Click here to switch to the map view.

The map label for this gene is proA [H]

Identifier: 19746585

GI number: 19746585

Start: 1398024

End: 1399274

Strand: Reverse

Name: proA [H]

Synonym: spyM18_1679

Alternate gene names: 19746585

Gene position: 1399274-1398024 (Counterclockwise)

Preceding gene: 19746586

Following gene: 19746584

Centisome position: 73.84

GC content: 42.69

Gene sequence:

>1251_bases
ATGACTGATATGAGAAGGTTAGGGCAAAGGGCAAAACAAGCTAGTCTTTTAATAGCACCTTTGTCGACGCAAATTAAAAA
TCGCTTTTTAAGCACCTTAGCAAAGGCATTAGTTGACGATACACAGACTCTCTTAGCCGCTAACCAAAAAGATTTAGCGA
ATGCTAAAGAACATGGTATTTCTGACATCATGATGGATCGCTTGCGCTTAACTTCAGAACGGATTAAAGCGATAGCACAG
GGAGTTCAACAGGTTGCTGACTTAGCTGATCCAATCGGACAAGTCATTAAGGGCTATACTAACCTCGATGGCCTTAAAAT
CCTCCAAAAGAGAGTTCCTCTAGGGGTGATTGCGATGATTTTTGAGAGTCGCCCGAATGTTTCAGTGGATGCTTTTAGTC
TGGCGTTCAAAACCAATAATGCCATCATCCTAAGGGGAGGAAAAGATGCCCTTCACTCAAATAAAGCTTTGGTGAAGTTG
ATCCGACAAAGTCTGGAAAAATCAGGGATCACCCCAGATGCTGTCCAGCTAGTTGAGGATCCCTCACATGCTGTTGCTGA
AGAATTGATGCAGGCAACGGACTATGTGGATGTGTTGATTCCACGTGGTGGTGCTAAATTAATTCAGACCGTTAAGGAAA
AAGCAAAAGTGCCCGTCATCGAAACAGGTGTGGGGAATGTGCATATCTATGTGGATGCTCAAGCTGACTTAGATATGGCT
ACTAATATTGTTATCAACGCTAAAACAAAGCGCCCAAGTGTTTGCAATGCAGCTGAGGGATTGGTAATTCACGAAGCTGT
AGCAGCAAGGTTTATTCCTATGCTTGAAAAAGCGATCAATCAGGTTCAGCCAGTAGAATGGCGGGCAGATGACAAGGCTT
TGCCGTTATTTGAGCAGGCAGTGCCTGCAAAAGCAGAGGATTTTGAGACCGAATTTTTAGATTATATCATGTCTGTTAAG
GTTGTTTCCTCTTTGGAAGAAGCTATTTCTTGGATAAATCAGCATACTAGTCACCATTCCGAAGCTATCATCACAAGGGA
TATTAAGGCAGCAGAGACCTTTCAAGATTTAGTGGATGCTGCTGCTGTTTATGTCAATGCTTCAACACGATTTACCGATG
GTTTTGTTTTTGGGCTTGGTGCTGAAATTGGGATTTCTACTCAAAAAATGCACGCCCGTGGGCCAATGGGCTTAGAAGCC
TTGACCAGCACTAAATTTTATATTAATGGGGATGGACATATCAGAGAATAA

Upstream 100 bases:

>100_bases
CAGATGGTCTTGATGAATGGAGCTAATCCCAGAGATATTTTAAGAGTGCTTGAAGGGCAACCACTAGGCACCTGGTTCAA
GCAGATAGAAGAGGTAACAC

Downstream 100 bases:

>100_bases
GCTACTAGAAGGTCCCTTAATGACTAATGAAAGAGAAAAAGAAGAAGCAAAGGTTGCTTTAGAAGAACTTTTACATCAGA
TTCAGGTGATTCATTTGGAA

Product: gamma-glutamyl phosphate reductase

Products: NA

Alternate protein names: GPR; Glutamate-5-semialdehyde dehydrogenase; Glutamyl-gamma-semialdehyde dehydrogenase; GSA dehydrogenase [H]

Number of amino acids: Translated: 416; Mature: 415

Protein sequence:

>416_residues
MTDMRRLGQRAKQASLLIAPLSTQIKNRFLSTLAKALVDDTQTLLAANQKDLANAKEHGISDIMMDRLRLTSERIKAIAQ
GVQQVADLADPIGQVIKGYTNLDGLKILQKRVPLGVIAMIFESRPNVSVDAFSLAFKTNNAIILRGGKDALHSNKALVKL
IRQSLEKSGITPDAVQLVEDPSHAVAEELMQATDYVDVLIPRGGAKLIQTVKEKAKVPVIETGVGNVHIYVDAQADLDMA
TNIVINAKTKRPSVCNAAEGLVIHEAVAARFIPMLEKAINQVQPVEWRADDKALPLFEQAVPAKAEDFETEFLDYIMSVK
VVSSLEEAISWINQHTSHHSEAIITRDIKAAETFQDLVDAAAVYVNASTRFTDGFVFGLGAEIGISTQKMHARGPMGLEA
LTSTKFYINGDGHIRE

Sequences:

>Translated_416_residues
MTDMRRLGQRAKQASLLIAPLSTQIKNRFLSTLAKALVDDTQTLLAANQKDLANAKEHGISDIMMDRLRLTSERIKAIAQ
GVQQVADLADPIGQVIKGYTNLDGLKILQKRVPLGVIAMIFESRPNVSVDAFSLAFKTNNAIILRGGKDALHSNKALVKL
IRQSLEKSGITPDAVQLVEDPSHAVAEELMQATDYVDVLIPRGGAKLIQTVKEKAKVPVIETGVGNVHIYVDAQADLDMA
TNIVINAKTKRPSVCNAAEGLVIHEAVAARFIPMLEKAINQVQPVEWRADDKALPLFEQAVPAKAEDFETEFLDYIMSVK
VVSSLEEAISWINQHTSHHSEAIITRDIKAAETFQDLVDAAAVYVNASTRFTDGFVFGLGAEIGISTQKMHARGPMGLEA
LTSTKFYINGDGHIRE
>Mature_415_residues
TDMRRLGQRAKQASLLIAPLSTQIKNRFLSTLAKALVDDTQTLLAANQKDLANAKEHGISDIMMDRLRLTSERIKAIAQG
VQQVADLADPIGQVIKGYTNLDGLKILQKRVPLGVIAMIFESRPNVSVDAFSLAFKTNNAIILRGGKDALHSNKALVKLI
RQSLEKSGITPDAVQLVEDPSHAVAEELMQATDYVDVLIPRGGAKLIQTVKEKAKVPVIETGVGNVHIYVDAQADLDMAT
NIVINAKTKRPSVCNAAEGLVIHEAVAARFIPMLEKAINQVQPVEWRADDKALPLFEQAVPAKAEDFETEFLDYIMSVKV
VSSLEEAISWINQHTSHHSEAIITRDIKAAETFQDLVDAAAVYVNASTRFTDGFVFGLGAEIGISTQKMHARGPMGLEAL
TSTKFYINGDGHIRE

Specific function: Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate [H]

COG id: COG0014

COG function: function code E; Gamma-glutamyl phosphate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyl phosphate reductase family [H]

Homologues:

Organism=Homo sapiens, GI62912457, Length=411, Percent_Identity=35.5231143552311, Blast_Score=259, Evalue=3e-69,
Organism=Homo sapiens, GI21361368, Length=411, Percent_Identity=35.5231143552311, Blast_Score=259, Evalue=4e-69,
Organism=Escherichia coli, GI1786438, Length=415, Percent_Identity=46.2650602409639, Blast_Score=383, Evalue=1e-107,
Organism=Caenorhabditis elegans, GI17569967, Length=417, Percent_Identity=38.8489208633094, Blast_Score=280, Evalue=1e-75,
Organism=Caenorhabditis elegans, GI17569969, Length=417, Percent_Identity=38.8489208633094, Blast_Score=279, Evalue=2e-75,
Organism=Saccharomyces cerevisiae, GI6324899, Length=434, Percent_Identity=35.2534562211982, Blast_Score=270, Evalue=3e-73,
Organism=Drosophila melanogaster, GI21357643, Length=423, Percent_Identity=35.9338061465721, Blast_Score=253, Evalue=1e-67,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016161
- InterPro:   IPR016163
- InterPro:   IPR016162
- InterPro:   IPR015590
- InterPro:   IPR000965
- InterPro:   IPR020593
- InterPro:   IPR012134 [H]

Pfam domain/function: PF00171 Aldedh [H]

EC number: =1.2.1.41 [H]

Molecular weight: Translated: 45408; Mature: 45277

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS01223 PROA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDMRRLGQRAKQASLLIAPLSTQIKNRFLSTLAKALVDDTQTLLAANQKDLANAKEHGI
CCHHHHHHHHHHHHCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCH
SDIMMDRLRLTSERIKAIAQGVQQVADLADPIGQVIKGYTNLDGLKILQKRVPLGVIAMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHH
FESRPNVSVDAFSLAFKTNNAIILRGGKDALHSNKALVKLIRQSLEKSGITPDAVQLVED
HHCCCCCCEEEEEEEEECCCEEEEECCHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHCC
PSHAVAEELMQATDYVDVLIPRGGAKLIQTVKEKAKVPVIETGVGNVHIYVDAQADLDMA
CCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCEEEECCCEEEEEEECCCCCCCC
TNIVINAKTKRPSVCNAAEGLVIHEAVAARFIPMLEKAINQVQPVEWRADDKALPLFEQA
CEEEEECCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
VPAKAEDFETEFLDYIMSVKVVSSLEEAISWINQHTSHHSEAIITRDIKAAETFQDLVDA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCHHHHHHHHHHHHH
AAVYVNASTRFTDGFVFGLGAEIGISTQKMHARGPMGLEALTSTKFYINGDGHIRE
HHHEEECCCEECCCEEEECCCCCCCCHHHHHCCCCCCHHHHHCEEEEECCCCCCCC
>Mature Secondary Structure 
TDMRRLGQRAKQASLLIAPLSTQIKNRFLSTLAKALVDDTQTLLAANQKDLANAKEHGI
CHHHHHHHHHHHHCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHCCH
SDIMMDRLRLTSERIKAIAQGVQQVADLADPIGQVIKGYTNLDGLKILQKRVPLGVIAMI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHCCHHHHHHH
FESRPNVSVDAFSLAFKTNNAIILRGGKDALHSNKALVKLIRQSLEKSGITPDAVQLVED
HHCCCCCCEEEEEEEEECCCEEEEECCHHHHHCCHHHHHHHHHHHHHCCCCHHHHHHHCC
PSHAVAEELMQATDYVDVLIPRGGAKLIQTVKEKAKVPVIETGVGNVHIYVDAQADLDMA
CCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHHHCCCCEEEECCCEEEEEEECCCCCCCC
TNIVINAKTKRPSVCNAAEGLVIHEAVAARFIPMLEKAINQVQPVEWRADDKALPLFEQA
CEEEEECCCCCCCCCCHHCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHH
VPAKAEDFETEFLDYIMSVKVVSSLEEAISWINQHTSHHSEAIITRDIKAAETFQDLVDA
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHCHHHHHHHHHHHHH
AAVYVNASTRFTDGFVFGLGAEIGISTQKMHARGPMGLEALTSTKFYINGDGHIRE
HHHEEECCCEECCCEEEECCCCCCCCHHHHHCCCCCCHHHHHCEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]