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The map label for this gene is GldA

Identifier: 20094666

GI number: 20094666

Start: 1215994

End: 1217055

Strand: Direct

Name: GldA

Synonym: MK1230

Alternate gene names: 20094666

Gene position: 1215994-1217055 (Clockwise)

Preceding gene: 20094661

Following gene: 20094670

Centisome position: 71.74

GC content: 65.44

Gene sequence:

>1062_bases
TTGAGCGTTCCCAAGAAACGCATGCAGCTCCCGAGAGAGGTCGTCGTGGGTTCGAACGTGCTCCCCGAAGTTCCGAAGCT
CCTACGTAGCGTCGGAGTACCGGACGGAGTCGTCGCGGTGTTCTCCGGGCGAACTACCATGAAGATCGCGGGGAACGAGG
TCGCCGACCACCTCGAGGAAGCCGGGTACCAGACGTCACCGGTGATCGTCAAGGGGTCGACCGGGGACGACGTGAAAAAA
GCTTTGGAGGCGCTGGACGAGATCGACGCGGACGTGGTAGCCGCGGTGGGCGGCGGTAAGGTCATCGACGTGGCGAAGGT
GGCGTCGTACCGTCGGGGTATCCCGTTCATCAGCGTCCCCACATCCGCCTCCCACGACGGCATCGCATCACCGTTCGCCT
CCATCCGCCGGGAGGGACGGCCGTACTCCGAGCCCGCCCAGGCTCCACTGGCCATCCTGGCGGACATAGAGGTCATCCGA
GAGGCCCCGGAGCGCCTCATCCGCGCCGGGGTCGGGGACGTCGTCTCCAACGTGACGGCGGTGAAGGACTGGCGACTGGC
GCACCGGCTCAGGAACGAGCCCTACAGCGAGTACGCGTCCTCCCTATCGCTGATGGCGGCCCGGATCGTGATGAAGAACG
CGAAACCCATCGGCAAGCTCCTCCCGGAAGGCATCAAGAAGCTGGTTCAAGCGCTCATCAGCGGCGGGGTGGCTATGAGT
ATCGCGGGCTCCTCCCGACCGTGCAGCGGGTCGGAGCACCTCTTCAGCCATGCCCTGGACGTGATCGCGGAACGTCCGGC
GCTTCACGGCGAGCAGTGCGGGGTCGGCACCATCATCATGGAGTACCTGCACGGGGGCAACTGGCGGGAAATCCGTGAGA
CGCTCGAAACGGCGGGCGCACCTACCACGGCCGAGGACCTAGGGGTAAGTGACGAGGAGATCATCGAAGCGCTCTGCCGG
GCGCACAAGATACGTCCGGACCGGTACACCATCTTGGGGGATAAAGGACTGACGCGCGAGGCCGCGGAGAGGGCGGCCGA
GGAGACGGGCGTCATTCAGTGA

Upstream 100 bases:

>100_bases
CCTTAACGGGGTACCTCACGTCCATTATCTCCGCGCTGCGCAAGACCTCCGCGTACCACTCCGAGAACTCCAATCGATCA
CCCCTCGGGGTCGACGGAAG

Downstream 100 bases:

>100_bases
ACCGCTCTTCGAACACGACCTCTTCCACGGCGTCGTCGTACTCTATCATCAGCTTCGCGAACCTCTGCTTCGCCCGGGCC
CACGCCGGATTGGCGGCGTC

Product: glycerol dehydrogenase

Products: NA

Alternate protein names: G1P dehydrogenase; G1PDH; Enantiomeric glycerophosphate synthase; sn-glycerol-1-phosphate dehydrogenase

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MSVPKKRMQLPREVVVGSNVLPEVPKLLRSVGVPDGVVAVFSGRTTMKIAGNEVADHLEEAGYQTSPVIVKGSTGDDVKK
ALEALDEIDADVVAAVGGGKVIDVAKVASYRRGIPFISVPTSASHDGIASPFASIRREGRPYSEPAQAPLAILADIEVIR
EAPERLIRAGVGDVVSNVTAVKDWRLAHRLRNEPYSEYASSLSLMAARIVMKNAKPIGKLLPEGIKKLVQALISGGVAMS
IAGSSRPCSGSEHLFSHALDVIAERPALHGEQCGVGTIIMEYLHGGNWREIRETLETAGAPTTAEDLGVSDEEIIEALCR
AHKIRPDRYTILGDKGLTREAAERAAEETGVIQ

Sequences:

>Translated_353_residues
MSVPKKRMQLPREVVVGSNVLPEVPKLLRSVGVPDGVVAVFSGRTTMKIAGNEVADHLEEAGYQTSPVIVKGSTGDDVKK
ALEALDEIDADVVAAVGGGKVIDVAKVASYRRGIPFISVPTSASHDGIASPFASIRREGRPYSEPAQAPLAILADIEVIR
EAPERLIRAGVGDVVSNVTAVKDWRLAHRLRNEPYSEYASSLSLMAARIVMKNAKPIGKLLPEGIKKLVQALISGGVAMS
IAGSSRPCSGSEHLFSHALDVIAERPALHGEQCGVGTIIMEYLHGGNWREIRETLETAGAPTTAEDLGVSDEEIIEALCR
AHKIRPDRYTILGDKGLTREAAERAAEETGVIQ
>Mature_352_residues
SVPKKRMQLPREVVVGSNVLPEVPKLLRSVGVPDGVVAVFSGRTTMKIAGNEVADHLEEAGYQTSPVIVKGSTGDDVKKA
LEALDEIDADVVAAVGGGKVIDVAKVASYRRGIPFISVPTSASHDGIASPFASIRREGRPYSEPAQAPLAILADIEVIRE
APERLIRAGVGDVVSNVTAVKDWRLAHRLRNEPYSEYASSLSLMAARIVMKNAKPIGKLLPEGIKKLVQALISGGVAMSI
AGSSRPCSGSEHLFSHALDVIAERPALHGEQCGVGTIIMEYLHGGNWREIRETLETAGAPTTAEDLGVSDEEIIEALCRA
HKIRPDRYTILGDKGLTREAAERAAEETGVIQ

Specific function: Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol-1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea

COG id: COG0371

COG function: function code C; Glycerol dehydrogenase and related enzymes

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glycerol-1-phosphate dehydrogenase family

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): G1PDH_METKA (Q8TW08)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614513.1
- ProteinModelPortal:   Q8TW08
- SMR:   Q8TW08
- GeneID:   1477825
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK1230
- NMPDR:   fig|190192.1.peg.1226
- HOGENOM:   HBG672951
- OMA:   VAMCIAG
- BioCyc:   MKAN190192:MK1230-MONOMER
- BRENDA:   1.1.1.261
- GO:   GO:0005737
- HAMAP:   MF_00497_A
- InterPro:   IPR002658
- InterPro:   IPR023002
- InterPro:   IPR016205
- PIRSF:   PIRSF000112

Pfam domain/function: PF01761 DHQ_synthase

EC number: =1.1.1.261

Molecular weight: Translated: 37643; Mature: 37511

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: BINDING 126-126 BINDING 130-130 BINDING 173-173 BINDING 257-257

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSVPKKRMQLPREVVVGSNVLPEVPKLLRSVGVPDGVVAVFSGRTTMKIAGNEVADHLEE
CCCCHHHHHCCHHHHHCCCCCHHHHHHHHHCCCCCCEEEEECCCEEEEECCHHHHHHHHH
AGYQTSPVIVKGSTGDDVKKALEALDEIDADVVAAVGGGKVIDVAKVASYRRGIPFISVP
CCCCCCCEEEECCCCHHHHHHHHHHHHCCHHHEEECCCCCHHHHHHHHHHHCCCCEEECC
TSASHDGIASPFASIRREGRPYSEPAQAPLAILADIEVIREAPERLIRAGVGDVVSNVTA
CCCCCCCHHHHHHHHHHCCCCCCCCHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKDWRLAHRLRNEPYSEYASSLSLMAARIVMKNAKPIGKLLPEGIKKLVQALISGGVAMS
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEE
IAGSSRPCSGSEHLFSHALDVIAERPALHGEQCGVGTIIMEYLHGGNWREIRETLETAGA
ECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCC
PTTAEDLGVSDEEIIEALCRAHKIRPDRYTILGDKGLTREAAERAAEETGVIQ
CCCHHHCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SVPKKRMQLPREVVVGSNVLPEVPKLLRSVGVPDGVVAVFSGRTTMKIAGNEVADHLEE
CCCHHHHHCCHHHHHCCCCCHHHHHHHHHCCCCCCEEEEECCCEEEEECCHHHHHHHHH
AGYQTSPVIVKGSTGDDVKKALEALDEIDADVVAAVGGGKVIDVAKVASYRRGIPFISVP
CCCCCCCEEEECCCCHHHHHHHHHHHHCCHHHEEECCCCCHHHHHHHHHHHCCCCEEECC
TSASHDGIASPFASIRREGRPYSEPAQAPLAILADIEVIREAPERLIRAGVGDVVSNVTA
CCCCCCCHHHHHHHHHHCCCCCCCCHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VKDWRLAHRLRNEPYSEYASSLSLMAARIVMKNAKPIGKLLPEGIKKLVQALISGGVAMS
HHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCEEEE
IAGSSRPCSGSEHLFSHALDVIAERPALHGEQCGVGTIIMEYLHGGNWREIRETLETAGA
ECCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHCCC
PTTAEDLGVSDEEIIEALCRAHKIRPDRYTILGDKGLTREAAERAAEETGVIQ
CCCHHHCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014