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The map label for this gene is lon [H]

Identifier: 197294735

GI number: 197294735

Start: 716544

End: 718907

Strand: Direct

Name: lon [H]

Synonym: PAa_0701

Alternate gene names: 197294735

Gene position: 716544-718907 (Clockwise)

Preceding gene: 197294734

Following gene: 197294738

Centisome position: 81.43

GC content: 29.65

Gene sequence:

>2364_bases
ATGAAAACAAAAATAATGAAAAAAACTAAAACTGTTGTAGATTTAGAACAAAACACACAAACGCAATTACCAGCTTTGGC
TATTAATGAAATTGTTCCAATGCCAAACGTTGATTTTCGTATTGAAATATCAGACAAACAATATATTAATGCTTTAAAGG
AATCAAAAGAACATCATGAATCTTTAGTTGTTATTTTAATAAGACCGGGATTTGGACAAGGAAAGCCAAAAATCACTGAA
TTGAATCGTTATGCGGTTTTGGCTCAAATAATTACACAAATTAAAATGCCTCAAGGATTTTATAAAGTAAGATTCCGCAT
TTTGCAAAGAGTCAAAGTTCAGAAATTTTTACAAAAAGAACCTTTTTTAAAAGTAGAATATCAAAATATTAACACTGTTT
TTGGCAAAATTGAGGAAGAAAAAACCTTAATGAAAATTGTTATTGATACGATTTTAAAAAAACCTTTTCAATTATTAAAC
CAAAGTAATAATAATTTTTTAGAAATGATTCAATTTGAGCAAGAAGTAGAAAAAATAACCGACATTATTATTTTTTATTT
ACGCATTGATAATTCCGAAAAATATAAATACTTAAAAGAAGCAGACCTTAATAAAAGACTTTTTAACATTTTAAGAGATA
TTGATATTTTAACTATGGGGATGCATTTAGAACAAAAAATTAACGAAAAAGTTAAAAAAAGTATTGATGAAAACCAAAAA
GAATTTTATTTAAGAGAAAAAATGAAAGCCATCCAAAACGAATTAGGCGATAAAGTTAAAAAAGAAGAAGAAATCGCAGA
ATTAAGAAAAAAAATTAACAACACTCCTCTTCCTGAATCAATTAAGAAAAAAGCTTTACAAGAACTGTCGCGTTATCAAT
CGTCTTCCTCTTTATTGGCGGAATCTTTTGTAATTAAAAATTATCTAGATTTTTTACTGGAACTCCCTTGGCAAAAAACT
ACTCAAGATATTGATGATTTAGCTCAAATAGAAAAATCTCTAGATGATGGTCATTATGGTTTGGCTAAAGTCAAAGAGCG
TATTTTAGAATATGCAGCAGTTAAAATTATGACCAAAAAAAATCCTCAAAACATTTTATGTTTAGTGGGTCCACCAGGGG
TTGGTAAAACTTCTTTGGTTTCTTCAATCGCCAAATCTTTAGGCAGAAAATTCATTAGGCAGTCTTTGGGAGGCATGAAA
GAAGAATCAGAAATTAGAGGCCACAGAAGAACATACATCGGAGCTATGCCAGGCCGCATTCTTGCAGGCATCAAAGAAGC
TCAAACAATGAATCCTGTTTTTTTATTAGATGAAATTGATAAATTAATTGCTAATTATAATTTTGACCCTGCATCAGCTT
TATTAGAAGTATTAGATCCACAACAAAACAAAACTTTTATTGATCATTTTTTATCAGAACCATTTGATTTGTCTCAAGTT
CTTTTCATTACTACTGCTAATTATTTAGATAATGTTCCTGAACCTTTAAAAGATCGAATGGAAATTATCGAAATGAATTC
TTACACCGAAAAAGATAAAGTTGAAATTGCTTCTAAATATCTTTTTCCTAAACAATTAGCAAATCACGGTCTTAATCATC
AAAATTTAATAATTGAAGATGGAACCTTTCTTTATTTAATTCGTCATTACACTAAAGAAGCGGGCGTAAGAGAATTGGAT
AGAATATTGTCAAATCTTACACGCAAAACAGTGAAAGAAATCCTGATCAACAAAAAAGAAAAAGTTATCATTAACACTCA
AAATGTTTCTGATTACTTAGGTAAAGAAAAATATTTGCATCTTTTAGCAGAAGAAAAAGAGCAAATAGGATCAACTAATG
GTCTGGCTTATACTTATTTTGGCGGCGAATTATTGAAAGTGGAAGTTACTTATTATAAAGGTAAAGGGCAATTATTTTTA
ACTGGTAAATTAGGCGATGTCCTTAAAGAAAGTGCTTATACTGCTTTAAGTTTTATTAAAGCTAATGCTGCAAAATTAGG
AATTATGGATAACAAGATCTTTTTAGAAAATGATTTTCATATACATCTTCCAGAAGGAGCAGTCCCGAAAGATGGTCCTT
CAGCAGGGATTACAATTGCAACTTCTCTTTTTTCTGCCATCACTCGCAAATATATTAAAAAAGGTTTGGGAATGACAGGA
GAAATCACTTTGAGAGGTGATGTTTTGGGCATTGGAGGATTAAAAGAAAAAGCTATTGCTGCCAATCGCAGTGGCCTTAA
CACTATTTTAATTCCTCAGGAAAATGTTAAAGATATTGAAGATATCCCTGAAGAAGTAAGAACTAAATTAAATATTATTC
CTGTTTCAGATGTTTGTGAAGTTTTTTCTAAAGTATTTCTTTAA

Upstream 100 bases:

>100_bases
TCTTGAAGTTTTAAAGCAAAATTTATTGTTAGATGAAGCTTGGGAATTAGTAATGAAAAATGTTGTTTTCGCTTAATTAA
AAAGTGAAAAGGAGTTCAAA

Downstream 100 bases:

>100_bases
TTAAAAAATATTTTAAAATAAAAAATACCACCCTAAAAGAGTGGTATTTTTTTTATCTTTTATTTTATAAAATAATTATT
TCTTTGGATGTTTTCTTTGT

Product: ATP-dependent Lon protease

Products: NA

Alternate protein names: ATP-dependent protease La [H]

Number of amino acids: Translated: 787; Mature: 787

Protein sequence:

>787_residues
MKTKIMKKTKTVVDLEQNTQTQLPALAINEIVPMPNVDFRIEISDKQYINALKESKEHHESLVVILIRPGFGQGKPKITE
LNRYAVLAQIITQIKMPQGFYKVRFRILQRVKVQKFLQKEPFLKVEYQNINTVFGKIEEEKTLMKIVIDTILKKPFQLLN
QSNNNFLEMIQFEQEVEKITDIIIFYLRIDNSEKYKYLKEADLNKRLFNILRDIDILTMGMHLEQKINEKVKKSIDENQK
EFYLREKMKAIQNELGDKVKKEEEIAELRKKINNTPLPESIKKKALQELSRYQSSSSLLAESFVIKNYLDFLLELPWQKT
TQDIDDLAQIEKSLDDGHYGLAKVKERILEYAAVKIMTKKNPQNILCLVGPPGVGKTSLVSSIAKSLGRKFIRQSLGGMK
EESEIRGHRRTYIGAMPGRILAGIKEAQTMNPVFLLDEIDKLIANYNFDPASALLEVLDPQQNKTFIDHFLSEPFDLSQV
LFITTANYLDNVPEPLKDRMEIIEMNSYTEKDKVEIASKYLFPKQLANHGLNHQNLIIEDGTFLYLIRHYTKEAGVRELD
RILSNLTRKTVKEILINKKEKVIINTQNVSDYLGKEKYLHLLAEEKEQIGSTNGLAYTYFGGELLKVEVTYYKGKGQLFL
TGKLGDVLKESAYTALSFIKANAAKLGIMDNKIFLENDFHIHLPEGAVPKDGPSAGITIATSLFSAITRKYIKKGLGMTG
EITLRGDVLGIGGLKEKAIAANRSGLNTILIPQENVKDIEDIPEEVRTKLNIIPVSDVCEVFSKVFL

Sequences:

>Translated_787_residues
MKTKIMKKTKTVVDLEQNTQTQLPALAINEIVPMPNVDFRIEISDKQYINALKESKEHHESLVVILIRPGFGQGKPKITE
LNRYAVLAQIITQIKMPQGFYKVRFRILQRVKVQKFLQKEPFLKVEYQNINTVFGKIEEEKTLMKIVIDTILKKPFQLLN
QSNNNFLEMIQFEQEVEKITDIIIFYLRIDNSEKYKYLKEADLNKRLFNILRDIDILTMGMHLEQKINEKVKKSIDENQK
EFYLREKMKAIQNELGDKVKKEEEIAELRKKINNTPLPESIKKKALQELSRYQSSSSLLAESFVIKNYLDFLLELPWQKT
TQDIDDLAQIEKSLDDGHYGLAKVKERILEYAAVKIMTKKNPQNILCLVGPPGVGKTSLVSSIAKSLGRKFIRQSLGGMK
EESEIRGHRRTYIGAMPGRILAGIKEAQTMNPVFLLDEIDKLIANYNFDPASALLEVLDPQQNKTFIDHFLSEPFDLSQV
LFITTANYLDNVPEPLKDRMEIIEMNSYTEKDKVEIASKYLFPKQLANHGLNHQNLIIEDGTFLYLIRHYTKEAGVRELD
RILSNLTRKTVKEILINKKEKVIINTQNVSDYLGKEKYLHLLAEEKEQIGSTNGLAYTYFGGELLKVEVTYYKGKGQLFL
TGKLGDVLKESAYTALSFIKANAAKLGIMDNKIFLENDFHIHLPEGAVPKDGPSAGITIATSLFSAITRKYIKKGLGMTG
EITLRGDVLGIGGLKEKAIAANRSGLNTILIPQENVKDIEDIPEEVRTKLNIIPVSDVCEVFSKVFL
>Mature_787_residues
MKTKIMKKTKTVVDLEQNTQTQLPALAINEIVPMPNVDFRIEISDKQYINALKESKEHHESLVVILIRPGFGQGKPKITE
LNRYAVLAQIITQIKMPQGFYKVRFRILQRVKVQKFLQKEPFLKVEYQNINTVFGKIEEEKTLMKIVIDTILKKPFQLLN
QSNNNFLEMIQFEQEVEKITDIIIFYLRIDNSEKYKYLKEADLNKRLFNILRDIDILTMGMHLEQKINEKVKKSIDENQK
EFYLREKMKAIQNELGDKVKKEEEIAELRKKINNTPLPESIKKKALQELSRYQSSSSLLAESFVIKNYLDFLLELPWQKT
TQDIDDLAQIEKSLDDGHYGLAKVKERILEYAAVKIMTKKNPQNILCLVGPPGVGKTSLVSSIAKSLGRKFIRQSLGGMK
EESEIRGHRRTYIGAMPGRILAGIKEAQTMNPVFLLDEIDKLIANYNFDPASALLEVLDPQQNKTFIDHFLSEPFDLSQV
LFITTANYLDNVPEPLKDRMEIIEMNSYTEKDKVEIASKYLFPKQLANHGLNHQNLIIEDGTFLYLIRHYTKEAGVRELD
RILSNLTRKTVKEILINKKEKVIINTQNVSDYLGKEKYLHLLAEEKEQIGSTNGLAYTYFGGELLKVEVTYYKGKGQLFL
TGKLGDVLKESAYTALSFIKANAAKLGIMDNKIFLENDFHIHLPEGAVPKDGPSAGITIATSLFSAITRKYIKKGLGMTG
EITLRGDVLGIGGLKEKAIAANRSGLNTILIPQENVKDIEDIPEEVRTKLNIIPVSDVCEVFSKVFL

Specific function: ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced

COG id: COG0466

COG function: function code O; ATP-dependent Lon protease, bacterial type

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Lon domain [H]

Homologues:

Organism=Homo sapiens, GI31377667, Length=839, Percent_Identity=36.4719904648391, Blast_Score=484, Evalue=1e-136,
Organism=Homo sapiens, GI21396489, Length=679, Percent_Identity=37.1134020618557, Blast_Score=447, Evalue=1e-125,
Organism=Escherichia coli, GI1786643, Length=776, Percent_Identity=40.5927835051546, Blast_Score=581, Evalue=1e-167,
Organism=Caenorhabditis elegans, GI17505831, Length=633, Percent_Identity=38.8625592417062, Blast_Score=432, Evalue=1e-121,
Organism=Caenorhabditis elegans, GI17556486, Length=525, Percent_Identity=39.2380952380952, Blast_Score=402, Evalue=1e-112,
Organism=Saccharomyces cerevisiae, GI6319449, Length=733, Percent_Identity=36.5620736698499, Blast_Score=445, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24666867, Length=680, Percent_Identity=37.9411764705882, Blast_Score=464, Evalue=1e-131,
Organism=Drosophila melanogaster, GI221513036, Length=680, Percent_Identity=37.9411764705882, Blast_Score=464, Evalue=1e-131,

Paralogues:

None

Copy number: 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR008269
- InterPro:   IPR004815
- InterPro:   IPR003111
- InterPro:   IPR008268
- InterPro:   IPR001984
- InterPro:   IPR015947
- InterPro:   IPR020568 [H]

Pfam domain/function: PF00004 AAA; PF02190 LON; PF05362 Lon_C [H]

EC number: =3.4.21.53 [H]

Molecular weight: Translated: 89897; Mature: 89897

Theoretical pI: Translated: 9.37; Mature: 9.37

Prosite motif: PS01046 LON_SER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKTKIMKKTKTVVDLEQNTQTQLPALAINEIVPMPNVDFRIEISDKQYINALKESKEHHE
CCCCHHHHHHHHEEECCCCCCCCCHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHCC
SLVVILIRPGFGQGKPKITELNRYAVLAQIITQIKMPQGFYKVRFRILQRVKVQKFLQKE
CEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHC
PFLKVEYQNINTVFGKIEEEKTLMKIVIDTILKKPFQLLNQSNNNFLEMIQFEQEVEKIT
CCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
DIIIFYLRIDNSEKYKYLKEADLNKRLFNILRDIDILTMGMHLEQKINEKVKKSIDENQK
HHEEEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
EFYLREKMKAIQNELGDKVKKEEEIAELRKKINNTPLPESIKKKALQELSRYQSSSSLLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ESFVIKNYLDFLLELPWQKTTQDIDDLAQIEKSLDDGHYGLAKVKERILEYAAVKIMTKK
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHEECC
NPQNILCLVGPPGVGKTSLVSSIAKSLGRKFIRQSLGGMKEESEIRGHRRTYIGAMPGRI
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHEECCCCHHH
LAGIKEAQTMNPVFLLDEIDKLIANYNFDPASALLEVLDPQQNKTFIDHFLSEPFDLSQV
HHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHH
LFITTANYLDNVPEPLKDRMEIIEMNSYTEKDKVEIASKYLFPKQLANHGLNHQNLIIED
HHHEEHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHCCCCCCEEEEEC
GTFLYLIRHYTKEAGVRELDRILSNLTRKTVKEILINKKEKVIINTQNVSDYLGKEKYLH
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHCHHHHHH
LLAEEKEQIGSTNGLAYTYFGGELLKVEVTYYKGKGQLFLTGKLGDVLKESAYTALSFIK
HHHHHHHHCCCCCCEEEEEECCEEEEEEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHH
ANAAKLGIMDNKIFLENDFHIHLPEGAVPKDGPSAGITIATSLFSAITRKYIKKGLGMTG
HCCHHEEEECCEEEEECCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCE
EITLRGDVLGIGGLKEKAIAANRSGLNTILIPQENVKDIEDIPEEVRTKLNIIPVSDVCE
EEEEECCEEECCCCHHHHHHCCCCCCEEEEECCCCCHHHHHCHHHHHHHEEEEEHHHHHH
VFSKVFL
HHHHHCC
>Mature Secondary Structure
MKTKIMKKTKTVVDLEQNTQTQLPALAINEIVPMPNVDFRIEISDKQYINALKESKEHHE
CCCCHHHHHHHHEEECCCCCCCCCHHHHHHCCCCCCCCEEEEECCHHHHHHHHHHHHHCC
SLVVILIRPGFGQGKPKITELNRYAVLAQIITQIKMPQGFYKVRFRILQRVKVQKFLQKE
CEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHC
PFLKVEYQNINTVFGKIEEEKTLMKIVIDTILKKPFQLLNQSNNNFLEMIQFEQEVEKIT
CCEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
DIIIFYLRIDNSEKYKYLKEADLNKRLFNILRDIDILTMGMHLEQKINEKVKKSIDENQK
HHEEEEEEECCCHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHH
EFYLREKMKAIQNELGDKVKKEEEIAELRKKINNTPLPESIKKKALQELSRYQSSSSLLA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
ESFVIKNYLDFLLELPWQKTTQDIDDLAQIEKSLDDGHYGLAKVKERILEYAAVKIMTKK
HHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHEECC
NPQNILCLVGPPGVGKTSLVSSIAKSLGRKFIRQSLGGMKEESEIRGHRRTYIGAMPGRI
CCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHCCHHHHEECCCCHHH
LAGIKEAQTMNPVFLLDEIDKLIANYNFDPASALLEVLDPQQNKTFIDHFLSEPFDLSQV
HHHHHHHHCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCHHH
LFITTANYLDNVPEPLKDRMEIIEMNSYTEKDKVEIASKYLFPKQLANHGLNHQNLIIED
HHHEEHHHHCCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCHHHHHHCCCCCCEEEEEC
GTFLYLIRHYTKEAGVRELDRILSNLTRKTVKEILINKKEKVIINTQNVSDYLGKEKYLH
CHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHHCHHHHHH
LLAEEKEQIGSTNGLAYTYFGGELLKVEVTYYKGKGQLFLTGKLGDVLKESAYTALSFIK
HHHHHHHHCCCCCCEEEEEECCEEEEEEEEEEECCCCEEEECCHHHHHHHHHHHHHHHHH
ANAAKLGIMDNKIFLENDFHIHLPEGAVPKDGPSAGITIATSLFSAITRKYIKKGLGMTG
HCCHHEEEECCEEEEECCCEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCE
EITLRGDVLGIGGLKEKAIAANRSGLNTILIPQENVKDIEDIPEEVRTKLNIIPVSDVCE
EEEEECCEEECCCCHHHHHHCCCCCCEEEEECCCCCHHHHHCHHHHHHHEEEEEHHHHHH
VFSKVFL
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA