Click here to switch to the map view.

The map label for this gene is CpsG_1

Identifier: 20094329

GI number: 20094329

Start: 841103

End: 842461

Strand: Reverse

Name: CpsG_1

Synonym: MK0893

Alternate gene names: 20094329

Gene position: 842461-841103 (Counterclockwise)

Preceding gene: 20094331

Following gene: 20094328

Centisome position: 49.7

GC content: 61.52

Gene sequence:

>1359_bases
GTGGGTAAATACTTCGGTACGTCCGGTATCCGCGGTAGAGTAGGGGAGTTCCTAACTCCAGAGCTCGCACTTCGAGCTGG
ACGCGCTCTCGGCGAGTACTTGGGTGGCGGCACGGTTGCCGTAGGTCGCGACACCCGGGTACACTGCGATGCCCTTCGCG
CAGCCGTGATCTCAGGACTGACCGCCCAAGGATGTGATGTTGTAGACATCGGGGTAGTGTGCACACCGACTCTGGGTTGT
TACGTGGCGACTGAGGGTCTCGACGCCGGTGTAATGATCACAGCTTCCCACAATCCTCCCGAGTACAACGGGATAAAGTT
CTGGGACTCTGACGGAATGGCGTTCTCGCCCGAACAAGAGCGTGAAATAGAGCAGATCATGGACGGCGATCTGGAGTACC
CGAATTGGGACGAGTACGGTGAGGTGGTCGACGACGAGACGGCGTTGAACGTACACGTGGAGAGGATACTGGACGAGGTC
TCCGTCGACGGGGACGGGCTACGCATCGTGGTGGACTGTGCCAACGGCCCCTCCGCGTTCGTCACTCCGGTAGTACTCCG
CGAGATGGGGTGCGAGGTAATCTCTCTAAACGCGCATCCTGATGGACACTTCCCGGGCCGGGAACCGGAGCCGAAGCCCG
AGAACCTGAAGGACCTCATGCGAACCGTGCGGGCGACGGATGCTGATCTGGGGATCGCCCACGACGGGGACGCTGATCGT
GTAGTTTTCGTCACCGAGGAAGGTAAGTTCGCCGGGTACGACGAAGTGCTGGCGTTGGTGTGCCGGCGAATCCTCGAGGA
GAAGGGTCCAGGGAAGGTCGCCGTGAACGTCGATGCTTCGATGGTTATCGACGAGGTAGTCCGCGAGATGGGCGGCGAGG
TGGTGAGGACCAAAGTGGGAGACGTCCACGTAGCCGCCGCGATACGGGAGGAAGGATGCGTCTTCGGAGGGGAACCGAAC
GGAACCTGGATACACCCGGACGTACACATGTGCCCCGACGGTCCGCTCTCCGCGGCGTGGATGGTGAGCTTGCTGATCGA
GGAAGGGCGACCGCTCTCGGAACTGTTAGCCGAGATCCCGAGCTACCCGGTCGTGCGCGAAACCGTCGAGTGTCCCGACG
AGCTCAAGCCCGAAGTGATGAGGCTGGTGGAGACGCGCCTCCGGGAGGCTTACGACGACATCGATACCGTAGACGGCGTT
CGTGTCGAACTGGACGATGGCTGGGTGCTCGTCAGGCCCTCCGGCACCGAACCGCTCATACGGATAACGGTGGAGGCGGA
GTCCGAGGAACGCGCCCGAGAGCTCAGGGATGAGTTCGTCGATATCGTCCGCAGGTGTGTCGAGGAGGTGAGGGAATGA

Upstream 100 bases:

>100_bases
GATCTCGCCGACCTCCGCCCGGAGCGCGCCCTTTAATTCCATTAGCGCCAACTCAACGTTATCCCCGGCGAGTAGGAACG
CGAACAAAGGGGGACCCCCC

Downstream 100 bases:

>100_bases
TCGGTATCGTGCTCGCGGCGGGCGAAGGTACCCGGATGCGACCGCTGACGAAGACACGGCCGAAGGTCCTCCTGCCGGTG
GCCGATCGCCGTCTTATCGA

Product: phosphomannomutase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MGKYFGTSGIRGRVGEFLTPELALRAGRALGEYLGGGTVAVGRDTRVHCDALRAAVISGLTAQGCDVVDIGVVCTPTLGC
YVATEGLDAGVMITASHNPPEYNGIKFWDSDGMAFSPEQEREIEQIMDGDLEYPNWDEYGEVVDDETALNVHVERILDEV
SVDGDGLRIVVDCANGPSAFVTPVVLREMGCEVISLNAHPDGHFPGREPEPKPENLKDLMRTVRATDADLGIAHDGDADR
VVFVTEEGKFAGYDEVLALVCRRILEEKGPGKVAVNVDASMVIDEVVREMGGEVVRTKVGDVHVAAAIREEGCVFGGEPN
GTWIHPDVHMCPDGPLSAAWMVSLLIEEGRPLSELLAEIPSYPVVRETVECPDELKPEVMRLVETRLREAYDDIDTVDGV
RVELDDGWVLVRPSGTEPLIRITVEAESEERARELRDEFVDIVRRCVEEVRE

Sequences:

>Translated_452_residues
MGKYFGTSGIRGRVGEFLTPELALRAGRALGEYLGGGTVAVGRDTRVHCDALRAAVISGLTAQGCDVVDIGVVCTPTLGC
YVATEGLDAGVMITASHNPPEYNGIKFWDSDGMAFSPEQEREIEQIMDGDLEYPNWDEYGEVVDDETALNVHVERILDEV
SVDGDGLRIVVDCANGPSAFVTPVVLREMGCEVISLNAHPDGHFPGREPEPKPENLKDLMRTVRATDADLGIAHDGDADR
VVFVTEEGKFAGYDEVLALVCRRILEEKGPGKVAVNVDASMVIDEVVREMGGEVVRTKVGDVHVAAAIREEGCVFGGEPN
GTWIHPDVHMCPDGPLSAAWMVSLLIEEGRPLSELLAEIPSYPVVRETVECPDELKPEVMRLVETRLREAYDDIDTVDGV
RVELDDGWVLVRPSGTEPLIRITVEAESEERARELRDEFVDIVRRCVEEVRE
>Mature_451_residues
GKYFGTSGIRGRVGEFLTPELALRAGRALGEYLGGGTVAVGRDTRVHCDALRAAVISGLTAQGCDVVDIGVVCTPTLGCY
VATEGLDAGVMITASHNPPEYNGIKFWDSDGMAFSPEQEREIEQIMDGDLEYPNWDEYGEVVDDETALNVHVERILDEVS
VDGDGLRIVVDCANGPSAFVTPVVLREMGCEVISLNAHPDGHFPGREPEPKPENLKDLMRTVRATDADLGIAHDGDADRV
VFVTEEGKFAGYDEVLALVCRRILEEKGPGKVAVNVDASMVIDEVVREMGGEVVRTKVGDVHVAAAIREEGCVFGGEPNG
TWIHPDVHMCPDGPLSAAWMVSLLIEEGRPLSELLAEIPSYPVVRETVECPDELKPEVMRLVETRLREAYDDIDTVDGVR
VELDDGWVLVRPSGTEPLIRITVEAESEERARELRDEFVDIVRRCVEEVRE

Specific function: Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family

Homologues:

Organism=Escherichia coli, GI1789566, Length=455, Percent_Identity=32.5274725274725, Blast_Score=190, Evalue=2e-49,
Organism=Escherichia coli, GI1788361, Length=449, Percent_Identity=29.1759465478842, Blast_Score=172, Evalue=4e-44,
Organism=Drosophila melanogaster, GI17864244, Length=517, Percent_Identity=24.3713733075435, Blast_Score=94, Evalue=2e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GLMM_METKA (Q8TWY8)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614176.1
- HSSP:   O58651
- ProteinModelPortal:   Q8TWY8
- SMR:   Q8TWY8
- GeneID:   1476994
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0893
- NMPDR:   fig|190192.1.peg.889
- HOGENOM:   HBG644964
- OMA:   RESNTED
- BioCyc:   MKAN190192:MK0893-MONOMER
- HAMAP:   MF_01554_A
- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841
- Gene3D:   G3DSA:3.40.120.10
- PRINTS:   PR00509

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV; SSF53738 A-D-PHexomutase_a/b/a-I/II/III

EC number: =5.4.2.10

Molecular weight: Translated: 49408; Mature: 49277

Theoretical pI: Translated: 4.16; Mature: 4.16

Prosite motif: PS00710 PGM_PMM

Important sites: ACT_SITE 96-96

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGKYFGTSGIRGRVGEFLTPELALRAGRALGEYLGGGTVAVGRDTRVHCDALRAAVISGL
CCCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCC
TAQGCDVVDIGVVCTPTLGCYVATEGLDAGVMITASHNPPEYNGIKFWDSDGMAFSPEQE
CCCCCCEEEECEEECCCCCEEEEECCCCCCEEEEECCCCCCCCCEEEECCCCCEECCHHH
REIEQIMDGDLEYPNWDEYGEVVDDETALNVHVERILDEVSVDGDGLRIVVDCANGPSAF
HHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHH
VTPVVLREMGCEVISLNAHPDGHFPGREPEPKPENLKDLMRTVRATDADLGIAHDGDADR
HHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEECCCCCCE
VVFVTEEGKFAGYDEVLALVCRRILEEKGPGKVAVNVDASMVIDEVVREMGGEVVRTKVG
EEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCCEEEEECC
DVHVAAAIREEGCVFGGEPNGTWIHPDVHMCPDGPLSAAWMVSLLIEEGRPLSELLAEIP
CEEEEEHHHHCCCEECCCCCCCEECCCCEECCCCCCHHHHHHHHHHHCCCCHHHHHHHCC
SYPVVRETVECPDELKPEVMRLVETRLREAYDDIDTVDGVRVELDDGWVLVRPSGTEPLI
CCCCHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEECCCCCCEE
RITVEAESEERARELRDEFVDIVRRCVEEVRE
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
GKYFGTSGIRGRVGEFLTPELALRAGRALGEYLGGGTVAVGRDTRVHCDALRAAVISGL
CCCCCCCCCCCCHHHHCCHHHHHHHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCC
TAQGCDVVDIGVVCTPTLGCYVATEGLDAGVMITASHNPPEYNGIKFWDSDGMAFSPEQE
CCCCCCEEEECEEECCCCCEEEEECCCCCCEEEEECCCCCCCCCEEEECCCCCEECCHHH
REIEQIMDGDLEYPNWDEYGEVVDDETALNVHVERILDEVSVDGDGLRIVVDCANGPSAF
HHHHHHHCCCCCCCCHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCHH
VTPVVLREMGCEVISLNAHPDGHFPGREPEPKPENLKDLMRTVRATDADLGIAHDGDADR
HHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCEECCCCCCE
VVFVTEEGKFAGYDEVLALVCRRILEEKGPGKVAVNVDASMVIDEVVREMGGEVVRTKVG
EEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEECCHHHHHHHHHHHHCCCEEEEECC
DVHVAAAIREEGCVFGGEPNGTWIHPDVHMCPDGPLSAAWMVSLLIEEGRPLSELLAEIP
CEEEEEHHHHCCCEECCCCCCCEECCCCEECCCCCCHHHHHHHHHHHCCCCHHHHHHHCC
SYPVVRETVECPDELKPEVMRLVETRLREAYDDIDTVDGVRVELDDGWVLVRPSGTEPLI
CCCCHHHHHCCCHHCCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCEEEEECCCCCCEE
RITVEAESEERARELRDEFVDIVRRCVEEVRE
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014