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The map label for this gene is 20093510

Identifier: 20093510

GI number: 20093510

Start: 63864

End: 65960

Strand: Reverse

Name: 20093510

Synonym: MK0070

Alternate gene names: NA

Gene position: 65960-63864 (Counterclockwise)

Preceding gene: 20093512

Following gene: 20093509

Centisome position: 3.89

GC content: 58.56

Gene sequence:

>2097_bases
GTGAGGGAGCCTACGAGGGAGGAATCGGAGGAGATCAAGGTAGTAGACGCCTACGTCAAGAGGTTCCAGAGGCTAGTCCA
GCTGGAGCGGGAAGCCGAGATGAAGGCGATGGAAGAGGAAATCAGGAAACTCTCAGGCAAGGAGCGTGAAAAGAAGGGGA
GGGCAGTACTCGGTCTGCGCGGTACGAGGGCAGGTCGGGAGGTCGGAGGTTACTACCTGGTGAAGTACGGCCGGTCTAAA
GAGATAGATACGCAAATATCCGTGGGCGATCTGGTCCTCGTGAGTCGCGGCGATCCACTGAAGAGCGATCTCACGGGAAC
CGTCGTGGAGAAGACCAAGCGCTCGATTACGGTGGCTTTCGACAGTCCTCCACCCAAGTGGGCCGTGGGTAAGGGGATCA
GGATCGACCTATACGCTAACGATGTAACTTTCCAGCGTATGATGGAGGCGCTAGAACGGATCAGACACGCTGAGGGTAGA
CTCCGAGAACTCAGGAACACGATCATCGGACTTAAGAATCCGAGCGACGCGGAGCCTATAGACGTGGACTTCGTCGATAC
TGACCTCAACTATTCCCAACGGGAGGCCGTAGAACACGCACTAGGGGCGCCGGATTTCTTCCTAATTCACGGCCCTCCGG
GTACTGGTAAGACCCGGACAATCACCGAGGTGATCGTTCAAGAGGTCCGGCGTGGTAACAAGGTCCTCGCGACGGCCGAG
TCCAACGTCGCAGCGGACAACATCCTGGAATATCTGGTAGAGCGTGGTGTGGAGGCCGTTAGGGTCGGACATCCGGCCCG
TGTCTCCAAGAAACTGAAGGAGCGGACACTTAGCGCGATCGTGGAAAACCACCCACTGTACAGGAAGGCGGAGCGTCTCC
GGGAGCGCGCTTACAGGCTCATCGAGAAGCGTGACCGGTACCAGCGCCCGGTGCCGAGGTGGCGTCGGGGGATGTCCGAC
GAGACCATACTCTACCTTGCGAGGGAAGGCAAGGGAGCCCGCGGGGTCCCACCACGCGTAATTCAGAGCATGGCTAAGTG
GATCCACATCAACAGGAAAGTCCAGAAACTCTTCGAGGAGGCGGAGCGACTGGAAGAGCGTGCCGTCCGGGAAGTACTAG
AGGAGGCTGAAGTCGTGGTCACTACGAACGCCAGTGCAGGGCTGGAGTTCCTCGAAGATATCGAGTTCGACGTCGCCGTA
GTCGACGAAGGATCGCAAGCCACGGAACCTTCAGCGCTCATTCCGATCTCTCGGGCCAAGAGGTTCATCATGGCCGGGGA
TCACAAGCAGTTGCCCCCGACCATCCTCAGTGAAGAGGCCCAGCCGGAGCTCTCTCGCACGCTCTTCGAGCGTTTGATCG
AAAAGCACCCGAAGCTCTCCAGGATGCTGAGAGTGCAGTACAGGATGCACGAGAACATCATGGAATTCCCGAACCGAGAG
TTTTACAACGGGAAGCTCGAGGCCCACTCGAGCGTCCGTCGTCACACGCTCGAGGACTTAGGTGTCGGCGATCCCGAAGT
CGGCAGACCCTGGGCTGACGTCCTACACCCCAAGGAGCCGCTGGGGTTCGTGGACACCTCGCGCTTACCCGAGCGTTTGC
GGAGGGAGCGACGCCGTCCCGGATCCAAATCCCGTGAAAATCCGATGGAAGCCGCGATAGTCGCCTTTCTGTCGGAACAA
CTGGTTCGGCAGGGGTTGTCTCAGGAGGATCTAGCCGTGATCAGTCCGTACGACGACCAAGTGGACCTGATTTCGAAGTC
CCTCGACGAACTCGGGCTCGGCGACGTCGAGGTGAACACAGTCGACGGGTTCCAGGGTCGAGAGAAGGAAGCCGTGATCG
TGTCCTTCGTCCGAAGCAATCCTAAGGGTGAAGTAGGGTTCCTAAGGGACATGAGGAGACTGAACGTCGCGATCACCAGG
CCTAGGCGGAAACTCATTTGTATCGGAGATTCCGGCACGCTTTCCAGCCATCCGACGTACCGCAGGTTCATTGAGCACGT
CAAGAGAAGCGGCGCACTGATAAAGCCGAACAATCTGCGCGAAGTGGCTTCCTACTTAGACCTGGTCCGCTTAGCACCCG
GACGTGCCAGGGGGTGA

Upstream 100 bases:

>100_bases
TGTGAGGCCCCACGAAGTCGGTAAAATCTGGCTGGCCAACCGAGCCGCGCTGTGCCGAGTCGAGCCTCGTGCGGCTCAGC
GTCTCCTAAGACATGCTGAC

Downstream 100 bases:

>100_bases
GTAGGATAGGCGAGATAGTAACGGAAATGTTCCAAGACGGGCGGTTGTTCCTGGGAATGGGCGAGTACGCTCAGACAGTG
GCTTACGACGAGCTCCTCCT

Product: superfamily I DNA/RNA helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 698; Mature: 698

Protein sequence:

>698_residues
MREPTREESEEIKVVDAYVKRFQRLVQLEREAEMKAMEEEIRKLSGKEREKKGRAVLGLRGTRAGREVGGYYLVKYGRSK
EIDTQISVGDLVLVSRGDPLKSDLTGTVVEKTKRSITVAFDSPPPKWAVGKGIRIDLYANDVTFQRMMEALERIRHAEGR
LRELRNTIIGLKNPSDAEPIDVDFVDTDLNYSQREAVEHALGAPDFFLIHGPPGTGKTRTITEVIVQEVRRGNKVLATAE
SNVAADNILEYLVERGVEAVRVGHPARVSKKLKERTLSAIVENHPLYRKAERLRERAYRLIEKRDRYQRPVPRWRRGMSD
ETILYLAREGKGARGVPPRVIQSMAKWIHINRKVQKLFEEAERLEERAVREVLEEAEVVVTTNASAGLEFLEDIEFDVAV
VDEGSQATEPSALIPISRAKRFIMAGDHKQLPPTILSEEAQPELSRTLFERLIEKHPKLSRMLRVQYRMHENIMEFPNRE
FYNGKLEAHSSVRRHTLEDLGVGDPEVGRPWADVLHPKEPLGFVDTSRLPERLRRERRRPGSKSRENPMEAAIVAFLSEQ
LVRQGLSQEDLAVISPYDDQVDLISKSLDELGLGDVEVNTVDGFQGREKEAVIVSFVRSNPKGEVGFLRDMRRLNVAITR
PRRKLICIGDSGTLSSHPTYRRFIEHVKRSGALIKPNNLREVASYLDLVRLAPGRARG

Sequences:

>Translated_698_residues
MREPTREESEEIKVVDAYVKRFQRLVQLEREAEMKAMEEEIRKLSGKEREKKGRAVLGLRGTRAGREVGGYYLVKYGRSK
EIDTQISVGDLVLVSRGDPLKSDLTGTVVEKTKRSITVAFDSPPPKWAVGKGIRIDLYANDVTFQRMMEALERIRHAEGR
LRELRNTIIGLKNPSDAEPIDVDFVDTDLNYSQREAVEHALGAPDFFLIHGPPGTGKTRTITEVIVQEVRRGNKVLATAE
SNVAADNILEYLVERGVEAVRVGHPARVSKKLKERTLSAIVENHPLYRKAERLRERAYRLIEKRDRYQRPVPRWRRGMSD
ETILYLAREGKGARGVPPRVIQSMAKWIHINRKVQKLFEEAERLEERAVREVLEEAEVVVTTNASAGLEFLEDIEFDVAV
VDEGSQATEPSALIPISRAKRFIMAGDHKQLPPTILSEEAQPELSRTLFERLIEKHPKLSRMLRVQYRMHENIMEFPNRE
FYNGKLEAHSSVRRHTLEDLGVGDPEVGRPWADVLHPKEPLGFVDTSRLPERLRRERRRPGSKSRENPMEAAIVAFLSEQ
LVRQGLSQEDLAVISPYDDQVDLISKSLDELGLGDVEVNTVDGFQGREKEAVIVSFVRSNPKGEVGFLRDMRRLNVAITR
PRRKLICIGDSGTLSSHPTYRRFIEHVKRSGALIKPNNLREVASYLDLVRLAPGRARG
>Mature_698_residues
MREPTREESEEIKVVDAYVKRFQRLVQLEREAEMKAMEEEIRKLSGKEREKKGRAVLGLRGTRAGREVGGYYLVKYGRSK
EIDTQISVGDLVLVSRGDPLKSDLTGTVVEKTKRSITVAFDSPPPKWAVGKGIRIDLYANDVTFQRMMEALERIRHAEGR
LRELRNTIIGLKNPSDAEPIDVDFVDTDLNYSQREAVEHALGAPDFFLIHGPPGTGKTRTITEVIVQEVRRGNKVLATAE
SNVAADNILEYLVERGVEAVRVGHPARVSKKLKERTLSAIVENHPLYRKAERLRERAYRLIEKRDRYQRPVPRWRRGMSD
ETILYLAREGKGARGVPPRVIQSMAKWIHINRKVQKLFEEAERLEERAVREVLEEAEVVVTTNASAGLEFLEDIEFDVAV
VDEGSQATEPSALIPISRAKRFIMAGDHKQLPPTILSEEAQPELSRTLFERLIEKHPKLSRMLRVQYRMHENIMEFPNRE
FYNGKLEAHSSVRRHTLEDLGVGDPEVGRPWADVLHPKEPLGFVDTSRLPERLRRERRRPGSKSRENPMEAAIVAFLSEQ
LVRQGLSQEDLAVISPYDDQVDLISKSLDELGLGDVEVNTVDGFQGREKEAVIVSFVRSNPKGEVGFLRDMRRLNVAITR
PRRKLICIGDSGTLSSHPTYRRFIEHVKRSGALIKPNNLREVASYLDLVRLAPGRARG

Specific function: Unknown

COG id: COG1112

COG function: function code L; Superfamily I DNA and RNA helicases and helicase subunits

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DNA2/NAM7 helicase family [H]

Homologues:

Organism=Homo sapiens, GI119392094, Length=693, Percent_Identity=35.7864357864358, Blast_Score=339, Evalue=5e-93,
Organism=Homo sapiens, GI122937299, Length=336, Percent_Identity=35.7142857142857, Blast_Score=192, Evalue=1e-48,
Organism=Homo sapiens, GI18375673, Length=578, Percent_Identity=28.5467128027682, Blast_Score=183, Evalue=4e-46,
Organism=Homo sapiens, GI113722133, Length=629, Percent_Identity=26.550079491256, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI156105695, Length=533, Percent_Identity=28.5178236397749, Blast_Score=143, Evalue=7e-34,
Organism=Homo sapiens, GI156105693, Length=533, Percent_Identity=28.5178236397749, Blast_Score=142, Evalue=8e-34,
Organism=Homo sapiens, GI254826809, Length=483, Percent_Identity=28.7784679089027, Blast_Score=142, Evalue=1e-33,
Organism=Homo sapiens, GI14251207, Length=334, Percent_Identity=30.5389221556886, Blast_Score=121, Evalue=2e-27,
Organism=Homo sapiens, GI255759908, Length=314, Percent_Identity=31.5286624203822, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI28626521, Length=324, Percent_Identity=29.0123456790123, Blast_Score=113, Evalue=5e-25,
Organism=Homo sapiens, GI255759910, Length=314, Percent_Identity=30.8917197452229, Blast_Score=113, Evalue=6e-25,
Organism=Homo sapiens, GI194272168, Length=349, Percent_Identity=29.512893982808, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI14211540, Length=349, Percent_Identity=29.512893982808, Blast_Score=112, Evalue=1e-24,
Organism=Homo sapiens, GI255759906, Length=269, Percent_Identity=29.7397769516729, Blast_Score=87, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17510163, Length=570, Percent_Identity=29.2982456140351, Blast_Score=173, Evalue=3e-43,
Organism=Caenorhabditis elegans, GI71981659, Length=519, Percent_Identity=27.9383429672447, Blast_Score=156, Evalue=4e-38,
Organism=Caenorhabditis elegans, GI17533987, Length=308, Percent_Identity=31.8181818181818, Blast_Score=128, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17533985, Length=308, Percent_Identity=31.8181818181818, Blast_Score=128, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI17531515, Length=569, Percent_Identity=23.3743409490334, Blast_Score=87, Evalue=4e-17,
Organism=Caenorhabditis elegans, GI17531513, Length=569, Percent_Identity=23.3743409490334, Blast_Score=86, Evalue=5e-17,
Organism=Caenorhabditis elegans, GI17538027, Length=336, Percent_Identity=25.8928571428571, Blast_Score=86, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI71986364, Length=308, Percent_Identity=25.6493506493506, Blast_Score=76, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17535407, Length=306, Percent_Identity=28.1045751633987, Blast_Score=67, Evalue=3e-11,
Organism=Saccharomyces cerevisiae, GI6322835, Length=691, Percent_Identity=30.246020260492, Blast_Score=254, Evalue=5e-68,
Organism=Saccharomyces cerevisiae, GI6323726, Length=572, Percent_Identity=30.0699300699301, Blast_Score=192, Evalue=2e-49,
Organism=Saccharomyces cerevisiae, GI6323462, Length=572, Percent_Identity=29.3706293706294, Blast_Score=180, Evalue=6e-46,
Organism=Saccharomyces cerevisiae, GI6321024, Length=537, Percent_Identity=30.5400372439479, Blast_Score=174, Evalue=5e-44,
Organism=Saccharomyces cerevisiae, GI6321958, Length=308, Percent_Identity=32.1428571428571, Blast_Score=148, Evalue=3e-36,
Organism=Drosophila melanogaster, GI18859757, Length=329, Percent_Identity=32.2188449848024, Blast_Score=161, Evalue=1e-39,
Organism=Drosophila melanogaster, GI281363531, Length=526, Percent_Identity=27.9467680608365, Blast_Score=153, Evalue=4e-37,
Organism=Drosophila melanogaster, GI281363529, Length=526, Percent_Identity=27.9467680608365, Blast_Score=153, Evalue=4e-37,
Organism=Drosophila melanogaster, GI24640932, Length=360, Percent_Identity=30.8333333333333, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI161077698, Length=360, Percent_Identity=30.8333333333333, Blast_Score=140, Evalue=3e-33,
Organism=Drosophila melanogaster, GI221330969, Length=520, Percent_Identity=26.9230769230769, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24660647, Length=520, Percent_Identity=26.9230769230769, Blast_Score=137, Evalue=2e-32,
Organism=Drosophila melanogaster, GI24649577, Length=499, Percent_Identity=26.8537074148297, Blast_Score=119, Evalue=5e-27,
Organism=Drosophila melanogaster, GI45550425, Length=344, Percent_Identity=29.0697674418605, Blast_Score=110, Evalue=2e-24,
Organism=Drosophila melanogaster, GI62471854, Length=612, Percent_Identity=22.8758169934641, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24656854, Length=612, Percent_Identity=22.8758169934641, Blast_Score=107, Evalue=3e-23,
Organism=Drosophila melanogaster, GI45553113, Length=560, Percent_Identity=27.5, Blast_Score=101, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR004483 [H]

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 79468; Mature: 79468

Theoretical pI: Translated: 9.80; Mature: 9.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MREPTREESEEIKVVDAYVKRFQRLVQLEREAEMKAMEEEIRKLSGKEREKKGRAVLGLR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEEC
GTRAGREVGGYYLVKYGRSKEIDTQISVGDLVLVSRGDPLKSDLTGTVVEKTKRSITVAF
CCCCCHHHCCEEEEEECCCCCCCCEEEECCEEEEECCCCCHHCCCHHHHHHCCCEEEEEE
DSPPPKWAVGKGIRIDLYANDVTFQRMMEALERIRHAEGRLRELRNTIIGLKNPSDAEPI
CCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
DVDFVDTDLNYSQREAVEHALGAPDFFLIHGPPGTGKTRTITEVIVQEVRRGNKVLATAE
EEEEEECCCCCHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEECC
SNVAADNILEYLVERGVEAVRVGHPARVSKKLKERTLSAIVENHPLYRKAERLRERAYRL
CCCCHHHHHHHHHHCCCHHEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IEKRDRYQRPVPRWRRGMSDETILYLAREGKGARGVPPRVIQSMAKWIHINRKVQKLFEE
HHHHHHHCCCCHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AERLEERAVREVLEEAEVVVTTNASAGLEFLEDIEFDVAVVDEGSQATEPSALIPISRAK
HHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHC
RFIMAGDHKQLPPTILSEEAQPELSRTLFERLIEKHPKLSRMLRVQYRMHENIMEFPNRE
HHHCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC
FYNGKLEAHSSVRRHTLEDLGVGDPEVGRPWADVLHPKEPLGFVDTSRLPERLRRERRRP
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCC
GSKSRENPMEAAIVAFLSEQLVRQGLSQEDLAVISPYDDQVDLISKSLDELGLGDVEVNT
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCEEEEE
VDGFQGREKEAVIVSFVRSNPKGEVGFLRDMRRLNVAITRPRRKLICIGDSGTLSSHPTY
ECCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHEEECCCCEEEEECCCCCCCCCCHH
RRFIEHVKRSGALIKPNNLREVASYLDLVRLAPGRARG
HHHHHHHHHCCCEECCCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MREPTREESEEIKVVDAYVKRFQRLVQLEREAEMKAMEEEIRKLSGKEREKKGRAVLGLR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHCCCEEEEEC
GTRAGREVGGYYLVKYGRSKEIDTQISVGDLVLVSRGDPLKSDLTGTVVEKTKRSITVAF
CCCCCHHHCCEEEEEECCCCCCCCEEEECCEEEEECCCCCHHCCCHHHHHHCCCEEEEEE
DSPPPKWAVGKGIRIDLYANDVTFQRMMEALERIRHAEGRLRELRNTIIGLKNPSDAEPI
CCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
DVDFVDTDLNYSQREAVEHALGAPDFFLIHGPPGTGKTRTITEVIVQEVRRGNKVLATAE
EEEEEECCCCCHHHHHHHHHCCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCEEEEECC
SNVAADNILEYLVERGVEAVRVGHPARVSKKLKERTLSAIVENHPLYRKAERLRERAYRL
CCCCHHHHHHHHHHCCCHHEECCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
IEKRDRYQRPVPRWRRGMSDETILYLAREGKGARGVPPRVIQSMAKWIHINRKVQKLFEE
HHHHHHHCCCCHHHHCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHH
AERLEERAVREVLEEAEVVVTTNASAGLEFLEDIEFDVAVVDEGSQATEPSALIPISRAK
HHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHCCCEEEEECCCCCCCCCCCCCCHHHHC
RFIMAGDHKQLPPTILSEEAQPELSRTLFERLIEKHPKLSRMLRVQYRMHENIMEFPNRE
HHHCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCCCC
FYNGKLEAHSSVRRHTLEDLGVGDPEVGRPWADVLHPKEPLGFVDTSRLPERLRRERRRP
CCCCCHHHHHHHHHHHHHHCCCCCCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHCCC
GSKSRENPMEAAIVAFLSEQLVRQGLSQEDLAVISPYDDQVDLISKSLDELGLGDVEVNT
CCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCEEECCCCCHHHHHHHHHHHCCCCCEEEEE
VDGFQGREKEAVIVSFVRSNPKGEVGFLRDMRRLNVAITRPRRKLICIGDSGTLSSHPTY
ECCCCCCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHEEECCCCEEEEECCCCCCCCCCHH
RRFIEHVKRSGALIKPNNLREVASYLDLVRLAPGRARG
HHHHHHHHHCCCEECCCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]