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The map label for this gene is pepA

Identifier: 197294266

GI number: 197294266

Start: 148444

End: 149925

Strand: Reverse

Name: pepA

Synonym: PAa_0129

Alternate gene names: 197294266

Gene position: 149925-148444 (Counterclockwise)

Preceding gene: 197294268

Following gene: 197294265

Centisome position: 17.04

GC content: 33.94

Gene sequence:

>1482_bases
ATGAAAATTTATTTTAAAAAAAATTATTTGCCAAGCATGGATGTTGACACAGCTGTTGTTTTACAAGTAGAAAAATACGA
AAATTCCTTTGGCTTAGAAGCAGTAGATCCCAAAGGAGTTGCTAAAAAAAGTTTTTTAAGAGAAAATTTTAAAGGAGTTT
TTGGCACTCAGGTCAAATTATTATACCCAGAAGGGTCACCTGTTGCTTGTTTACAAGTAATGGGATTAGGAAAACAAGAA
GAAATTAATGACCAAACTTTTTTAAAAACAGGAGGCCTTTGCTTTCCTCAACTTAATAAAGCTAATAAAGTGGTTGTTTT
TGCTGATGCTTTAGGAATTGAGAATCAAACTTCCCAAGTAATGCATTTTGCTTTAGGTCTTTTATTAAGAAGTTACTCTT
TTAAACATTATCACACACAAAAAACAAAAAATGAAAAAAATTTAGAAATTACTTTTATTACTGAAAATGCTGAATTATGT
CAAAAAGAATTTGATGATGTAAAAGCTATCTTAGGAGGGGTTAATTTAACTAAAGAATTAGTTAATGAACCTGCTAACAT
TTTAGGAACTAACGAATTTGTTGAAAGAACACAACAACTACAAACTCTCGGAGTTGAAGTTGAAGTTTTAAACAAAGAAA
CCTTAGAAAAATTAGGAATGAATGCTTTATTAGGAGTTGCTCAAGGATCCCAAAGACCTCCTTATTTAGTAGTCATGAAA
TGGCTAGGTGGCAACGAAAATGAAAAACCAGTAGCTTTTGTAGGCAAAGGAGTTGTCTTTGATACTGGCGGTATTTCTCT
AAAACCTTCTAATAAAATGGAAGATATGAAAGGTGATATGGCAGGAGCCGCAACTGTAGTAGGATTAATGCATGCTTTAG
CTGCTAGAAAAGCAAAAGTAAATGTCTTAGGAGTAATTGGTTTAGTTGAAAATATGCCTGGTTCAAACGCACAACGTCCT
GGTGATATTGTCACTTCAATGTCTGGACAAACCATCGAAGTTATCAACACTGATGCTGAAGGAAGGCTTGTCCTAGCAGA
TGCTTTATGGTATTGCAAAACTAAATTGCAACCCAAAATGATAATCGATTTGGCTACTTTAACCGGAGCCATTGTAGTTG
CTTTAGGATATGAATATGCAGGGCTTTTTTCTAACAATAAAGAATTAGTAAAACAATTAGTTCATTCGGGAGAAGTTACA
GAAGAAAAAGTTTGGCAATTCCCTTTAGGTCCTGAATATGATAGATTAGTAGATGGCAAATTTGCTGATATTTCTAATTG
TCCTGTAGGTTACGGCGCTGGTTCTATTACTGCAGCCCAATTTTTAAAACGTTTTGTAGGTGACGATATTCCTTGGGCTC
ACATAGATATTGCGGGTGTTGCTTCAGGCAAAAAGAAAAACGAATTCAACTCTTCTTGGGCTTCTGGATTCGGAGTGCGT
CTTTTAAATCATTTAGTTAAAGATTATTACGAAAATAAATGA

Upstream 100 bases:

>100_bases
TTTTGATTTTTCTTTAAAAAAATATTGTCCTTTTGGGATTCCTTTTTTTATATTTTTTTAACAATTTTGTTTTTCAAAAT
AAGAAATAGGGGTATACGTT

Downstream 100 bases:

>100_bases
TTAAAAAATTACGATTAAGAAAAAATCTTCTTTACGTTGTTAAAACTTAAGGCTATTTAAAAATAGCTTTTTTTTATTAT
TAAATAGTAAAAATCAAGGT

Product: Leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase

Number of amino acids: Translated: 493; Mature: 493

Protein sequence:

>493_residues
MKIYFKKNYLPSMDVDTAVVLQVEKYENSFGLEAVDPKGVAKKSFLRENFKGVFGTQVKLLYPEGSPVACLQVMGLGKQE
EINDQTFLKTGGLCFPQLNKANKVVVFADALGIENQTSQVMHFALGLLLRSYSFKHYHTQKTKNEKNLEITFITENAELC
QKEFDDVKAILGGVNLTKELVNEPANILGTNEFVERTQQLQTLGVEVEVLNKETLEKLGMNALLGVAQGSQRPPYLVVMK
WLGGNENEKPVAFVGKGVVFDTGGISLKPSNKMEDMKGDMAGAATVVGLMHALAARKAKVNVLGVIGLVENMPGSNAQRP
GDIVTSMSGQTIEVINTDAEGRLVLADALWYCKTKLQPKMIIDLATLTGAIVVALGYEYAGLFSNNKELVKQLVHSGEVT
EEKVWQFPLGPEYDRLVDGKFADISNCPVGYGAGSITAAQFLKRFVGDDIPWAHIDIAGVASGKKKNEFNSSWASGFGVR
LLNHLVKDYYENK

Sequences:

>Translated_493_residues
MKIYFKKNYLPSMDVDTAVVLQVEKYENSFGLEAVDPKGVAKKSFLRENFKGVFGTQVKLLYPEGSPVACLQVMGLGKQE
EINDQTFLKTGGLCFPQLNKANKVVVFADALGIENQTSQVMHFALGLLLRSYSFKHYHTQKTKNEKNLEITFITENAELC
QKEFDDVKAILGGVNLTKELVNEPANILGTNEFVERTQQLQTLGVEVEVLNKETLEKLGMNALLGVAQGSQRPPYLVVMK
WLGGNENEKPVAFVGKGVVFDTGGISLKPSNKMEDMKGDMAGAATVVGLMHALAARKAKVNVLGVIGLVENMPGSNAQRP
GDIVTSMSGQTIEVINTDAEGRLVLADALWYCKTKLQPKMIIDLATLTGAIVVALGYEYAGLFSNNKELVKQLVHSGEVT
EEKVWQFPLGPEYDRLVDGKFADISNCPVGYGAGSITAAQFLKRFVGDDIPWAHIDIAGVASGKKKNEFNSSWASGFGVR
LLNHLVKDYYENK
>Mature_493_residues
MKIYFKKNYLPSMDVDTAVVLQVEKYENSFGLEAVDPKGVAKKSFLRENFKGVFGTQVKLLYPEGSPVACLQVMGLGKQE
EINDQTFLKTGGLCFPQLNKANKVVVFADALGIENQTSQVMHFALGLLLRSYSFKHYHTQKTKNEKNLEITFITENAELC
QKEFDDVKAILGGVNLTKELVNEPANILGTNEFVERTQQLQTLGVEVEVLNKETLEKLGMNALLGVAQGSQRPPYLVVMK
WLGGNENEKPVAFVGKGVVFDTGGISLKPSNKMEDMKGDMAGAATVVGLMHALAARKAKVNVLGVIGLVENMPGSNAQRP
GDIVTSMSGQTIEVINTDAEGRLVLADALWYCKTKLQPKMIIDLATLTGAIVVALGYEYAGLFSNNKELVKQLVHSGEVT
EEKVWQFPLGPEYDRLVDGKFADISNCPVGYGAGSITAAQFLKRFVGDDIPWAHIDIAGVASGKKKNEFNSSWASGFGVR
LLNHLVKDYYENK

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family

Homologues:

Organism=Homo sapiens, GI41393561, Length=315, Percent_Identity=41.5873015873016, Blast_Score=232, Evalue=7e-61,
Organism=Homo sapiens, GI47155554, Length=322, Percent_Identity=36.3354037267081, Blast_Score=170, Evalue=3e-42,
Organism=Escherichia coli, GI1790710, Length=415, Percent_Identity=37.5903614457831, Blast_Score=254, Evalue=6e-69,
Organism=Escherichia coli, GI87082123, Length=321, Percent_Identity=36.7601246105919, Blast_Score=180, Evalue=2e-46,
Organism=Caenorhabditis elegans, GI17556903, Length=322, Percent_Identity=31.9875776397516, Blast_Score=153, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI17565172, Length=154, Percent_Identity=38.3116883116883, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24661038, Length=288, Percent_Identity=40.2777777777778, Blast_Score=198, Evalue=6e-51,
Organism=Drosophila melanogaster, GI21355725, Length=288, Percent_Identity=39.5833333333333, Blast_Score=197, Evalue=1e-50,
Organism=Drosophila melanogaster, GI20129969, Length=287, Percent_Identity=34.8432055749129, Blast_Score=189, Evalue=3e-48,
Organism=Drosophila melanogaster, GI24662227, Length=287, Percent_Identity=34.8432055749129, Blast_Score=185, Evalue=7e-47,
Organism=Drosophila melanogaster, GI161077148, Length=288, Percent_Identity=35.0694444444444, Blast_Score=178, Evalue=9e-45,
Organism=Drosophila melanogaster, GI20130057, Length=288, Percent_Identity=35.0694444444444, Blast_Score=178, Evalue=9e-45,
Organism=Drosophila melanogaster, GI20129963, Length=372, Percent_Identity=30.9139784946237, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI21355645, Length=288, Percent_Identity=32.2916666666667, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI24662223, Length=288, Percent_Identity=32.2916666666667, Blast_Score=170, Evalue=2e-42,
Organism=Drosophila melanogaster, GI21357381, Length=362, Percent_Identity=32.0441988950276, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI221379063, Length=362, Percent_Identity=32.0441988950276, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI221379062, Length=362, Percent_Identity=32.0441988950276, Blast_Score=165, Evalue=5e-41,
Organism=Drosophila melanogaster, GI19922386, Length=288, Percent_Identity=33.6805555555556, Blast_Score=164, Evalue=1e-40,
Organism=Drosophila melanogaster, GI24646701, Length=253, Percent_Identity=27.6679841897233, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI24646703, Length=253, Percent_Identity=27.6679841897233, Blast_Score=80, Evalue=4e-15,
Organism=Drosophila melanogaster, GI21358201, Length=253, Percent_Identity=27.6679841897233, Blast_Score=80, Evalue=4e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AMPA_PHYAS (B1V932)

Other databases:

- EMBL:   AM422018
- RefSeq:   YP_001798807.1
- ProteinModelPortal:   B1V932
- SMR:   B1V932
- MEROPS:   M17.003
- GeneID:   6798916
- GenomeReviews:   AM422018_GR
- HOGENOM:   HBG742580
- OMA:   NMHLMRY
- ProtClustDB:   CLSK2406803
- GO:   GO:0005737
- GO:   GO:0006508
- HAMAP:   MF_00181
- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283
- PANTHER:   PTHR11963:SF3
- PRINTS:   PR00481

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N

EC number: =3.4.11.1; =3.4.11.10

Molecular weight: Translated: 53999; Mature: 53999

Theoretical pI: Translated: 6.64; Mature: 6.64

Prosite motif: PS00631 CYTOSOL_AP

Important sites: ACT_SITE 268-268 ACT_SITE 342-342

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKIYFKKNYLPSMDVDTAVVLQVEKYENSFGLEAVDPKGVAKKSFLRENFKGVFGTQVKL
CEEEEECCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEE
LYPEGSPVACLQVMGLGKQEEINDQTFLKTGGLCFPQLNKANKVVVFADALGIENQTSQV
EECCCCCHHHHHHHCCCCCHHCCCCHHHHCCCCCCCCCCCCCEEEEEEECCCCCCHHHHH
MHFALGLLLRSYSFKHYHTQKTKNEKNLEITFITENAELCQKEFDDVKAILGGVNLTKEL
HHHHHHHHHHHCCCCHHCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCHHHHHH
VNEPANILGTNEFVERTQQLQTLGVEVEVLNKETLEKLGMNALLGVAQGSQRPPYLVVMK
HCCCHHHCCCHHHHHHHHHHHHHCCEEEECCHHHHHHHCCHHHHHHHCCCCCCCEEEEEE
WLGGNENEKPVAFVGKGVVFDTGGISLKPSNKMEDMKGDMAGAATVVGLMHALAARKAKV
ECCCCCCCCCEEEEECCEEEECCCEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCE
NVLGVIGLVENMPGSNAQRPGDIVTSMSGQTIEVINTDAEGRLVLADALWYCKTKLQPKM
EEEEEEEHHHCCCCCCCCCCCHHHCCCCCCEEEEEECCCCCCEEEEHHHHHHHHCCCCHH
IIDLATLTGAIVVALGYEYAGLFSNNKELVKQLVHSGEVTEEKVWQFPLGPEYDRLVDGK
EEEHHHHHHHHHHHHCCHHEEECCCCHHHHHHHHHCCCCCHHHHEECCCCCCHHHHCCCC
FADISNCPVGYGAGSITAAQFLKRFVGDDIPWAHIDIAGVASGKKKNEFNSSWASGFGVR
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHH
LLNHLVKDYYENK
HHHHHHHHHHCCC
>Mature Secondary Structure
MKIYFKKNYLPSMDVDTAVVLQVEKYENSFGLEAVDPKGVAKKSFLRENFKGVFGTQVKL
CEEEEECCCCCCCCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCEEEE
LYPEGSPVACLQVMGLGKQEEINDQTFLKTGGLCFPQLNKANKVVVFADALGIENQTSQV
EECCCCCHHHHHHHCCCCCHHCCCCHHHHCCCCCCCCCCCCCEEEEEEECCCCCCHHHHH
MHFALGLLLRSYSFKHYHTQKTKNEKNLEITFITENAELCQKEFDDVKAILGGVNLTKEL
HHHHHHHHHHHCCCCHHCCCCCCCCCCEEEEEEECCHHHHHHHHHHHHHHHCCCHHHHHH
VNEPANILGTNEFVERTQQLQTLGVEVEVLNKETLEKLGMNALLGVAQGSQRPPYLVVMK
HCCCHHHCCCHHHHHHHHHHHHHCCEEEECCHHHHHHHCCHHHHHHHCCCCCCCEEEEEE
WLGGNENEKPVAFVGKGVVFDTGGISLKPSNKMEDMKGDMAGAATVVGLMHALAARKAKV
ECCCCCCCCCEEEEECCEEEECCCEEECCCCCHHHHCCHHHHHHHHHHHHHHHHHHHCCE
NVLGVIGLVENMPGSNAQRPGDIVTSMSGQTIEVINTDAEGRLVLADALWYCKTKLQPKM
EEEEEEEHHHCCCCCCCCCCCHHHCCCCCCEEEEEECCCCCCEEEEHHHHHHHHCCCCHH
IIDLATLTGAIVVALGYEYAGLFSNNKELVKQLVHSGEVTEEKVWQFPLGPEYDRLVDGK
EEEHHHHHHHHHHHHCCHHEEECCCCHHHHHHHHHCCCCCHHHHEECCCCCCHHHHCCCC
FADISNCPVGYGAGSITAAQFLKRFVGDDIPWAHIDIAGVASGKKKNEFNSSWASGFGVR
CCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCCCCCCCHHHHHHHHH
LLNHLVKDYYENK
HHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA