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The map label for this gene is aroE [H]

Identifier: 19746518

GI number: 19746518

Start: 1315318

End: 1316196

Strand: Reverse

Name: aroE [H]

Synonym: spyM18_1592

Alternate gene names: 19746518

Gene position: 1316196-1315318 (Counterclockwise)

Preceding gene: 19746519

Following gene: 19746516

Centisome position: 69.46

GC content: 45.73

Gene sequence:

>879_bases
ATGTCAGAACGTTTATCAGGCCACACCCTGCTGGTCTCTTTGCTTGCTACCCCTATTCGTCATAGTTTGTCTCCCAAAAT
GCACAATGAAGCCTATGCTAAACTGGGGCTGGATTATGCCTACCTTGCTTTTGAAGTAGGGACAGAGCAATTAGCAGATG
CCGTGCAAGGGATTCGTGCCTTAGGAATTCGTGGCTCCAATGTGTCTATGCCAAATAAAGAAGCTATTTTACCCTTATTG
GATGACTTGTCCCCAGCTGCTGAGTTGGTCGGTGCAGTCAATACGGTTGTCAATAAGGATGGTAAAGGACATCTCGTGGG
GCATATTACAGACGGTATAGGAGCGCTCAGAGCCTTGGCTGACGAAGGAGTGTCGGTAAAGAACAAAATCATTACCCTAG
CAGGAGTTGGTGGGGCTGGGAAAGCTATCGCTGTCCAGCTCGCTTTTGACGGCGCCAAAGAGATTCGTTTGTTTAACCGA
CAAGCTACACGTCTAAGTAGCGTTCAAAAGCTTGTGACAAAACTGAACCAGCTAACAAGGACTAAAGTAACCCTTCAAGA
CTTGGAAGATCAGACTGCCTTTAAGGAGGCCATCAGGGAATCTCATCTATTTATTGATGCTACAAGTGTAGGAATGAAGC
CTTTAGAAAATCTAAGTTTGATTACCGACCCCGAGCTCATTCGCCCAGACTTGGTAGTCTTTGACATCGTGTACAGCCCA
GCAGAAACCAAGTTACTAGCCTTTGCCCGTCAACATGGCGCCCAAAAAGTCATTAATGGGCTAGGGATGGTGCTTTATCA
AGGAGCAGAAGCTTTTAAATTAATCACTGGTCAAGACATGCCAGTTGACGCTATTAAACCTCTTTTAGGTGATAAGTAA

Upstream 100 bases:

>100_bases
GATGAATTCTGTAAAATAAGGTATAATAAAAAACAAATAGGCGTCCTTTATTACGTGAAAGGCGCCTTTACAAGGTTGAA
ATGGAAAGTGAGATTTCTAA

Downstream 100 bases:

>100_bases
CTCAACCCTTTTTAAAGAACTTTTTAAGTAAGCTTAATTATGATATATTAATAAGAGATGGAGCAGTCATCATGGGCTGC
TAAAATTCTTTTTGCGAGAG

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 292; Mature: 291

Protein sequence:

>292_residues
MSERLSGHTLLVSLLATPIRHSLSPKMHNEAYAKLGLDYAYLAFEVGTEQLADAVQGIRALGIRGSNVSMPNKEAILPLL
DDLSPAAELVGAVNTVVNKDGKGHLVGHITDGIGALRALADEGVSVKNKIITLAGVGGAGKAIAVQLAFDGAKEIRLFNR
QATRLSSVQKLVTKLNQLTRTKVTLQDLEDQTAFKEAIRESHLFIDATSVGMKPLENLSLITDPELIRPDLVVFDIVYSP
AETKLLAFARQHGAQKVINGLGMVLYQGAEAFKLITGQDMPVDAIKPLLGDK

Sequences:

>Translated_292_residues
MSERLSGHTLLVSLLATPIRHSLSPKMHNEAYAKLGLDYAYLAFEVGTEQLADAVQGIRALGIRGSNVSMPNKEAILPLL
DDLSPAAELVGAVNTVVNKDGKGHLVGHITDGIGALRALADEGVSVKNKIITLAGVGGAGKAIAVQLAFDGAKEIRLFNR
QATRLSSVQKLVTKLNQLTRTKVTLQDLEDQTAFKEAIRESHLFIDATSVGMKPLENLSLITDPELIRPDLVVFDIVYSP
AETKLLAFARQHGAQKVINGLGMVLYQGAEAFKLITGQDMPVDAIKPLLGDK
>Mature_291_residues
SERLSGHTLLVSLLATPIRHSLSPKMHNEAYAKLGLDYAYLAFEVGTEQLADAVQGIRALGIRGSNVSMPNKEAILPLLD
DLSPAAELVGAVNTVVNKDGKGHLVGHITDGIGALRALADEGVSVKNKIITLAGVGGAGKAIAVQLAFDGAKEIRLFNRQ
ATRLSSVQKLVTKLNQLTRTKVTLQDLEDQTAFKEAIRESHLFIDATSVGMKPLENLSLITDPELIRPDLVVFDIVYSPA
ETKLLAFARQHGAQKVINGLGMVLYQGAEAFKLITGQDMPVDAIKPLLGDK

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family [H]

Homologues:

Organism=Escherichia coli, GI1787983, Length=280, Percent_Identity=47.5, Blast_Score=266, Evalue=2e-72,
Organism=Escherichia coli, GI1789675, Length=266, Percent_Identity=29.3233082706767, Blast_Score=102, Evalue=2e-23,
Organism=Saccharomyces cerevisiae, GI6320332, Length=285, Percent_Identity=29.1228070175439, Blast_Score=88, Evalue=1e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151 [H]

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N [H]

EC number: =1.1.1.25 [H]

Molecular weight: Translated: 31290; Mature: 31159

Theoretical pI: Translated: 7.26; Mature: 7.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSERLSGHTLLVSLLATPIRHSLSPKMHNEAYAKLGLDYAYLAFEVGTEQLADAVQGIRA
CCCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHEEHHCHHHHHHHHHHHHH
LGIRGSNVSMPNKEAILPLLDDLSPAAELVGAVNTVVNKDGKGHLVGHITDGIGALRALA
HCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHH
DEGVSVKNKIITLAGVGGAGKAIAVQLAFDGAKEIRLFNRQATRLSSVQKLVTKLNQLTR
HCCCCCCCEEEEEEECCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TKVTLQDLEDQTAFKEAIRESHLFIDATSVGMKPLENLSLITDPELIRPDLVVFDIVYSP
HHHHHHHHHHHHHHHHHHHHCCEEEEEHHCCCCCHHCCCCCCCCHHHCCCEEEEEEEECC
AETKLLAFARQHGAQKVINGLGMVLYQGAEAFKLITGQDMPVDAIKPLLGDK
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCCCCHHHHHHHHCCC
>Mature Secondary Structure 
SERLSGHTLLVSLLATPIRHSLSPKMHNEAYAKLGLDYAYLAFEVGTEQLADAVQGIRA
CCCCCHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCHHHHEEHHCHHHHHHHHHHHHH
LGIRGSNVSMPNKEAILPLLDDLSPAAELVGAVNTVVNKDGKGHLVGHITDGIGALRALA
HCCCCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEEEHHHHHHHHHHH
DEGVSVKNKIITLAGVGGAGKAIAVQLAFDGAKEIRLFNRQATRLSSVQKLVTKLNQLTR
HCCCCCCCEEEEEEECCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TKVTLQDLEDQTAFKEAIRESHLFIDATSVGMKPLENLSLITDPELIRPDLVVFDIVYSP
HHHHHHHHHHHHHHHHHHHHCCEEEEEHHCCCCCHHCCCCCCCCHHHCCCEEEEEEEECC
AETKLLAFARQHGAQKVINGLGMVLYQGAEAFKLITGQDMPVDAIKPLLGDK
CHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHEEEECCCCCCHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11296296 [H]