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The map label for this gene is spa [H]

Identifier: 19746885

GI number: 19746885

Start: 1707653

End: 1709365

Strand: Reverse

Name: spa [H]

Synonym: spyM18_2046

Alternate gene names: 19746885

Gene position: 1709365-1707653 (Counterclockwise)

Preceding gene: 19746888

Following gene: 19746884

Centisome position: 90.2

GC content: 36.54

Gene sequence:

>1713_bases
ATGTTTTTGAGAAATAAAAAGCAAAAATTTAGCATCAGAAAACTAAGTGCTGGTGCAGCATCAGTATTAGTTGCAGCAAG
TGTGTTGGGAGGGGGAGTAAGTGCGTATGCAGATTCAGTAAGTGGATTAGAGGTGGCAGACCCCTCTGATAGTAAGAAAC
TTATTGAATTAGGTTTGGCTAAATACCTTAATGATAAATTACCCTTTAAAACTAAAGAAGATTCAGAGATTTTATCAGAG
TTACGTGATGTATTAAAAAATGCTAATCCAGAAACATTAAAAAGTTTACTTAATGGTATGGATCAAGGACATATATCATT
TTCTGATAGAAATAATCGCTACAACCGTTTATCTCAATATATAAATAGTTTTAGAAAAGATGATGATGACTATCTACATA
ATGGATATTCTTTAGGAAGTTTAGTGATTGAAGCAATTAAATACCGTTTAGATAGTGAGTCACATCTAAAGGAAGAATTA
CTTAAACAGACTGCAGAACTTGAGCAACGTAAGAATGCAGAAGTTGATTTAAAATCTGAAAAAAAGAGACTTGAAGCGCA
AATAGAAAAAGTAGGATATGATATTGCTAATAAACAGCAAGAATTAGAAAAAGCGCGTTCAGATCAAAAAGAGTTAAGTG
AATCTATTCAAAAATTAACGTCACGATTTAAAAAAGAAAGTGATGCTAAACAAAAAGAACTAGATGAAGCTAAGGCGGCA
AATAAATCTCTTTCAGAGTCAGCAACAAAAACATTAGCTAGATCATCTAAGATAACTAATGAATTAAAGGATAAGTTGGC
GGCTTCAGAAAAAGATAAAAATCGTGCATTTCAAGTTTCTTCAGAGCTAGCTAATAAGTTGCATGAAACAGAAACTAGTC
GTGATAAGGCTTTAGCAGAATCAAAAGAATTAGCAGATAAATTGGCAGTTAAAACAGCAGAAGCTGAAAAGTTAATGGAA
AACGTTGGTAGTCTAGACCGCTTGGTAGAGTCTGCAAAACGTGAAATGGCTCAAAAATTAGCAGAAATTGACCAATTAAC
TGCTGATAAGGCTAAGGCTGATGCAGAGCTTGCAGCTGCAAATGACACCATTGCATCACTTCAAACAGAGCTAGAAAAAG
TTAAGACAGAGCTTGCTGTTTCAGAGCGCTTGATCGAATCAGGTAAACGTGAAATTGCTGAGCTTGAAAAACAAAAAGAT
GCTTCTGATAAGGCTTTAGCAGAATCACAAGCTAATGTAGCAGAGCTTGAAAAACAAAAAGCAGCATCAGATGCTAAGGT
AGCAGAGCTTGAAAAAGAAGTTGAAGCTGCTAAAGCTGAGGTTGCAGATCTTAAAGCACAATTAGCTAAGAAAGAAGAAG
AGCTTGAAGCCGTTAAGAAAGAAAAAGAAGCGCTTGAAGCTAAGATTGAAGAGCTCAAAAAAGCTCATGCTGAGGAACTT
TCAAAACTTAAAGAAATGCTTGAGAAGAAAGACCATGCGAATGCAGATCTTCAAGCAGAAATCAACCGCTTGAAGCAAGA
GCTAGCTGACAGGATTAAGTCATTGTCACAAGGTGGTCGTGCTTCACAAACAAACCCAGGCTCTACAACTGCTAAAGCAG
GTCAATTGCCATCTACTGGTGAGTCTGCTAACCCATTCTTCACTATTGCAGCTCTTACCGTCATCGCTGGTGCTGGTATG
GCTGTGGTGTCTCCTAAACGCAAAGAAAACTAA

Upstream 100 bases:

>100_bases
CATAAAGAAGTTTCTGCCATTAAAATAAAAGCACCATGAGACTATAATAGTATGGTAAAACAAAAAAGTATGCCCATAAC
GGGTAGAGAGGAATTGACAT

Downstream 100 bases:

>100_bases
GCTCTTTCCTCTTTCCCCAATGGACAATAGCCGAAATAATAGAGCGACTATCGTTCTAACACAAAAGCAACAGACCAAGA
GCTGTTGCTTTTTGTGATCG

Product: streptococcal protective antigen

Products: NA

Alternate protein names: MRP protein [H]

Number of amino acids: Translated: 570; Mature: 570

Protein sequence:

>570_residues
MFLRNKKQKFSIRKLSAGAASVLVAASVLGGGVSAYADSVSGLEVADPSDSKKLIELGLAKYLNDKLPFKTKEDSEILSE
LRDVLKNANPETLKSLLNGMDQGHISFSDRNNRYNRLSQYINSFRKDDDDYLHNGYSLGSLVIEAIKYRLDSESHLKEEL
LKQTAELEQRKNAEVDLKSEKKRLEAQIEKVGYDIANKQQELEKARSDQKELSESIQKLTSRFKKESDAKQKELDEAKAA
NKSLSESATKTLARSSKITNELKDKLAASEKDKNRAFQVSSELANKLHETETSRDKALAESKELADKLAVKTAEAEKLME
NVGSLDRLVESAKREMAQKLAEIDQLTADKAKADAELAAANDTIASLQTELEKVKTELAVSERLIESGKREIAELEKQKD
ASDKALAESQANVAELEKQKAASDAKVAELEKEVEAAKAEVADLKAQLAKKEEELEAVKKEKEALEAKIEELKKAHAEEL
SKLKEMLEKKDHANADLQAEINRLKQELADRIKSLSQGGRASQTNPGSTTAKAGQLPSTGESANPFFTIAALTVIAGAGM
AVVSPKRKEN

Sequences:

>Translated_570_residues
MFLRNKKQKFSIRKLSAGAASVLVAASVLGGGVSAYADSVSGLEVADPSDSKKLIELGLAKYLNDKLPFKTKEDSEILSE
LRDVLKNANPETLKSLLNGMDQGHISFSDRNNRYNRLSQYINSFRKDDDDYLHNGYSLGSLVIEAIKYRLDSESHLKEEL
LKQTAELEQRKNAEVDLKSEKKRLEAQIEKVGYDIANKQQELEKARSDQKELSESIQKLTSRFKKESDAKQKELDEAKAA
NKSLSESATKTLARSSKITNELKDKLAASEKDKNRAFQVSSELANKLHETETSRDKALAESKELADKLAVKTAEAEKLME
NVGSLDRLVESAKREMAQKLAEIDQLTADKAKADAELAAANDTIASLQTELEKVKTELAVSERLIESGKREIAELEKQKD
ASDKALAESQANVAELEKQKAASDAKVAELEKEVEAAKAEVADLKAQLAKKEEELEAVKKEKEALEAKIEELKKAHAEEL
SKLKEMLEKKDHANADLQAEINRLKQELADRIKSLSQGGRASQTNPGSTTAKAGQLPSTGESANPFFTIAALTVIAGAGM
AVVSPKRKEN
>Mature_570_residues
MFLRNKKQKFSIRKLSAGAASVLVAASVLGGGVSAYADSVSGLEVADPSDSKKLIELGLAKYLNDKLPFKTKEDSEILSE
LRDVLKNANPETLKSLLNGMDQGHISFSDRNNRYNRLSQYINSFRKDDDDYLHNGYSLGSLVIEAIKYRLDSESHLKEEL
LKQTAELEQRKNAEVDLKSEKKRLEAQIEKVGYDIANKQQELEKARSDQKELSESIQKLTSRFKKESDAKQKELDEAKAA
NKSLSESATKTLARSSKITNELKDKLAASEKDKNRAFQVSSELANKLHETETSRDKALAESKELADKLAVKTAEAEKLME
NVGSLDRLVESAKREMAQKLAEIDQLTADKAKADAELAAANDTIASLQTELEKVKTELAVSERLIESGKREIAELEKQKD
ASDKALAESQANVAELEKQKAASDAKVAELEKEVEAAKAEVADLKAQLAKKEEELEAVKKEKEALEAKIEELKKAHAEEL
SKLKEMLEKKDHANADLQAEINRLKQELADRIKSLSQGGRASQTNPGSTTAKAGQLPSTGESANPFFTIAALTVIAGAGM
AVVSPKRKEN

Specific function: Binds IgG molecules of the Ig1, Ig2 and Ig4 subclasses, and also binds fibrinogen [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted, cell wall; Peptidoglycan-anchor (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI167614504, Length=337, Percent_Identity=23.7388724035608, Blast_Score=66, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005877
- InterPro:   IPR019948
- InterPro:   IPR019950
- InterPro:   IPR019931
- InterPro:   IPR001899 [H]

Pfam domain/function: PF00746 Gram_pos_anchor; PF04650 YSIRK_signal [H]

EC number: NA

Molecular weight: Translated: 62738; Mature: 62738

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS50847 GRAM_POS_ANCHORING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLRNKKQKFSIRKLSAGAASVLVAASVLGGGVSAYADSVSGLEVADPSDSKKLIELGLA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCHHHHHHHHHH
KYLNDKLPFKTKEDSEILSELRDVLKNANPETLKSLLNGMDQGHISFSDRNNRYNRLSQY
HHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEECCCCCHHHHHHHH
INSFRKDDDDYLHNGYSLGSLVIEAIKYRLDSESHLKEELLKQTAELEQRKNAEVDLKSE
HHHHCCCCHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHH
KKRLEAQIEKVGYDIANKQQELEKARSDQKELSESIQKLTSRFKKESDAKQKELDEAKAA
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NKSLSESATKTLARSSKITNELKDKLAASEKDKNRAFQVSSELANKLHETETSRDKALAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKELADKLAVKTAEAEKLMENVGSLDRLVESAKREMAQKLAEIDQLTADKAKADAELAAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NDTIASLQTELEKVKTELAVSERLIESGKREIAELEKQKDASDKALAESQANVAELEKQK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
AASDAKVAELEKEVEAAKAEVADLKAQLAKKEEELEAVKKEKEALEAKIEELKKAHAEEL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKLKEMLEKKDHANADLQAEINRLKQELADRIKSLSQGGRASQTNPGSTTAKAGQLPSTG
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
ESANPFFTIAALTVIAGAGMAVVSPKRKEN
CCCCCHHHHHHHHHHHCCCHHHCCCCCCCC
>Mature Secondary Structure
MFLRNKKQKFSIRKLSAGAASVLVAASVLGGGVSAYADSVSGLEVADPSDSKKLIELGLA
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHCCCCCCCCCCCCHHHHHHHHHH
KYLNDKLPFKTKEDSEILSELRDVLKNANPETLKSLLNGMDQGHISFSDRNNRYNRLSQY
HHHCCCCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCEEECCCCCHHHHHHHH
INSFRKDDDDYLHNGYSLGSLVIEAIKYRLDSESHLKEELLKQTAELEQRKNAEVDLKSE
HHHHCCCCHHHHHCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCHHHH
KKRLEAQIEKVGYDIANKQQELEKARSDQKELSESIQKLTSRFKKESDAKQKELDEAKAA
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NKSLSESATKTLARSSKITNELKDKLAASEKDKNRAFQVSSELANKLHETETSRDKALAE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKELADKLAVKTAEAEKLMENVGSLDRLVESAKREMAQKLAEIDQLTADKAKADAELAAA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NDTIASLQTELEKVKTELAVSERLIESGKREIAELEKQKDASDKALAESQANVAELEKQK
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHH
AASDAKVAELEKEVEAAKAEVADLKAQLAKKEEELEAVKKEKEALEAKIEELKKAHAEEL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SKLKEMLEKKDHANADLQAEINRLKQELADRIKSLSQGGRASQTNPGSTTAKAGQLPSTG
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
ESANPFFTIAALTVIAGAGMAVVSPKRKEN
CCCCCHHHHHHHHHHHCCCHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1588817; 1528877 [H]