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The map label for this gene is RRP4

Identifier: 20093820

GI number: 20093820

Start: 367335

End: 368054

Strand: Reverse

Name: RRP4

Synonym: MK0382

Alternate gene names: NA

Gene position: 368054-367335 (Counterclockwise)

Preceding gene: 20093821

Following gene: 20093819

Centisome position: 21.71

GC content: 58.33

Gene sequence:

>720_bases
GTGCCCGAGTTCGAGCTGTACGTCGAGGACCGTCAGGTCGTCACTCCCGGTGAGTTGTTGGCTAGAGGGCAGGTGATCGC
GAGCGAGGGGACGTACACCAGTGGGGACGAGGTATACTCTAAAGTCACCGGACTCGTCGACATCGACGGCCGTAGGATCA
GAGTGATACCGCTGGCCGGCCCCTACAGGCCCTCTCCGGGCGATTTCGTCGTTGGGATCGTGGAGGAGGTGAAGTTCTCA
AGCTGGCTCATCGACGTTCGTGCGCCTCTTCCGGCGATACTTCACGTGTCGAACGCTCTTGAGGAAGAAGTCGATCTCAT
TGAAACCGACCTTTCCAGGTACTACCGGCCGGGAGATGTTATAACGGCGGTCGTTCGAGAGGTGGATCCGGTACAACGCG
TGGAACTGTCTCTGCTCGAAGACGATGCTCCGACGAGGCTCGGCCGACTTCAGGGTGGTCAGGTCGTAGAGATAGACCCC
GTGAAGGTCCCCAGGGTGATCGGACGTAAAGGTTCCATGATCAAGATGCTCAAGCGCGTTCTCGGCTGTGACATCGTCGT
GGGCGCCAATGGACGGATATACGTGCGTGCTCGGGAGGAACCGAAGAAAGAACGAGAGCTCCTCGCCGTACGAGCTATCC
GCGAGATCGAGCGTCGATCGCATCTCCGTGGTCTTACCGACTGGTTGAAAGCGAATCTAAAACGACTCTCACGGTGGTGA

Upstream 100 bases:

>100_bases
CCGGCGGAGGTGCTGGATCTCGAGGATGCGAAACACGCCCTCGAGCTCGTAGTCGAGGTCGTGCAAAGGTTCCCGGATTA
CGTGCCGAGGTGATGTAAGC

Downstream 100 bases:

>100_bases
TCGGCAAAATGGAGGAGAGGCCAGAGCGGTTGATCTCGGAGGACGGTCTGAGGCTGGACGGTCGCAAGCCCGATGAGATG
CGTCCGCTGAAGATTCAAGC

Product: exosome complex RNA-binding protein Rrp4

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 239; Mature: 238

Protein sequence:

>239_residues
MPEFELYVEDRQVVTPGELLARGQVIASEGTYTSGDEVYSKVTGLVDIDGRRIRVIPLAGPYRPSPGDFVVGIVEEVKFS
SWLIDVRAPLPAILHVSNALEEEVDLIETDLSRYYRPGDVITAVVREVDPVQRVELSLLEDDAPTRLGRLQGGQVVEIDP
VKVPRVIGRKGSMIKMLKRVLGCDIVVGANGRIYVRAREEPKKERELLAVRAIREIERRSHLRGLTDWLKANLKRLSRW

Sequences:

>Translated_239_residues
MPEFELYVEDRQVVTPGELLARGQVIASEGTYTSGDEVYSKVTGLVDIDGRRIRVIPLAGPYRPSPGDFVVGIVEEVKFS
SWLIDVRAPLPAILHVSNALEEEVDLIETDLSRYYRPGDVITAVVREVDPVQRVELSLLEDDAPTRLGRLQGGQVVEIDP
VKVPRVIGRKGSMIKMLKRVLGCDIVVGANGRIYVRAREEPKKERELLAVRAIREIERRSHLRGLTDWLKANLKRLSRW
>Mature_238_residues
PEFELYVEDRQVVTPGELLARGQVIASEGTYTSGDEVYSKVTGLVDIDGRRIRVIPLAGPYRPSPGDFVVGIVEEVKFSS
WLIDVRAPLPAILHVSNALEEEVDLIETDLSRYYRPGDVITAVVREVDPVQRVELSLLEDDAPTRLGRLQGGQVVEIDPV
KVPRVIGRKGSMIKMLKRVLGCDIVVGANGRIYVRAREEPKKERELLAVRAIREIERRSHLRGLTDWLKANLKRLSRW

Specific function: Probably involved in degradation of a variety of RNA species; could act a RNA-binding component of the exosome (Potential)

COG id: COG1097

COG function: function code J; RNA-binding protein Rrp4 and related proteins (contain S1 domain and KH domain)

Gene ontology:

Cell location: Cytoplasm (Potential)

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 S1 motif domain

Homologues:

Organism=Saccharomyces cerevisiae, GI6321860, Length=216, Percent_Identity=26.3888888888889, Blast_Score=70, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ECR1_METKA (Q8TYC0)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_613667.1
- ProteinModelPortal:   Q8TYC0
- SMR:   Q8TYC0
- GeneID:   1477685
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0382
- NMPDR:   fig|190192.1.peg.380
- HOGENOM:   HBG392276
- OMA:   GQNGRIW
- ProtClustDB:   PRK04163
- BioCyc:   MKAN190192:MK0382-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00623
- InterPro:   IPR004087
- InterPro:   IPR018111
- InterPro:   IPR012340
- InterPro:   IPR016027
- InterPro:   IPR003029
- InterPro:   IPR022967
- Gene3D:   G3DSA:2.40.50.140
- SMART:   SM00322
- SMART:   SM00316

Pfam domain/function: PF00013 KH_1; SSF50249 Nucleic_acid_OB

EC number: NA

Molecular weight: Translated: 26915; Mature: 26783

Theoretical pI: Translated: 7.51; Mature: 7.51

Prosite motif: PS50084 KH_TYPE_1; PS50126 S1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPEFELYVEDRQVVTPGELLARGQVIASEGTYTSGDEVYSKVTGLVDIDGRRIRVIPLAG
CCCCEEEECCCEEECHHHHHHCCEEEECCCCCCCHHHHHHHHHCEEEECCCEEEEEECCC
PYRPSPGDFVVGIVEEVKFSSWLIDVRAPLPAILHVSNALEEEVDLIETDLSRYYRPGDV
CCCCCCCCEEEHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
ITAVVREVDPVQRVELSLLEDDAPTRLGRLQGGQVVEIDPVKVPRVIGRKGSMIKMLKRV
HHHHHHHCCHHHHHHHHHHCCCCCHHHHHCCCCEEEEECCCCCCHHHCCCCHHHHHHHHH
LGCDIVVGANGRIYVRAREEPKKERELLAVRAIREIERRSHLRGLTDWLKANLKRLSRW
HCCEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
PEFELYVEDRQVVTPGELLARGQVIASEGTYTSGDEVYSKVTGLVDIDGRRIRVIPLAG
CCCEEEECCCEEECHHHHHHCCEEEECCCCCCCHHHHHHHHHCEEEECCCEEEEEECCC
PYRPSPGDFVVGIVEEVKFSSWLIDVRAPLPAILHVSNALEEEVDLIETDLSRYYRPGDV
CCCCCCCCEEEHHHHHHHHHHEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHH
ITAVVREVDPVQRVELSLLEDDAPTRLGRLQGGQVVEIDPVKVPRVIGRKGSMIKMLKRV
HHHHHHHCCHHHHHHHHHHCCCCCHHHHHCCCCEEEEECCCCCCHHHCCCCHHHHHHHHH
LGCDIVVGANGRIYVRAREEPKKERELLAVRAIREIERRSHLRGLTDWLKANLKRLSRW
HCCEEEECCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014