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The map label for this gene is HisD

Identifier: 20094148

GI number: 20094148

Start: 676444

End: 677739

Strand: Reverse

Name: HisD

Synonym: MK0711

Alternate gene names: 20094148

Gene position: 677739-676444 (Counterclockwise)

Preceding gene: 20094149

Following gene: 20094147

Centisome position: 39.99

GC content: 67.28

Gene sequence:

>1296_bases
ATGAGGCTGCTGGTGCGACCTGAAGAGGAAGAGCTGGAACGCGTCCTACGCAGGTCGGAGATGGACGTGACGGAGGTCCT
ACCCGACGTCGAGCGGATCTTCGAGGACGTAGTCGAACGCGGTGACGAGGCGCTACTGGAGTACACCGAACGGTTCGACG
GGGTGAAGCTGGAAGCCGAGGACCTCCGGGTATCCGAGGACGATTTCGAGGTCGCCCGCGAGCTCGTGGACGAGCGTACC
GTGGAGGCCCTCGAGGAGGCGGCCCACCGCATCGAGGAGTTCCACAGGAAGACCCTACCCCGCGTGGACAGGATCACCTT
CGACGTGGAGGGGACGGAGTGCGGTCTCACGCTCCGACCCATCCCGAGGGTAGGGTGCTACGTGCCCGGTGGGCGCGCGG
CCTACCCGTCAACGGCCCTCATGACCGTGATACCGGCACGCGTCGCGGGATGTCGCGAGGTGGTCGTGTGTACACCTCCC
GCGGATAACGACGTGCGGGCCTCGCCGGAGGTGCTGGTGGCGGTCGAGATAGCCGGCGCGGATGCCGTTTATCGTGTCGG
CGGCGCGCAGGCCATCGCGGCGCTGGCCGCGGGAACCGAGACCGTGCTCCGGGTCGATAAGATCGTGGGTCCCGGGAACG
TCTACGTGACCGCGGCTAAGCTCCTGGCATACTCCAGAGGGCTAACCGACGTGGACATGCCGGCGGGTCCCTCCGAGGTG
TTCGTGATCGCGGACGACTCGGCCAACCCGGACTGGCTGGCGCGGGACCTCATCGCCCAAGCGGAACACGATCCCCACGC
CGCGGCGGTACTGGCCACCGACTCGGAGGAGATAGCCCGTGCGGTGAAGGAGCGTGTCGAGGAGCTGCTGGACGCGGGAA
TAGAGCGGGAGGAGATCGTCCTGAAGGCGCTCGACAGGAACGGATGGATAGTCGTGCTCGACTCGCTGGAGGAGTGCGTC
CGACTGGCCAATCGGTACGCCCCGGAACACCTACAGCTGTGCGTGGAGAACCCGGAAGAGCTGTTACAGGACGTGGAGAA
CGCGGGCGCCGTCTTCGTGGGCCACCTGACCGCGGTACCCTTCGGGGACTACGCCACGGGCCCCAACCACGTGCTGCCGA
CCGGCGGGTTCGCACGGGCCAGGGGGGCCCTAGGTACGTGGGACTTCGTGAAGATCATCCCGATCCAGCGGTTACGGGAG
GGGGACGTGGAGCGTCTGGCTCCGATCGTCGAGGAGCTGGCCGAGCGTGAGGGCCTACCGAACCACGCGGAGGCGGTGAG
GGCGCGCAGGTCCTGA

Upstream 100 bases:

>100_bases
GACCCGGATCGTGCGAAGGGTGTGCTCCGGGAGTACGATAACGGGCGCGTGCTGGCCCGGGTTCTGGACCACATCCGAGA
GCGGCTGCGGGTGTTGGCCG

Downstream 100 bases:

>100_bases
GGGTTCTTAAGGGCAGCCACGTGCGCGGACGGGGGTGTGGAAGGTGCTCAAGGACGCGTACACGGCCGACGTCACTCCCG
AGCGGGACGGAGAGGAGGTG

Product: histidinol dehydrogenase

Products: NA

Alternate protein names: HDH

Number of amino acids: Translated: 431; Mature: 431

Protein sequence:

>431_residues
MRLLVRPEEEELERVLRRSEMDVTEVLPDVERIFEDVVERGDEALLEYTERFDGVKLEAEDLRVSEDDFEVARELVDERT
VEALEEAAHRIEEFHRKTLPRVDRITFDVEGTECGLTLRPIPRVGCYVPGGRAAYPSTALMTVIPARVAGCREVVVCTPP
ADNDVRASPEVLVAVEIAGADAVYRVGGAQAIAALAAGTETVLRVDKIVGPGNVYVTAAKLLAYSRGLTDVDMPAGPSEV
FVIADDSANPDWLARDLIAQAEHDPHAAAVLATDSEEIARAVKERVEELLDAGIEREEIVLKALDRNGWIVVLDSLEECV
RLANRYAPEHLQLCVENPEELLQDVENAGAVFVGHLTAVPFGDYATGPNHVLPTGGFARARGALGTWDFVKIIPIQRLRE
GDVERLAPIVEELAEREGLPNHAEAVRARRS

Sequences:

>Translated_431_residues
MRLLVRPEEEELERVLRRSEMDVTEVLPDVERIFEDVVERGDEALLEYTERFDGVKLEAEDLRVSEDDFEVARELVDERT
VEALEEAAHRIEEFHRKTLPRVDRITFDVEGTECGLTLRPIPRVGCYVPGGRAAYPSTALMTVIPARVAGCREVVVCTPP
ADNDVRASPEVLVAVEIAGADAVYRVGGAQAIAALAAGTETVLRVDKIVGPGNVYVTAAKLLAYSRGLTDVDMPAGPSEV
FVIADDSANPDWLARDLIAQAEHDPHAAAVLATDSEEIARAVKERVEELLDAGIEREEIVLKALDRNGWIVVLDSLEECV
RLANRYAPEHLQLCVENPEELLQDVENAGAVFVGHLTAVPFGDYATGPNHVLPTGGFARARGALGTWDFVKIIPIQRLRE
GDVERLAPIVEELAEREGLPNHAEAVRARRS
>Mature_431_residues
MRLLVRPEEEELERVLRRSEMDVTEVLPDVERIFEDVVERGDEALLEYTERFDGVKLEAEDLRVSEDDFEVARELVDERT
VEALEEAAHRIEEFHRKTLPRVDRITFDVEGTECGLTLRPIPRVGCYVPGGRAAYPSTALMTVIPARVAGCREVVVCTPP
ADNDVRASPEVLVAVEIAGADAVYRVGGAQAIAALAAGTETVLRVDKIVGPGNVYVTAAKLLAYSRGLTDVDMPAGPSEV
FVIADDSANPDWLARDLIAQAEHDPHAAAVLATDSEEIARAVKERVEELLDAGIEREEIVLKALDRNGWIVVLDSLEECV
RLANRYAPEHLQLCVENPEELLQDVENAGAVFVGHLTAVPFGDYATGPNHVLPTGGFARARGALGTWDFVKIIPIQRLRE
GDVERLAPIVEELAEREGLPNHAEAVRARRS

Specific function: Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine

COG id: COG0141

COG function: function code E; Histidinol dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the histidinol dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1788331, Length=423, Percent_Identity=42.789598108747, Blast_Score=303, Evalue=1e-83,
Organism=Saccharomyces cerevisiae, GI6319819, Length=433, Percent_Identity=41.3394919168591, Blast_Score=306, Evalue=5e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HISX_METKA (Q8TXG3)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_613995.1
- ProteinModelPortal:   Q8TXG3
- SMR:   Q8TXG3
- GeneID:   1476812
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0711
- NMPDR:   fig|190192.1.peg.708
- HOGENOM:   HBG329596
- OMA:   IEAFHRQ
- BioCyc:   MKAN190192:MK0711-MONOMER
- BRENDA:   1.1.1.23
- HAMAP:   MF_01024
- InterPro:   IPR016161
- InterPro:   IPR022695
- InterPro:   IPR001692
- InterPro:   IPR012131
- PANTHER:   PTHR21256:SF2
- PIRSF:   PIRSF000099
- PRINTS:   PR00083
- TIGRFAMs:   TIGR00069

Pfam domain/function: PF00815 Histidinol_dh; SSF53720 Aldehyde_DH/Histidinol_DH

EC number: =1.1.1.23

Molecular weight: Translated: 47335; Mature: 47335

Theoretical pI: Translated: 4.31; Mature: 4.31

Prosite motif: PS00611 HISOL_DEHYDROGENASE

Important sites: ACT_SITE 329-329 ACT_SITE 330-330 BINDING 127-127 BINDING 190-190 BINDING 213-213 BINDING 238-238 BINDING 260-260 BINDING 263-263 BINDING 330-330 BINDING 363-363 BINDING 417-417 BINDING 422-422

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLLVRPEEEELERVLRRSEMDVTEVLPDVERIFEDVVERGDEALLEYTERFDGVKLEAE
CCEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEHH
DLRVSEDDFEVARELVDERTVEALEEAAHRIEEFHRKTLPRVDRITFDVEGTECGLTLRP
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEECCCCCCEEECC
IPRVGCYVPGGRAAYPSTALMTVIPARVAGCREVVVCTPPADNDVRASPEVLVAVEIAGA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEEEEEECC
DAVYRVGGAQAIAALAAGTETVLRVDKIVGPGNVYVTAAKLLAYSRGLTDVDMPAGPSEV
CHHHHCCCHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEE
FVIADDSANPDWLARDLIAQAEHDPHAAAVLATDSEEIARAVKERVEELLDAGIEREEIV
EEEECCCCCHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHH
LKALDRNGWIVVLDSLEECVRLANRYAPEHLQLCVENPEELLQDVENAGAVFVGHLTAVP
HHHCCCCCCEEEHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHCCCEEEEEEEECC
FGDYATGPNHVLPTGGFARARGALGTWDFVKIIPIQRLREGDVERLAPIVEELAEREGLP
CCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
NHAEAVRARRS
CHHHHHHHCCC
>Mature Secondary Structure
MRLLVRPEEEELERVLRRSEMDVTEVLPDVERIFEDVVERGDEALLEYTERFDGVKLEAE
CCEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCEEEHH
DLRVSEDDFEVARELVDERTVEALEEAAHRIEEFHRKTLPRVDRITFDVEGTECGLTLRP
HCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEEEECCCCCCEEECC
IPRVGCYVPGGRAAYPSTALMTVIPARVAGCREVVVCTPPADNDVRASPEVLVAVEIAGA
CCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCEEEEEEEECC
DAVYRVGGAQAIAALAAGTETVLRVDKIVGPGNVYVTAAKLLAYSRGLTDVDMPAGPSEV
CHHHHCCCHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCEE
FVIADDSANPDWLARDLIAQAEHDPHAAAVLATDSEEIARAVKERVEELLDAGIEREEIV
EEEECCCCCHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHCCCCHHHHH
LKALDRNGWIVVLDSLEECVRLANRYAPEHLQLCVENPEELLQDVENAGAVFVGHLTAVP
HHHCCCCCCEEEHHHHHHHHHHHHHCCHHHHHHHHCCHHHHHHHHHHCCCEEEEEEEECC
FGDYATGPNHVLPTGGFARARGALGTWDFVKIIPIQRLREGDVERLAPIVEELAEREGLP
CCCCCCCCCCCCCCCCHHHHCCCCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCC
NHAEAVRARRS
CHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11930014