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The map label for this gene is tabA [H]

Identifier: 197119232

GI number: 197119232

Start: 3289975

End: 3291240

Strand: Direct

Name: tabA [H]

Synonym: Gbem_2859

Alternate gene names: 197119232

Gene position: 3289975-3291240 (Clockwise)

Preceding gene: 197119231

Following gene: 197119234

Centisome position: 71.29

GC content: 61.85

Gene sequence:

>1266_bases
ATGCCGATGTCAGCTTCTTTCAAGGACCGCCTGTTCCCCCGCATCCCGCAGATCCAGCAGCACTTCCAGACCCCGTTCCA
CATCTACGATGAATCCGGCATCAGGGAAACCGGCGCGCAGCTGGTCAAGGCCTTCTCCGGCATCCCCGGGTTCCGCGAGT
TCTTTGCGGTAAAGGCGCTTCCCAACCGCGAAATTCTGAAGCTCATGAAAGAGATGGGCTTCGGTTTCGACTGCAGCTCC
ATTCCCGAGGTGATCCTCGCCCGCGAACTCGGGGCAAGGCCTGAAGACATCATGTTCACCTCCAACAACACCAGCCAGGA
AGAGTTCGATTTCGCTACCCAGGACGGCGGGTGCATCATGAACCTCGACGACATCTCCCTCATCGAAAAGGTGCCGCACT
TCCCGGAGATGATCTGCTTCCGCTACAACCCGGGACCGCGCCGCACCGGCAACGTGATCATCGGCAACCCCGAAGAGGCG
AAGTACGGCGTTTCGCACGAACAGGTCGTAGAGGCCTACCGCCAGGCGAAGGAGCGCGGCGCCACCCGCTTCGGCCTGCA
CACCATGGTAGCCTCCAACGAGCTGGACTACACCTACATCGTCGAGACCGCGCGCATGGTACTCGAGGTAGCCGAGGAAG
TCGAAGCTGCTTTGGGCATCAAGTTCGAGTTCGTCAACATCGGCGGCGGCTTCGGCATCCCCTATCGTCCGGAACAAAAG
ACGCTCGATCTGGCCAGGATGTCGGCCGAGGTCACCGAGCTCTTCGACGGCTTCCGCAAGCGCCACGGCCACGCACCCGC
GATGTTCATGGAAAGCGGCCGCTTCATGACCGGCCCCCACGGCGCCCTGGTCACTACCGCCATCAACAGCAAGGACACCT
ACCGCAGGTACATCGGCGTCGACGCCTGTATGTCCGCGCTGATGCGCCCTGCCCTTTACGGCGCCTACCACCATATCGAC
GTCCTCGGCAAGGACCGGGACCCGAAAACCGAGATCTACGACGTGGTCGGTTCGCTTTGCGAGAATAACGACAAATTCGC
GGTACAGCGCGAACTCCAGCCGATCGAGGACGGCGACATCCTTGTCATCCATGATTCCGGCGCCCACGGCCACGCCATGG
GGTTCCAGTACAACGGCCGCCTGCGTCCCAAGGAGCTGATGCTGCGCGCCGACGGTCGCGTCGAGCTGATAAGAAGGGCC
GAGACCGTGGAGGATTACTTCGCCACCTACGACTTCGAGCCCTCCGTCCTCCCCGCCGGCGCCTAA

Upstream 100 bases:

>100_bases
GTAAAGGAAACCAGAAGGGTCGATCTGGTGCATGCCGAGCGAGACCTTTAACAAGCGACGCAGCGAAGAGCAATTAATAA
AGCCAGAGGAGACCTATTCA

Downstream 100 bases:

>100_bases
AGCGCGCAGACGGAACAAGGTCGCAAAACGACAAAGGCATCCGGCTATAAGGCCGGATGCCTTTTCTAGTTATTGCTACC
GGAAATGTCGCCGCTTAGAG

Product: ornithine/diaminopimelate/arginine decarboxylase-like protein TabA

Products: L-lysine; CO2

Alternate protein names: NA

Number of amino acids: Translated: 421; Mature: 420

Protein sequence:

>421_residues
MPMSASFKDRLFPRIPQIQQHFQTPFHIYDESGIRETGAQLVKAFSGIPGFREFFAVKALPNREILKLMKEMGFGFDCSS
IPEVILARELGARPEDIMFTSNNTSQEEFDFATQDGGCIMNLDDISLIEKVPHFPEMICFRYNPGPRRTGNVIIGNPEEA
KYGVSHEQVVEAYRQAKERGATRFGLHTMVASNELDYTYIVETARMVLEVAEEVEAALGIKFEFVNIGGGFGIPYRPEQK
TLDLARMSAEVTELFDGFRKRHGHAPAMFMESGRFMTGPHGALVTTAINSKDTYRRYIGVDACMSALMRPALYGAYHHID
VLGKDRDPKTEIYDVVGSLCENNDKFAVQRELQPIEDGDILVIHDSGAHGHAMGFQYNGRLRPKELMLRADGRVELIRRA
ETVEDYFATYDFEPSVLPAGA

Sequences:

>Translated_421_residues
MPMSASFKDRLFPRIPQIQQHFQTPFHIYDESGIRETGAQLVKAFSGIPGFREFFAVKALPNREILKLMKEMGFGFDCSS
IPEVILARELGARPEDIMFTSNNTSQEEFDFATQDGGCIMNLDDISLIEKVPHFPEMICFRYNPGPRRTGNVIIGNPEEA
KYGVSHEQVVEAYRQAKERGATRFGLHTMVASNELDYTYIVETARMVLEVAEEVEAALGIKFEFVNIGGGFGIPYRPEQK
TLDLARMSAEVTELFDGFRKRHGHAPAMFMESGRFMTGPHGALVTTAINSKDTYRRYIGVDACMSALMRPALYGAYHHID
VLGKDRDPKTEIYDVVGSLCENNDKFAVQRELQPIEDGDILVIHDSGAHGHAMGFQYNGRLRPKELMLRADGRVELIRRA
ETVEDYFATYDFEPSVLPAGA
>Mature_420_residues
PMSASFKDRLFPRIPQIQQHFQTPFHIYDESGIRETGAQLVKAFSGIPGFREFFAVKALPNREILKLMKEMGFGFDCSSI
PEVILARELGARPEDIMFTSNNTSQEEFDFATQDGGCIMNLDDISLIEKVPHFPEMICFRYNPGPRRTGNVIIGNPEEAK
YGVSHEQVVEAYRQAKERGATRFGLHTMVASNELDYTYIVETARMVLEVAEEVEAALGIKFEFVNIGGGFGIPYRPEQKT
LDLARMSAEVTELFDGFRKRHGHAPAMFMESGRFMTGPHGALVTTAINSKDTYRRYIGVDACMSALMRPALYGAYHHIDV
LGKDRDPKTEIYDVVGSLCENNDKFAVQRELQPIEDGDILVIHDSGAHGHAMGFQYNGRLRPKELMLRADGRVELIRRAE
TVEDYFATYDFEPSVLPAGA

Specific function: Involved in tabtoxin production and pathogenicity [H]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=435, Percent_Identity=21.6091954022989, Blast_Score=78, Evalue=2e-14,
Organism=Escherichia coli, GI1789203, Length=411, Percent_Identity=29.4403892944039, Blast_Score=146, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI17562780, Length=377, Percent_Identity=22.2811671087533, Blast_Score=65, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: 4.1.1.20

Molecular weight: Translated: 47360; Mature: 47228

Theoretical pI: Translated: 5.34; Mature: 5.34

Prosite motif: PS00878 ODR_DC_2_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.0 %Met     (Translated Protein)
5.2 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPMSASFKDRLFPRIPQIQQHFQTPFHIYDESGIRETGAQLVKAFSGIPGFREFFAVKAL
CCCCCCHHHHHCCCCHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHCC
PNREILKLMKEMGFGFDCSSIPEVILARELGARPEDIMFTSNNTSQEEFDFATQDGGCIM
CCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHCCCEECCCCEEE
NLDDISLIEKVPHFPEMICFRYNPGPRRTGNVIIGNPEEAKYGVSHEQVVEAYRQAKERG
ECHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEECCCCHHHCCCCHHHHHHHHHHHHHCC
ATRFGLHTMVASNELDYTYIVETARMVLEVAEEVEAALGIKFEFVNIGGGFGIPYRPEQK
CHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCHH
TLDLARMSAEVTELFDGFRKRHGHAPAMFMESGRFMTGPHGALVTTAINSKDTYRRYIGV
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEECCCCEEEEEEECCCHHHHHHHCH
DACMSALMRPALYGAYHHIDVLGKDRDPKTEIYDVVGSLCENNDKFAVQRELQPIEDGDI
HHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCE
LVIHDSGAHGHAMGFQYNGRLRPKELMLRADGRVELIRRAETVEDYFATYDFEPSVLPAG
EEEECCCCCCCEECEEECCCCCHHHHHEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
A
C
>Mature Secondary Structure 
PMSASFKDRLFPRIPQIQQHFQTPFHIYDESGIRETGAQLVKAFSGIPGFREFFAVKAL
CCCCCHHHHHCCCCHHHHHHHCCCEEEECCCCCHHHHHHHHHHHHCCCCHHHHHHHHCC
PNREILKLMKEMGFGFDCSSIPEVILARELGARPEDIMFTSNNTSQEEFDFATQDGGCIM
CCHHHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCCCEEEECCCCCHHHCCCEECCCCEEE
NLDDISLIEKVPHFPEMICFRYNPGPRRTGNVIIGNPEEAKYGVSHEQVVEAYRQAKERG
ECHHHHHHHHCCCCCCEEEEEECCCCCCCCCEEECCCCHHHCCCCHHHHHHHHHHHHHCC
ATRFGLHTMVASNELDYTYIVETARMVLEVAEEVEAALGIKFEFVNIGGGFGIPYRPEQK
CHHHHHHHHEECCCCCCHHHHHHHHHHHHHHHHHHHHHCCEEEEEEECCCCCCCCCCCHH
TLDLARMSAEVTELFDGFRKRHGHAPAMFMESGRFMTGPHGALVTTAINSKDTYRRYIGV
HHHHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCEEECCCCEEEEEEECCCHHHHHHHCH
DACMSALMRPALYGAYHHIDVLGKDRDPKTEIYDVVGSLCENNDKFAVQRELQPIEDGDI
HHHHHHHHHHHHHHHHHEEEEECCCCCCHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCE
LVIHDSGAHGHAMGFQYNGRLRPKELMLRADGRVELIRRAETVEDYFATYDFEPSVLPAG
EEEECCCCCCCEECEEECCCCCHHHHHEECCCHHHHHHHHHHHHHHHHHCCCCCCCCCCC
A
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: D-Lysine; Pyridoxal 5'-phosphate [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): 1.7 {meso-2,6-diamininoheptanedioate}} [C]

Substrates: meso-2,6-diaminoheptanedioate

Specific reaction: meso-2,6-diaminoheptanedioate = L-lysine + CO2

General reaction: Decarboxylation [C]

Inhibitor: 2, 3-Diaminopropionic acid; Glutamic acid; L-Cystine; L-Lysine; Penicillamine [C]

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1515668 [H]