Click here to switch to the map view.

The map label for this gene is norM-1 [H]

Identifier: 197120354

GI number: 197120354

Start: 4530725

End: 4532068

Strand: Direct

Name: norM-1 [H]

Synonym: Gbem_3993

Alternate gene names: 197120354

Gene position: 4530725-4532068 (Clockwise)

Preceding gene: 308535398

Following gene: 197120355

Centisome position: 98.17

GC content: 61.98

Gene sequence:

>1344_bases
TTGAAGCGTCTCTTTATCAAAAGAAGAAGGAAACCGGTCTCGATCCGCCGCAACGTCGCGGCGCTTTCGATGCCGGTGCT
CCTGTCGTCCCTGTTCCAGCGCCTGGTTTCCATCGTCGACATCTTCATGGTCGGCGGGTTGGGAGCGGCTGCCATCGCCG
CCACCGGCCTCGGCCAGTTGCTGATCTTCGTGACCATGACGGTGTTCTGGGGGCTTTCCACCGGCGCCAACGTGGTTATA
GCGCATCTTTGGGGCGCGGGGCGCCAACTTGAGGCACGCCGGGCGGGCTTCGCCTCGCTTTTGCTTTGCGCCCTTCTCGC
CGTGGCGGCGACCCTTTTGGGGATTGGTTTCGGCAGCGAGGTGGCAACCTTCATGGGGGCGAGCAGCGACGTCCTGGCCT
ACGCCTCGCCTTATATCCGACTGGTCTTTCTCTACTTCGCCTTTACCGCCGGACTCAACATCCTCTCCGCCATCAGCCAG
GGGACCGGCAACACCAGGACGCCGATGGAGGCCATCCTCCTGGTCAATATCCTGCACGTGGTCATCGCCTACCCGCTCAT
CTACGGCAAGTTCGGCTTCCCCCGCTACGGTGTGATTGGTGCCGCTTACGCGATCAACATCTCGGAGGCTGCAGGATTCA
TCTACCTCCTGATCCAGTCGCTCAGGAAGGGGTATCTGAAGATTGGCCCTCCCGACATGGTGCTCCTGAATAAAGTATGG
AAGATCGGCTACCCGGTCGCGCTGGAGCGGATCGCCCAGCAGTCGGGACAGCTTTTCTACTCCAAGTTCATCATCGGCTT
CGGCACCGCCGCCTACGCGGCGCACCAGATCGGGCTCTCCATCGAATCTCTTTCCTTCATGCCCGGGGCCGGCATGGGGA
TCGCCGCCGCCACCTTGATGGGACAGTCGCTGGGCGCCAAGAAACTCAGGCGCGCCCACATGAGCCACACCGAAGCGCTG
CGGCTCGCCATCATCGTCATGGCCTGCATGGCGCTCCTCTTTTTCTTCATTCCGCACCACCTGATCGCCCTCTTCACCAG
CGATCCCGACGTCATCGAAAAAGGAAGCGTCTTCCTGAAGCTGGTCGCCTTCGCCCAGGTGCCGCTCGCCATCTCCTTCG
TCTATGCCGGGAGCCTGCGCGGTACCGGCGACACGCATTACGTCTTCCTGGTAACACTCGTCGCCATGTGGGGGATCAGG
GTGCTTCTCTCCTACGTCGCCGCAGTCCCGCTGCACCTCTCGCTCTACGCCGTCTGGGGGGTGTTCCTGGTGGACTGGTT
CTTCCGGGCCGGCGCTTTCTATTGGCGCTACCAGCGCCGCGACCTGCACAGCGTCATCATCTAG

Upstream 100 bases:

>100_bases
GCGGCATGGCCTGATCCGCAACCGGCGGTGTAATAGCAGCTTGGGCCGGGGCCTCCATGGACCCGGCCTTCACTTTTTTC
TAAGCGAGAGTCCCCAAATC

Downstream 100 bases:

>100_bases
GCGATGCAGCTTTCCTTTGCACCTACCACGGACGGAGTCGAGCTGCAGCGACTGCTTCAGCAGCTCCTGGTTCCCGGGTC
TCTTCTCGACGTGCCGCTCG

Product: sodium-driven efflux pump MatE

Products: NA

Alternate protein names: Multidrug-efflux transporter [H]

Number of amino acids: Translated: 447; Mature: 447

Protein sequence:

>447_residues
MKRLFIKRRRKPVSIRRNVAALSMPVLLSSLFQRLVSIVDIFMVGGLGAAAIAATGLGQLLIFVTMTVFWGLSTGANVVI
AHLWGAGRQLEARRAGFASLLLCALLAVAATLLGIGFGSEVATFMGASSDVLAYASPYIRLVFLYFAFTAGLNILSAISQ
GTGNTRTPMEAILLVNILHVVIAYPLIYGKFGFPRYGVIGAAYAINISEAAGFIYLLIQSLRKGYLKIGPPDMVLLNKVW
KIGYPVALERIAQQSGQLFYSKFIIGFGTAAYAAHQIGLSIESLSFMPGAGMGIAAATLMGQSLGAKKLRRAHMSHTEAL
RLAIIVMACMALLFFFIPHHLIALFTSDPDVIEKGSVFLKLVAFAQVPLAISFVYAGSLRGTGDTHYVFLVTLVAMWGIR
VLLSYVAAVPLHLSLYAVWGVFLVDWFFRAGAFYWRYQRRDLHSVII

Sequences:

>Translated_447_residues
MKRLFIKRRRKPVSIRRNVAALSMPVLLSSLFQRLVSIVDIFMVGGLGAAAIAATGLGQLLIFVTMTVFWGLSTGANVVI
AHLWGAGRQLEARRAGFASLLLCALLAVAATLLGIGFGSEVATFMGASSDVLAYASPYIRLVFLYFAFTAGLNILSAISQ
GTGNTRTPMEAILLVNILHVVIAYPLIYGKFGFPRYGVIGAAYAINISEAAGFIYLLIQSLRKGYLKIGPPDMVLLNKVW
KIGYPVALERIAQQSGQLFYSKFIIGFGTAAYAAHQIGLSIESLSFMPGAGMGIAAATLMGQSLGAKKLRRAHMSHTEAL
RLAIIVMACMALLFFFIPHHLIALFTSDPDVIEKGSVFLKLVAFAQVPLAISFVYAGSLRGTGDTHYVFLVTLVAMWGIR
VLLSYVAAVPLHLSLYAVWGVFLVDWFFRAGAFYWRYQRRDLHSVII
>Mature_447_residues
MKRLFIKRRRKPVSIRRNVAALSMPVLLSSLFQRLVSIVDIFMVGGLGAAAIAATGLGQLLIFVTMTVFWGLSTGANVVI
AHLWGAGRQLEARRAGFASLLLCALLAVAATLLGIGFGSEVATFMGASSDVLAYASPYIRLVFLYFAFTAGLNILSAISQ
GTGNTRTPMEAILLVNILHVVIAYPLIYGKFGFPRYGVIGAAYAINISEAAGFIYLLIQSLRKGYLKIGPPDMVLLNKVW
KIGYPVALERIAQQSGQLFYSKFIIGFGTAAYAAHQIGLSIESLSFMPGAGMGIAAATLMGQSLGAKKLRRAHMSHTEAL
RLAIIVMACMALLFFFIPHHLIALFTSDPDVIEKGSVFLKLVAFAQVPLAISFVYAGSLRGTGDTHYVFLVTLVAMWGIR
VLLSYVAAVPLHLSLYAVWGVFLVDWFFRAGAFYWRYQRRDLHSVII

Specific function: Multidrug efflux pump [H]

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Escherichia coli, GI226510954, Length=446, Percent_Identity=29.5964125560538, Blast_Score=172, Evalue=4e-44,
Organism=Escherichia coli, GI48994890, Length=410, Percent_Identity=24.390243902439, Blast_Score=87, Evalue=3e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48617; Mature: 48617

Theoretical pI: Translated: 10.54; Mature: 10.54

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLFIKRRRKPVSIRRNVAALSMPVLLSSLFQRLVSIVDIFMVGGLGAAAIAATGLGQL
CCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LIFVTMTVFWGLSTGANVVIAHLWGAGRQLEARRAGFASLLLCALLAVAATLLGIGFGSE
HHHHHHHHHHCCCCCCCEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
VATFMGASSDVLAYASPYIRLVFLYFAFTAGLNILSAISQGTGNTRTPMEAILLVNILHV
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
VIAYPLIYGKFGFPRYGVIGAAYAINISEAAGFIYLLIQSLRKGYLKIGPPDMVLLNKVW
HHHHHHHHCCCCCCCHHHHHHHHEEEHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHH
KIGYPVALERIAQQSGQLFYSKFIIGFGTAAYAAHQIGLSIESLSFMPGAGMGIAAATLM
HCCCHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHH
GQSLGAKKLRRAHMSHTEALRLAIIVMACMALLFFFIPHHLIALFTSDPDVIEKGSVFLK
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHH
LVAFAQVPLAISFVYAGSLRGTGDTHYVFLVTLVAMWGIRVLLSYVAAVPLHLSLYAVWG
HHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFLVDWFFRAGAFYWRYQRRDLHSVII
HHHHHHHHHCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKRLFIKRRRKPVSIRRNVAALSMPVLLSSLFQRLVSIVDIFMVGGLGAAAIAATGLGQL
CCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHH
LIFVTMTVFWGLSTGANVVIAHLWGAGRQLEARRAGFASLLLCALLAVAATLLGIGFGSE
HHHHHHHHHHCCCCCCCEEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
VATFMGASSDVLAYASPYIRLVFLYFAFTAGLNILSAISQGTGNTRTPMEAILLVNILHV
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
VIAYPLIYGKFGFPRYGVIGAAYAINISEAAGFIYLLIQSLRKGYLKIGPPDMVLLNKVW
HHHHHHHHCCCCCCCHHHHHHHHEEEHHHHHHHHHHHHHHHHCCCEECCCCHHHHHHHHH
KIGYPVALERIAQQSGQLFYSKFIIGFGTAAYAAHQIGLSIESLSFMPGAGMGIAAATLM
HCCCHHHHHHHHHHHCHHHHHHHHHHCCHHHHHHHHHCCCHHHCCCCCCCCCHHHHHHHH
GQSLGAKKLRRAHMSHTEALRLAIIVMACMALLFFFIPHHLIALFTSDPDVIEKGSVFLK
HHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHCCHHHHH
LVAFAQVPLAISFVYAGSLRGTGDTHYVFLVTLVAMWGIRVLLSYVAAVPLHLSLYAVWG
HHHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFLVDWFFRAGAFYWRYQRRDLHSVII
HHHHHHHHHCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]