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The map label for this gene is lrp [H]

Identifier: 197119231

GI number: 197119231

Start: 3289461

End: 3289925

Strand: Direct

Name: lrp [H]

Synonym: Gbem_2858

Alternate gene names: 197119231

Gene position: 3289461-3289925 (Clockwise)

Preceding gene: 197119228

Following gene: 197119232

Centisome position: 71.28

GC content: 58.28

Gene sequence:

>465_bases
ATGATTGACGACATAGACATTCACATACTGGAAATCCTTCAGGAGAAAGCTCGGATCCCGAACGCCGAGGTTGCCCGGCA
AGTCGGTATGGCTCCTTCTGCCGTCTTAGAGCGGATCCGGAAGCTGGAGGAACGCGGCATCGTAGAGGGGTACGAAGTAA
GGCTGAACCCCGTTTGTTTTCACCAGGGGTTAGCCGCCTTCGTTTTCATAGAAGCGGAAGGGAATTCCAGCGAGACGGCC
GAGGCGCTAGCCGGCATGACTTCCGTCCAGGAGGTGCACCAGGTGGTCGGTCCGGACGGTTTCCTGGTGAAGCTGAGAAC
CGCCGACAACGCGACCCTTGCCCGGATTTTGCGCCACCAGATCCAGCCGCTCAAGGGGGTCAAGTCGACCCGCACCCAGA
TCGTCCTGGAGACCGTAAAGGAAACCAGAAGGGTCGATCTGGTGCATGCCGAGCGAGACCTTTAA

Upstream 100 bases:

>100_bases
CACGGGTGAAGGTTTGACAGTATGGGGTGTCTGGCATCAAAAAATTCTTTACAACTGGCATAACAGCGAATACAATTCGC
CCTAGGCGGTGTAAACGAGA

Downstream 100 bases:

>100_bases
CAAGCGACGCAGCGAAGAGCAATTAATAAAGCCAGAGGAGACCTATTCAATGCCGATGTCAGCTTCTTTCAAGGACCGCC
TGTTCCCCCGCATCCCGCAG

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 154; Mature: 154

Protein sequence:

>154_residues
MIDDIDIHILEILQEKARIPNAEVARQVGMAPSAVLERIRKLEERGIVEGYEVRLNPVCFHQGLAAFVFIEAEGNSSETA
EALAGMTSVQEVHQVVGPDGFLVKLRTADNATLARILRHQIQPLKGVKSTRTQIVLETVKETRRVDLVHAERDL

Sequences:

>Translated_154_residues
MIDDIDIHILEILQEKARIPNAEVARQVGMAPSAVLERIRKLEERGIVEGYEVRLNPVCFHQGLAAFVFIEAEGNSSETA
EALAGMTSVQEVHQVVGPDGFLVKLRTADNATLARILRHQIQPLKGVKSTRTQIVLETVKETRRVDLVHAERDL
>Mature_154_residues
MIDDIDIHILEILQEKARIPNAEVARQVGMAPSAVLERIRKLEERGIVEGYEVRLNPVCFHQGLAAFVFIEAEGNSSETA
EALAGMTSVQEVHQVVGPDGFLVKLRTADNATLARILRHQIQPLKGVKSTRTQIVLETVKETRRVDLVHAERDL

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=148, Percent_Identity=35.8108108108108, Blast_Score=97, Evalue=3e-22,
Organism=Escherichia coli, GI1790182, Length=140, Percent_Identity=29.2857142857143, Blast_Score=64, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 17155; Mature: 17155

Theoretical pI: Translated: 6.02; Mature: 6.02

Prosite motif: PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIDDIDIHILEILQEKARIPNAEVARQVGMAPSAVLERIRKLEERGIVEGYEVRLNPVCF
CCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEECHHHH
HQGLAAFVFIEAEGNSSETAEALAGMTSVQEVHQVVGPDGFLVKLRTADNATLARILRHQ
HCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHH
IQPLKGVKSTRTQIVLETVKETRRVDLVHAERDL
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure
MIDDIDIHILEILQEKARIPNAEVARQVGMAPSAVLERIRKLEERGIVEGYEVRLNPVCF
CCCCHHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHCCCCCCCEEEECHHHH
HQGLAAFVFIEAEGNSSETAEALAGMTSVQEVHQVVGPDGFLVKLRTADNATLARILRHQ
HCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCHHHHHHHHHH
IQPLKGVKSTRTQIVLETVKETRRVDLVHAERDL
HHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]