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The map label for this gene is csdB [H]

Identifier: 197294589

GI number: 197294589

Start: 552632

End: 553852

Strand: Reverse

Name: csdB [H]

Synonym: PAa_0545

Alternate gene names: 197294589

Gene position: 553852-552632 (Counterclockwise)

Preceding gene: 197294590

Following gene: 197294588

Centisome position: 62.94

GC content: 27.93

Gene sequence:

>1221_bases
ATGGAGGCACAAATAGTGTTAAAAAACCCTTTGCGATCGCTTTTTCCCATTTTTAAAGCCAACCCCAAACTTGTTTATTT
TGATTCTGCTGCAACTTCTTTAAAACCTAAAAAAGTAATAGATGAATTGACTTCTTTTTATTATAATAATGGAATGGCTA
ATAAATCTTTTGCTTTTTTATCATCTCAAACTAATTTATTGATTAACGAAACTAGAAAAAAAACTGCTTTTTTTTTGAAT
TGTTTACCTGAAGAAATTATTTTTACTAAAGGAACTACTGATTCTCTTAATTTATTGGCTCAAAGCTTAGGCGAACTTTT
AGAAGAAGGAGATGAAATTATTGTATCAGAATTAGATCACAATTCTTCTGTGCTTCCTTGGTTAAAACAAGCCAAAAGAA
AAAAAGCCAAAATAGTTTTTGTTCCTTTAGATTCCAACAATAAAATAACGGTTGAAAATTTTTCAAAAGTTTTAACTAAA
AAAACTAAAATAGTAGCTTTAACACACATTTCTAATTTATTAGGGTACATGACACCTATAAAAGAAATAATTGATTTATC
TCATCAACAAAACACTTTAGTGGTCATCGATGCTGCTCAATCAGCGGCTCATTTTCCTATAGATGTTAAAGCTTTGAATT
CCGATTTTTTGGCTTTTTCGGCCCATAAATTATATGGCCCTTTTGGAGTAGGTGTTTTATTTGGGAAAATTTCGCTTTTG
AAAAAATTAAAACCAACTTTTTTTGGAGGTAACTCCATTCAAGAATTTTCATTAAATGATTTTGTGTTAAACGAACCTCC
TCATAAGTTTGAAGCAGGCACCCTTAATATTGCAGGAATTATTGCTTTTAAAAAAGCTTTAGAATTTATTCAAGAAATTG
GTTTTGAAAAGATTCAAAGCATTGAAAAAAATATTTATCAAGGAATCATCAAAGAATTAGAAAAAATTCCTGAAATAACT
ATTTATAATCCTCAATCTTTGGACATTATTTCTTTTAATTTCAACCATATTCATGCTCATGATGTAGAAAATTTTTTAGC
CCAAGAAAATATTTATGTAAAAACAGGTAGGTGTTGTGCTTTTTTGGCAGCAAAAAAAATTAACCAGACAAGTTTAGTGC
GTATTTCTGTAGGTGTTTATAATAATCAAGAAGATATTGATATTTTAATTAAAAATTTAAAAAAAGCACGAGATTTTTTT
ATAAAATGTGCTAAAAAGTAA

Upstream 100 bases:

>100_bases
TTTAATTGACAAAAAAAACACTTTATTTAATAAATACGTTCTTTTAAAAAAAGGAAAAAAAAACAACTCTTTAATTATTT
TGAACTAATTTTATAATAAA

Downstream 100 bases:

>100_bases
AAGGTTTTAAAATGTTAGAAATAAATAAATTATATCGCGATATAATTATGAAACATTATCAAGAACCTCAAAATTGGGGT
TTATCACAAGACAAAAGCTT

Product: Selenocysteine lyase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 406; Mature: 406

Protein sequence:

>406_residues
MEAQIVLKNPLRSLFPIFKANPKLVYFDSAATSLKPKKVIDELTSFYYNNGMANKSFAFLSSQTNLLINETRKKTAFFLN
CLPEEIIFTKGTTDSLNLLAQSLGELLEEGDEIIVSELDHNSSVLPWLKQAKRKKAKIVFVPLDSNNKITVENFSKVLTK
KTKIVALTHISNLLGYMTPIKEIIDLSHQQNTLVVIDAAQSAAHFPIDVKALNSDFLAFSAHKLYGPFGVGVLFGKISLL
KKLKPTFFGGNSIQEFSLNDFVLNEPPHKFEAGTLNIAGIIAFKKALEFIQEIGFEKIQSIEKNIYQGIIKELEKIPEIT
IYNPQSLDIISFNFNHIHAHDVENFLAQENIYVKTGRCCAFLAAKKINQTSLVRISVGVYNNQEDIDILIKNLKKARDFF
IKCAKK

Sequences:

>Translated_406_residues
MEAQIVLKNPLRSLFPIFKANPKLVYFDSAATSLKPKKVIDELTSFYYNNGMANKSFAFLSSQTNLLINETRKKTAFFLN
CLPEEIIFTKGTTDSLNLLAQSLGELLEEGDEIIVSELDHNSSVLPWLKQAKRKKAKIVFVPLDSNNKITVENFSKVLTK
KTKIVALTHISNLLGYMTPIKEIIDLSHQQNTLVVIDAAQSAAHFPIDVKALNSDFLAFSAHKLYGPFGVGVLFGKISLL
KKLKPTFFGGNSIQEFSLNDFVLNEPPHKFEAGTLNIAGIIAFKKALEFIQEIGFEKIQSIEKNIYQGIIKELEKIPEIT
IYNPQSLDIISFNFNHIHAHDVENFLAQENIYVKTGRCCAFLAAKKINQTSLVRISVGVYNNQEDIDILIKNLKKARDFF
IKCAKK
>Mature_406_residues
MEAQIVLKNPLRSLFPIFKANPKLVYFDSAATSLKPKKVIDELTSFYYNNGMANKSFAFLSSQTNLLINETRKKTAFFLN
CLPEEIIFTKGTTDSLNLLAQSLGELLEEGDEIIVSELDHNSSVLPWLKQAKRKKAKIVFVPLDSNNKITVENFSKVLTK
KTKIVALTHISNLLGYMTPIKEIIDLSHQQNTLVVIDAAQSAAHFPIDVKALNSDFLAFSAHKLYGPFGVGVLFGKISLL
KKLKPTFFGGNSIQEFSLNDFVLNEPPHKFEAGTLNIAGIIAFKKALEFIQEIGFEKIQSIEKNIYQGIIKELEKIPEIT
IYNPQSLDIISFNFNHIHAHDVENFLAQENIYVKTGRCCAFLAAKKINQTSLVRISVGVYNNQEDIDILIKNLKKARDFF
IKCAKK

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=401, Percent_Identity=20.6982543640898, Blast_Score=105, Evalue=1e-22,
Organism=Homo sapiens, GI156713448, Length=301, Percent_Identity=26.578073089701, Blast_Score=82, Evalue=1e-15,
Organism=Escherichia coli, GI1787970, Length=393, Percent_Identity=36.6412213740458, Blast_Score=295, Evalue=3e-81,
Organism=Escherichia coli, GI1789175, Length=399, Percent_Identity=34.0852130325814, Blast_Score=257, Evalue=9e-70,
Organism=Escherichia coli, GI48994898, Length=391, Percent_Identity=23.5294117647059, Blast_Score=128, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI25143064, Length=408, Percent_Identity=22.7941176470588, Blast_Score=117, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI193211090, Length=304, Percent_Identity=26.9736842105263, Blast_Score=94, Evalue=1e-19,
Organism=Caenorhabditis elegans, GI25147498, Length=377, Percent_Identity=25.1989389920424, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17533177, Length=226, Percent_Identity=25.2212389380531, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319831, Length=392, Percent_Identity=23.469387755102, Blast_Score=116, Evalue=5e-27,
Organism=Drosophila melanogaster, GI20129463, Length=397, Percent_Identity=23.4256926952141, Blast_Score=119, Evalue=4e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 45679; Mature: 45679

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEAQIVLKNPLRSLFPIFKANPKLVYFDSAATSLKPKKVIDELTSFYYNNGMANKSFAFL
CCCEEEECCHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEE
SSQTNLLINETRKKTAFFLNCLPEEIIFTKGTTDSLNLLAQSLGELLEEGDEIIVSELDH
CCCCCEEEEHHHHHHHHHHHCCCHHHEEECCCCHHHHHHHHHHHHHHHCCCEEEEEECCC
NSSVLPWLKQAKRKKAKIVFVPLDSNNKITVENFSKVLTKKTKIVALTHISNLLGYMTPI
CCCCCHHHHHHHCCCCEEEEEEECCCCEEEHHHHHHHHHCCHHEEEHHHHHHHHHHHHHH
KEIIDLSHQQNTLVVIDAAQSAAHFPIDVKALNSDFLAFSAHKLYGPFGVGVLFGKISLL
HHHHHCCCCCCEEEEEECCCCCCCCCEEEEECCCCCEEEEHHHHCCCHHHHHHHHHHHHH
KKLKPTFFGGNSIQEFSLNDFVLNEPPHKFEAGTLNIAGIIAFKKALEFIQEIGFEKIQS
HHCCCCEECCCCEEECCCCCEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCHHHHHH
IEKNIYQGIIKELEKIPEITIYNPQSLDIISFNFNHIHAHDVENFLAQENIYVKTGRCCA
HHHHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCEEEHHHHHHHHHCCCEEEECCCHHH
FLAAKKINQTSLVRISVGVYNNQEDIDILIKNLKKARDFFIKCAKK
HHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEAQIVLKNPLRSLFPIFKANPKLVYFDSAATSLKPKKVIDELTSFYYNNGMANKSFAFL
CCCEEEECCHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCEEEE
SSQTNLLINETRKKTAFFLNCLPEEIIFTKGTTDSLNLLAQSLGELLEEGDEIIVSELDH
CCCCCEEEEHHHHHHHHHHHCCCHHHEEECCCCHHHHHHHHHHHHHHHCCCEEEEEECCC
NSSVLPWLKQAKRKKAKIVFVPLDSNNKITVENFSKVLTKKTKIVALTHISNLLGYMTPI
CCCCCHHHHHHHCCCCEEEEEEECCCCEEEHHHHHHHHHCCHHEEEHHHHHHHHHHHHHH
KEIIDLSHQQNTLVVIDAAQSAAHFPIDVKALNSDFLAFSAHKLYGPFGVGVLFGKISLL
HHHHHCCCCCCEEEEEECCCCCCCCCEEEEECCCCCEEEEHHHHCCCHHHHHHHHHHHHH
KKLKPTFFGGNSIQEFSLNDFVLNEPPHKFEAGTLNIAGIIAFKKALEFIQEIGFEKIQS
HHCCCCEECCCCEEECCCCCEEECCCCCCCCCCCEEHHHHHHHHHHHHHHHHHCHHHHHH
IEKNIYQGIIKELEKIPEITIYNPQSLDIISFNFNHIHAHDVENFLAQENIYVKTGRCCA
HHHHHHHHHHHHHHHCCCEEEECCCCEEEEEECCCEEEHHHHHHHHHCCCEEEECCCHHH
FLAAKKINQTSLVRISVGVYNNQEDIDILIKNLKKARDFFIKCAKK
HHHHHHCCCCEEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]