| Definition | Streptococcus pyogenes MGAS8232, complete genome. |
|---|---|
| Accession | NC_003485 |
| Length | 1,895,017 |
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The map label for this gene is relA [H]
Identifier: 19746884
GI number: 19746884
Start: 1705216
End: 1707435
Strand: Reverse
Name: relA [H]
Synonym: spyM18_2045
Alternate gene names: 19746884
Gene position: 1707435-1705216 (Counterclockwise)
Preceding gene: 19746885
Following gene: 19746883
Centisome position: 90.1
GC content: 43.92
Gene sequence:
>2220_bases ATGGTTAAAGAAATCAATTTATCAGGAGAGGAAGTTGTTGCCCTTGCTGCCAAGTACATGACAGATGGTGACGTCGAGCT TGTGCAAAAGGCGCTTGATTATGCGACAGCTGCTCATTTTTACCAGGTTAGAAAGTCGGGGGAGCCTTATATTGTGCACC CTATTCAGGTAGCAGCAATCCTAGCAGACCTGCATTTGGACGCTGTGACAGTTGCCTGTGGCTTTTTACATGATGTCGTA GAAGATACGGATATTACCTTAGATGAGATCGAAGCAGACTTTGGCCAAGATGCTCGTGATATCGTTGATGGTGTCACCAA GTTAGGTAAAGTTGAGTACAAATCTCATGAGGAGCAACTCGCCGAAAACCATCGCAAAATGCTGATGGCTATGTCCAAAG ATATTCGCGTGATTTTGGTGAAATTAGCTGACCGCCTGCATAATATGCGTACCCTCAAACATTTGCGCAAGGACAAACAA GAGCGCATTTCGCGCGAAACCATGGAAATCTATGCCCCCTTGGCGCATCGTTTGGGGATTAGTCGTATCAAATGGGAACT AGAAGATTTGGCTTTTCGTTACCTCAATGAAACCGAATTTTACAAAATTTCCCATATGATGAAAGAAAAACGTCGCGAGC GTGAAGCTTTGGTAGAGGCTATTGTCAGTAAGGTCAAAACCTATACGACACAACAAGGGTTGTTTGGAGATGTGTATGGC CGACCAAAACACATTTATTCGATTTATCGGAAAATGCGGGACAAAAAGAAACGTTTCGATCAGATTTTTGATCTGATTGC CATTCGTTGTGTCATGGAAACGCAAAGCGATGTCTATGCTATGGTTGGCTATATTCACGAGCTTTGGCGTCCCATGCCAG GTCGCTTCAAGGATTATATTGCAGCTCCTAAAGCTAATGGCTATCAGTCGATTCATACTACTGTTTATGGGCCAAAAGGA CCTATTGAGATTCAAATCAGAACTAAGGACATGCATCAAGTGGCTGAGTATGGGGTTGCTGCTCACTGGGCTTATAAAAA AGGCGTGCGTGGTAAGGTCAATCAAGCTGAGCAAGCCGTTGGCATGAACTGGATCAAAGAGCTGGTAGAATTGCAAGATG CCTCAAATGGCGATGCAGTGGACTTTGTGGATTCGGTCAAAGAAGACATTTTTTCTGAGCGGATTTATGTCTTTACACCG ACAGGGGCTGTTCAGGAGTTGCCAAAAGAATCAGGTCCTATTGATTTTGCTTATGCGATCCATACGCAAATCGGTGAAAA AGCAACAGGTGCCAAAGTCAATGGACGTATGGTTCCTCTCACTGCCAAGTTAAAAACAGGAGATGTGGTTGAAATCATCA CCAATGCCAATTCCTTTGGCCCTAGTCGAGACTGGGTAAAACTGGTCAAAACCAATAAGGCTCGCAACAAAATTCGTCAG TTCTTTAAAAATCAAGACAAGGAATTGTCAGTGAATAAAGGCCGTGATTTGTTGGTGTCTTATTTTCAAGAGCAGGGCTA CGTTGCCAATAAATACCTTGACAAAAAACGCATTGAAGCGATCCTTCCAAAAGTCAGTGTGAAGAGCGAAGAATCGCTCT ATGCAGCCGTTGGGTTTGGTGACATTAGTCCTATCAGTGTCTTTAACAAGTTAACCGAAAAAGAGCGCCGTGAAGAAGAA AGGGCCAAGGCTAAAGCAGAAGCAGAAGAATTGGTTAAGGGCGGTGAGGTCAAACACGAAAACAAAGATGTGCTCAAGGT TCGCAGTGAAAATGGAGTCATTATCCAAGGAGCATCAGGCCTCTTGATGCGGATTGCCAAGTGTTGTAATCCTGTACCTG GTGATCCTATTGACGGCTACATTACCAAAGGGCGTGGCATTGCGATTCACAGATCGGATTGTCATAACATTAAGAGTCAA GATGGCTACCAAGAACGCTTGATTGAGGTCGAGTGGGATTTGGACAATTCGAGTAAAGATTATCAGGCTGAAATTGATAT CTATGGGCTCAATCGTAGTGGTCTGCTTAATGATGTGCTCCAAATTTTATCAAACTCAACCAAGAGCATATCGACAGTCA ATGCTCAGCCGACCAAGGACATGAAGTTTGCTAATATTCACGTGAGCTTTGGCATTCCAAATCTGACGCATCTGACCACT GTTGTCGAAAAAATCAAGGCAGTTCCAGATGTTTATAGCGTGAAGCGGACCAATGGCTAA
Upstream 100 bases:
>100_bases GCAAAAGGTGCATGCCTTTTAGCAGCTTTGAGGATTCCTTCTTTTGCTTTTACAGTGAAAGTGTTAAAATAGGAAAAACA ACTAGTAATTGAGGAAGTAA
Downstream 100 bases:
>100_bases GAAAGGATAAAAACATGAAACTTGTTTTGCAACGGGTCAAAGAGGCCTCTGTTTCTATTGATGGGAAAATTGCTGGCGCT ATTAATCAAGGATTGTTGTT
Product: (p)ppGpp synthetase
Products: NA
Alternate protein names: GTP pyrophosphokinase; (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; Stringent response-like protein; ppGpp synthase I; Guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase; Penta-phosphate guanosine-3'-pyrophosphohydrolase; (ppGpp)ase [H]
Number of amino acids: Translated: 739; Mature: 739
Protein sequence:
>739_residues MVKEINLSGEEVVALAAKYMTDGDVELVQKALDYATAAHFYQVRKSGEPYIVHPIQVAAILADLHLDAVTVACGFLHDVV EDTDITLDEIEADFGQDARDIVDGVTKLGKVEYKSHEEQLAENHRKMLMAMSKDIRVILVKLADRLHNMRTLKHLRKDKQ ERISRETMEIYAPLAHRLGISRIKWELEDLAFRYLNETEFYKISHMMKEKRREREALVEAIVSKVKTYTTQQGLFGDVYG RPKHIYSIYRKMRDKKKRFDQIFDLIAIRCVMETQSDVYAMVGYIHELWRPMPGRFKDYIAAPKANGYQSIHTTVYGPKG PIEIQIRTKDMHQVAEYGVAAHWAYKKGVRGKVNQAEQAVGMNWIKELVELQDASNGDAVDFVDSVKEDIFSERIYVFTP TGAVQELPKESGPIDFAYAIHTQIGEKATGAKVNGRMVPLTAKLKTGDVVEIITNANSFGPSRDWVKLVKTNKARNKIRQ FFKNQDKELSVNKGRDLLVSYFQEQGYVANKYLDKKRIEAILPKVSVKSEESLYAAVGFGDISPISVFNKLTEKERREEE RAKAKAEAEELVKGGEVKHENKDVLKVRSENGVIIQGASGLLMRIAKCCNPVPGDPIDGYITKGRGIAIHRSDCHNIKSQ DGYQERLIEVEWDLDNSSKDYQAEIDIYGLNRSGLLNDVLQILSNSTKSISTVNAQPTKDMKFANIHVSFGIPNLTHLTT VVEKIKAVPDVYSVKRTNG
Sequences:
>Translated_739_residues MVKEINLSGEEVVALAAKYMTDGDVELVQKALDYATAAHFYQVRKSGEPYIVHPIQVAAILADLHLDAVTVACGFLHDVV EDTDITLDEIEADFGQDARDIVDGVTKLGKVEYKSHEEQLAENHRKMLMAMSKDIRVILVKLADRLHNMRTLKHLRKDKQ ERISRETMEIYAPLAHRLGISRIKWELEDLAFRYLNETEFYKISHMMKEKRREREALVEAIVSKVKTYTTQQGLFGDVYG RPKHIYSIYRKMRDKKKRFDQIFDLIAIRCVMETQSDVYAMVGYIHELWRPMPGRFKDYIAAPKANGYQSIHTTVYGPKG PIEIQIRTKDMHQVAEYGVAAHWAYKKGVRGKVNQAEQAVGMNWIKELVELQDASNGDAVDFVDSVKEDIFSERIYVFTP TGAVQELPKESGPIDFAYAIHTQIGEKATGAKVNGRMVPLTAKLKTGDVVEIITNANSFGPSRDWVKLVKTNKARNKIRQ FFKNQDKELSVNKGRDLLVSYFQEQGYVANKYLDKKRIEAILPKVSVKSEESLYAAVGFGDISPISVFNKLTEKERREEE RAKAKAEAEELVKGGEVKHENKDVLKVRSENGVIIQGASGLLMRIAKCCNPVPGDPIDGYITKGRGIAIHRSDCHNIKSQ DGYQERLIEVEWDLDNSSKDYQAEIDIYGLNRSGLLNDVLQILSNSTKSISTVNAQPTKDMKFANIHVSFGIPNLTHLTT VVEKIKAVPDVYSVKRTNG >Mature_739_residues MVKEINLSGEEVVALAAKYMTDGDVELVQKALDYATAAHFYQVRKSGEPYIVHPIQVAAILADLHLDAVTVACGFLHDVV EDTDITLDEIEADFGQDARDIVDGVTKLGKVEYKSHEEQLAENHRKMLMAMSKDIRVILVKLADRLHNMRTLKHLRKDKQ ERISRETMEIYAPLAHRLGISRIKWELEDLAFRYLNETEFYKISHMMKEKRREREALVEAIVSKVKTYTTQQGLFGDVYG RPKHIYSIYRKMRDKKKRFDQIFDLIAIRCVMETQSDVYAMVGYIHELWRPMPGRFKDYIAAPKANGYQSIHTTVYGPKG PIEIQIRTKDMHQVAEYGVAAHWAYKKGVRGKVNQAEQAVGMNWIKELVELQDASNGDAVDFVDSVKEDIFSERIYVFTP TGAVQELPKESGPIDFAYAIHTQIGEKATGAKVNGRMVPLTAKLKTGDVVEIITNANSFGPSRDWVKLVKTNKARNKIRQ FFKNQDKELSVNKGRDLLVSYFQEQGYVANKYLDKKRIEAILPKVSVKSEESLYAAVGFGDISPISVFNKLTEKERREEE RAKAKAEAEELVKGGEVKHENKDVLKVRSENGVIIQGASGLLMRIAKCCNPVPGDPIDGYITKGRGIAIHRSDCHNIKSQ DGYQERLIEVEWDLDNSSKDYQAEIDIYGLNRSGLLNDVLQILSNSTKSISTVNAQPTKDMKFANIHVSFGIPNLTHLTT VVEKIKAVPDVYSVKRTNG
Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes both the formation of pppGpp wh
COG id: COG0317
COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Contains 1 HD domain [H]
Homologues:
Organism=Homo sapiens, GI38348360, Length=132, Percent_Identity=41.6666666666667, Blast_Score=73, Evalue=8e-13, Organism=Escherichia coli, GI1790082, Length=729, Percent_Identity=39.917695473251, Blast_Score=551, Evalue=1e-158, Organism=Escherichia coli, GI1789147, Length=698, Percent_Identity=36.2464183381089, Blast_Score=472, Evalue=1e-134, Organism=Caenorhabditis elegans, GI25143118, Length=137, Percent_Identity=38.6861313868613, Blast_Score=73, Evalue=5e-13,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002912 - InterPro: IPR012675 - InterPro: IPR003607 - InterPro: IPR007685 - InterPro: IPR004811 - InterPro: IPR004095 - InterPro: IPR012676 [H]
Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]
EC number: =2.7.6.5; =3.1.7.2 [H]
Molecular weight: Translated: 83674; Mature: 83674
Theoretical pI: Translated: 8.53; Mature: 8.53
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.7 %Cys (Translated Protein) 2.4 %Met (Translated Protein) 3.1 %Cys+Met (Translated Protein) 0.7 %Cys (Mature Protein) 2.4 %Met (Mature Protein) 3.1 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MVKEINLSGEEVVALAAKYMTDGDVELVQKALDYATAAHFYQVRKSGEPYIVHPIQVAAI CCEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHH LADLHLDAVTVACGFLHDVVEDTDITLDEIEADFGQDARDIVDGVTKLGKVEYKSHEEQL HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHH AENHRKMLMAMSKDIRVILVKLADRLHNMRTLKHLRKDKQERISRETMEIYAPLAHRLGI HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH SRIKWELEDLAFRYLNETEFYKISHMMKEKRREREALVEAIVSKVKTYTTQQGLFGDVYG HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC RPKHIYSIYRKMRDKKKRFDQIFDLIAIRCVMETQSDVYAMVGYIHELWRPMPGRFKDYI CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH AAPKANGYQSIHTTVYGPKGPIEIQIRTKDMHQVAEYGVAAHWAYKKGVRGKVNQAEQAV CCCCCCCCCEEEEEEECCCCCEEEEEECCHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHH GMNWIKELVELQDASNGDAVDFVDSVKEDIFSERIYVFTPTGAVQELPKESGPIDFAYAI HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCEEEECCCHHHHHCCCCCCCCEEEEEE HTQIGEKATGAKVNGRMVPLTAKLKTGDVVEIITNANSFGPSRDWVKLVKTNKARNKIRQ HHHHCCCCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH FFKNQDKELSVNKGRDLLVSYFQEQGYVANKYLDKKRIEAILPKVSVKSEESLYAAVGFG HHCCCCCEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCC DISPISVFNKLTEKERREEERAKAKAEAEELVKGGEVKHENKDVLKVRSENGVIIQGASG CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEEECCCH LLMRIAKCCNPVPGDPIDGYITKGRGIAIHRSDCHNIKSQDGYQERLIEVEWDLDNSSKD HHHHHHHHCCCCCCCCCCCEEECCCCEEEECCHHCCCCCCCCHHHCEEEEEECCCCCCCC YQAEIDIYGLNRSGLLNDVLQILSNSTKSISTVNAQPTKDMKFANIHVSFGIPNLTHLTT EEEEEEEEECCCCCHHHHHHHHHCCCCCCEEECCCCCCCCCEEEEEEEEECCCCHHHHHH VVEKIKAVPDVYSVKRTNG HHHHHHHCCCHHHHCCCCC >Mature Secondary Structure MVKEINLSGEEVVALAAKYMTDGDVELVQKALDYATAAHFYQVRKSGEPYIVHPIQVAAI CCEECCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCEEECHHHHHHH LADLHLDAVTVACGFLHDVVEDTDITLDEIEADFGQDARDIVDGVTKLGKVEYKSHEEQL HHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCHHHHHHHHH AENHRKMLMAMSKDIRVILVKLADRLHNMRTLKHLRKDKQERISRETMEIYAPLAHRLGI HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCH SRIKWELEDLAFRYLNETEFYKISHMMKEKRREREALVEAIVSKVKTYTTQQGLFGDVYG HHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC RPKHIYSIYRKMRDKKKRFDQIFDLIAIRCVMETQSDVYAMVGYIHELWRPMPGRFKDYI CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHH AAPKANGYQSIHTTVYGPKGPIEIQIRTKDMHQVAEYGVAAHWAYKKGVRGKVNQAEQAV CCCCCCCCCEEEEEEECCCCCEEEEEECCHHHHHHHHCHHHHHHHHCCCCCCCCHHHHHH GMNWIKELVELQDASNGDAVDFVDSVKEDIFSERIYVFTPTGAVQELPKESGPIDFAYAI HHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCEEEECCCHHHHHCCCCCCCCEEEEEE HTQIGEKATGAKVNGRMVPLTAKLKTGDVVEIITNANSFGPSRDWVKLVKTNKARNKIRQ HHHHCCCCCCCCCCCEEEEEEEECCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH FFKNQDKELSVNKGRDLLVSYFQEQGYVANKYLDKKRIEAILPKVSVKSEESLYAAVGFG HHCCCCCEEECCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCC DISPISVFNKLTEKERREEERAKAKAEAEELVKGGEVKHENKDVLKVRSENGVIIQGASG CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCEEEECCCH LLMRIAKCCNPVPGDPIDGYITKGRGIAIHRSDCHNIKSQDGYQERLIEVEWDLDNSSKD HHHHHHHHCCCCCCCCCCCEEECCCCEEEECCHHCCCCCCCCHHHCEEEEEECCCCCCCC YQAEIDIYGLNRSGLLNDVLQILSNSTKSISTVNAQPTKDMKFANIHVSFGIPNLTHLTT EEEEEEEEECCCCCHHHHHHHHHCCCCCCEEECCCCCCCCCEEEEEEEEECCCCHHHHHH VVEKIKAVPDVYSVKRTNG HHHHHHHCCCHHHHCCCCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 8232196 [H]