Click here to switch to the map view.

The map label for this gene is UppS

Identifier: 20094204

GI number: 20094204

Start: 728211

End: 729026

Strand: Reverse

Name: UppS

Synonym: MK0767

Alternate gene names: 20094204

Gene position: 729026-728211 (Counterclockwise)

Preceding gene: 20094209

Following gene: 20094203

Centisome position: 43.01

GC content: 56.74

Gene sequence:

>816_bases
TTGAAACGCGTCACCGGGGTGAACTCTCGCCGCGTGCTGCGGCAGGCCGTTCGCGTCTCGCTTAAGCCGGTATATAAGAT
GTACGAGAGGATACTTGAGGAGAAGGTGAAGGAAGGCAGAGTCCCTGAGCATGTAGGCATCATTATGGACGGAAACAGAA
GGTTCGCCCGAGAGCTGGGATTGGAACCGTGGGAAGGTCATCGGTACGGAGCTGACAAACTCGAGGACGTGCTGGAGTGG
TGTCTCGACTTAGGTGTTAAGGCTGTTACTGTGTACGCGCTGTCTACCGAGAACCTGAACCGACCGAAGGAGGAGCTCAA
GCGGCTCTTCGACCTCATGGAAGAGCGGTTCAAGGCACTCGCGGAGAGCGAGCGGATCCATCGACGAAAGGTCGCCGTCC
GTGCCGTCGGGAGGCTCCATCTGCTCCCGACCCGTGTCCGCAGAGCTATCAAAAAGGCCGAACGCGCCACTAAGGAGTAC
AAGGACAGGTTCCTGAACGTCGCCGTAGCCTACGGTGGGAGGCAGGAGATTATCGACGCTGTTCGCGAGATAGCGCACGA
CGTGAAAGTCGGCCGGCTCGACCCCGATGAGATCGATGAAGGAACGTTCAGAAAGTACGTATACGTGGGAGATCTCCCGG
ATCCGGAGCTGATCATAAGAACCAGTGGTGAGGAAAGACTCAGCAACTTCCTGCTCTGGTACTCCGCGTACTCCGAGCTG
TACTTTGTGGACGTGTACTGGCCTGAGTTTCGGAAGATTGACTTGCTGCGCGCGATCCGTGAATTCCAGAAGCGTGAAAG
AAGATTCGGGCGGTAA

Upstream 100 bases:

>100_bases
TAGCAAGCCGTTCGATGGCCTTCAGGTTGTCGTGGGTGTCCGACAAGATCCCGATCATCATGAATCCCCCTTGAGGGGGT
GAGGAAGGTTACCCGAAGTT

Downstream 100 bases:

>100_bases
GGGGGGAGAGGAATGAAGGAGTTGATGGGTGTAGAGCCGCAGACCGAAGGACAGGAGCGACTGGTCGAAGCGCTGCTAAA
CGAGGAGAATGAAATAGTGG

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MKRVTGVNSRRVLRQAVRVSLKPVYKMYERILEEKVKEGRVPEHVGIIMDGNRRFARELGLEPWEGHRYGADKLEDVLEW
CLDLGVKAVTVYALSTENLNRPKEELKRLFDLMEERFKALAESERIHRRKVAVRAVGRLHLLPTRVRRAIKKAERATKEY
KDRFLNVAVAYGGRQEIIDAVREIAHDVKVGRLDPDEIDEGTFRKYVYVGDLPDPELIIRTSGEERLSNFLLWYSAYSEL
YFVDVYWPEFRKIDLLRAIREFQKRERRFGR

Sequences:

>Translated_271_residues
MKRVTGVNSRRVLRQAVRVSLKPVYKMYERILEEKVKEGRVPEHVGIIMDGNRRFARELGLEPWEGHRYGADKLEDVLEW
CLDLGVKAVTVYALSTENLNRPKEELKRLFDLMEERFKALAESERIHRRKVAVRAVGRLHLLPTRVRRAIKKAERATKEY
KDRFLNVAVAYGGRQEIIDAVREIAHDVKVGRLDPDEIDEGTFRKYVYVGDLPDPELIIRTSGEERLSNFLLWYSAYSEL
YFVDVYWPEFRKIDLLRAIREFQKRERRFGR
>Mature_271_residues
MKRVTGVNSRRVLRQAVRVSLKPVYKMYERILEEKVKEGRVPEHVGIIMDGNRRFARELGLEPWEGHRYGADKLEDVLEW
CLDLGVKAVTVYALSTENLNRPKEELKRLFDLMEERFKALAESERIHRRKVAVRAVGRLHLLPTRVRRAIKKAERATKEY
KDRFLNVAVAYGGRQEIIDAVREIAHDVKVGRLDPDEIDEGTFRKYVYVGDLPDPELIIRTSGEERLSNFLLWYSAYSEL
YFVDVYWPEFRKIDLLRAIREFQKRERRFGR

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is probably the precursor of glycosyl carrier lipids

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580742, Length=239, Percent_Identity=45.6066945606695, Blast_Score=223, Evalue=1e-58,
Organism=Homo sapiens, GI45580738, Length=239, Percent_Identity=45.6066945606695, Blast_Score=223, Evalue=2e-58,
Organism=Escherichia coli, GI1786371, Length=227, Percent_Identity=41.4096916299559, Blast_Score=184, Evalue=5e-48,
Organism=Caenorhabditis elegans, GI71993029, Length=239, Percent_Identity=37.6569037656904, Blast_Score=168, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6319474, Length=226, Percent_Identity=36.7256637168142, Blast_Score=137, Evalue=2e-33,
Organism=Saccharomyces cerevisiae, GI6323748, Length=247, Percent_Identity=34.8178137651822, Blast_Score=123, Evalue=3e-29,
Organism=Drosophila melanogaster, GI18857969, Length=244, Percent_Identity=39.344262295082, Blast_Score=177, Evalue=4e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_METKA (Q8TXA7)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_614051.1
- ProteinModelPortal:   Q8TXA7
- SMR:   Q8TXA7
- GeneID:   1476868
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0767
- NMPDR:   fig|190192.1.peg.764
- HOGENOM:   HBG627837
- OMA:   YGGQQEI
- BioCyc:   MKAN190192:MK0767-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 32078; Mature: 32078

Theoretical pI: Translated: 10.08; Mature: 10.08

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 50-50

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVTGVNSRRVLRQAVRVSLKPVYKMYERILEEKVKEGRVPEHVGIIMDGNRRFARELG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHCC
LEPWEGHRYGADKLEDVLEWCLDLGVKAVTVYALSTENLNRPKEELKRLFDLMEERFKAL
CCCCCCCCCCHHHHHHHHHHHHHCCCHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
AESERIHRRKVAVRAVGRLHLLPTRVRRAIKKAERATKEYKDRFLNVAVAYGGRQEIIDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
VREIAHDVKVGRLDPDEIDEGTFRKYVYVGDLPDPELIIRTSGEERLSNFLLWYSAYSEL
HHHHHHHHCCCCCCHHHCCCCCCEEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHHCCE
YFVDVYWPEFRKIDLLRAIREFQKRERRFGR
EEEEEECCCHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKRVTGVNSRRVLRQAVRVSLKPVYKMYERILEEKVKEGRVPEHVGIIMDGNRRFARELG
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCHHHHHHCC
LEPWEGHRYGADKLEDVLEWCLDLGVKAVTVYALSTENLNRPKEELKRLFDLMEERFKAL
CCCCCCCCCCHHHHHHHHHHHHHCCCHHHEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
AESERIHRRKVAVRAVGRLHLLPTRVRRAIKKAERATKEYKDRFLNVAVAYGGRQEIIDA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH
VREIAHDVKVGRLDPDEIDEGTFRKYVYVGDLPDPELIIRTSGEERLSNFLLWYSAYSEL
HHHHHHHHCCCCCCHHHCCCCCCEEEEEECCCCCCCEEEECCCHHHHHHHHHHHHHHCCE
YFVDVYWPEFRKIDLLRAIREFQKRERRFGR
EEEEEECCCHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014