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The map label for this gene is groEL [H]

Identifier: 197294781

GI number: 197294781

Start: 775042

End: 776652

Strand: Direct

Name: groEL [H]

Synonym: PAa_0761

Alternate gene names: 197294781

Gene position: 775042-776652 (Clockwise)

Preceding gene: 197294780

Following gene: 197294782

Centisome position: 88.08

GC content: 33.46

Gene sequence:

>1611_bases
ATGAGTAAAAAAATCCTTTATGGCAAAGACGCAAGAAAAGCATTATTACAAGGTGTAGATGCAATTGCAAACACTGTCAA
AGTTACTTTAGGACCAAAAGGGCGTAATGTTGTTTTAGAAAAATCTTACGAATCTCCTGTTATTGTCAATGATGGTGTTT
CGATTGCTAAAGAAATTGAATTAAAAAACCCTTATCAAAATATGGGCGCTAAATTAGTTTATGAAGTTGCCGCAAAAACT
AATGATTTAGCAGGTGATGGAACAACTACTGCCACTGTTTTGGCTCAAAGCATGATTCATCGTGGTTTTAAAGCGATTGA
TTCAGGAGCAAATCCGATGTTAGTGAAAGAAGGAATTCAAAAAGCAGCTCAAGTGGTTTCTGAAAAACTTTTAGAAAAAT
CCAAAAAAGTAGCGCTTCAAACCGATATCCAAAACATCGCATCAATTTCTTCTGGTAGTCAAGAAATTGGAAAAATAATC
GCTCAAGCAATGGAAAAAGTAGGCAAAAACGGCGTTATTAACGTTGATGAATCTAAAGGATTTGAAACAAATTTAGAAGT
TGTTCAAGGTTTGCAATATGATAAAGGTTATGCCTCTCCTTATTTTGCTTCTGACAGAGAAAGCATGGCAGTAGAATTAA
GTCAACCTTTAGTTTTAGTTACTGATCACAAAATTAGTACAATTCAAGAAATTTTGGCTATTTTAGAAAACGTAGTTAAA
GAATCCAAAGCTTTATTAATTATTGCAGAATCAGTAGAAACTGAAGTTTTAGGGGTTTTGGTAGCTAATAAATTAAGAGG
GACTTTTAATGTAGTTGTTACTAATGCTCCTGGTTTTGGCGACAACCAAAAAGAAACCTTACAAGATATTGCTGCTTTAA
CTAAAGCAACTTTTGTTTCTAAAGATCTCAACATGAAACTAGCAGATGTAAAAACTGCTGACCTAGGAACCATTAATAAA
GTCATTATTAAAAAAGATAATACTACTTTAGTGGGTGCAACTCCAAATAAAGCTTTAGAGCAACGAATTCAATTATTAGA
AACTCAAATTAAAAATTCAACAGTTGATTATGAAACTAAATCTTTACAAGAAAGATTGGCGAAATTAACTGGTGGGATTG
CTTTAATTAAAGTAGGAGCAACTACCGATACCGAATTGAAAGATAAAAAATTACGTTTAGAAGACGCTCTTAACGCAACC
AAAGCGGCTGTGACCGAAGGAACTGTAGTCGGAGGCGGTAAAGCATTAGTTGAAGTTTATCAAGAATTAAAAGACACTTT
ATTTGATGAAAATAAAGAAATTCAAAAAGGGATTAACGTAGTTATTGAAAGTCTTTTAACTCCTACTTACCAAATTGCTG
AAAATGCTGGGTTTGATGGTGACCACATTGTAAGACAACAATTAAACCAAAAAACTAATTTTGGATTTGATGCCAAAAAC
GGTAAATACGTTGACTTGTTGGATGCAGGGATCATTGACCCTACTAAAGTGAATCGCCAAGCAGTTATTAATTCAGCCTC
AATTTCTTCTTTAATGATTACAACTCAAGCAGCTGTTGTGACAATTAAAGACGATGCAGCTAATCAATTAGGAAAAGAAT
TGCAAGAATAA

Upstream 100 bases:

>100_bases
GGTAGTAAAATTAATTTACAAGAAGAAGAATATTTAATTGTATCTGTAAAAGATATTTTGGCTCAAATTAAGTAAAAATG
GAATTAAGGAGTAAAATCAA

Downstream 100 bases:

>100_bases
TTTTATTTAACAAAATACAAAAATATTTTAAATGTTTTTACTTTTTAAAGTTGTTGATTGTTTAATTCCTCCTCATTTTT
TAAAATTTTTTAATTATTAT

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein; Protein Cpn60 [H]

Number of amino acids: Translated: 536; Mature: 535

Protein sequence:

>536_residues
MSKKILYGKDARKALLQGVDAIANTVKVTLGPKGRNVVLEKSYESPVIVNDGVSIAKEIELKNPYQNMGAKLVYEVAAKT
NDLAGDGTTTATVLAQSMIHRGFKAIDSGANPMLVKEGIQKAAQVVSEKLLEKSKKVALQTDIQNIASISSGSQEIGKII
AQAMEKVGKNGVINVDESKGFETNLEVVQGLQYDKGYASPYFASDRESMAVELSQPLVLVTDHKISTIQEILAILENVVK
ESKALLIIAESVETEVLGVLVANKLRGTFNVVVTNAPGFGDNQKETLQDIAALTKATFVSKDLNMKLADVKTADLGTINK
VIIKKDNTTLVGATPNKALEQRIQLLETQIKNSTVDYETKSLQERLAKLTGGIALIKVGATTDTELKDKKLRLEDALNAT
KAAVTEGTVVGGGKALVEVYQELKDTLFDENKEIQKGINVVIESLLTPTYQIAENAGFDGDHIVRQQLNQKTNFGFDAKN
GKYVDLLDAGIIDPTKVNRQAVINSASISSLMITTQAAVVTIKDDAANQLGKELQE

Sequences:

>Translated_536_residues
MSKKILYGKDARKALLQGVDAIANTVKVTLGPKGRNVVLEKSYESPVIVNDGVSIAKEIELKNPYQNMGAKLVYEVAAKT
NDLAGDGTTTATVLAQSMIHRGFKAIDSGANPMLVKEGIQKAAQVVSEKLLEKSKKVALQTDIQNIASISSGSQEIGKII
AQAMEKVGKNGVINVDESKGFETNLEVVQGLQYDKGYASPYFASDRESMAVELSQPLVLVTDHKISTIQEILAILENVVK
ESKALLIIAESVETEVLGVLVANKLRGTFNVVVTNAPGFGDNQKETLQDIAALTKATFVSKDLNMKLADVKTADLGTINK
VIIKKDNTTLVGATPNKALEQRIQLLETQIKNSTVDYETKSLQERLAKLTGGIALIKVGATTDTELKDKKLRLEDALNAT
KAAVTEGTVVGGGKALVEVYQELKDTLFDENKEIQKGINVVIESLLTPTYQIAENAGFDGDHIVRQQLNQKTNFGFDAKN
GKYVDLLDAGIIDPTKVNRQAVINSASISSLMITTQAAVVTIKDDAANQLGKELQE
>Mature_535_residues
SKKILYGKDARKALLQGVDAIANTVKVTLGPKGRNVVLEKSYESPVIVNDGVSIAKEIELKNPYQNMGAKLVYEVAAKTN
DLAGDGTTTATVLAQSMIHRGFKAIDSGANPMLVKEGIQKAAQVVSEKLLEKSKKVALQTDIQNIASISSGSQEIGKIIA
QAMEKVGKNGVINVDESKGFETNLEVVQGLQYDKGYASPYFASDRESMAVELSQPLVLVTDHKISTIQEILAILENVVKE
SKALLIIAESVETEVLGVLVANKLRGTFNVVVTNAPGFGDNQKETLQDIAALTKATFVSKDLNMKLADVKTADLGTINKV
IIKKDNTTLVGATPNKALEQRIQLLETQIKNSTVDYETKSLQERLAKLTGGIALIKVGATTDTELKDKKLRLEDALNATK
AAVTEGTVVGGGKALVEVYQELKDTLFDENKEIQKGINVVIESLLTPTYQIAENAGFDGDHIVRQQLNQKTNFGFDAKNG
KYVDLLDAGIIDPTKVNRQAVINSASISSLMITTQAAVVTIKDDAANQLGKELQE

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=524, Percent_Identity=44.6564885496183, Blast_Score=434, Evalue=1e-121,
Organism=Homo sapiens, GI31542947, Length=524, Percent_Identity=44.6564885496183, Blast_Score=434, Evalue=1e-121,
Organism=Homo sapiens, GI24307939, Length=193, Percent_Identity=26.9430051813472, Blast_Score=68, Evalue=2e-11,
Organism=Homo sapiens, GI5453603, Length=186, Percent_Identity=31.7204301075269, Blast_Score=67, Evalue=4e-11,
Organism=Homo sapiens, GI38455427, Length=119, Percent_Identity=30.2521008403361, Blast_Score=66, Evalue=8e-11,
Organism=Escherichia coli, GI1790586, Length=530, Percent_Identity=48.1132075471698, Blast_Score=484, Evalue=1e-138,
Organism=Caenorhabditis elegans, GI17555558, Length=530, Percent_Identity=43.5849056603774, Blast_Score=423, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI193210679, Length=226, Percent_Identity=42.0353982300885, Blast_Score=157, Evalue=1e-38,
Organism=Caenorhabditis elegans, GI25144674, Length=523, Percent_Identity=24.0917782026769, Blast_Score=72, Evalue=5e-13,
Organism=Caenorhabditis elegans, GI25147750, Length=188, Percent_Identity=30.8510638297872, Blast_Score=67, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6323288, Length=524, Percent_Identity=42.5572519083969, Blast_Score=427, Evalue=1e-120,
Organism=Saccharomyces cerevisiae, GI6322524, Length=582, Percent_Identity=21.9931271477663, Blast_Score=78, Evalue=4e-15,
Organism=Saccharomyces cerevisiae, GI6320058, Length=154, Percent_Identity=29.2207792207792, Blast_Score=73, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6322049, Length=205, Percent_Identity=29.7560975609756, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24641193, Length=524, Percent_Identity=43.5114503816794, Blast_Score=436, Evalue=1e-122,
Organism=Drosophila melanogaster, GI24641191, Length=524, Percent_Identity=43.5114503816794, Blast_Score=436, Evalue=1e-122,
Organism=Drosophila melanogaster, GI45550936, Length=521, Percent_Identity=42.9942418426104, Blast_Score=426, Evalue=1e-119,
Organism=Drosophila melanogaster, GI45550132, Length=521, Percent_Identity=42.9942418426104, Blast_Score=426, Evalue=1e-119,
Organism=Drosophila melanogaster, GI45550935, Length=521, Percent_Identity=42.9942418426104, Blast_Score=426, Evalue=1e-119,
Organism=Drosophila melanogaster, GI17864606, Length=528, Percent_Identity=40.1515151515151, Blast_Score=408, Evalue=1e-114,
Organism=Drosophila melanogaster, GI24584129, Length=523, Percent_Identity=34.9904397705545, Blast_Score=298, Evalue=8e-81,
Organism=Drosophila melanogaster, GI19921262, Length=523, Percent_Identity=34.9904397705545, Blast_Score=298, Evalue=8e-81,
Organism=Drosophila melanogaster, GI18858175, Length=528, Percent_Identity=24.0530303030303, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI28571140, Length=528, Percent_Identity=24.0530303030303, Blast_Score=75, Evalue=2e-13,
Organism=Drosophila melanogaster, GI17647245, Length=191, Percent_Identity=27.7486910994764, Blast_Score=70, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24583944, Length=557, Percent_Identity=21.5439856373429, Blast_Score=68, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24645179, Length=510, Percent_Identity=21.3725490196078, Blast_Score=67, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24652903, Length=172, Percent_Identity=27.906976744186, Blast_Score=65, Evalue=9e-11,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 57725; Mature: 57594

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKKILYGKDARKALLQGVDAIANTVKVTLGPKGRNVVLEKSYESPVIVNDGVSIAKEIE
CCCCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEECCCCCEEEECCCHHHHHHC
LKNPYQNMGAKLVYEVAAKTNDLAGDGTTTATVLAQSMIHRGFKAIDSGANPMLVKEGIQ
CCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
KAAQVVSEKLLEKSKKVALQTDIQNIASISSGSQEIGKIIAQAMEKVGKNGVINVDESKG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEECCCCCC
FETNLEVVQGLQYDKGYASPYFASDRESMAVELSQPLVLVTDHKISTIQEILAILENVVK
CCCCHHHHHCCCCCCCCCCCCCCCCCHHHEEEECCCEEEEECCCHHHHHHHHHHHHHHHH
ESKALLIIAESVETEVLGVLVANKLRGTFNVVVTNAPGFGDNQKETLQDIAALTKATFVS
CCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
KDLNMKLADVKTADLGTINKVIIKKDNTTLVGATPNKALEQRIQLLETQIKNSTVDYETK
CCCCEEEECCCCCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHH
SLQERLAKLTGGIALIKVGATTDTELKDKKLRLEDALNATKAAVTEGTVVGGGKALVEVY
HHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHH
QELKDTLFDENKEIQKGINVVIESLLTPTYQIAENAGFDGDHIVRQQLNQKTNFGFDAKN
HHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCC
GKYVDLLDAGIIDPTKVNRQAVINSASISSLMITTQAAVVTIKDDAANQLGKELQE
CCEEEEECCCCCCCCCCCHHHHHCCCCHHHEEEEEEEEEEEECCHHHHHHHHHHCC
>Mature Secondary Structure 
SKKILYGKDARKALLQGVDAIANTVKVTLGPKGRNVVLEKSYESPVIVNDGVSIAKEIE
CCCCCCCCHHHHHHHHHHHHHHHEEEEEECCCCCEEEEEECCCCCEEEECCCHHHHHHC
LKNPYQNMGAKLVYEVAAKTNDLAGDGTTTATVLAQSMIHRGFKAIDSGANPMLVKEGIQ
CCCCHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
KAAQVVSEKLLEKSKKVALQTDIQNIASISSGSQEIGKIIAQAMEKVGKNGVINVDESKG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCCEEECCCCCC
FETNLEVVQGLQYDKGYASPYFASDRESMAVELSQPLVLVTDHKISTIQEILAILENVVK
CCCCHHHHHCCCCCCCCCCCCCCCCCHHHEEEECCCEEEEECCCHHHHHHHHHHHHHHHH
ESKALLIIAESVETEVLGVLVANKLRGTFNVVVTNAPGFGDNQKETLQDIAALTKATFVS
CCCEEEEEECCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHH
KDLNMKLADVKTADLGTINKVIIKKDNTTLVGATPNKALEQRIQLLETQIKNSTVDYETK
CCCCEEEECCCCCCCCCCEEEEEECCCCEEEECCCCHHHHHHHHHHHHHHHCCCCCCHHH
SLQERLAKLTGGIALIKVGATTDTELKDKKLRLEDALNATKAAVTEGTVVGGGKALVEVY
HHHHHHHHHHCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCEECCHHHHHHHH
QELKDTLFDENKEIQKGINVVIESLLTPTYQIAENAGFDGDHIVRQQLNQKTNFGFDAKN
HHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCC
GKYVDLLDAGIIDPTKVNRQAVINSASISSLMITTQAAVVTIKDDAANQLGKELQE
CCEEEEECCCCCCCCCCCHHHHHCCCCHHHEEEEEEEEEEEECCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA