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The map label for this gene is gla [H]

Identifier: 19746782

GI number: 19746782

Start: 1593157

End: 1594104

Strand: Reverse

Name: gla [H]

Synonym: spyM18_1917

Alternate gene names: 19746782

Gene position: 1594104-1593157 (Counterclockwise)

Preceding gene: 19746783

Following gene: 19746780

Centisome position: 84.12

GC content: 37.97

Gene sequence:

>948_bases
ATGATCATTTTATTTATTATTTTATTACCTTTACATTCATCAATAAGCTTGTTAAAATGGTATTTGTTATATTTTATTAT
TTGGAGGAAACCAGAAAACATGGAAATGACATGGACTGTGAAATACATCACAGAATTTATCGCAACGGCTTTTTTGATTA
TTTTGGGGAATGGAGCTGTTGCTAACGTCGACTTAAAAGGAACAAAAGGACATAACTCAGGTTGGTTAGTGATTGCTTTT
GGCTATGGCTTAGGAGTTATGATGCCAGCTTTGATGTTTGGTAATGTATCTGGAAACCATATTAATCCTGCTTTCACAGT
TGGACTAGCAGTATCAGGCTTGTTCCCATGGGCTCACGTCTTACAATACGTTGTGGCACAATTACTTGGAGCTATCTTTG
GTCAGTTGGTAGTGGTAATGGTTTATAAACCTTACTTTATGAAAACTGAAAATCCAAATCATGTTTTAGGCTCATTCTCA
ACGATTTCATCTCTTGATAATGGTCAAAAAGACAGCCATAAAGTCTCTTATATCAATGGTTTCTTAAACGAATTTGTAGG
TTCATTTGTTCTTTTCTTTGGTGCTTTGGCTTTGACTAAAAACTACTTTGGGGTAGAGTTAGTTGGTAAATTGATTGAAG
CAGGTTACGACCAAACAACTGCAGCAACACAAATTTCACCATACGTGACAGGCTCATTGGCGGTTGCTCACATTGGTATT
GGTTTCTTAGTTATGGTCTTGGTTACTTCATTAGGTGGACCAACTGGGCCAGCACTAAACCCAGCGCGTGATTTTGGGCC
TCGTTTGTTACACCACTTCTTACCAAAATCAGTTCTTGGTCAAGCCAAAGGTGATTCAAAATGGTGGTATGCATGGGTTC
CTGTAGTTGCACCTATCTTAGCGGCGATAGTAGCCGTAGCAGCGTTTAAATACCTTTATATCAGATAA

Upstream 100 bases:

>100_bases
AATAAAAAATGTTATAATACTATGAAATAAAGTGATAAAGATAAGGTCTTTTATGGTCCTTTTCTTTACCGCTTTTATTA
TTGTGTGAAAATAACACTTA

Downstream 100 bases:

>100_bases
AAAAAGAACTAAAGCTTCTTTTAGACTCAAGACAAGCTCGCTTAAGGAACTTGTCTTTTTTATATGAGTTAAGCGAAATC
TAATGCAAACTTGACTGTCT

Product: glycerol uptake facilitator

Products: glycerol [Cytoplasm] [C]

Alternate protein names: Aquaglyceroporin; Glyceroaquaporin [H]

Number of amino acids: Translated: 315; Mature: 315

Protein sequence:

>315_residues
MIILFIILLPLHSSISLLKWYLLYFIIWRKPENMEMTWTVKYITEFIATAFLIILGNGAVANVDLKGTKGHNSGWLVIAF
GYGLGVMMPALMFGNVSGNHINPAFTVGLAVSGLFPWAHVLQYVVAQLLGAIFGQLVVVMVYKPYFMKTENPNHVLGSFS
TISSLDNGQKDSHKVSYINGFLNEFVGSFVLFFGALALTKNYFGVELVGKLIEAGYDQTTAATQISPYVTGSLAVAHIGI
GFLVMVLVTSLGGPTGPALNPARDFGPRLLHHFLPKSVLGQAKGDSKWWYAWVPVVAPILAAIVAVAAFKYLYIR

Sequences:

>Translated_315_residues
MIILFIILLPLHSSISLLKWYLLYFIIWRKPENMEMTWTVKYITEFIATAFLIILGNGAVANVDLKGTKGHNSGWLVIAF
GYGLGVMMPALMFGNVSGNHINPAFTVGLAVSGLFPWAHVLQYVVAQLLGAIFGQLVVVMVYKPYFMKTENPNHVLGSFS
TISSLDNGQKDSHKVSYINGFLNEFVGSFVLFFGALALTKNYFGVELVGKLIEAGYDQTTAATQISPYVTGSLAVAHIGI
GFLVMVLVTSLGGPTGPALNPARDFGPRLLHHFLPKSVLGQAKGDSKWWYAWVPVVAPILAAIVAVAAFKYLYIR
>Mature_315_residues
MIILFIILLPLHSSISLLKWYLLYFIIWRKPENMEMTWTVKYITEFIATAFLIILGNGAVANVDLKGTKGHNSGWLVIAF
GYGLGVMMPALMFGNVSGNHINPAFTVGLAVSGLFPWAHVLQYVVAQLLGAIFGQLVVVMVYKPYFMKTENPNHVLGSFS
TISSLDNGQKDSHKVSYINGFLNEFVGSFVLFFGALALTKNYFGVELVGKLIEAGYDQTTAATQISPYVTGSLAVAHIGI
GFLVMVLVTSLGGPTGPALNPARDFGPRLLHHFLPKSVLGQAKGDSKWWYAWVPVVAPILAAIVAVAAFKYLYIR

Specific function: Mixed channel protein that transports both water and glycerol [H]

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4826645, Length=298, Percent_Identity=30.2013422818792, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI22538420, Length=276, Percent_Identity=30.4347826086957, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI157266307, Length=280, Percent_Identity=27.5, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI4502187, Length=280, Percent_Identity=28.2142857142857, Blast_Score=80, Evalue=2e-15,
Organism=Escherichia coli, GI1790362, Length=288, Percent_Identity=29.8611111111111, Blast_Score=86, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17558372, Length=284, Percent_Identity=27.112676056338, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994009, Length=271, Percent_Identity=26.9372693726937, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71992966, Length=277, Percent_Identity=27.0758122743682, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI17544068, Length=272, Percent_Identity=25.7352941176471, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17531431, Length=279, Percent_Identity=26.5232974910394, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17531429, Length=279, Percent_Identity=26.5232974910394, Blast_Score=72, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6321054, Length=226, Percent_Identity=31.858407079646, Blast_Score=88, Evalue=1e-18,
Organism=Drosophila melanogaster, GI45550503, Length=275, Percent_Identity=25.8181818181818, Blast_Score=65, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 34422; Mature: 34422

Theoretical pI: Translated: 9.70; Mature: 9.70

Prosite motif: PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIILFIILLPLHSSISLLKWYLLYFIIWRKPENMEMTWTVKYITEFIATAFLIILGNGAV
CHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCE
ANVDLKGTKGHNSGWLVIAFGYGLGVMMPALMFGNVSGNHINPAFTVGLAVSGLFPWAHV
EEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCHHHHH
LQYVVAQLLGAIFGQLVVVMVYKPYFMKTENPNHVLGSFSTISSLDNGQKDSHKVSYING
HHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHCCHHHHHHHCCCCCCCHHHHHHHH
FLNEFVGSFVLFFGALALTKNYFGVELVGKLIEAGYDQTTAATQISPYVTGSLAVAHIGI
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHCCCCHHHHHHHHHHHHH
GFLVMVLVTSLGGPTGPALNPARDFGPRLLHHFLPKSVLGQAKGDSKWWYAWVPVVAPIL
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCCCCCEEEEHHHHHHHHH
AAIVAVAAFKYLYIR
HHHHHHHHHHHHHCC
>Mature Secondary Structure
MIILFIILLPLHSSISLLKWYLLYFIIWRKPENMEMTWTVKYITEFIATAFLIILGNGAV
CHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHHHHHHCCCCCE
ANVDLKGTKGHNSGWLVIAFGYGLGVMMPALMFGNVSGNHINPAFTVGLAVSGLFPWAHV
EEEEECCCCCCCCCEEEEEECCCHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHCHHHHH
LQYVVAQLLGAIFGQLVVVMVYKPYFMKTENPNHVLGSFSTISSLDNGQKDSHKVSYING
HHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCHHCCHHHHHHHCCCCCCCHHHHHHHH
FLNEFVGSFVLFFGALALTKNYFGVELVGKLIEAGYDQTTAATQISPYVTGSLAVAHIGI
HHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCCCHHHHCCCCHHHHHHHHHHHHH
GFLVMVLVTSLGGPTGPALNPARDFGPRLLHHFLPKSVLGQAKGDSKWWYAWVPVVAPIL
HHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCHHHHCCCCCCCCEEEEHHHHHHHHH
AAIVAVAAFKYLYIR
HHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glycerol [Periplasm] [C]

Specific reaction: glycerol [Periplasm] = glycerol [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 11337471 [H]