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The map label for this gene is glmU [C]

Identifier: 20094328

GI number: 20094328

Start: 839829

End: 841106

Strand: Reverse

Name: glmU [C]

Synonym: MK0892

Alternate gene names: 20094328

Gene position: 841106-839829 (Counterclockwise)

Preceding gene: 20094329

Following gene: 20094326

Centisome position: 49.62

GC content: 60.95

Gene sequence:

>1278_bases
ATGATCGGTATCGTGCTCGCGGCGGGCGAAGGTACCCGGATGCGACCGCTGACGAAGACACGGCCGAAGGTCCTCCTGCC
GGTGGCCGATCGCCGTCTTATCGACTTCTCCATCGAGGCCATGAAGCGCATCGGAGTGGAACACCTCGTGGTGGTCGTGG
AATACCTGGCCGAGAAGGTGGAACGGTACGTCAAGGATCGCTGGGGCGATTCCTTCGAGCTGGAGTTCGTCCGTCAGGGT
AAGCCCCTGGGAACAGCCCACGCTGTGTACGTCGCGTGGCGGGAGATCGAACCCGACGAGACCGTGGTCATCACAAACGG
GGACTTGGTGTTCGATTCGGAGTTGCTCGAGCGCGCGGTACGTGAGCACGAAGGCGTCGCCTCAATGGTGCTAGTGGAGG
TCGAGGATCCGTCGGAATTCGGGGTCGCGAGACTACAAGACGGGTACGTGGTGGAGCTCGTGGAGAAACCCAAGCCCGAG
GAGGCTCCCTCCAACCTGGCGAACGCGGGAGTGTACGTGGCGGAACCGGAGTTCGAGAGGTTTTTGGAACGAGTCAAACC
CTCTCCGCGGGGCGAGTTCGAGATCACCGATGCGCTGCTCGACGCCGCCATCGATGAAGGTGTTCTAGGGATTTCGTACG
ACGGGTTCTGGTCCGACGTAGGTCGCCCGTGGGACCTACTCGACGCCAACGCTTGGGCACTTCGGAACGCGATGTCGCGT
CCCGAGGTTGAAGGAGTCATCGAGGAGAACGTGGAGCTGAGAGGACCGGTGTGGGTAGCCGAGGATGCGATCCTCAGGTC
GGGAGCCGTAGTCGAAGGGCCCGCCTATATAGGCCCGGGGTGCGAAATCGGACCCAACTGCTACATCCGACCGGCGACGA
CGCTGGTCCGGGACGTCCGCATCGGCCAAGCCGTCGAAATCAAGAACTCAATAATCATGGAGGGGACGAACGTCAGCCAC
CTCTCCTACGTGGGAGACAGCGTTATCGGGGCCAAGTGCAACCTGGGAGCCGGTACCATCATCGCCAACCTCAGACACGA
TGAACGCAACGTGAAAGTAGTAGTCAAGGGCGAGCTCGAGGATACCGGTAGGAGGAAGTTCGGAGCCGTACTGGGTGATG
GGGTTAAAACAGGGATCAACACCTCTATACTGCCGGGACGGAAACTGGGCCCGTACTCGGCCACCGCACCTTCCACCGTC
GTCCGTAAGAACGTCCCGGAGGGCAAGATGCTAGTTCAAGGTGACCAGATCCTAGTCGATTGGGAGGGACGCGGATGA

Upstream 100 bases:

>100_bases
TCATACGGATAACGGTGGAGGCGGAGTCCGAGGAACGCGCCCGAGAGCTCAGGGATGAGTTCGTCGATATCGTCCGCAGG
TGTGTCGAGGAGGTGAGGGA

Downstream 100 bases:

>100_bases
CGATGTCCCGCGCTACTGAAGGATGATGACGATTGGACCGCGGACGCGTCCTCAGCTGAGCATCCACCTCAACAACTTCT
TTCCGGCAACGGTGAACGTT

Product: translation initiation factor eIF2B subunit

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 425; Mature: 425

Protein sequence:

>425_residues
MIGIVLAAGEGTRMRPLTKTRPKVLLPVADRRLIDFSIEAMKRIGVEHLVVVVEYLAEKVERYVKDRWGDSFELEFVRQG
KPLGTAHAVYVAWREIEPDETVVITNGDLVFDSELLERAVREHEGVASMVLVEVEDPSEFGVARLQDGYVVELVEKPKPE
EAPSNLANAGVYVAEPEFERFLERVKPSPRGEFEITDALLDAAIDEGVLGISYDGFWSDVGRPWDLLDANAWALRNAMSR
PEVEGVIEENVELRGPVWVAEDAILRSGAVVEGPAYIGPGCEIGPNCYIRPATTLVRDVRIGQAVEIKNSIIMEGTNVSH
LSYVGDSVIGAKCNLGAGTIIANLRHDERNVKVVVKGELEDTGRRKFGAVLGDGVKTGINTSILPGRKLGPYSATAPSTV
VRKNVPEGKMLVQGDQILVDWEGRG

Sequences:

>Translated_425_residues
MIGIVLAAGEGTRMRPLTKTRPKVLLPVADRRLIDFSIEAMKRIGVEHLVVVVEYLAEKVERYVKDRWGDSFELEFVRQG
KPLGTAHAVYVAWREIEPDETVVITNGDLVFDSELLERAVREHEGVASMVLVEVEDPSEFGVARLQDGYVVELVEKPKPE
EAPSNLANAGVYVAEPEFERFLERVKPSPRGEFEITDALLDAAIDEGVLGISYDGFWSDVGRPWDLLDANAWALRNAMSR
PEVEGVIEENVELRGPVWVAEDAILRSGAVVEGPAYIGPGCEIGPNCYIRPATTLVRDVRIGQAVEIKNSIIMEGTNVSH
LSYVGDSVIGAKCNLGAGTIIANLRHDERNVKVVVKGELEDTGRRKFGAVLGDGVKTGINTSILPGRKLGPYSATAPSTV
VRKNVPEGKMLVQGDQILVDWEGRG
>Mature_425_residues
MIGIVLAAGEGTRMRPLTKTRPKVLLPVADRRLIDFSIEAMKRIGVEHLVVVVEYLAEKVERYVKDRWGDSFELEFVRQG
KPLGTAHAVYVAWREIEPDETVVITNGDLVFDSELLERAVREHEGVASMVLVEVEDPSEFGVARLQDGYVVELVEKPKPE
EAPSNLANAGVYVAEPEFERFLERVKPSPRGEFEITDALLDAAIDEGVLGISYDGFWSDVGRPWDLLDANAWALRNAMSR
PEVEGVIEENVELRGPVWVAEDAILRSGAVVEGPAYIGPGCEIGPNCYIRPATTLVRDVRIGQAVEIKNSIIMEGTNVSH
LSYVGDSVIGAKCNLGAGTIIANLRHDERNVKVVVKGELEDTGRRKFGAVLGDGVKTGINTSILPGRKLGPYSATAPSTV
VRKNVPEGKMLVQGDQILVDWEGRG

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=346, Percent_Identity=26.3005780346821, Blast_Score=117, Evalue=2e-26,
Organism=Homo sapiens, GI11761621, Length=346, Percent_Identity=26.3005780346821, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI1790168, Length=457, Percent_Identity=25.601750547046, Blast_Score=127, Evalue=1e-30,
Organism=Escherichia coli, GI1788351, Length=242, Percent_Identity=28.099173553719, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790224, Length=287, Percent_Identity=26.8292682926829, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1787488, Length=296, Percent_Identity=28.0405405405405, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI1788355, Length=280, Percent_Identity=26.0714285714286, Blast_Score=75, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI133931050, Length=353, Percent_Identity=30.028328611898, Blast_Score=142, Evalue=4e-34,
Organism=Caenorhabditis elegans, GI17509979, Length=347, Percent_Identity=24.7838616714697, Blast_Score=71, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17509981, Length=338, Percent_Identity=24.2603550295858, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6320148, Length=352, Percent_Identity=29.2613636363636, Blast_Score=125, Evalue=1e-29,
Organism=Drosophila melanogaster, GI21355443, Length=340, Percent_Identity=28.8235294117647, Blast_Score=121, Evalue=1e-27,
Organism=Drosophila melanogaster, GI24644084, Length=340, Percent_Identity=28.8235294117647, Blast_Score=121, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 46544; Mature: 46544

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGIVLAAGEGTRMRPLTKTRPKVLLPVADRRLIDFSIEAMKRIGVEHLVVVVEYLAEKV
CEEEEEECCCCCCCCCCCCCCCEEEEEECCCEEEHHHHHHHHHCCHHHHHHHHHHHHHHH
ERYVKDRWGDSFELEFVRQGKPLGTAHAVYVAWREIEPDETVVITNGDLVFDSELLERAV
HHHHHHHCCCCEEEEEEECCCCCCCEEEEEEEEEECCCCCEEEEECCCEEECHHHHHHHH
REHEGVASMVLVEVEDPSEFGVARLQDGYVVELVEKPKPEEAPSNLANAGVYVAEPEFER
HHHCCCEEEEEEEECCCCCCCCEEECCCEEEEEECCCCCCCCCCHHHHCCEEEECHHHHH
FLERVKPSPRGEFEITDALLDAAIDEGVLGISYDGFWSDVGRPWDLLDANAWALRNAMSR
HHHHCCCCCCCCEEHHHHHHHHHHCCCEEEEEECCHHHHCCCCCCCCCCCHHHHHHHCCC
PEVEGVIEENVELRGPVWVAEDAILRSGAVVEGPAYIGPGCEIGPNCYIRPATTLVRDVR
CCHHHHHHCCCEECCCEEEECHHHHHCCCEEECCCEECCCCCCCCCCEEEHHHHHHHHHH
IGQAVEIKNSIIMEGTNVSHLSYVGDSVIGAKCNLGAGTIIANLRHDERNVKVVVKGELE
CCCEEEECCEEEEECCCCCHHHHCCCCEECCEECCCCCEEEEEEEECCCCEEEEEEECCC
DTGRRKFGAVLGDGVKTGINTSILPGRKLGPYSATAPSTVVRKNVPEGKMLVQGDQILVD
CCCHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCEEEECCEEEEE
WEGRG
ECCCC
>Mature Secondary Structure
MIGIVLAAGEGTRMRPLTKTRPKVLLPVADRRLIDFSIEAMKRIGVEHLVVVVEYLAEKV
CEEEEEECCCCCCCCCCCCCCCEEEEEECCCEEEHHHHHHHHHCCHHHHHHHHHHHHHHH
ERYVKDRWGDSFELEFVRQGKPLGTAHAVYVAWREIEPDETVVITNGDLVFDSELLERAV
HHHHHHHCCCCEEEEEEECCCCCCCEEEEEEEEEECCCCCEEEEECCCEEECHHHHHHHH
REHEGVASMVLVEVEDPSEFGVARLQDGYVVELVEKPKPEEAPSNLANAGVYVAEPEFER
HHHCCCEEEEEEEECCCCCCCCEEECCCEEEEEECCCCCCCCCCHHHHCCEEEECHHHHH
FLERVKPSPRGEFEITDALLDAAIDEGVLGISYDGFWSDVGRPWDLLDANAWALRNAMSR
HHHHCCCCCCCCEEHHHHHHHHHHCCCEEEEEECCHHHHCCCCCCCCCCCHHHHHHHCCC
PEVEGVIEENVELRGPVWVAEDAILRSGAVVEGPAYIGPGCEIGPNCYIRPATTLVRDVR
CCHHHHHHCCCEECCCEEEECHHHHHCCCEEECCCEECCCCCCCCCCEEEHHHHHHHHHH
IGQAVEIKNSIIMEGTNVSHLSYVGDSVIGAKCNLGAGTIIANLRHDERNVKVVVKGELE
CCCEEEECCEEEEECCCCCHHHHCCCCEECCEECCCCCEEEEEEEECCCCEEEEEEECCC
DTGRRKFGAVLGDGVKTGINTSILPGRKLGPYSATAPSTVVRKNVPEGKMLVQGDQILVD
CCCHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCEEEECCEEEEE
WEGRG
ECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA