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The map label for this gene is SEN2_2

Identifier: 20093835

GI number: 20093835

Start: 379182

End: 379682

Strand: Reverse

Name: SEN2_2

Synonym: MK0397

Alternate gene names: NA

Gene position: 379682-379182 (Counterclockwise)

Preceding gene: 20093836

Following gene: 20093834

Centisome position: 22.4

GC content: 49.7

Gene sequence:

>501_bases
ATGGCGGCGAAAGGCGAGTTAGTCGGATCGAAGGTGCTCGTTCGGAATGACCGAGATGCGAACAGACTGTACTCCTCCAT
GTACGGGAAACCGTCACGTCGCGGTCTGCAATTGTGGCCTGAAGAAGCGCTATTCTTATGTGAGATCGGTAGGCTTGAAG
TCCGTAGTGGAAACGTACGGATTAGTCCGGAGGAGCTGATGGATAGGTTCGTGGAGGAGGATCCGAGATTCCCCGTGCGC
TACGCAGTATACGCTGATCTCAGACGACGTGGATGGAAGCCCAAACCAGGCCGCAAATTCGGGACTGAATTTCGGGCGTT
CCGCGGTGAAGACGAAAGGATAGCCGTCAAAGTACTGCAGGAGGAATTGGATGAATTTACGGCTCAGGATATTTTGGAAT
GGTTAAAACTAGTTGAAGGTACGGAGTTCGAACTGGTAGTAGCTATAGTAGATAACGACTATGACTTGAATTACTATGTG
TTTTCAGAACTAGTTCTCTAG

Upstream 100 bases:

>100_bases
CGTGTGCGTGTGAACGGTAAGCTCGTCAGGAAGCCTTGGTGGCTGGTGTCCCCTGGAGACGAAATCGAAGTTGACGGTGT
TACCGTGCGGGTGGAAGACA

Downstream 100 bases:

>100_bases
GGGAACTTTCACTTGCGAAAGCGTTTCCAGACTGCTCTCGGTCTCTATCCTGGAATGGGGGATCGACCGCGTCGACTTGG
GTCTAGACTATTGTACGCGG

Product: tRNA splicing endonuclease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 166; Mature: 165

Protein sequence:

>166_residues
MAAKGELVGSKVLVRNDRDANRLYSSMYGKPSRRGLQLWPEEALFLCEIGRLEVRSGNVRISPEELMDRFVEEDPRFPVR
YAVYADLRRRGWKPKPGRKFGTEFRAFRGEDERIAVKVLQEELDEFTAQDILEWLKLVEGTEFELVVAIVDNDYDLNYYV
FSELVL

Sequences:

>Translated_166_residues
MAAKGELVGSKVLVRNDRDANRLYSSMYGKPSRRGLQLWPEEALFLCEIGRLEVRSGNVRISPEELMDRFVEEDPRFPVR
YAVYADLRRRGWKPKPGRKFGTEFRAFRGEDERIAVKVLQEELDEFTAQDILEWLKLVEGTEFELVVAIVDNDYDLNYYV
FSELVL
>Mature_165_residues
AAKGELVGSKVLVRNDRDANRLYSSMYGKPSRRGLQLWPEEALFLCEIGRLEVRSGNVRISPEELMDRFVEEDPRFPVRY
AVYADLRRRGWKPKPGRKFGTEFRAFRGEDERIAVKVLQEELDEFTAQDILEWLKLVEGTEFELVVAIVDNDYDLNYYVF
SELVL

Specific function: Unknown

COG id: COG1676

COG function: function code J; tRNA splicing endonuclease

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ENDAL_METKA (Q8TGZ5)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_613682.1
- ProteinModelPortal:   Q8TGZ5
- SMR:   Q8TGZ5
- GeneID:   1477700
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0397
- NMPDR:   fig|190192.1.peg.395
- BioCyc:   MKAN190192:MK0397-MONOMER
- HAMAP:   MF_01833
- InterPro:   IPR011856
- InterPro:   IPR006676
- InterPro:   IPR006677
- InterPro:   IPR006678
- InterPro:   IPR016442
- Gene3D:   G3DSA:3.40.1350.10
- PIRSF:   PIRSF005285
- TIGRFAMs:   TIGR00324

Pfam domain/function: PF01974 tRNA_int_endo; PF02778 tRNA_int_endo_N; SSF53032 tRNA_int_endo_C; SSF55267 tRNA_int_endo_N

EC number: NA

Molecular weight: Translated: 19413; Mature: 19282

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKGELVGSKVLVRNDRDANRLYSSMYGKPSRRGLQLWPEEALFLCEIGRLEVRSGNVR
CCCCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCEECCCHHEEEEECCCEEEECCCEE
ISPEELMDRFVEEDPRFPVRYAVYADLRRRGWKPKPGRKFGTEFRAFRGEDERIAVKVLQ
ECHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHCCHHHHHCCCCHHHHHHHHH
EELDEFTAQDILEWLKLVEGTEFELVVAIVDNDYDLNYYVFSELVL
HHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHCC
>Mature Secondary Structure 
AAKGELVGSKVLVRNDRDANRLYSSMYGKPSRRGLQLWPEEALFLCEIGRLEVRSGNVR
CCCCCCCCCEEEEECCCHHHHHHHHHCCCCCCCCCEECCCHHEEEEECCCEEEECCCEE
ISPEELMDRFVEEDPRFPVRYAVYADLRRRGWKPKPGRKFGTEFRAFRGEDERIAVKVLQ
ECHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCHHCCHHHHHCCCCHHHHHHHHH
EELDEFTAQDILEWLKLVEGTEFELVVAIVDNDYDLNYYVFSELVL
HHHHHHHHHHHHHHHHHHCCCCEEEEEEEECCCCCCHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014