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The map label for this gene is serS [H]

Identifier: 197294640

GI number: 197294640

Start: 590081

End: 591337

Strand: Reverse

Name: serS [H]

Synonym: PAa_0596

Alternate gene names: 197294640

Gene position: 591337-590081 (Counterclockwise)

Preceding gene: 197294641

Following gene: 197294639

Centisome position: 67.2

GC content: 32.06

Gene sequence:

>1257_bases
ATGTTAGATCTTAATTATGTAGTTAAAAACTTATCACATGTTTTGACCAAATTAGAAACAAGAAATCACCCCTTAGATGA
TTTGAAAAAACTTCCTCTTTTATCTTCTCAAAGAAAAGAGTTGTTGTTAAAAATTCAAAAATTAAGACAACAAAAAAATA
AAACAGCTCAAATAAATGCAACTCAACCACAAAACCTTTTAAAGAAGGATAATGATAAGTCTTTAACTCGTCATTTAGAG
GAACAATTGAAAACAGTTGAAACTGCTATTTATGATATTTTAAGCAACACTCCTAATTTACCACACGATTCTTTGCCAAT
TGGAAAAGATGAACAGGCCAATCAAGAAATAAGCCGTCATGGTGTAATTCCTCAGTTTGATTTTCCTGTCAAAGACCATG
TTGCTTTAGCGAAAAAACTTGATATTTTAGATTTTGAAAAGGCTGCAAAAATTACTGGTAGTCGTTTTGTTGTTTGCAAA
GGATTGGGTGCTCGTTTAGAAAGAGCTTTAATCCAATTCATGATGGATTTGCATAGTACAAAAGGTTATCAAGAAATCAT
CCCTCCTTATATTATCAATGAAAAATCGATGTTTGCAACTGGTCAGTTGCCTAAATTTGAAGCAGAAGTTTTTAAAATAT
CGCACCATAAAAATAATTGGTATCTTAATCCAACAGCTGAAGTCCCTACTATTAATTTACATCGTGATGAATTTTTTCCA
CGCAACGCTTTACCATTAAAATATGTTGCTTACACAACTTCATTCCGCCAAGAAGCCGGTTCTGCAGGTTCTTATTCAAG
AGGTATTTTTAGACAACATCAATTCAATAAAGTTGAATTAATCCAATTTTGTCATCCCCAAAATTCCTATTCTTTATTGG
ATCAAATGTTGCAAGATTCGTGCGCTGTTTTGGATTTGTTAAAACTTCCATATAGAGTGATTGTTTTGTCAACAGGAGAT
TTAGGTTTTGGGATGTCTAAAACTTATGATATAGAGGTTTTTATCCCAAGTTCTAATTGTTATCGCGAAATTGCCTCCAT
TAGTAATTCTGAGAGTTTCCAATCTAGACGTGCTAATATTAAGTTCCATAATCCGAACAATAACAAAAAAGAATACCTTC
ATATTTTAAATGGTTCTGGTTTAGCTATTGGAAGGACTGTGATTGCTATTTTAGAAAATTACCAAAATTCCGATGGCACT
ATTCGCGTTCCTGAAGTTTTAATTCCTTTTTTAGGAACAGATATTATTAAGCGTTAA

Upstream 100 bases:

>100_bases
TAAGTTGTAATTAAAAAATTTATTTGTTTTCTCAAATTACAAAAAAGCTTCTCTTAAAAATACTTTTTCAAAAAAATAAA
ACAAGATTAATAGGTATTAT

Downstream 100 bases:

>100_bases
GTCAAATCCACATAGATTTGATTTTTTTATTTTTCAATATATAAATTTATATTCTTCAAACACCTTTATATAATTAATTT
TTAAACAACTTTAAAACCAT

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase [H]

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MLDLNYVVKNLSHVLTKLETRNHPLDDLKKLPLLSSQRKELLLKIQKLRQQKNKTAQINATQPQNLLKKDNDKSLTRHLE
EQLKTVETAIYDILSNTPNLPHDSLPIGKDEQANQEISRHGVIPQFDFPVKDHVALAKKLDILDFEKAAKITGSRFVVCK
GLGARLERALIQFMMDLHSTKGYQEIIPPYIINEKSMFATGQLPKFEAEVFKISHHKNNWYLNPTAEVPTINLHRDEFFP
RNALPLKYVAYTTSFRQEAGSAGSYSRGIFRQHQFNKVELIQFCHPQNSYSLLDQMLQDSCAVLDLLKLPYRVIVLSTGD
LGFGMSKTYDIEVFIPSSNCYREIASISNSESFQSRRANIKFHNPNNNKKEYLHILNGSGLAIGRTVIAILENYQNSDGT
IRVPEVLIPFLGTDIIKR

Sequences:

>Translated_418_residues
MLDLNYVVKNLSHVLTKLETRNHPLDDLKKLPLLSSQRKELLLKIQKLRQQKNKTAQINATQPQNLLKKDNDKSLTRHLE
EQLKTVETAIYDILSNTPNLPHDSLPIGKDEQANQEISRHGVIPQFDFPVKDHVALAKKLDILDFEKAAKITGSRFVVCK
GLGARLERALIQFMMDLHSTKGYQEIIPPYIINEKSMFATGQLPKFEAEVFKISHHKNNWYLNPTAEVPTINLHRDEFFP
RNALPLKYVAYTTSFRQEAGSAGSYSRGIFRQHQFNKVELIQFCHPQNSYSLLDQMLQDSCAVLDLLKLPYRVIVLSTGD
LGFGMSKTYDIEVFIPSSNCYREIASISNSESFQSRRANIKFHNPNNNKKEYLHILNGSGLAIGRTVIAILENYQNSDGT
IRVPEVLIPFLGTDIIKR
>Mature_418_residues
MLDLNYVVKNLSHVLTKLETRNHPLDDLKKLPLLSSQRKELLLKIQKLRQQKNKTAQINATQPQNLLKKDNDKSLTRHLE
EQLKTVETAIYDILSNTPNLPHDSLPIGKDEQANQEISRHGVIPQFDFPVKDHVALAKKLDILDFEKAAKITGSRFVVCK
GLGARLERALIQFMMDLHSTKGYQEIIPPYIINEKSMFATGQLPKFEAEVFKISHHKNNWYLNPTAEVPTINLHRDEFFP
RNALPLKYVAYTTSFRQEAGSAGSYSRGIFRQHQFNKVELIQFCHPQNSYSLLDQMLQDSCAVLDLLKLPYRVIVLSTGD
LGFGMSKTYDIEVFIPSSNCYREIASISNSESFQSRRANIKFHNPNNNKKEYLHILNGSGLAIGRTVIAILENYQNSDGT
IRVPEVLIPFLGTDIIKR

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) [H]

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily [H]

Homologues:

Organism=Homo sapiens, GI16306548, Length=356, Percent_Identity=33.9887640449438, Blast_Score=203, Evalue=2e-52,
Organism=Homo sapiens, GI8923421, Length=343, Percent_Identity=29.4460641399417, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI225579074, Length=323, Percent_Identity=30.030959752322, Blast_Score=155, Evalue=8e-38,
Organism=Escherichia coli, GI1787120, Length=429, Percent_Identity=44.0559440559441, Blast_Score=356, Evalue=2e-99,
Organism=Caenorhabditis elegans, GI17539260, Length=342, Percent_Identity=33.9181286549708, Blast_Score=192, Evalue=2e-49,
Organism=Caenorhabditis elegans, GI17542084, Length=348, Percent_Identity=26.4367816091954, Blast_Score=138, Evalue=5e-33,
Organism=Saccharomyces cerevisiae, GI6320226, Length=353, Percent_Identity=31.728045325779, Blast_Score=186, Evalue=5e-48,
Organism=Saccharomyces cerevisiae, GI6321799, Length=285, Percent_Identity=34.3859649122807, Blast_Score=176, Evalue=6e-45,
Organism=Drosophila melanogaster, GI24581334, Length=355, Percent_Identity=33.2394366197183, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI17737985, Length=319, Percent_Identity=28.5266457680251, Blast_Score=132, Evalue=3e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978 [H]

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b [H]

EC number: =6.1.1.11 [H]

Molecular weight: Translated: 47727; Mature: 47727

Theoretical pI: Translated: 9.51; Mature: 9.51

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDLNYVVKNLSHVLTKLETRNHPLDDLKKLPLLSSQRKELLLKIQKLRQQKNKTAQINA
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEC
TQPQNLLKKDNDKSLTRHLEEQLKTVETAIYDILSNTPNLPHDSLPIGKDEQANQEISRH
CCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHC
GVIPQFDFPVKDHVALAKKLDILDFEKAAKITGSRFVVCKGLGARLERALIQFMMDLHST
CCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHC
KGYQEIIPPYIINEKSMFATGQLPKFEAEVFKISHHKNNWYLNPTAEVPTINLHRDEFFP
CCHHHHCCCEEECCCCEEECCCCCCHHHHHEEEEECCCCEEECCCCCCCEEEECHHHCCC
RNALPLKYVAYTTSFRQEAGSAGSYSRGIFRQHQFNKVELIQFCHPQNSYSLLDQMLQDS
CCCCCEEEEHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHH
CAVLDLLKLPYRVIVLSTGDLGFGMSKTYDIEVFIPSSNCYREIASISNSESFQSRRANI
HHHHHHHHCCEEEEEEECCCCCCCCCCEEEEEEEECCCHHHHHHHHCCCCHHHHHHCCCE
KFHNPNNNKKEYLHILNGSGLAIGRTVIAILENYQNSDGTIRVPEVLIPFLGTDIIKR
EEECCCCCHHHEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLDLNYVVKNLSHVLTKLETRNHPLDDLKKLPLLSSQRKELLLKIQKLRQQKNKTAQINA
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCEEEEC
TQPQNLLKKDNDKSLTRHLEEQLKTVETAIYDILSNTPNLPHDSLPIGKDEQANQEISRH
CCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHC
GVIPQFDFPVKDHVALAKKLDILDFEKAAKITGSRFVVCKGLGARLERALIQFMMDLHST
CCCCCCCCCHHHHHHHHHHCCCHHHHHHHHCCCCEEEEECCHHHHHHHHHHHHHHHHHHC
KGYQEIIPPYIINEKSMFATGQLPKFEAEVFKISHHKNNWYLNPTAEVPTINLHRDEFFP
CCHHHHCCCEEECCCCEEECCCCCCHHHHHEEEEECCCCEEECCCCCCCEEEECHHHCCC
RNALPLKYVAYTTSFRQEAGSAGSYSRGIFRQHQFNKVELIQFCHPQNSYSLLDQMLQDS
CCCCCEEEEHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCHHHHHHHHHHHH
CAVLDLLKLPYRVIVLSTGDLGFGMSKTYDIEVFIPSSNCYREIASISNSESFQSRRANI
HHHHHHHHCCEEEEEEECCCCCCCCCCEEEEEEEECCCHHHHHHHHCCCCHHHHHHCCCE
KFHNPNNNKKEYLHILNGSGLAIGRTVIAILENYQNSDGTIRVPEVLIPFLGTDIIKR
EEECCCCCHHHEEEEECCCCCHHHHHHHHHHHHCCCCCCCEEHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA