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The map label for this gene is ato-4 [H]

Identifier: 197120258

GI number: 197120258

Start: 4433563

End: 4435125

Strand: Direct

Name: ato-4 [H]

Synonym: Gbem_3897

Alternate gene names: 197120258

Gene position: 4433563-4435125 (Clockwise)

Preceding gene: 197120256

Following gene: 197120259

Centisome position: 96.07

GC content: 62.12

Gene sequence:

>1563_bases
ATGTCCGAATTGCACAGCAGAATCAGGAAATCCAGCCTTCGCGGCAGGATCAAGACCGTCGATGAAGTGATCCCGATGTT
CAAGAACGGGATGAACGTAGGGTGGTCCGGGTTTACCCCCGCCGGTTACCCGAAGATGGTCCCCATCGCCCTGGCGGACC
ATGTGGAAAAGAACCAGTTGCAGGGAAAGCTGAAGTTCAACCTGTACATCGGCGCATCGGTCGGGGTCGAGACCGAGGAC
CGCTGGGCGTCGCTCGACATGATCGACCGCCGCTGGCCCTATCAGACCGGTAAGAACATCCAAGCCGGCATCAACGAAGG
GCGCATCCGGATGGGTGACAAGCACCTCTCCATGTTCGCCCAGGACCTTGGCTACGGCTTCTACACCAAGCACAACGACG
GCCGCCTCGACATCGCCATCATCGAGTGCTCGGCGATAACCGAGAACGGCGAGCTGGTCCTCACCGCCTCCTGCGGCGCA
GTCCCCGAGATCGTGCAGATCGCTGACAAGATCATCATCGAGATCAACACCTCGATCCCGAGCTTCGAAGGGTTGCACGA
CATCGTCGAGCCGATCGCTCCGCCCAACCGCCTCCCCTACCTGATCTGCCGCGTCGACGACCGTGCCGGTTCCCCGTACG
TCCGCGTCGATAACGACAAGATCGTCGCCATCGTCGAGTCCAACCGTCCCGACAACGGCCGCGCCTTCAGCGAGCAGGAC
GACACCTCCGAAGCCATCGCCAACAACATCATCGACTTCTTCTCCCACGAGGTGAAGGTGGGAAGGCTGCCGAAAAACCT
GCTGCCGCTGCAGTCCGGCGTGGGCTCCATCGCCAACGCGGTCATCGGCGGGCTGGCCAACGGCCCGTTCACCGGCCTCA
AGGTCTGGACCGAGGTGCTGCAGGACACCATGCTCGACTTCTTCGACTCCGGCAAGCTCGACTTCGCCTCTACGGTCTCG
CTTTCATTCTCGGTCGACGGCTTCAAGCGCTTCTACGACAACTGGGACAAGTACAGCGACAAGGTGATGATGCGTCCGCT
CTCCATCGCCAACCACCCCGAGCCGATCCGCCGCCTCGGCTGCATCGCGATGAACACCCCGGTGGAGTTCGACATCTACG
CCCACGCGAACTCCACGCTGGTAGGCGGTACCCGGATGATCAACGGCATCGGCGGCTCCGGCGACTTCCTCAGGAACGCG
TACCTCTCCATCATGCACACCCCGTCGGCGCGCCCGACCAAGACCGATCCGACCGGCATCACCTGCGTCGTTCCGCACGT
GCCGCACGTCGACCATACCGAGCACGACCTTGACGTGCTGGTCACCGAGCAGGGTCTTGCCGACCTGCGCGGCCTCGACC
CGAAAAGCCGCGCCAAGCTCATCATCGAGAAGTGCGCGCACCCCGATTACAAGCCGCTTTTGCAGGACTACTTCGAGCGC
GCGGCAAAGGACTGCCTGGCACGCAAAGCAGGGCACGAGCCGCAGCTTCTGGACCGCGTCTTCAAGATGCAGGTGAACCT
GGCCCAGAAAGGGACCATGAAGATCGACAGCTGGGACATCTAG

Upstream 100 bases:

>100_bases
CAATCAAAACAGCGTGCTGTTATGTTGTATTCGAACGAACGTTCGATTCCTATTACCATGGAAGCTATGCCACAATAGCT
CGTCAGGAGGGTTCCGGAAG

Downstream 100 bases:

>100_bases
TTTCCAGGCATCGCGAATAAGGACGGCAGGGGGCCTCAGGCCACCCTGCCGTTTTTTTTTGTGCGCAGCATCAGCAAAAT
GTTTGACGGGCGTGAGGTAA

Product: succinyl:acetate CoA transferase

Products: propionate; succinyl-CoA [C]

Alternate protein names: NA

Number of amino acids: Translated: 520; Mature: 519

Protein sequence:

>520_residues
MSELHSRIRKSSLRGRIKTVDEVIPMFKNGMNVGWSGFTPAGYPKMVPIALADHVEKNQLQGKLKFNLYIGASVGVETED
RWASLDMIDRRWPYQTGKNIQAGINEGRIRMGDKHLSMFAQDLGYGFYTKHNDGRLDIAIIECSAITENGELVLTASCGA
VPEIVQIADKIIIEINTSIPSFEGLHDIVEPIAPPNRLPYLICRVDDRAGSPYVRVDNDKIVAIVESNRPDNGRAFSEQD
DTSEAIANNIIDFFSHEVKVGRLPKNLLPLQSGVGSIANAVIGGLANGPFTGLKVWTEVLQDTMLDFFDSGKLDFASTVS
LSFSVDGFKRFYDNWDKYSDKVMMRPLSIANHPEPIRRLGCIAMNTPVEFDIYAHANSTLVGGTRMINGIGGSGDFLRNA
YLSIMHTPSARPTKTDPTGITCVVPHVPHVDHTEHDLDVLVTEQGLADLRGLDPKSRAKLIIEKCAHPDYKPLLQDYFER
AAKDCLARKAGHEPQLLDRVFKMQVNLAQKGTMKIDSWDI

Sequences:

>Translated_520_residues
MSELHSRIRKSSLRGRIKTVDEVIPMFKNGMNVGWSGFTPAGYPKMVPIALADHVEKNQLQGKLKFNLYIGASVGVETED
RWASLDMIDRRWPYQTGKNIQAGINEGRIRMGDKHLSMFAQDLGYGFYTKHNDGRLDIAIIECSAITENGELVLTASCGA
VPEIVQIADKIIIEINTSIPSFEGLHDIVEPIAPPNRLPYLICRVDDRAGSPYVRVDNDKIVAIVESNRPDNGRAFSEQD
DTSEAIANNIIDFFSHEVKVGRLPKNLLPLQSGVGSIANAVIGGLANGPFTGLKVWTEVLQDTMLDFFDSGKLDFASTVS
LSFSVDGFKRFYDNWDKYSDKVMMRPLSIANHPEPIRRLGCIAMNTPVEFDIYAHANSTLVGGTRMINGIGGSGDFLRNA
YLSIMHTPSARPTKTDPTGITCVVPHVPHVDHTEHDLDVLVTEQGLADLRGLDPKSRAKLIIEKCAHPDYKPLLQDYFER
AAKDCLARKAGHEPQLLDRVFKMQVNLAQKGTMKIDSWDI
>Mature_519_residues
SELHSRIRKSSLRGRIKTVDEVIPMFKNGMNVGWSGFTPAGYPKMVPIALADHVEKNQLQGKLKFNLYIGASVGVETEDR
WASLDMIDRRWPYQTGKNIQAGINEGRIRMGDKHLSMFAQDLGYGFYTKHNDGRLDIAIIECSAITENGELVLTASCGAV
PEIVQIADKIIIEINTSIPSFEGLHDIVEPIAPPNRLPYLICRVDDRAGSPYVRVDNDKIVAIVESNRPDNGRAFSEQDD
TSEAIANNIIDFFSHEVKVGRLPKNLLPLQSGVGSIANAVIGGLANGPFTGLKVWTEVLQDTMLDFFDSGKLDFASTVSL
SFSVDGFKRFYDNWDKYSDKVMMRPLSIANHPEPIRRLGCIAMNTPVEFDIYAHANSTLVGGTRMINGIGGSGDFLRNAY
LSIMHTPSARPTKTDPTGITCVVPHVPHVDHTEHDLDVLVTEQGLADLRGLDPKSRAKLIIEKCAHPDYKPLLQDYFERA
AKDCLARKAGHEPQLLDRVFKMQVNLAQKGTMKIDSWDI

Specific function: Forms succinyl-CoA from succinate and acetyl-CoA [H]

COG id: COG0427

COG function: function code C; Acetyl-CoA hydrolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acetyl-CoA hydrolase/transferase family [H]

Homologues:

Organism=Escherichia coli, GI1789287, Length=499, Percent_Identity=42.685370741483, Blast_Score=390, Evalue=1e-109,
Organism=Saccharomyces cerevisiae, GI6319456, Length=518, Percent_Identity=57.5289575289575, Blast_Score=613, Evalue=1e-176,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003702
- InterPro:   IPR006472
- InterPro:   IPR017821 [H]

Pfam domain/function: PF02550 AcetylCoA_hydro; PF04223 CitF [H]

EC number: NA

Molecular weight: Translated: 57690; Mature: 57558

Theoretical pI: Translated: 6.46; Mature: 6.46

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSELHSRIRKSSLRGRIKTVDEVIPMFKNGMNVGWSGFTPAGYPKMVPIALADHVEKNQL
CHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHCC
QGKLKFNLYIGASVGVETEDRWASLDMIDRRWPYQTGKNIQAGINEGRIRMGDKHLSMFA
CEEEEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECHHHHHHHH
QDLGYGFYTKHNDGRLDIAIIECSAITENGELVLTASCGAVPEIVQIADKIIIEINTSIP
HHHCCCEEEECCCCEEEEEEEEEEEECCCCCEEEEECCCCCHHHHHHHCEEEEEEECCCC
SFEGLHDIVEPIAPPNRLPYLICRVDDRAGSPYVRVDNDKIVAIVESNRPDNGRAFSEQD
CCCHHHHHHHCCCCCCCCCEEEEEEECCCCCCEEEECCCEEEEEEECCCCCCCCCCCCCC
DTSEAIANNIIDFFSHEVKVGRLPKNLLPLQSGVGSIANAVIGGLANGPFTGLKVWTEVL
CHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
QDTMLDFFDSGKLDFASTVSLSFSVDGFKRFYDNWDKYSDKVMMRPLSIANHPEPIRRLG
HHHHHHHHCCCCCCEEEEEEEEEEHHHHHHHHHCHHHHCCHHEECCHHCCCCCHHHHHHC
CIAMNTPVEFDIYAHANSTLVGGTRMINGIGGSGDFLRNAYLSIMHTPSARPTKTDPTGI
CEEECCCEEEEEEEECCCEEECCHHEEECCCCCHHHHHHHHHHEEECCCCCCCCCCCCCE
TCVVPHVPHVDHTEHDLDVLVTEQGLADLRGLDPKSRAKLIIEKCAHPDYKPLLQDYFER
EEEECCCCCCCCCCCCCEEEEECCCHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
AAKDCLARKAGHEPQLLDRVFKMQVNLAQKGTMKIDSWDI
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEECCCCC
>Mature Secondary Structure 
SELHSRIRKSSLRGRIKTVDEVIPMFKNGMNVGWSGFTPAGYPKMVPIALADHVEKNQL
HHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHCC
QGKLKFNLYIGASVGVETEDRWASLDMIDRRWPYQTGKNIQAGINEGRIRMGDKHLSMFA
CEEEEEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCCCCCCCEEECHHHHHHHH
QDLGYGFYTKHNDGRLDIAIIECSAITENGELVLTASCGAVPEIVQIADKIIIEINTSIP
HHHCCCEEEECCCCEEEEEEEEEEEECCCCCEEEEECCCCCHHHHHHHCEEEEEEECCCC
SFEGLHDIVEPIAPPNRLPYLICRVDDRAGSPYVRVDNDKIVAIVESNRPDNGRAFSEQD
CCCHHHHHHHCCCCCCCCCEEEEEEECCCCCCEEEECCCEEEEEEECCCCCCCCCCCCCC
DTSEAIANNIIDFFSHEVKVGRLPKNLLPLQSGVGSIANAVIGGLANGPFTGLKVWTEVL
CHHHHHHHHHHHHHHCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
QDTMLDFFDSGKLDFASTVSLSFSVDGFKRFYDNWDKYSDKVMMRPLSIANHPEPIRRLG
HHHHHHHHCCCCCCEEEEEEEEEEHHHHHHHHHCHHHHCCHHEECCHHCCCCCHHHHHHC
CIAMNTPVEFDIYAHANSTLVGGTRMINGIGGSGDFLRNAYLSIMHTPSARPTKTDPTGI
CEEECCCEEEEEEEECCCEEECCHHEEECCCCCHHHHHHHHHHEEECCCCCCCCCCCCCE
TCVVPHVPHVDHTEHDLDVLVTEQGLADLRGLDPKSRAKLIIEKCAHPDYKPLLQDYFER
EEEECCCCCCCCCCCCCEEEEECCCHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHH
AAKDCLARKAGHEPQLLDRVFKMQVNLAQKGTMKIDSWDI
HHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: propionyl-CoA; succinate [C]

Specific reaction: propionyl-CoA + succinate = propionate + succinyl-CoA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8550525 [H]