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The map label for this gene is msrR [H]

Identifier: 19746323

GI number: 19746323

Start: 1133057

End: 1134508

Strand: Reverse

Name: msrR [H]

Synonym: spyM18_1362

Alternate gene names: 19746323

Gene position: 1134508-1133057 (Counterclockwise)

Preceding gene: 19746324

Following gene: 19746322

Centisome position: 59.87

GC content: 38.22

Gene sequence:

>1452_bases
ATGACAAAATACCCCATGGGTGGCCTTAGTCACCATGAAGAATTACGTTATTTTTATCTCCTAAGGAATTTGAGTTACCT
TAGTGAGAATGAAAAAAAAGAGTTTGCTTTTTTAAAATCTAAATTGGAAATTGGTCGAGCTTATGCGCCTTCTAAGCAGC
ATTATAGGAAGTCAAAACGGCAAGAACCTTACTTTGAAGATGACTACTATAACGACTACTCACCAAATGATTTACTAGAA
GATGATGACGTCAATCATGACTCTTCTTTTGTTCCATATGGTTTACCGATATATCCTAAAGAAGACAGATATTTAAACAA
AAAAACAAAACTTACAGCTCGTAGACCTATAGATGCTCCGCAGCCTATTGATGAAGATGATGCTTTTTTAACAGAATCTG
TTGCTCGTTGTGCTCTTCCTAGATCTCAAAAAAGAAAGCATAAGAAAAAAGGATGTATGAAATGGTTTTTTAACATTCTT
GGCTTATTGCTAATGACTGTGCTTATGGGGTTAGGGTTGATGTTTGCAAAAGGGGTTTTTGATATTTCTACTAATAAAGC
TAATTACAAACCAGCTGTTTCCCAAGCTTTTGATGGTCAAGAAACTCAAGATGGTACGAACATTCTGGTTTTGGGTTCTG
ACCAACGAGTTACTCAAGGTTCTACAGATGCTCGCACAGATACCATTATGGTTGTCAATGTCGGCAACCATGCTAAAAAA
ATAAAAATGGTCTCTTTTATGCGTGACACTTTGATTAACATTCCAGGATACAGTTATAATGATAATTCGTATGATCTTAA
ATTAAATAGTGCATTTAATCTTGGAGAGCAAGAAGATCACCACGGAGCAGAGTACGTTCGACGGGCCTTAAAACATAATT
TTGATATCGACATTAAGTATTATGTGATGGTAGATTTTGAAACATTTGCAGAAGCTATTGACACCTTGTTTCCAAATGGT
GTTAAGATTGATGCCAAATTTGCGACAGTAGGTGGTGTAGCTGTTGACTCCGTAGAAGTTCCAGATGACCTGCGAATGAA
AAATGGGGTTGTTCCCAACCAAACCATCGAAGTTGGAGAACAACGCATGGATGGTAGAACCTTGCTCAACTATGCTCGTT
TCCGTAAAGATGACGAAGGAGATTTCGGACGAACCGTCCGGCAGCAACAGGTTATGTCAGCTGTTATGTCCCAAATCAAG
GACCCAACTAAACTCTTTACAGGGTCTGCGGCTATTGGTAAAATCTATGCGCTGACTTCGACCAATGTTTCTTTTCCATT
TGTTGTTAAAAATGGTGTTTCTGTTTTAGGAAGTGGGAAAAATGGAGTTGAGCACGTGACCATCCCAGAAAATGGGGATT
GGGTTGACGAATACGATATGTATGGAGGACAAGCTCTTTACATAGATTTTGATAAGTATCAGAAAACGTTAGCCAAATTA
GGTCTGCGCTAA

Upstream 100 bases:

>100_bases
TCTATAATGATTAAAATTTTGAGAGGACAATCTGGCTAATATAGGTTATAATGGTAGTATTCGTTAAAAGTGCAATTGTA
ATACTAAGAGATGATAAGAT

Downstream 100 bases:

>100_bases
GATATGGTATAATGGAGAGTAACTAAAGTTGCTCTTCTTTTTTGAGCAATGGTTAGCCCTAGAAAAGGAAAAAGAATAAG
AATGTTGAAAAAAAATGATA

Product: PBP 5 synthesis repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 483; Mature: 482

Protein sequence:

>483_residues
MTKYPMGGLSHHEELRYFYLLRNLSYLSENEKKEFAFLKSKLEIGRAYAPSKQHYRKSKRQEPYFEDDYYNDYSPNDLLE
DDDVNHDSSFVPYGLPIYPKEDRYLNKKTKLTARRPIDAPQPIDEDDAFLTESVARCALPRSQKRKHKKKGCMKWFFNIL
GLLLMTVLMGLGLMFAKGVFDISTNKANYKPAVSQAFDGQETQDGTNILVLGSDQRVTQGSTDARTDTIMVVNVGNHAKK
IKMVSFMRDTLINIPGYSYNDNSYDLKLNSAFNLGEQEDHHGAEYVRRALKHNFDIDIKYYVMVDFETFAEAIDTLFPNG
VKIDAKFATVGGVAVDSVEVPDDLRMKNGVVPNQTIEVGEQRMDGRTLLNYARFRKDDEGDFGRTVRQQQVMSAVMSQIK
DPTKLFTGSAAIGKIYALTSTNVSFPFVVKNGVSVLGSGKNGVEHVTIPENGDWVDEYDMYGGQALYIDFDKYQKTLAKL
GLR

Sequences:

>Translated_483_residues
MTKYPMGGLSHHEELRYFYLLRNLSYLSENEKKEFAFLKSKLEIGRAYAPSKQHYRKSKRQEPYFEDDYYNDYSPNDLLE
DDDVNHDSSFVPYGLPIYPKEDRYLNKKTKLTARRPIDAPQPIDEDDAFLTESVARCALPRSQKRKHKKKGCMKWFFNIL
GLLLMTVLMGLGLMFAKGVFDISTNKANYKPAVSQAFDGQETQDGTNILVLGSDQRVTQGSTDARTDTIMVVNVGNHAKK
IKMVSFMRDTLINIPGYSYNDNSYDLKLNSAFNLGEQEDHHGAEYVRRALKHNFDIDIKYYVMVDFETFAEAIDTLFPNG
VKIDAKFATVGGVAVDSVEVPDDLRMKNGVVPNQTIEVGEQRMDGRTLLNYARFRKDDEGDFGRTVRQQQVMSAVMSQIK
DPTKLFTGSAAIGKIYALTSTNVSFPFVVKNGVSVLGSGKNGVEHVTIPENGDWVDEYDMYGGQALYIDFDKYQKTLAKL
GLR
>Mature_482_residues
TKYPMGGLSHHEELRYFYLLRNLSYLSENEKKEFAFLKSKLEIGRAYAPSKQHYRKSKRQEPYFEDDYYNDYSPNDLLED
DDVNHDSSFVPYGLPIYPKEDRYLNKKTKLTARRPIDAPQPIDEDDAFLTESVARCALPRSQKRKHKKKGCMKWFFNILG
LLLMTVLMGLGLMFAKGVFDISTNKANYKPAVSQAFDGQETQDGTNILVLGSDQRVTQGSTDARTDTIMVVNVGNHAKKI
KMVSFMRDTLINIPGYSYNDNSYDLKLNSAFNLGEQEDHHGAEYVRRALKHNFDIDIKYYVMVDFETFAEAIDTLFPNGV
KIDAKFATVGGVAVDSVEVPDDLRMKNGVVPNQTIEVGEQRMDGRTLLNYARFRKDDEGDFGRTVRQQQVMSAVMSQIKD
PTKLFTGSAAIGKIYALTSTNVSFPFVVKNGVSVLGSGKNGVEHVTIPENGDWVDEYDMYGGQALYIDFDKYQKTLAKLG
LR

Specific function: Involved in sarA attenuation. Affects resistance to oxacillin and teicoplanin, as well as the synthesis of virulence factors [H]

COG id: COG1316

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the LytR/CpsA/Psr regulatory protein family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004474 [H]

Pfam domain/function: PF03816 LytR_cpsA_psr [H]

EC number: NA

Molecular weight: Translated: 54833; Mature: 54702

Theoretical pI: Translated: 6.87; Mature: 6.87

Prosite motif: PS00018 EF_HAND_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTKYPMGGLSHHEELRYFYLLRNLSYLSENEKKEFAFLKSKLEIGRAYAPSKQHYRKSKR
CCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHC
QEPYFEDDYYNDYSPNDLLEDDDVNHDSSFVPYGLPIYPKEDRYLNKKTKLTARRPIDAP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCEEECCCCCCC
QPIDEDDAFLTESVARCALPRSQKRKHKKKGCMKWFFNILGLLLMTVLMGLGLMFAKGVF
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
DISTNKANYKPAVSQAFDGQETQDGTNILVLGSDQRVTQGSTDARTDTIMVVNVGNHAKK
EEECCCCCCCCHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCCHHH
IKMVSFMRDTLINIPGYSYNDNSYDLKLNSAFNLGEQEDHHGAEYVRRALKHNFDIDIKY
HHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEE
YVMVDFETFAEAIDTLFPNGVKIDAKFATVGGVAVDSVEVPDDLRMKNGVVPNQTIEVGE
EEEEEHHHHHHHHHHHCCCCEEEEEEEEEECCEEECCCCCCHHHHHHCCCCCCCHHHHHH
QRMDGRTLLNYARFRKDDEGDFGRTVRQQQVMSAVMSQIKDPTKLFTGSAAIGKIYALTS
HHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCCCHHCEEEEEEE
TNVSFPFVVKNGVSVLGSGKNGVEHVTIPENGDWVDEYDMYGGQALYIDFDKYQKTLAKL
CCCCCCEEECCCCEEEECCCCCCEEEECCCCCCCCHHHHCCCCEEEEEEHHHHHHHHHHH
GLR
CCC
>Mature Secondary Structure 
TKYPMGGLSHHEELRYFYLLRNLSYLSENEKKEFAFLKSKLEIGRAYAPSKQHYRKSKR
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHC
QEPYFEDDYYNDYSPNDLLEDDDVNHDSSFVPYGLPIYPKEDRYLNKKTKLTARRPIDAP
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCEEECCCCCCC
QPIDEDDAFLTESVARCALPRSQKRKHKKKGCMKWFFNILGLLLMTVLMGLGLMFAKGVF
CCCCCCHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
DISTNKANYKPAVSQAFDGQETQDGTNILVLGSDQRVTQGSTDARTDTIMVVNVGNHAKK
EEECCCCCCCCHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCEEEEEECCCCHHH
IKMVSFMRDTLINIPGYSYNDNSYDLKLNSAFNLGEQEDHHGAEYVRRALKHNFDIDIKY
HHHHHHHHHHHHCCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEE
YVMVDFETFAEAIDTLFPNGVKIDAKFATVGGVAVDSVEVPDDLRMKNGVVPNQTIEVGE
EEEEEHHHHHHHHHHHCCCCEEEEEEEEEECCEEECCCCCCHHHHHHCCCCCCCHHHHHH
QRMDGRTLLNYARFRKDDEGDFGRTVRQQQVMSAVMSQIKDPTKLFTGSAAIGKIYALTS
HHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCCCHHCEEEEEEE
TNVSFPFVVKNGVSVLGSGKNGVEHVTIPENGDWVDEYDMYGGQALYIDFDKYQKTLAKL
CCCCCCEEECCCCEEEECCCCCCEEEECCCCCCCCHHHHCCCCEEEEEEHHHHHHHHHHH
GLR
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12878519 [H]