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The map label for this gene is cheA-4 [H]

Identifier: 197120303

GI number: 197120303

Start: 4479056

End: 4480867

Strand: Direct

Name: cheA-4 [H]

Synonym: Gbem_3942

Alternate gene names: 197120303

Gene position: 4479056-4480867 (Clockwise)

Preceding gene: 197120302

Following gene: 197120304

Centisome position: 97.05

GC content: 62.36

Gene sequence:

>1812_bases
ATGGCTATAGACTGCGAAGATCAGGAGCTACTCGAAGGTTTCCTTGCGGAAACCACGGAACTCCTCGAAAAACTTGACGA
CGACCTGATCACCTTGGAGAAGAGCCCGGACGACGCCGAACTGATGAATCGGATCTTCCGCTCCATCCACACGGTCAAAG
GGGCCTCCAGCTTCCTCGGGTTCGACATGCTGGTCAAAGTGACTCACAAGACCGAGGATGTGCTGAACCGCCTGAGAAAG
GGGGAGCTCTTCCTCAACCCAGAGATCATGGACGTGATCCTGGAGGCGGTCGACCTGGTGAAGACACTGGTGGCCGACAT
CAAGGGAGGGGATATCGTCGAGAGGGACCTCGAGGGGACCATCTCCAAGCTGATTCCGTTTCTCTCCGAGAACGCGACCG
AAGCTACGGTGCTCGCCCCTACCTCGGCTCCCAAGGAGGAGAAGGTCGCGACGCCTCCTCCCCCCGAGTCAGCCGCGGAT
GCAGAAGCGAAAGCAGCCGGTGAGAAGGAGAGCGCACCCGCCGATACCGGTGCGCCCACAACGGCAGCCGCGGCGCCGGT
GGCGCAGCCCAAGCCTCAGCCGGTCAAGGAGCCGCAAAAGCCTGCCCCCAAAGGGGAGGAGCTGGCCGACAACTCCACCG
TGCGCGTCGACGTGAAGCGCCTGGACGACCTGATGAACCAGGTCGGCGAGCTGGTGCTCGAGCGCAACCGGATGATCCAG
CTGCACAGCGACTACCAGACGGGTCTCGACCCCACCGGCTTCGGCGATGATTTCGGGAAACTCTCCAAGAGGCTCAACTT
CGTCACCTCCGAGCTGCAGATGCAGGTTCTCAAGATGCGGATGCTGCCGGTGGAGAAGGTCTTCAAGAAGTTCCCGCGCA
TCGTCAGGAATCTGGCGCGCGACCTCGGCAAGGAAGTGGACTTGGTCATCATCGGCGAGGAGACCGAACTCGACCGCTCC
GTCGTCGACGAGATCGGGGACCCCTTGATCCACCTGATCCGCAACGCCCTGGACCACGGCCTGGAAACTCCGGACCAGCG
CCTTTCCGCCGGCAAGGACCGCACCGGCACCGTGGTCCTCTCCGCCGCCCACGAGGGGAACCAGATCGTCATCAGCATCA
AGGACGACGGCCGGGGCATAGACCCCGAGCGGATCTCGAAGAAGGCGCTGGAGAAGGGGCTCGTCACCGAGGAACAGCTC
GCTTCCATGGGGAACCGCGAGATCCTCGACCTCCTCTTCCTCCCGGGCTTCTCGACCAAGGAGCAGACCACCGACCTCTC
CGGCCGCGGCGTCGGCATGGACGTGGTGCGCACCAACATCAGGAAGTTAAACGGCATCATCGAGATCAAAAACGACGTCG
GGCACGGCACCGAGTTCATACTGAAGCTCCCGCTCACCCTGGCCATCATCCAGTCCCTGCTGGTGGAGGTGGAGAAGGAG
GTCTACTCCATACCGCTTGCGTCGGTCATCGAGACCATGCGGGTGAGCAAGAGCGAGTTCCACATGATCGGCGGACAGGA
AGTGCTCAAATTGAGGGACTCGGTGCTCCCGCTCCTGCGGCTGCAACAGACCTTCAGCTGCCAGGAGGTCTACACCGATC
GCGACACCTGCTACGTGGTCATAGTCGGCGTAGCCGAGAAGCGCATCGGCCTCATCGTCACCAGGCTCCTGGGGCAGCAG
GAGGTCGCCATCAAGTCGCTGGGCAAGTTCCTGGCCAATCTTCCTGGCATCGGCGGTTCAACCATCATGGGCGACGGGCG
GGTGGCACTGATCGTGGATCCGATCGGTCTGATCGGGGGCGGGGCAGCCTGA

Upstream 100 bases:

>100_bases
CGACTTGGAGCGGATGTTCTCCGCCGACGAGCGCAGGCTGTTCAGCAACGTAGGTTAAGGTACCAACAGGGGAAAGCCTT
CCCCCTTCCCGGAGCGCATC

Downstream 100 bases:

>100_bases
GGGGAAGATAATGGCATTAGACATGAAACCATTCGACGCGAAAGCGGCCCCGAAGATCAACGAAAAGGACTTCGAGCAGC
TTCGGGACTATATATATAAC

Product: chemotaxis sensor histidine kinase CheA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 603; Mature: 602

Protein sequence:

>603_residues
MAIDCEDQELLEGFLAETTELLEKLDDDLITLEKSPDDAELMNRIFRSIHTVKGASSFLGFDMLVKVTHKTEDVLNRLRK
GELFLNPEIMDVILEAVDLVKTLVADIKGGDIVERDLEGTISKLIPFLSENATEATVLAPTSAPKEEKVATPPPPESAAD
AEAKAAGEKESAPADTGAPTTAAAAPVAQPKPQPVKEPQKPAPKGEELADNSTVRVDVKRLDDLMNQVGELVLERNRMIQ
LHSDYQTGLDPTGFGDDFGKLSKRLNFVTSELQMQVLKMRMLPVEKVFKKFPRIVRNLARDLGKEVDLVIIGEETELDRS
VVDEIGDPLIHLIRNALDHGLETPDQRLSAGKDRTGTVVLSAAHEGNQIVISIKDDGRGIDPERISKKALEKGLVTEEQL
ASMGNREILDLLFLPGFSTKEQTTDLSGRGVGMDVVRTNIRKLNGIIEIKNDVGHGTEFILKLPLTLAIIQSLLVEVEKE
VYSIPLASVIETMRVSKSEFHMIGGQEVLKLRDSVLPLLRLQQTFSCQEVYTDRDTCYVVIVGVAEKRIGLIVTRLLGQQ
EVAIKSLGKFLANLPGIGGSTIMGDGRVALIVDPIGLIGGGAA

Sequences:

>Translated_603_residues
MAIDCEDQELLEGFLAETTELLEKLDDDLITLEKSPDDAELMNRIFRSIHTVKGASSFLGFDMLVKVTHKTEDVLNRLRK
GELFLNPEIMDVILEAVDLVKTLVADIKGGDIVERDLEGTISKLIPFLSENATEATVLAPTSAPKEEKVATPPPPESAAD
AEAKAAGEKESAPADTGAPTTAAAAPVAQPKPQPVKEPQKPAPKGEELADNSTVRVDVKRLDDLMNQVGELVLERNRMIQ
LHSDYQTGLDPTGFGDDFGKLSKRLNFVTSELQMQVLKMRMLPVEKVFKKFPRIVRNLARDLGKEVDLVIIGEETELDRS
VVDEIGDPLIHLIRNALDHGLETPDQRLSAGKDRTGTVVLSAAHEGNQIVISIKDDGRGIDPERISKKALEKGLVTEEQL
ASMGNREILDLLFLPGFSTKEQTTDLSGRGVGMDVVRTNIRKLNGIIEIKNDVGHGTEFILKLPLTLAIIQSLLVEVEKE
VYSIPLASVIETMRVSKSEFHMIGGQEVLKLRDSVLPLLRLQQTFSCQEVYTDRDTCYVVIVGVAEKRIGLIVTRLLGQQ
EVAIKSLGKFLANLPGIGGSTIMGDGRVALIVDPIGLIGGGAA
>Mature_602_residues
AIDCEDQELLEGFLAETTELLEKLDDDLITLEKSPDDAELMNRIFRSIHTVKGASSFLGFDMLVKVTHKTEDVLNRLRKG
ELFLNPEIMDVILEAVDLVKTLVADIKGGDIVERDLEGTISKLIPFLSENATEATVLAPTSAPKEEKVATPPPPESAADA
EAKAAGEKESAPADTGAPTTAAAAPVAQPKPQPVKEPQKPAPKGEELADNSTVRVDVKRLDDLMNQVGELVLERNRMIQL
HSDYQTGLDPTGFGDDFGKLSKRLNFVTSELQMQVLKMRMLPVEKVFKKFPRIVRNLARDLGKEVDLVIIGEETELDRSV
VDEIGDPLIHLIRNALDHGLETPDQRLSAGKDRTGTVVLSAAHEGNQIVISIKDDGRGIDPERISKKALEKGLVTEEQLA
SMGNREILDLLFLPGFSTKEQTTDLSGRGVGMDVVRTNIRKLNGIIEIKNDVGHGTEFILKLPLTLAIIQSLLVEVEKEV
YSIPLASVIETMRVSKSEFHMIGGQEVLKLRDSVLPLLRLQQTFSCQEVYTDRDTCYVVIVGVAEKRIGLIVTRLLGQQE
VAIKSLGKFLANLPGIGGSTIMGDGRVALIVDPIGLIGGGAA

Specific function: Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY [H]

COG id: COG0643

COG function: function code NT; Chemotaxis protein histidine kinase and related kinases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HPt domain [H]

Homologues:

Organism=Escherichia coli, GI1788197, Length=652, Percent_Identity=35.5828220858896, Blast_Score=372, Evalue=1e-104,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR002545
- InterPro:   IPR015162
- InterPro:   IPR004358
- InterPro:   IPR008207
- InterPro:   IPR004105
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF01584 CheW; PF09078 CheY-binding; PF02895 H-kinase_dim; PF02518 HATPase_c; PF01627 Hpt [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 65753; Mature: 65621

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS50851 CHEW ; PS50894 HPT ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAIDCEDQELLEGFLAETTELLEKLDDDLITLEKSPDDAELMNRIFRSIHTVKGASSFLG
CCCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHH
FDMLVKVTHKTEDVLNRLRKGELFLNPEIMDVILEAVDLVKTLVADIKGGDIVERDLEGT
HHHHHHHHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
ISKLIPFLSENATEATVLAPTSAPKEEKVATPPPPESAADAEAKAAGEKESAPADTGAPT
HHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCC
TAAAAPVAQPKPQPVKEPQKPAPKGEELADNSTVRVDVKRLDDLMNQVGELVLERNRMIQ
CCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEE
LHSDYQTGLDPTGFGDDFGKLSKRLNFVTSELQMQVLKMRMLPVEKVFKKFPRIVRNLAR
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
DLGKEVDLVIIGEETELDRSVVDEIGDPLIHLIRNALDHGLETPDQRLSAGKDRTGTVVL
HCCCCCCEEEECCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCEEEE
SAAHEGNQIVISIKDDGRGIDPERISKKALEKGLVTEEQLASMGNREILDLLFLPGFSTK
EECCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHCCCCCCC
EQTTDLSGRGVGMDVVRTNIRKLNGIIEIKNDVGHGTEFILKLPLTLAIIQSLLVEVEKE
CCCCCCCCCCCCHHHHHHHHHHHHCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VYSIPLASVIETMRVSKSEFHMIGGQEVLKLRDSVLPLLRLQQTFSCQEVYTDRDTCYVV
HHHCCHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEE
IVGVAEKRIGLIVTRLLGQQEVAIKSLGKFLANLPGIGGSTIMGDGRVALIVDPIGLIGG
EEECCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEECCCEEEEEECCHHCCCC
GAA
CCC
>Mature Secondary Structure 
AIDCEDQELLEGFLAETTELLEKLDDDLITLEKSPDDAELMNRIFRSIHTVKGASSFLG
CCCCCHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHHHHCCHHHHHH
FDMLVKVTHKTEDVLNRLRKGELFLNPEIMDVILEAVDLVKTLVADIKGGDIVERDLEGT
HHHHHHHHHHHHHHHHHHHCCCEEECHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
ISKLIPFLSENATEATVLAPTSAPKEEKVATPPPPESAADAEAKAAGEKESAPADTGAPT
HHHHHHHHCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCC
TAAAAPVAQPKPQPVKEPQKPAPKGEELADNSTVRVDVKRLDDLMNQVGELVLERNRMIQ
CCCCCCCCCCCCCCCCCCCCCCCCCCHHCCCCEEEEEHHHHHHHHHHHHHHHHHCCCEEE
LHSDYQTGLDPTGFGDDFGKLSKRLNFVTSELQMQVLKMRMLPVEKVFKKFPRIVRNLAR
EECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHH
DLGKEVDLVIIGEETELDRSVVDEIGDPLIHLIRNALDHGLETPDQRLSAGKDRTGTVVL
HCCCCCCEEEECCCCHHHHHHHHHHCHHHHHHHHHHHHCCCCCCHHHHHCCCCCCCEEEE
SAAHEGNQIVISIKDDGRGIDPERISKKALEKGLVTEEQLASMGNREILDLLFLPGFSTK
EECCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCCHHHHHCCCCHHHHHHHHCCCCCCC
EQTTDLSGRGVGMDVVRTNIRKLNGIIEIKNDVGHGTEFILKLPLTLAIIQSLLVEVEKE
CCCCCCCCCCCCHHHHHHHHHHHHCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
VYSIPLASVIETMRVSKSEFHMIGGQEVLKLRDSVLPLLRLQQTFSCQEVYTDRDTCYVV
HHHCCHHHHHHHHHCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCEEEE
IVGVAEKRIGLIVTRLLGQQEVAIKSLGKFLANLPGIGGSTIMGDGRVALIVDPIGLIGG
EEECCHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCCCCCCEEECCCEEEEEECCHHCCCC
GAA
CCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2002011; 9097040; 9278503; 3510184; 2832069; 2068106; 8555213; 8639521; 9020767; 9437425; 9636149 [H]