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The map label for this gene is holA [H]

Identifier: 19746369

GI number: 19746369

Start: 1183312

End: 1184352

Strand: Reverse

Name: holA [H]

Synonym: spyM18_1415

Alternate gene names: 19746369

Gene position: 1184352-1183312 (Counterclockwise)

Preceding gene: 19746370

Following gene: 19746368

Centisome position: 62.5

GC content: 36.79

Gene sequence:

>1041_bases
ATGATTGCGATAGAAAAGATTGAAAAACTGAGTAAAGAAAATTTGGGTCTTATAACCCTTGTCACAGGAGATGACATTGG
TCAGTATAGCCAGTTGAAATCCCGCTTAATGGAGCAGATTGCTTTTGATAAGGATGATTTGGCCTATTCTTACTTTGATA
TGTCTGAGGCCGCTTATCAGGATGCAGAAATGGATCTAGTGAGCCTACCCTTCTTTGCTGAGCAGAAGGTGGTCATTTTT
GACCATTTGTTAGATATCACGACCAATAAAAAAAGTTTCTTAAAAGAAAAAGACTTAAAGACCTTTGAAGCCTATTTAGA
AAATCCCTTAGAGACTACTCGACTAATTATCTTTGCTCCAGGTAAATTGGATAGTAAGAGACGGCTTGTTAAGCTTTTGA
AACGTGATGCCCTTGTTTTAGAAGCCAACCCTCTGAAAGAAGCAGAGCTAAGAACTTATTTTCAAAAATACAGTCATCAA
CTGGGTTTAGGTTTCGAGAGTGGTGCCTTTGACCAATTACTTTTGAAATCAAACGATGATTTTAGTCAAATCATGAAAAA
CATGGCCTTTTTAAAAGCCTATAAAAAAACGGGAAATATTAGCCTAACTGATATTGAGCAAGCCATTCCTAAAAGTTTAC
AAGATAATATTTTCGATCTGACTAGACTTGTCCTAGGAGGTAAAATTGATGCGGCTAGAGATTTGATTCATGATTTACGG
TTATCTGGAGAAGATGACATTAAATTAATCGCTATCATGCTAGGCCAATTTCGCTTATTTTTGCAGCTGACTATTCTTGC
TAGAGACGTAAAAAACGAGCAACAACTAGTGATTAGTTTATCAGATATTCTTGGGCGGCGGGTTAATCCTTACCAGGTCA
AGTATGCGTTAAAGGATTCTAGGACCTTATCTCTTGCCTTTCTAACAGGAGCGGTGAAAACCTTGATTGAGACAGATTAC
CAGATAAAAACAGGACTTTATGAGAAGAGTTATCTAGTTGATATTGCTCTCTTAAAAATCATGACTCACTCTCAAAAATA
G

Upstream 100 bases:

>100_bases
ACAAGCTGGCATCTTGAAACGGTCCGTTAGTTAAAATTCCAGCCTGACGAAGAAACAGGCAGTCGCTTTCCTTTTAGGAG
AAAGATGATATAATAAAAGC

Downstream 100 bases:

>100_bases
GCATTGGACCGCTTTCCAAGAGATAATCAAATTAGTTGAAAGCTCTTATTTTTTGCGATAAGATAGACGTATCATAAAGG
AAAAGAGGACAGGAAAATGG

Product: DNA polymerase III subunit delta

Products: diphosphate; DNAn+1

Alternate protein names: NA

Number of amino acids: Translated: 346; Mature: 346

Protein sequence:

>346_residues
MIAIEKIEKLSKENLGLITLVTGDDIGQYSQLKSRLMEQIAFDKDDLAYSYFDMSEAAYQDAEMDLVSLPFFAEQKVVIF
DHLLDITTNKKSFLKEKDLKTFEAYLENPLETTRLIIFAPGKLDSKRRLVKLLKRDALVLEANPLKEAELRTYFQKYSHQ
LGLGFESGAFDQLLLKSNDDFSQIMKNMAFLKAYKKTGNISLTDIEQAIPKSLQDNIFDLTRLVLGGKIDAARDLIHDLR
LSGEDDIKLIAIMLGQFRLFLQLTILARDVKNEQQLVISLSDILGRRVNPYQVKYALKDSRTLSLAFLTGAVKTLIETDY
QIKTGLYEKSYLVDIALLKIMTHSQK

Sequences:

>Translated_346_residues
MIAIEKIEKLSKENLGLITLVTGDDIGQYSQLKSRLMEQIAFDKDDLAYSYFDMSEAAYQDAEMDLVSLPFFAEQKVVIF
DHLLDITTNKKSFLKEKDLKTFEAYLENPLETTRLIIFAPGKLDSKRRLVKLLKRDALVLEANPLKEAELRTYFQKYSHQ
LGLGFESGAFDQLLLKSNDDFSQIMKNMAFLKAYKKTGNISLTDIEQAIPKSLQDNIFDLTRLVLGGKIDAARDLIHDLR
LSGEDDIKLIAIMLGQFRLFLQLTILARDVKNEQQLVISLSDILGRRVNPYQVKYALKDSRTLSLAFLTGAVKTLIETDY
QIKTGLYEKSYLVDIALLKIMTHSQK
>Mature_346_residues
MIAIEKIEKLSKENLGLITLVTGDDIGQYSQLKSRLMEQIAFDKDDLAYSYFDMSEAAYQDAEMDLVSLPFFAEQKVVIF
DHLLDITTNKKSFLKEKDLKTFEAYLENPLETTRLIIFAPGKLDSKRRLVKLLKRDALVLEANPLKEAELRTYFQKYSHQ
LGLGFESGAFDQLLLKSNDDFSQIMKNMAFLKAYKKTGNISLTDIEQAIPKSLQDNIFDLTRLVLGGKIDAARDLIHDLR
LSGEDDIKLIAIMLGQFRLFLQLTILARDVKNEQQLVISLSDILGRRVNPYQVKYALKDSRTLSLAFLTGAVKTLIETDY
QIKTGLYEKSYLVDIALLKIMTHSQK

Specific function: Unknown

COG id: COG1466

COG function: function code L; DNA polymerase III, delta subunit

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008921
- InterPro:   IPR010372
- InterPro:   IPR005790 [H]

Pfam domain/function: PF06144 DNA_pol3_delta [H]

EC number: 2.7.7.7

Molecular weight: Translated: 39497; Mature: 39497

Theoretical pI: Translated: 6.55; Mature: 6.55

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIAIEKIEKLSKENLGLITLVTGDDIGQYSQLKSRLMEQIAFDKDDLAYSYFDMSEAAYQ
CCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCEEHHHCHHHHHHC
DAEMDLVSLPFFAEQKVVIFDHLLDITTNKKSFLKEKDLKTFEAYLENPLETTRLIIFAP
CCCCCEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
GKLDSKRRLVKLLKRDALVLEANPLKEAELRTYFQKYSHQLGLGFESGAFDQLLLKSNDD
CCCCHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCC
FSQIMKNMAFLKAYKKTGNISLTDIEQAIPKSLQDNIFDLTRLVLGGKIDAARDLIHDLR
HHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LSGEDDIKLIAIMLGQFRLFLQLTILARDVKNEQQLVISLSDILGRRVNPYQVKYALKDS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEHHHHHCCCCCCEEEEEEECCC
RTLSLAFLTGAVKTLIETDYQIKTGLYEKSYLVDIALLKIMTHSQK
CEEEHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MIAIEKIEKLSKENLGLITLVTGDDIGQYSQLKSRLMEQIAFDKDDLAYSYFDMSEAAYQ
CCCHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHCCCCCCCEEHHHCHHHHHHC
DAEMDLVSLPFFAEQKVVIFDHLLDITTNKKSFLKEKDLKTFEAYLENPLETTRLIIFAP
CCCCCEEECCCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEECC
GKLDSKRRLVKLLKRDALVLEANPLKEAELRTYFQKYSHQLGLGFESGAFDQLLLKSNDD
CCCCHHHHHHHHHHHCCEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHHCCCCC
FSQIMKNMAFLKAYKKTGNISLTDIEQAIPKSLQDNIFDLTRLVLGGKIDAARDLIHDLR
HHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
LSGEDDIKLIAIMLGQFRLFLQLTILARDVKNEQQLVISLSDILGRRVNPYQVKYALKDS
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHEEEHHHHHCCCCCCEEEEEEECCC
RTLSLAFLTGAVKTLIETDYQIKTGLYEKSYLVDIALLKIMTHSQK
CEEEHHHHHHHHHHHHHCCCHHHCCCCCHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: deoxynucleoside triphosphate; DNAn

Specific reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8969508; 9384377 [H]