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The map label for this gene is GCN3 [H]

Identifier: 20093773

GI number: 20093773

Start: 326767

End: 327753

Strand: Reverse

Name: GCN3 [H]

Synonym: MK0335

Alternate gene names: 20093773

Gene position: 327753-326767 (Counterclockwise)

Preceding gene: 20093775

Following gene: 20093772

Centisome position: 19.34

GC content: 66.06

Gene sequence:

>987_bases
GTGAAGCCCGTGTCCGCGTTTAAAACGTTGACGTTGCGGGTGTACTGGGACGAGGCACGGTTCGAGGTCCTGGACCAAAC
GGAGCTACCGGACCGAGAGGTTTGGCGTGAATGCACGTCCTACGAGGACGCCGCGGAAGCGATCGAGAACATGCGCGTCC
GAGGGGCACCTCTCATCGGCGCCGTCGCCGCCTTGGGCGCGTGGGTGGCGTACGAGCGGGACGAGGACTACGGAGAGGCC
ATCGAACGACTCCGTAATACACGTCCGACGGCACGCAACCTCTTCTGGGCGCTCGAGAGGATGGAGGAAGCCAAAAACCC
GCGGAAGGAGGCCGAGCGGATCCTCCGGGAAGACGTGGAAGTGAATCGGGAGCTCGGCGACCATGGGGCCGAACTACTGC
CCGACGAGTGCACGGTGCTCACCCACTGCAACGCCGGAGCCCTCGCCTGCGTGGACTGGGGGACGGCCCTCGGTGTCGTC
CGGTCCGCGGTGTTCAACATGAGCAAAGAGGTCGAGGTCATCGCGACCGAGACGCGTCCCGTGCAGCAGGGGGCACGACT
CACCTGTTGGGAACTCTCGAGGGACGGCATACCGGTGACGCTGATAGCCGACACGGCCGTGGGGTACGTGCTGGCGAGCG
GTAAGGTCGACGCGATCATCGTGGGGGCGGACCGCATCGCCCTGGACGGGTCCGTCGCCAACAAGATCGGGACCTACCAG
ATCGCCGTGCTGGCGGACCGCCACGACGTACCTTTCTACGTGGCGGCTCCCACCAGTACCATCGACCCCGAGACCGAGAC
CGGCGAAGACATCCCGATCGAGCACAGGTCCGAGGACGAGGTGAAGAACGTCCGCGGTGTCCGGGTGGCCCCGGAGGACG
TGCCGGCCCTCAACCCGGCGTTCGACGTCACGCCACCGGAGCTCATCGACGCGATCATCACCGAGAAGGGCGTCGTCGAG
CCCCAGGAGGTGGCCGACCTGGTATGA

Upstream 100 bases:

>100_bases
GTAACACCCCGATCACATCGTGACTCCCGGCGCCCTCCCCTCATAACCCGATCGTCATCTCAGTCACCTTATCAGCATCC
CGCTCCGGTCATCGGGAGGG

Downstream 100 bases:

>100_bases
ACGACCTCCTCGACCCGATACGCGGGATCCCCGTAGACCTCGAGCTCGTGAGGAGAGAACTAGACGTCGACCTCCCCACG
GCCCGGTACCTGGTACGCAC

Product: translation initiation factor eIF-2B alpha subunit

Products: NA

Alternate protein names: M1Pi; MTR-1-P isomerase; S-methyl-5-thioribose-1-phosphate isomerase [H]

Number of amino acids: Translated: 328; Mature: 328

Protein sequence:

>328_residues
MKPVSAFKTLTLRVYWDEARFEVLDQTELPDREVWRECTSYEDAAEAIENMRVRGAPLIGAVAALGAWVAYERDEDYGEA
IERLRNTRPTARNLFWALERMEEAKNPRKEAERILREDVEVNRELGDHGAELLPDECTVLTHCNAGALACVDWGTALGVV
RSAVFNMSKEVEVIATETRPVQQGARLTCWELSRDGIPVTLIADTAVGYVLASGKVDAIIVGADRIALDGSVANKIGTYQ
IAVLADRHDVPFYVAAPTSTIDPETETGEDIPIEHRSEDEVKNVRGVRVAPEDVPALNPAFDVTPPELIDAIITEKGVVE
PQEVADLV

Sequences:

>Translated_328_residues
MKPVSAFKTLTLRVYWDEARFEVLDQTELPDREVWRECTSYEDAAEAIENMRVRGAPLIGAVAALGAWVAYERDEDYGEA
IERLRNTRPTARNLFWALERMEEAKNPRKEAERILREDVEVNRELGDHGAELLPDECTVLTHCNAGALACVDWGTALGVV
RSAVFNMSKEVEVIATETRPVQQGARLTCWELSRDGIPVTLIADTAVGYVLASGKVDAIIVGADRIALDGSVANKIGTYQ
IAVLADRHDVPFYVAAPTSTIDPETETGEDIPIEHRSEDEVKNVRGVRVAPEDVPALNPAFDVTPPELIDAIITEKGVVE
PQEVADLV
>Mature_328_residues
MKPVSAFKTLTLRVYWDEARFEVLDQTELPDREVWRECTSYEDAAEAIENMRVRGAPLIGAVAALGAWVAYERDEDYGEA
IERLRNTRPTARNLFWALERMEEAKNPRKEAERILREDVEVNRELGDHGAELLPDECTVLTHCNAGALACVDWGTALGVV
RSAVFNMSKEVEVIATETRPVQQGARLTCWELSRDGIPVTLIADTAVGYVLASGKVDAIIVGADRIALDGSVANKIGTYQ
IAVLADRHDVPFYVAAPTSTIDPETETGEDIPIEHRSEDEVKNVRGVRVAPEDVPALNPAFDVTPPELIDAIITEKGVVE
PQEVADLV

Specific function: Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) [H]

COG id: COG0182

COG function: function code J; Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily [H]

Homologues:

Organism=Homo sapiens, GI72534748, Length=350, Percent_Identity=40.8571428571429, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI23943880, Length=327, Percent_Identity=36.697247706422, Blast_Score=173, Evalue=2e-43,
Organism=Homo sapiens, GI4503503, Length=291, Percent_Identity=28.1786941580756, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI78000156, Length=157, Percent_Identity=31.8471337579618, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI78000158, Length=157, Percent_Identity=31.8471337579618, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI187607323, Length=157, Percent_Identity=31.8471337579618, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI7657058, Length=160, Percent_Identity=29.375, Blast_Score=69, Evalue=8e-12,
Organism=Caenorhabditis elegans, GI17557462, Length=330, Percent_Identity=37.5757575757576, Blast_Score=196, Evalue=2e-50,
Organism=Caenorhabditis elegans, GI17557123, Length=158, Percent_Identity=32.2784810126582, Blast_Score=82, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6325375, Length=381, Percent_Identity=35.4330708661417, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6322878, Length=212, Percent_Identity=31.1320754716981, Blast_Score=86, Evalue=6e-18,
Organism=Drosophila melanogaster, GI21357667, Length=354, Percent_Identity=39.5480225988701, Blast_Score=221, Evalue=4e-58,
Organism=Drosophila melanogaster, GI24651647, Length=354, Percent_Identity=39.5480225988701, Blast_Score=221, Evalue=4e-58,
Organism=Drosophila melanogaster, GI21358605, Length=235, Percent_Identity=28.0851063829787, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI281364091, Length=153, Percent_Identity=32.0261437908497, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24659399, Length=153, Percent_Identity=32.0261437908497, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24659407, Length=153, Percent_Identity=32.0261437908497, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI19922816, Length=153, Percent_Identity=32.0261437908497, Blast_Score=73, Evalue=3e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000649
- InterPro:   IPR005251
- InterPro:   IPR011559 [H]

Pfam domain/function: PF01008 IF-2B [H]

EC number: =5.3.1.23 [H]

Molecular weight: Translated: 36146; Mature: 36146

Theoretical pI: Translated: 4.25; Mature: 4.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKPVSAFKTLTLRVYWDEARFEVLDQTELPDREVWRECTSYEDAAEAIENMRVRGAPLIG
CCCHHCEEEEEEEEEECCHHHHHHCCCCCCHHHHHHHHHCHHHHHHHHHCCCCCCCCHHH
AVAALGAWVAYERDEDYGEAIERLRNTRPTARNLFWALERMEEAKNPRKEAERILREDVE
HHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
VNRELGDHGAELLPDECTVLTHCNAGALACVDWGTALGVVRSAVFNMSKEVEVIATETRP
HHHHHHCCCHHCCCCCCEEEEECCCCEEEEEHHHHHHHHHHHHHHCCCCCEEEEEECCCC
VQQGARLTCWELSRDGIPVTLIADTAVGYVLASGKVDAIIVGADRIALDGSVANKIGTYQ
HHCCCCEEEEEECCCCCCEEEEECCCEEEEEECCCCCEEEEECCEEEECCHHHHCCCCEE
IAVLADRHDVPFYVAAPTSTIDPETETGEDIPIEHRSEDEVKNVRGVRVAPEDVPALNPA
EEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCEECCCCCCCCCCC
FDVTPPELIDAIITEKGVVEPQEVADLV
CCCCCHHHHHHHHHCCCCCCHHHHHCCC
>Mature Secondary Structure
MKPVSAFKTLTLRVYWDEARFEVLDQTELPDREVWRECTSYEDAAEAIENMRVRGAPLIG
CCCHHCEEEEEEEEEECCHHHHHHCCCCCCHHHHHHHHHCHHHHHHHHHCCCCCCCCHHH
AVAALGAWVAYERDEDYGEAIERLRNTRPTARNLFWALERMEEAKNPRKEAERILREDVE
HHHHHHHHHHCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHH
VNRELGDHGAELLPDECTVLTHCNAGALACVDWGTALGVVRSAVFNMSKEVEVIATETRP
HHHHHHCCCHHCCCCCCEEEEECCCCEEEEEHHHHHHHHHHHHHHCCCCCEEEEEECCCC
VQQGARLTCWELSRDGIPVTLIADTAVGYVLASGKVDAIIVGADRIALDGSVANKIGTYQ
HHCCCCEEEEEECCCCCCEEEEECCCEEEEEECCCCCEEEEECCEEEECCHHHHCCCCEE
IAVLADRHDVPFYVAAPTSTIDPETETGEDIPIEHRSEDEVKNVRGVRVAPEDVPALNPA
EEEEECCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCHHHHHHCCCCEECCCCCCCCCCC
FDVTPPELIDAIITEKGVVEPQEVADLV
CCCCCHHHHHHHHHCCCCCCHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA