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The map label for this gene is GuaA_1

Identifier: 20093801

GI number: 20093801

Start: 351081

End: 352025

Strand: Direct

Name: GuaA_1

Synonym: MK0363

Alternate gene names: 20093801

Gene position: 351081-352025 (Clockwise)

Preceding gene: 20093792

Following gene: 20093802

Centisome position: 20.71

GC content: 58.41

Gene sequence:

>945_bases
ATGTTCGACCCGAAAAAGTTCGTCGAAGAGGCTATCGAGGAGTTACGCCGGGAGATAGGGGATAGGAAAGCCATCATCGC
CGTATCCGGCGGCGTCGATAGCACCACCGCCGCCGTTTTAACACATCGGGCCATCGGGAGCCACCTGGTGTGCGTGTTCG
TCGATCACGGTTTCATGCGCAAGGGCGAGCCGGAGCGCATCCGCGAGCTACTGGAAGAAGAACTGGGTTTGAACCTCCGG
TTCGTCGAAGCCGCCGAGGAGTTCTTCGAGGCACTCCGAGGGGTCACCGATCCCGAGGAGAAGAGGAAAATCATCGGAGA
GAAGTTCATCGAAGTGTTCGAGCGGATAGCGGAGGAGGAAGAAGCTGAAGTGCTCGTTCAAGGTACGATCGCACCCGATA
TCATCGAGTCCGAGCGTGGAATCAAGTCCCACCACAACGTCGGTGGACTGCCCGAAAAGCTGAACCTCGACGTCGTGGAA
CCACTTCGGGACCTATACAAGGATGAGGTGAGGGAAGTGGCTCGCTACCTAGGAATACCCGATGAAATCGTGGAGCGCAT
GCCGTTCCCCGGCCCCGGTCTCGCAGTTCGAGTGCTCGGGGAGGTAACGCCTGAGAAGGTCGAGATCGTGCGTGAGGCGA
ACGCTATCGTGGAAGAAGAGGTCGAGAAGGCCGTCGAAGAGGGGAAGATGTCGAAGCCGTGGCAGGCCTTCGCTGCACTC
CTGGACTGCAAGGCCACCGGAGTGAAAGGTGACGAGCGGGACTACGGATGGGTCATCGCCGTTCGGATCGTCGAATCGAT
CGACGCGATGATAGCGGACGTACCCGAGGTTCCGTGGGAGGTCCTCCGCAACATTCAGGACCGGATCACCAGCGAGGTAC
CTGAGGTAACCAGAGTTTTGTTCGACATAACCCCTAAACCCCCTGCAACGATCGAGTTCGAGTGA

Upstream 100 bases:

>100_bases
CGTGTGCGATACCGCACGCTCCCTCTCTCGGATCGAGAACGCGTTCAATTTGGTTGCGGATCCCCTCCAACAGGCATACC
ACCTCTTCGGGGGATGTACC

Downstream 100 bases:

>100_bases
GGGGGACGCGCGTTGGCTTTCGTCGTCATCCCCTCGGTCGATGTAGTCGAGGGGAAGTGTGTGCAGCTTGTCGAAGGAGA
TCCGGAACGGAGGACGTTCG

Product: GMP synthase subunit B

Products: NA

Alternate protein names: GMP synthetase

Number of amino acids: Translated: 314; Mature: 314

Protein sequence:

>314_residues
MFDPKKFVEEAIEELRREIGDRKAIIAVSGGVDSTTAAVLTHRAIGSHLVCVFVDHGFMRKGEPERIRELLEEELGLNLR
FVEAAEEFFEALRGVTDPEEKRKIIGEKFIEVFERIAEEEEAEVLVQGTIAPDIIESERGIKSHHNVGGLPEKLNLDVVE
PLRDLYKDEVREVARYLGIPDEIVERMPFPGPGLAVRVLGEVTPEKVEIVREANAIVEEEVEKAVEEGKMSKPWQAFAAL
LDCKATGVKGDERDYGWVIAVRIVESIDAMIADVPEVPWEVLRNIQDRITSEVPEVTRVLFDITPKPPATIEFE

Sequences:

>Translated_314_residues
MFDPKKFVEEAIEELRREIGDRKAIIAVSGGVDSTTAAVLTHRAIGSHLVCVFVDHGFMRKGEPERIRELLEEELGLNLR
FVEAAEEFFEALRGVTDPEEKRKIIGEKFIEVFERIAEEEEAEVLVQGTIAPDIIESERGIKSHHNVGGLPEKLNLDVVE
PLRDLYKDEVREVARYLGIPDEIVERMPFPGPGLAVRVLGEVTPEKVEIVREANAIVEEEVEKAVEEGKMSKPWQAFAAL
LDCKATGVKGDERDYGWVIAVRIVESIDAMIADVPEVPWEVLRNIQDRITSEVPEVTRVLFDITPKPPATIEFE
>Mature_314_residues
MFDPKKFVEEAIEELRREIGDRKAIIAVSGGVDSTTAAVLTHRAIGSHLVCVFVDHGFMRKGEPERIRELLEEELGLNLR
FVEAAEEFFEALRGVTDPEEKRKIIGEKFIEVFERIAEEEEAEVLVQGTIAPDIIESERGIKSHHNVGGLPEKLNLDVVE
PLRDLYKDEVREVARYLGIPDEIVERMPFPGPGLAVRVLGEVTPEKVEIVREANAIVEEEVEKAVEEGKMSKPWQAFAAL
LDCKATGVKGDERDYGWVIAVRIVESIDAMIADVPEVPWEVLRNIQDRITSEVPEVTRVLFDITPKPPATIEFE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=362, Percent_Identity=32.5966850828729, Blast_Score=159, Evalue=3e-39,
Organism=Escherichia coli, GI1788854, Length=322, Percent_Identity=47.2049689440994, Blast_Score=300, Evalue=7e-83,
Organism=Caenorhabditis elegans, GI71992717, Length=365, Percent_Identity=30.958904109589, Blast_Score=148, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI133901714, Length=365, Percent_Identity=30.958904109589, Blast_Score=147, Evalue=5e-36,
Organism=Caenorhabditis elegans, GI71992710, Length=365, Percent_Identity=30.958904109589, Blast_Score=147, Evalue=5e-36,
Organism=Saccharomyces cerevisiae, GI6323873, Length=322, Percent_Identity=49.3788819875776, Blast_Score=291, Evalue=1e-79,
Organism=Drosophila melanogaster, GI281365319, Length=310, Percent_Identity=35.8064516129032, Blast_Score=157, Evalue=1e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAAB_METKA (Q8TYD7)

Other databases:

- EMBL:   AE009439
- RefSeq:   NP_613648.1
- ProteinModelPortal:   Q8TYD7
- SMR:   Q8TYD7
- GeneID:   1477666
- GenomeReviews:   AE009439_GR
- KEGG:   mka:MK0363
- NMPDR:   fig|190192.1.peg.361
- HOGENOM:   HBG391775
- OMA:   QGTIAPD
- ProtClustDB:   PRK00919
- BioCyc:   MKAN190192:MK0363-MONOMER
- BRENDA:   6.3.5.2
- GO:   GO:0005737
- HAMAP:   MF_00345
- InterPro:   IPR001674
- InterPro:   IPR014729
- InterPro:   IPR020536
- Gene3D:   G3DSA:3.40.50.620
- TIGRFAMs:   TIGR00884

Pfam domain/function: PF00958 GMP_synt_C; PF02568 ThiI

EC number: =6.3.5.2

Molecular weight: Translated: 35328; Mature: 35328

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDPKKFVEEAIEELRREIGDRKAIIAVSGGVDSTTAAVLTHRAIGSHLVCVFVDHGFMR
CCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHCCEEEEEECCCCCC
KGEPERIRELLEEELGLNLRFVEAAEEFFEALRGVTDPEEKRKIIGEKFIEVFERIAEEE
CCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCHH
EAEVLVQGTIAPDIIESERGIKSHHNVGGLPEKLNLDVVEPLRDLYKDEVREVARYLGIP
HHHEEEECCCCHHHHHHHCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
DEIVERMPFPGPGLAVRVLGEVTPEKVEIVREANAIVEEEVEKAVEEGKMSKPWQAFAAL
HHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LDCKATGVKGDERDYGWVIAVRIVESIDAMIADVPEVPWEVLRNIQDRITSEVPEVTRVL
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
FDITPKPPATIEFE
HHCCCCCCCCCCCC
>Mature Secondary Structure
MFDPKKFVEEAIEELRREIGDRKAIIAVSGGVDSTTAAVLTHRAIGSHLVCVFVDHGFMR
CCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCHHHHHHHHHHHHHCCEEEEEECCCCCC
KGEPERIRELLEEELGLNLRFVEAAEEFFEALRGVTDPEEKRKIIGEKFIEVFERIAEEE
CCCHHHHHHHHHHHHCCCEEHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCHH
EAEVLVQGTIAPDIIESERGIKSHHNVGGLPEKLNLDVVEPLRDLYKDEVREVARYLGIP
HHHEEEECCCCHHHHHHHCCCHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCC
DEIVERMPFPGPGLAVRVLGEVTPEKVEIVREANAIVEEEVEKAVEEGKMSKPWQAFAAL
HHHHHHCCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHH
LDCKATGVKGDERDYGWVIAVRIVESIDAMIADVPEVPWEVLRNIQDRITSEVPEVTRVL
HHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHH
FDITPKPPATIEFE
HHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11930014