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The map label for this gene is PncB [H]

Identifier: 20094836

GI number: 20094836

Start: 1424001

End: 1425185

Strand: Reverse

Name: PncB [H]

Synonym: MK1400

Alternate gene names: 20094836

Gene position: 1425185-1424001 (Counterclockwise)

Preceding gene: 20094838

Following gene: 20094835

Centisome position: 84.08

GC content: 66.08

Gene sequence:

>1185_bases
GTGCGCCTTCACGTGGCCACGGAGGACGAGATAAGACGCGGTGAGACCGCGGATGTGTACTTCAGGAGGATCAGAAAGGT
ACTGGAGGAAGAAGGCCTCGCCGACACCGAGGTGGTCGCCGAGATCTCCACGCGGTCGTTACCGGAGGGTTGGGAGTGGG
GTGTCCTGTGCGGCGTCGAAGAGGCGCTAGCGTTGCTCGAAGGTCGGGACGTTACGGTGTACGCGATGGACGAAGGTGAG
GTGTTCCGACCCGGGCAGCCGGTGATGAGGATTGAGGGGCCTTACGTCGAGTTCTGCGAGCTCGAGACGGCGCTGATCGG
GTGCCTGGCTAAGGCCACCGGGATCGCCACGAAAGCTGCGAGGTGCAAGGTCGCGGCCGGCGGTAAGCCGGTGTACAGCT
TCGGAATCCGTCGGCAACACCCGGCGATCGCCCCGATGGTGGACAGGGCGGCGTACGTGGGCGGGTGCGACGGGGTCTCC
GGGATCAAGGGGGCGGAGCTGATCGGGGAGCGGCCCGTGGGCACCATGCCGCACGCGTTCGTCCTGGTGTTCGGGGACCA
GCGGAAGGCCTGGCGAGCGTTCGACGAGCACGTGCCGGAGGACGTCCCCAGGATAGCTCTCGTGGACACGATGTACGACG
AGGTGGAGGAGGCGCTGATGGCGGCCGAAGAGCTGAGGGAGAGGCTGGACGGGGTGAGGCTCGACACACCGTCCTCGCGC
CGGGGCGACATGGCGGAGATCGTACGTGAAGTCAGATGGGAGCTGGACCTCCGAGGGTACGAGCACGTCAAGATCATGGT
GTCCGGAGGGTTGGACGAGGGCGAGATCCGACGGCTCGCGGAGGTGGGAGCCGACGCGTTCGGCGTGGGCACGGCGATCT
CGGACGCACCGGCGGTGGACTTCGCGATGGACCTGGTGGAGATCGAAGGTGAACCGAGGTCGAAGCGGGGGAAGCTCTCC
GGAGCGAAACAAGTCTGGAGGTGCCCGAACTGTCTGGACGACGTCGTGCTCCCTCGGGGTAAGGAGCCGAGTCCCTGTCC
GGAATGTGGGTCGGAACGCGAGCCGCTGCTGCGGAAGTTCGTGGAGGAGGGTGAGGTAGTCCGGGAACCGAAGTCTCCCA
AGGAGGCTCGGAGGCATGTGCTGGAGACTGTCGGGGAGCTCGAGGGCCTCGACCTGACGGAGTAA

Upstream 100 bases:

>100_bases
CGCTCTCGGCTCCTTTCCGCCCAGTTCGCCCCGACCGGACCGACGGTGTGAGGATAAAGCTTTCGATTCTCGCGGGGATG
CCCCGCGGGGGTGCGTGTGA

Downstream 100 bases:

>100_bases
GGCCCCGTTCCCTCGTGGCTCCGGTGTCGGGATTCCAGGGACCACCGGGGGCCTCGGAGTTGGAGCAACTGGGACGTGCA
CTGTTAGAAACGGTGCAGAA

Product: nicotinate phosphoribosyltransferase

Products: NA

Alternate protein names: NAPRTase [H]

Number of amino acids: Translated: 394; Mature: 394

Protein sequence:

>394_residues
MRLHVATEDEIRRGETADVYFRRIRKVLEEEGLADTEVVAEISTRSLPEGWEWGVLCGVEEALALLEGRDVTVYAMDEGE
VFRPGQPVMRIEGPYVEFCELETALIGCLAKATGIATKAARCKVAAGGKPVYSFGIRRQHPAIAPMVDRAAYVGGCDGVS
GIKGAELIGERPVGTMPHAFVLVFGDQRKAWRAFDEHVPEDVPRIALVDTMYDEVEEALMAAEELRERLDGVRLDTPSSR
RGDMAEIVREVRWELDLRGYEHVKIMVSGGLDEGEIRRLAEVGADAFGVGTAISDAPAVDFAMDLVEIEGEPRSKRGKLS
GAKQVWRCPNCLDDVVLPRGKEPSPCPECGSEREPLLRKFVEEGEVVREPKSPKEARRHVLETVGELEGLDLTE

Sequences:

>Translated_394_residues
MRLHVATEDEIRRGETADVYFRRIRKVLEEEGLADTEVVAEISTRSLPEGWEWGVLCGVEEALALLEGRDVTVYAMDEGE
VFRPGQPVMRIEGPYVEFCELETALIGCLAKATGIATKAARCKVAAGGKPVYSFGIRRQHPAIAPMVDRAAYVGGCDGVS
GIKGAELIGERPVGTMPHAFVLVFGDQRKAWRAFDEHVPEDVPRIALVDTMYDEVEEALMAAEELRERLDGVRLDTPSSR
RGDMAEIVREVRWELDLRGYEHVKIMVSGGLDEGEIRRLAEVGADAFGVGTAISDAPAVDFAMDLVEIEGEPRSKRGKLS
GAKQVWRCPNCLDDVVLPRGKEPSPCPECGSEREPLLRKFVEEGEVVREPKSPKEARRHVLETVGELEGLDLTE
>Mature_394_residues
MRLHVATEDEIRRGETADVYFRRIRKVLEEEGLADTEVVAEISTRSLPEGWEWGVLCGVEEALALLEGRDVTVYAMDEGE
VFRPGQPVMRIEGPYVEFCELETALIGCLAKATGIATKAARCKVAAGGKPVYSFGIRRQHPAIAPMVDRAAYVGGCDGVS
GIKGAELIGERPVGTMPHAFVLVFGDQRKAWRAFDEHVPEDVPRIALVDTMYDEVEEALMAAEELRERLDGVRLDTPSSR
RGDMAEIVREVRWELDLRGYEHVKIMVSGGLDEGEIRRLAEVGADAFGVGTAISDAPAVDFAMDLVEIEGEPRSKRGKLS
GAKQVWRCPNCLDDVVLPRGKEPSPCPECGSEREPLLRKFVEEGEVVREPKSPKEARRHVLETVGELEGLDLTE

Specific function: Catalyzes the conversion of nicotinic acid (NA) to NA mononucleotide (NaMN) [H]

COG id: COG1488

COG function: function code H; Nicotinic acid phosphoribosyltransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NAPRTase family [H]

Homologues:

Organism=Homo sapiens, GI194394158, Length=410, Percent_Identity=26.0975609756098, Blast_Score=89, Evalue=9e-18,
Organism=Caenorhabditis elegans, GI71997952, Length=421, Percent_Identity=24.2280285035629, Blast_Score=85, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI71997947, Length=421, Percent_Identity=24.2280285035629, Blast_Score=85, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71997955, Length=129, Percent_Identity=34.8837209302326, Blast_Score=71, Evalue=8e-13,
Organism=Drosophila melanogaster, GI24581587, Length=395, Percent_Identity=28.1012658227848, Blast_Score=92, Evalue=6e-19,
Organism=Drosophila melanogaster, GI161076680, Length=161, Percent_Identity=35.4037267080745, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24581595, Length=161, Percent_Identity=35.4037267080745, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI28574709, Length=161, Percent_Identity=35.4037267080745, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24581593, Length=161, Percent_Identity=35.4037267080745, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24581591, Length=161, Percent_Identity=35.4037267080745, Blast_Score=78, Evalue=9e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015977
- InterPro:   IPR007229
- InterPro:   IPR006405
- InterPro:   IPR002638 [H]

Pfam domain/function: PF04095 NAPRTase [H]

EC number: =2.4.2.11 [H]

Molecular weight: Translated: 43466; Mature: 43466

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLHVATEDEIRRGETADVYFRRIRKVLEEEGLADTEVVAEISTRSLPEGWEWGVLCGVE
CEEECCCHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCEEECHH
EALALLEGRDVTVYAMDEGEVFRPGQPVMRIEGPYVEFCELETALIGCLAKATGIATKAA
HHHHHHCCCCEEEEEECCCCEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RCKVAAGGKPVYSFGIRRQHPAIAPMVDRAAYVGGCDGVSGIKGAELIGERPVGTMPHAF
HEEEECCCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCEE
VLVFGDQRKAWRAFDEHVPEDVPRIALVDTMYDEVEEALMAAEELRERLDGVRLDTPSSR
EEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
RGDMAEIVREVRWELDLRGYEHVKIMVSGGLDEGEIRRLAEVGADAFGVGTAISDAPAVD
CCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHCCCHHCCCCCCCCCCHHH
FAMDLVEIEGEPRSKRGKLSGAKQVWRCPNCLDDVVLPRGKEPSPCPECGSEREPLLRKF
HHHHHHHCCCCCCCCCCCCCCHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHH
VEEGEVVREPKSPKEARRHVLETVGELEGLDLTE
HHCCHHHCCCCCHHHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MRLHVATEDEIRRGETADVYFRRIRKVLEEEGLADTEVVAEISTRSLPEGWEWGVLCGVE
CEEECCCHHHHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCCCCCCEEECHH
EALALLEGRDVTVYAMDEGEVFRPGQPVMRIEGPYVEFCELETALIGCLAKATGIATKAA
HHHHHHCCCCEEEEEECCCCEECCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHH
RCKVAAGGKPVYSFGIRRQHPAIAPMVDRAAYVGGCDGVSGIKGAELIGERPVGTMPHAF
HEEEECCCCCHHHHCCCCCCCCCCHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCEE
VLVFGDQRKAWRAFDEHVPEDVPRIALVDTMYDEVEEALMAAEELRERLDGVRLDTPSSR
EEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
RGDMAEIVREVRWELDLRGYEHVKIMVSGGLDEGEIRRLAEVGADAFGVGTAISDAPAVD
CCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHCCCHHCCCCCCCCCCHHH
FAMDLVEIEGEPRSKRGKLSGAKQVWRCPNCLDDVVLPRGKEPSPCPECGSEREPLLRKF
HHHHHHHCCCCCCCCCCCCCCHHHHHCCCCHHHHHHCCCCCCCCCCCCCCCCCCHHHHHH
VEEGEVVREPKSPKEARRHVLETVGELEGLDLTE
HHCCHHHCCCCCHHHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]