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The map label for this gene is srtN [H]

Identifier: 197119181

GI number: 197119181

Start: 3237979

End: 3238821

Strand: Reverse

Name: srtN [H]

Synonym: Gbem_2808

Alternate gene names: 197119181

Gene position: 3238821-3237979 (Counterclockwise)

Preceding gene: 197119182

Following gene: 197119180

Centisome position: 70.18

GC content: 65.95

Gene sequence:

>843_bases
ATGGATCTCTCCAGGAGTTTCGAACAGGCGGCGGAACTGGTGGCGCAGGCCAAGGCGCTGGTCGTGACCGCCGGAGCTGG
CATGGGGGTGGATTCGGGGCTGCCGGATTTCCGCGGCGACCAGGGGTTCTGGACCGCGTATCCCTTGTACCAGAGGCTCG
GCATCAGCTTCGTCGATGCGGCGAACCCGGAGCATTTCGAGCGCGATCCCCGCTTCGGCTGGGGGTTCTACGGCCACCGC
ACCAACCTGTACCGGGAAACTGTCCCGCACCCGGGCTTCCAACTGCTGCTCGATTGGGCCAAGCGCTGCCGGCTCGACTG
CTTCGTCGCCACCTCCAACGTCGACGGCCAGTTCCAAAAGGCCGGCTTCGCCGCAGACGCCGTGCTGGAATTCCACGGCT
CCATCCATCACCTCCAGTGCACCAGGCCCTGCAGCAGCGCCATCTGGGAGAACAGGGAAGAGTTCCGGATCGACACCGAG
ACAATGCGGGCCGACCATGTCCCGCTTTGCCCCCGTTGCGGTTCATCCGCACGCCCCAACATCCTCATGTTTGGCGATTA
CTGCTGGATCGACGACCGCACCATGCGCCAGCAGGAGCGCTTCCGGCAGTTCCTCTCCCGGCAGGGGGCGGGGAGGATCG
TGGTGGTCGAGATGGGAGCCGGGACCGCCATCCCCACCGTGCGCGCCGCCAGCGAGCGGATCGGCGCCCTGGCCCATGGG
CGCGTCATCAGGATCAACCCGCGCGAGCCGCAGATTTCCAAACCTCACCTCTCCCTTCCCTGCGGAGCCCTGGAGGGGCT
TAACGGAATAGAGGAGATGCTCCGCCTTCGCTCAAGGCCCTGA

Upstream 100 bases:

>100_bases
TTAACGGCGGCAGCCGCGGTTTCCTGGTTTCCATGCCCCCCTCCGAGCTGGTGCGGGTGCTGCAGCCGGTACTGGTGAAA
GTCGGTATCTAGGAGGAGCG

Downstream 100 bases:

>100_bases
AATGAGGGTCCCTTCCTTCGTTGAACCCCGCCGATAAAAAAACCTTGCCATACCAATTCCTTACTGCTAGTATTGCTCAT
TTTTTAGGCAGATAAGGAAC

Product: NAD-dependent protein deacetylase

Products: NA

Alternate protein names: Regulatory protein SIR2 homolog 1 [H]

Number of amino acids: Translated: 280; Mature: 280

Protein sequence:

>280_residues
MDLSRSFEQAAELVAQAKALVVTAGAGMGVDSGLPDFRGDQGFWTAYPLYQRLGISFVDAANPEHFERDPRFGWGFYGHR
TNLYRETVPHPGFQLLLDWAKRCRLDCFVATSNVDGQFQKAGFAADAVLEFHGSIHHLQCTRPCSSAIWENREEFRIDTE
TMRADHVPLCPRCGSSARPNILMFGDYCWIDDRTMRQQERFRQFLSRQGAGRIVVVEMGAGTAIPTVRAASERIGALAHG
RVIRINPREPQISKPHLSLPCGALEGLNGIEEMLRLRSRP

Sequences:

>Translated_280_residues
MDLSRSFEQAAELVAQAKALVVTAGAGMGVDSGLPDFRGDQGFWTAYPLYQRLGISFVDAANPEHFERDPRFGWGFYGHR
TNLYRETVPHPGFQLLLDWAKRCRLDCFVATSNVDGQFQKAGFAADAVLEFHGSIHHLQCTRPCSSAIWENREEFRIDTE
TMRADHVPLCPRCGSSARPNILMFGDYCWIDDRTMRQQERFRQFLSRQGAGRIVVVEMGAGTAIPTVRAASERIGALAHG
RVIRINPREPQISKPHLSLPCGALEGLNGIEEMLRLRSRP
>Mature_280_residues
MDLSRSFEQAAELVAQAKALVVTAGAGMGVDSGLPDFRGDQGFWTAYPLYQRLGISFVDAANPEHFERDPRFGWGFYGHR
TNLYRETVPHPGFQLLLDWAKRCRLDCFVATSNVDGQFQKAGFAADAVLEFHGSIHHLQCTRPCSSAIWENREEFRIDTE
TMRADHVPLCPRCGSSARPNILMFGDYCWIDDRTMRQQERFRQFLSRQGAGRIVVVEMGAGTAIPTVRAASERIGALAHG
RVIRINPREPQISKPHLSLPCGALEGLNGIEEMLRLRSRP

Specific function: Modulates the activities of several enzymes which are inactive in their acetylated form [H]

COG id: COG0846

COG function: function code K; NAD-dependent protein deacetylases, SIR2 family

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 deacetylase sirtuin-type domain [H]

Homologues:

Organism=Homo sapiens, GI300795542, Length=196, Percent_Identity=27.5510204081633, Blast_Score=72, Evalue=5e-13,
Organism=Homo sapiens, GI13787215, Length=199, Percent_Identity=26.6331658291457, Blast_Score=72, Evalue=7e-13,
Organism=Homo sapiens, GI6912664, Length=199, Percent_Identity=26.6331658291457, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI7657575, Length=197, Percent_Identity=28.4263959390863, Blast_Score=68, Evalue=8e-12,
Organism=Drosophila melanogaster, GI17137536, Length=228, Percent_Identity=28.0701754385965, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003000 [H]

Pfam domain/function: PF02146 SIR2 [H]

EC number: 3.5.1.- [C]

Molecular weight: Translated: 31404; Mature: 31404

Theoretical pI: Translated: 7.78; Mature: 7.78

Prosite motif: PS50305 SIRTUIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.9 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDLSRSFEQAAELVAQAKALVVTAGAGMGVDSGLPDFRGDQGFWTAYPLYQRLGISFVDA
CCCCHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCCEEHHHHHHHHCCEEEEC
ANPEHFERDPRFGWGFYGHRTNLYRETVPHPGFQLLLDWAKRCRLDCFVATSNVDGQFQK
CCCHHHCCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCEEEEEEECCCCCCHHH
AGFAADAVLEFHGSIHHLQCTRPCSSAIWENREEFRIDTETMRADHVPLCPRCGSSARPN
CCCHHHHHHHHCCCEEEEEECCCHHHHHHCCCHHEEECHHHHCCCCCCCCCCCCCCCCCC
ILMFGDYCWIDDRTMRQQERFRQFLSRQGAGRIVVVEMGAGTAIPTVRAASERIGALAHG
EEEEECEEEECCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCC
RVIRINPREPQISKPHLSLPCGALEGLNGIEEMLRLRSRP
EEEEECCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHCCC
>Mature Secondary Structure
MDLSRSFEQAAELVAQAKALVVTAGAGMGVDSGLPDFRGDQGFWTAYPLYQRLGISFVDA
CCCCHHHHHHHHHHHHHHEEEEECCCCCCCCCCCCCCCCCCCCEEHHHHHHHHCCEEEEC
ANPEHFERDPRFGWGFYGHRTNLYRETVPHPGFQLLLDWAKRCRLDCFVATSNVDGQFQK
CCCHHHCCCCCCCCCCCCCCCCHHHHCCCCCHHHHHHHHHHHCCEEEEEEECCCCCCHHH
AGFAADAVLEFHGSIHHLQCTRPCSSAIWENREEFRIDTETMRADHVPLCPRCGSSARPN
CCCHHHHHHHHCCCEEEEEECCCHHHHHHCCCHHEEECHHHHCCCCCCCCCCCCCCCCCC
ILMFGDYCWIDDRTMRQQERFRQFLSRQGAGRIVVVEMGAGTAIPTVRAASERIGALAHG
EEEEECEEEECCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCC
RVIRINPREPQISKPHLSLPCGALEGLNGIEEMLRLRSRP
EEEEECCCCCCCCCCCCCCCCHHHHCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]