHHHHHHH
EELGKGEKVFGREGNVGPRDDDEIGVLAVRGGEVVGDHTVMALGEYERIELTHRALSRDA
HHHCCCCEEECCCCCCCCCCCCCEEEEEEECCEEECCCEEEEECCCHHHHHHHHHHHHHH
FAKGALVAAKFVVEAPPGIYSMRDVLFGGKRGEGL
HHCCHHEEEEEEEECCCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014