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The map label for this gene is yesM [H]

Identifier: 19746499

GI number: 19746499

Start: 1297069

End: 1298802

Strand: Reverse

Name: yesM [H]

Synonym: spyM18_1569

Alternate gene names: 19746499

Gene position: 1298802-1297069 (Counterclockwise)

Preceding gene: 19746500

Following gene: 19746498

Centisome position: 68.54

GC content: 42.39

Gene sequence:

>1734_bases
ATGAAGCGTTATCCCCTACTGGTCCAGTTGATTTCGTATGTCTTTGTGATCGTAATTGCCCTTATTACCACACTGGGCTT
ACTCTATTACCAGACCAGTTCTCGTAATATCAGGCAGTTAATTGAACGTGATACTCGGCAGAGCATTCGGCAAAGTTCCC
AATTTATTGACGCTTACATCAAGCCTCTTAAAGAAACAACTTCGGTGCTGGCGAAAAATACGGAAATTCAAGCCTTTGCT
AGTCAAATTCATCAAGAAAATGACAAGCAGGTCCTTCAGCTCATGAAGATGGTTCTTGCGACCAATTCCGATTTACAAGC
AGCTGTTCTGGTGACTAAGGATGGTCGAACGGTGTCTACCAATTCTCAGTTGATTATGAAAACCTCCAGTGATATGATGG
CAGAACCCTGGTATAAAGCAGCCATAGACCGTCAAGCCATGCCAATCTTAACCCCAGCTCGGCAATTATCCCTTTCTTCT
AAAAAAGAATGGGTAGTTTCTGTGACCCAAGAGGTAGTGGATGCTGCTGGTCATAATTTAGGCGTGCTAAGACTTGATAT
TGCATACCCGACCATTAAAGCGTCTTTAGATCAGCTTCAGCTAGGCCGCCAAGGCTTTGCATTTATTGTGAATGATAAGC
ATGAATTTGTTTACCATCCCAAAAAGAGTGTTTACAGTTCTTCTAAGGAGATGGCTGCGATGAAGCCTTATTTGGCTATT
AAAAATGGCTACGCCAAGGATAAATCATCCTTTGTTTATCAAAGGGTCATTCCCAACAGTCAATGGACTTTGATTGGTGT
TGCTTCCTTGGACCAATTGCACCGAGTACAACGTCAGATTTTTTGGTCCTTCCTTGGGATGGGACTTCTAGCCTGTCTTA
TTTGTGGCCTTACGACTATTTTAGTCTTACGTAAATGGATTCGTCCCATTCAACAATTGCAGCAGGTGATTCTGGCTATT
CAAAAAGGGAACCGTCAGTTGCGCGCCCAAGAAACGGGTTCTCCGGAATTGACAGACCTTGCCCATCAGTTTAATGCGCT
CTTAGATCAAATTGATAGCTTGATGGTTGCCGTTGCGGATAAGGAAAAGGAGATTGGGCAGTACAGGTTACAAGCCTTGG
CTAGTCAGATTAACCCGCATTTTCTCTATAACACCTTGGACACTATTATTTGGATGGCAGAATTTAATGACAGCAAGCGC
GTGGTAGAAGTGACCAAGTCTCTAGCTAAGTATTTTCGTTTGGCCCTTAATCAGGGGAATGACTATATTCGTTTAGCAGA
TGAACTGGATCACGTTAGCCAATACCTCTTTATTCAAAAACAGCGTTACGGAGACAAGTTAACTTATGACGTTCAAGGCT
TAGATGCCTATGCTGATTTTATTATTCCTAAACTCATCTTACAACCCTTGGTGGAAAATGCCATTTACCACGGAATTAAA
GAAGTGGACCGCAAGGGCATGATCAAGGTTACGGTATCTGAGACAGCTCAACATCTGATTTTGACCGTCTGGGATAATGG
TAAAGGAATAGAAGCATCTGCTTTAACAAATAGTCAAAGTTTACTGACTAGAGGAGGAGTAGGTCTTAAAAACGTCGACC
AACGATTGAAGCTCCAATATGGAGAGGCTTATCAGATGACCATTCATAGCCAGTCAGACCACTTCACTGAAATACAATTA
AGCCTTCCTAAAATGCATGAATTAATGGCAGACGACACACAGGAAAACGAGTAA

Upstream 100 bases:

>100_bases
TTGCAGAGCAGGTCGGCTTTGAGGACATGAATTATTTTTCTCAGCGCTTTAAGCAACTGGTAGGCGTTACCCCAAGTCAG
TATAAAAAAGGAGGCCAGGC

Downstream 100 bases:

>100_bases
GGTTACAGGAAGTGCATGTCAGCCATTTCCCTAAGTTAGGGTATTGGAGATAAGAACCTTAGAAAGGATATCATGAATTT
AGCAACTGACTATTTTAGCC

Product: histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 577; Mature: 577

Protein sequence:

>577_residues
MKRYPLLVQLISYVFVIVIALITTLGLLYYQTSSRNIRQLIERDTRQSIRQSSQFIDAYIKPLKETTSVLAKNTEIQAFA
SQIHQENDKQVLQLMKMVLATNSDLQAAVLVTKDGRTVSTNSQLIMKTSSDMMAEPWYKAAIDRQAMPILTPARQLSLSS
KKEWVVSVTQEVVDAAGHNLGVLRLDIAYPTIKASLDQLQLGRQGFAFIVNDKHEFVYHPKKSVYSSSKEMAAMKPYLAI
KNGYAKDKSSFVYQRVIPNSQWTLIGVASLDQLHRVQRQIFWSFLGMGLLACLICGLTTILVLRKWIRPIQQLQQVILAI
QKGNRQLRAQETGSPELTDLAHQFNALLDQIDSLMVAVADKEKEIGQYRLQALASQINPHFLYNTLDTIIWMAEFNDSKR
VVEVTKSLAKYFRLALNQGNDYIRLADELDHVSQYLFIQKQRYGDKLTYDVQGLDAYADFIIPKLILQPLVENAIYHGIK
EVDRKGMIKVTVSETAQHLILTVWDNGKGIEASALTNSQSLLTRGGVGLKNVDQRLKLQYGEAYQMTIHSQSDHFTEIQL
SLPKMHELMADDTQENE

Sequences:

>Translated_577_residues
MKRYPLLVQLISYVFVIVIALITTLGLLYYQTSSRNIRQLIERDTRQSIRQSSQFIDAYIKPLKETTSVLAKNTEIQAFA
SQIHQENDKQVLQLMKMVLATNSDLQAAVLVTKDGRTVSTNSQLIMKTSSDMMAEPWYKAAIDRQAMPILTPARQLSLSS
KKEWVVSVTQEVVDAAGHNLGVLRLDIAYPTIKASLDQLQLGRQGFAFIVNDKHEFVYHPKKSVYSSSKEMAAMKPYLAI
KNGYAKDKSSFVYQRVIPNSQWTLIGVASLDQLHRVQRQIFWSFLGMGLLACLICGLTTILVLRKWIRPIQQLQQVILAI
QKGNRQLRAQETGSPELTDLAHQFNALLDQIDSLMVAVADKEKEIGQYRLQALASQINPHFLYNTLDTIIWMAEFNDSKR
VVEVTKSLAKYFRLALNQGNDYIRLADELDHVSQYLFIQKQRYGDKLTYDVQGLDAYADFIIPKLILQPLVENAIYHGIK
EVDRKGMIKVTVSETAQHLILTVWDNGKGIEASALTNSQSLLTRGGVGLKNVDQRLKLQYGEAYQMTIHSQSDHFTEIQL
SLPKMHELMADDTQENE
>Mature_577_residues
MKRYPLLVQLISYVFVIVIALITTLGLLYYQTSSRNIRQLIERDTRQSIRQSSQFIDAYIKPLKETTSVLAKNTEIQAFA
SQIHQENDKQVLQLMKMVLATNSDLQAAVLVTKDGRTVSTNSQLIMKTSSDMMAEPWYKAAIDRQAMPILTPARQLSLSS
KKEWVVSVTQEVVDAAGHNLGVLRLDIAYPTIKASLDQLQLGRQGFAFIVNDKHEFVYHPKKSVYSSSKEMAAMKPYLAI
KNGYAKDKSSFVYQRVIPNSQWTLIGVASLDQLHRVQRQIFWSFLGMGLLACLICGLTTILVLRKWIRPIQQLQQVILAI
QKGNRQLRAQETGSPELTDLAHQFNALLDQIDSLMVAVADKEKEIGQYRLQALASQINPHFLYNTLDTIIWMAEFNDSKR
VVEVTKSLAKYFRLALNQGNDYIRLADELDHVSQYLFIQKQRYGDKLTYDVQGLDAYADFIIPKLILQPLVENAIYHGIK
EVDRKGMIKVTVSETAQHLILTVWDNGKGIEASALTNSQSLLTRGGVGLKNVDQRLKLQYGEAYQMTIHSQSDHFTEIQL
SLPKMHELMADDTQENE

Specific function: Member of the two-component regulatory system yesM/yesN. Probably activates yesN by phosphorylation [H]

COG id: COG2972

COG function: function code T; Predicted signal transduction protein with a C-terminal ATPase domain

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788446, Length=197, Percent_Identity=32.48730964467, Blast_Score=122, Evalue=5e-29,
Organism=Escherichia coli, GI1788723, Length=225, Percent_Identity=35.5555555555556, Blast_Score=118, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR010559
- InterPro:   IPR005467 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF06580 His_kinase [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 65531; Mature: 65531

Theoretical pI: Translated: 9.21; Mature: 9.21

Prosite motif: PS50885 HAMP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRYPLLVQLISYVFVIVIALITTLGLLYYQTSSRNIRQLIERDTRQSIRQSSQFIDAYI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KPLKETTSVLAKNTEIQAFASQIHQENDKQVLQLMKMVLATNSDLQAAVLVTKDGRTVST
HHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEC
NSQLIMKTSSDMMAEPWYKAAIDRQAMPILTPARQLSLSSKKEWVVSVTQEVVDAAGHNL
CCEEEEEECCCHHHCCHHHHHHCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCC
GVLRLDIAYPTIKASLDQLQLGRQGFAFIVNDKHEFVYHPKKSVYSSSKEMAAMKPYLAI
EEEEEEEECCHHHHHHHHHHHCCCCCEEEEECCCCEEECCHHHHHCCCHHHHHHCCHHHC
KNGYAKDKSSFVYQRVIPNSQWTLIGVASLDQLHRVQRQIFWSFLGMGLLACLICGLTTI
CCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVLRKWIRPIQQLQQVILAIQKGNRQLRAQETGSPELTDLAHQFNALLDQIDSLMVAVAD
HHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
KEKEIGQYRLQALASQINPHFLYNTLDTIIWMAEFNDSKRVVEVTKSLAKYFRLALNQGN
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHEEHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
DYIRLADELDHVSQYLFIQKQRYGDKLTYDVQGLDAYADFIIPKLILQPLVENAIYHGIK
CEEEEHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVDRKGMIKVTVSETAQHLILTVWDNGKGIEASALTNSQSLLTRGGVGLKNVDQRLKLQY
HHCCCCEEEEEHHHCCCEEEEEEEECCCCCCHHHCCCCHHHHHHCCCCHHHHHHHHHHHC
GEAYQMTIHSQSDHFTEIQLSLPKMHELMADDTQENE
CCEEEEEEECCCCCCEEEEECCHHHHHHHCCCCCCCC
>Mature Secondary Structure
MKRYPLLVQLISYVFVIVIALITTLGLLYYQTSSRNIRQLIERDTRQSIRQSSQFIDAYI
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
KPLKETTSVLAKNTEIQAFASQIHQENDKQVLQLMKMVLATNSDLQAAVLVTKDGRTVST
HHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEECCCCEEEC
NSQLIMKTSSDMMAEPWYKAAIDRQAMPILTPARQLSLSSKKEWVVSVTQEVVDAAGHNL
CCEEEEEECCCHHHCCHHHHHHCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHHHHCCCCC
GVLRLDIAYPTIKASLDQLQLGRQGFAFIVNDKHEFVYHPKKSVYSSSKEMAAMKPYLAI
EEEEEEEECCHHHHHHHHHHHCCCCCEEEEECCCCEEECCHHHHHCCCHHHHHHCCHHHC
KNGYAKDKSSFVYQRVIPNSQWTLIGVASLDQLHRVQRQIFWSFLGMGLLACLICGLTTI
CCCCCCCHHHHHHHHHCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LVLRKWIRPIQQLQQVILAIQKGNRQLRAQETGSPELTDLAHQFNALLDQIDSLMVAVAD
HHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHC
KEKEIGQYRLQALASQINPHFLYNTLDTIIWMAEFNDSKRVVEVTKSLAKYFRLALNQGN
CHHHHHHHHHHHHHHHCCCHHHHHHHHHHEEHHHCCCCHHHHHHHHHHHHHHHHHHHCCC
DYIRLADELDHVSQYLFIQKQRYGDKLTYDVQGLDAYADFIIPKLILQPLVENAIYHGIK
CEEEEHHHHHHHHHHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHH
EVDRKGMIKVTVSETAQHLILTVWDNGKGIEASALTNSQSLLTRGGVGLKNVDQRLKLQY
HHCCCCEEEEEHHHCCCEEEEEEEECCCCCCHHHCCCCHHHHHHCCCCHHHHHHHHHHHC
GEAYQMTIHSQSDHFTEIQLSLPKMHELMADDTQENE
CCEEEEEEECCCCCCEEEEECCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]