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The map label for this gene is TIP49 [C]

Identifier: 20093447

GI number: 20093447

Start: 7315

End: 8682

Strand: Reverse

Name: TIP49 [C]

Synonym: MK0007

Alternate gene names: 20093447

Gene position: 8682-7315 (Counterclockwise)

Preceding gene: 20093450

Following gene: 20093446

Centisome position: 0.51

GC content: 60.31

Gene sequence:

>1368_bases
TTGGTGGAGATCAAGGAGATCGGCGAAGTTTCCACGGAGGAAACATCACCGGGAGCGCACTCGCACATCACCGGTCTCGG
CCTCGATGAGAACCTCAAGGCGAAGCCCGTCGGAGACGGTTTGGTGGGACAGGAGGAGGCTCGTGAAGCCGCCGGAATAG
TCGTCGAGATGGTCAAGCAGGGTCGGCGTGCGGGTCACGGTCTCCTTCTCGTCGGTCCGCCCGGCACGGGTAAGACGGCG
ATCGCGTACGGTATAGCCAGAGAACTCGGTGAAGACGTTCCGTTCGTATCCATCTCCGGTTCCGAGATCTACGGCACGAA
CCTCAGCAAGACGGAGTTCTTACAGCAGGCGATACGGCGGGCTATTGGTGTCGAGTTCACGGAGACGCGGGAGGTGATCG
AGGGGAAGGTCGAAAGCCTCGAGATCGAGCGTGCTAAGCACCCGCTCTCCCCGTACATGGAGGTGCCCAGCGGGGCCATC
ATCGAGCTCAAGACTCAGGATGACCACCGAAGGTTCAAGGTACCGGAGGAGATAGCGATCCAGCTGGTGCAGGCCGGTGT
CCGTGAGGGTGATGTCATCCAGATCGACGTAGAAAGCGGTCACGTGACGAAGCTCGGACGGGCGAAGGACGCGCTCGAGG
AGGAAGAGGAAGAGCTCCTAGGAGTCCACGCGGTAGAGCTCCCGGAAGGTCCGGTGCAGAAGAAGAAGGAGATCAAGCGC
GTGGTAACCCTGCACGACCTCGACATGGCCAACGTGCGGGCCGGTCGACTCCTGGGCTTCCGTGAGGAGGAGATTACCGA
CGAGATCCGTCAGAAGGTGGACGAGCGGGTCCAGAAGATGGTCGACGAAGGTGAGGCCAGTTTAGTCCCGGGAGTACTGT
TCATAGACGAAGCGCACATGCTGGACATAGAGGCGTTCGCGTTCTTGAACAGGTCGCTGGAGGAGGAGATCGCCCCGATC
CTCGTGATGGCTACTAACAGGGCCATGGCGAAGGTACGCGGGACGGATGAGGAGGCCCCTCACGGGATTCCGGGCGATCT
GCTGGACCGCATGCTGATCGCGAGAACCAGGCCCTTCGAGCGTCACGAAATCCACGAGATCATTGGAATCAGGGCCCGAG
TCCAAGATATCCAGCTGACGGACGAAGCTCATGAGTACCTGACGGATCTCGGCGAGGAGAAGTCCATACGGTACGCGACG
CGACTCTTGGAGCCCGCTCGAATCGTGGCGGAGAAGGAAGGGTCCGAGGTCGTGGAGAAGAAGCACGTGGAGCGTGTTGA
GGAGGTTTTCACCGACGTTTCGGACAGTGTCGAGTACATGGAACGCATGCGGAGGGAGCTGCCAGTCATGAAGTACCTGA
CCGGCTGA

Upstream 100 bases:

>100_bases
TAAATGTTGCTTGAAACCATTCGAATGACGATTACGAACTTCAATAGCTACCCAAAAATAATAAATATAAGTGCATGTTG
ATCGGCGGGGGTGCCGAAAG

Downstream 100 bases:

>100_bases
TCTCCTCCGACCGAATCGGTTTTTATCACGGGCGATGTGATCCCCCGGGGACGTCGAGATGGCCGAGCACGAGCTACGCG
TTCTCGAGATACCGTGGGTG

Product: DNA helicase TIP49, TBP-interacting protein

Products: NA

Alternate protein names: TIP49-Like Protein; TIP49 Domain Protein; TIP49 Domain-Containing Protein; Tbp-Interacting Protein Tip; DNA Helicase; TBP-Interacting Proten; TIP49-Like; DNA Helicase TIP; TIP49 C-Terminal Domain Family Protein

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MVEIKEIGEVSTEETSPGAHSHITGLGLDENLKAKPVGDGLVGQEEAREAAGIVVEMVKQGRRAGHGLLLVGPPGTGKTA
IAYGIARELGEDVPFVSISGSEIYGTNLSKTEFLQQAIRRAIGVEFTETREVIEGKVESLEIERAKHPLSPYMEVPSGAI
IELKTQDDHRRFKVPEEIAIQLVQAGVREGDVIQIDVESGHVTKLGRAKDALEEEEEELLGVHAVELPEGPVQKKKEIKR
VVTLHDLDMANVRAGRLLGFREEEITDEIRQKVDERVQKMVDEGEASLVPGVLFIDEAHMLDIEAFAFLNRSLEEEIAPI
LVMATNRAMAKVRGTDEEAPHGIPGDLLDRMLIARTRPFERHEIHEIIGIRARVQDIQLTDEAHEYLTDLGEEKSIRYAT
RLLEPARIVAEKEGSEVVEKKHVERVEEVFTDVSDSVEYMERMRRELPVMKYLTG

Sequences:

>Translated_455_residues
MVEIKEIGEVSTEETSPGAHSHITGLGLDENLKAKPVGDGLVGQEEAREAAGIVVEMVKQGRRAGHGLLLVGPPGTGKTA
IAYGIARELGEDVPFVSISGSEIYGTNLSKTEFLQQAIRRAIGVEFTETREVIEGKVESLEIERAKHPLSPYMEVPSGAI
IELKTQDDHRRFKVPEEIAIQLVQAGVREGDVIQIDVESGHVTKLGRAKDALEEEEEELLGVHAVELPEGPVQKKKEIKR
VVTLHDLDMANVRAGRLLGFREEEITDEIRQKVDERVQKMVDEGEASLVPGVLFIDEAHMLDIEAFAFLNRSLEEEIAPI
LVMATNRAMAKVRGTDEEAPHGIPGDLLDRMLIARTRPFERHEIHEIIGIRARVQDIQLTDEAHEYLTDLGEEKSIRYAT
RLLEPARIVAEKEGSEVVEKKHVERVEEVFTDVSDSVEYMERMRRELPVMKYLTG
>Mature_455_residues
MVEIKEIGEVSTEETSPGAHSHITGLGLDENLKAKPVGDGLVGQEEAREAAGIVVEMVKQGRRAGHGLLLVGPPGTGKTA
IAYGIARELGEDVPFVSISGSEIYGTNLSKTEFLQQAIRRAIGVEFTETREVIEGKVESLEIERAKHPLSPYMEVPSGAI
IELKTQDDHRRFKVPEEIAIQLVQAGVREGDVIQIDVESGHVTKLGRAKDALEEEEEELLGVHAVELPEGPVQKKKEIKR
VVTLHDLDMANVRAGRLLGFREEEITDEIRQKVDERVQKMVDEGEASLVPGVLFIDEAHMLDIEAFAFLNRSLEEEIAPI
LVMATNRAMAKVRGTDEEAPHGIPGDLLDRMLIARTRPFERHEIHEIIGIRARVQDIQLTDEAHEYLTDLGEEKSIRYAT
RLLEPARIVAEKEGSEVVEKKHVERVEEVFTDVSDSVEYMERMRRELPVMKYLTG

Specific function: Seems To Act As An ATP-Dependent Zinc Metallopeptidase. Involved In The Degradation Of Sigma-32. Degrades Carboxy- Terminal-Tagged Cytoplasmic Proteins. These Proteins Are Tagged With An 11-Amino-Acid Nonpolar Destabilizing Tail VIa A Mechanism Involving

COG id: COG1224

COG function: function code K; DNA helicase TIP49, TBP-interacting protein

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI4506753, Length=444, Percent_Identity=45.045045045045, Blast_Score=369, Evalue=1e-102,
Organism=Homo sapiens, GI5730023, Length=427, Percent_Identity=42.6229508196721, Blast_Score=351, Evalue=8e-97,
Organism=Caenorhabditis elegans, GI17542510, Length=438, Percent_Identity=42.2374429223744, Blast_Score=345, Evalue=2e-95,
Organism=Caenorhabditis elegans, GI17558290, Length=442, Percent_Identity=37.3303167420815, Blast_Score=283, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6325021, Length=430, Percent_Identity=43.2558139534884, Blast_Score=357, Evalue=3e-99,
Organism=Saccharomyces cerevisiae, GI6320396, Length=438, Percent_Identity=44.2922374429224, Blast_Score=342, Evalue=7e-95,
Organism=Drosophila melanogaster, GI17737635, Length=427, Percent_Identity=43.559718969555, Blast_Score=345, Evalue=3e-95,
Organism=Drosophila melanogaster, GI21358125, Length=437, Percent_Identity=44.3935926773455, Blast_Score=326, Evalue=2e-89,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: 3.4.24.- [C]

Molecular weight: Translated: 50707; Mature: 50707

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVEIKEIGEVSTEETSPGAHSHITGLGLDENLKAKPVGDGLVGQEEAREAAGIVVEMVKQ
CCCHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
GRRAGHGLLLVGPPGTGKTAIAYGIARELGEDVPFVSISGSEIYGTNLSKTEFLQQAIRR
HHHCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCEEEECCCEEECCCCCHHHHHHHHHHH
AIGVEFTETREVIEGKVESLEIERAKHPLSPYMEVPSGAIIELKTQDDHRRFKVPEEIAI
HHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCEEEEECCCCCCCCCCCHHHHH
QLVQAGVREGDVIQIDVESGHVTKLGRAKDALEEEEEELLGVHAVELPEGPVQKKKEIKR
HHHHHCCCCCCEEEEEECCCCEEEHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHH
VVTLHDLDMANVRAGRLLGFREEEITDEIRQKVDERVQKMVDEGEASLVPGVLFIDEAHM
HHHHHCCCHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCEEEECCCHH
LDIEAFAFLNRSLEEEIAPILVMATNRAMAKVRGTDEEAPHGIPGDLLDRMLIARTRPFE
HHHHHHHHHHHHHHHHHCCEEEEECCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCH
RHEIHEIIGIRARVQDIQLTDEAHEYLTDLGEEKSIRYATRLLEPARIVAEKEGSEVVEK
HHHHHHHHHHHHHHHHEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
KHVERVEEVFTDVSDSVEYMERMRRELPVMKYLTG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCC
>Mature Secondary Structure
MVEIKEIGEVSTEETSPGAHSHITGLGLDENLKAKPVGDGLVGQEEAREAAGIVVEMVKQ
CCCHHHHCCCCCCCCCCCCCCCEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHH
GRRAGHGLLLVGPPGTGKTAIAYGIARELGEDVPFVSISGSEIYGTNLSKTEFLQQAIRR
HHHCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCEEEECCCEEECCCCCHHHHHHHHHHH
AIGVEFTETREVIEGKVESLEIERAKHPLSPYMEVPSGAIIELKTQDDHRRFKVPEEIAI
HHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCEEEEECCCCCCCCCCCHHHHH
QLVQAGVREGDVIQIDVESGHVTKLGRAKDALEEEEEELLGVHAVELPEGPVQKKKEIKR
HHHHHCCCCCCEEEEEECCCCEEEHHHHHHHHHHHHHHHHCCEEEECCCCCHHHHHHHHH
VVTLHDLDMANVRAGRLLGFREEEITDEIRQKVDERVQKMVDEGEASLVPGVLFIDEAHM
HHHHHCCCHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHCCCEEEECCCHH
LDIEAFAFLNRSLEEEIAPILVMATNRAMAKVRGTDEEAPHGIPGDLLDRMLIARTRPFE
HHHHHHHHHHHHHHHHHCCEEEEECCCHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCH
RHEIHEIIGIRARVQDIQLTDEAHEYLTDLGEEKSIRYATRLLEPARIVAEKEGSEVVEK
HHHHHHHHHHHHHHHHEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHH
KHVERVEEVFTDVSDSVEYMERMRRELPVMKYLTG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Metalloendopeptidases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA